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However, in most current systems, the registration between imaging modalities is performed manually by vertebral column matching which can be subjective, inaccurate and time consuming depending on experience. Our objective was to evaluate feasibility and accuracy of image-based automated 2D-3D image fusion between preoperative CTA and intraoperative fluoroscopy based on vertebral column matching.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A single-center study with offline procedure data was conducted in 10 consecutive patients which had endovascular aortic repair in which we evaluated unreleased automated fusion software provided by Philips (Best, the Netherlands). Fluoroscopy and digital subtraction angiography images were collected after the procedures and the vertebral column was fused fully automatically. Primary endpoints were feasibility and accuracy of bone alignment (mm). Secondary endpoint was vascular alignment (mm) between the lowest renal artery orifices. Clinical non-inferiority was defined at a mismatch of\u2009&lt;\u20091\u00a0mm.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 87 automated measurements and 40 manual measurements were performed on vertebrae T12\u2013L5 in all 10 patients. Manual correction was needed in 3 of the 10 patients due to incomplete visibility of the vertebral edges in the fluoroscopy image. Median difference between automated fusion and manual fusion was 0.1\u00a0mm for bone alignment (<jats:italic>p<\/jats:italic>\u2009=\u20090.94). The vascular alignment was 4.9\u00a0mm (0.7\u201317.5\u00a0mm) for manual and 5.5\u00a0mm (1.0\u201314.0\u00a0mm) for automated fusion. This did not improve, due to the presence of stiff wires and stent graft.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Automated image fusion was feasible when all vertebral edges were visible. Accuracy was non-inferior to manual image fusion regarding bone alignment. Future developments should focus on intraoperative image-based correction of vascular alignment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11548-023-02832-2","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T14:04:23Z","timestamp":1675173863000},"page":"1533-1541","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Automated image fusion during endovascular aneurysm repair: a feasibility and accuracy study"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-3016","authenticated-orcid":false,"given":"Stefan P. 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