{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:04:40Z","timestamp":1790348680331,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"MEDITWIN Bpifrance i-Demo project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J CARS"],"DOI":"10.1007\/s11548-026-03712-1","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:55:43Z","timestamp":1779447343000},"page":"1379-1386","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Personalization of liver microwave ablation simulation"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-0670","authenticated-orcid":false,"given":"Francesco","family":"Dettori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Nahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Duprez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"issue":"10","key":"3712_CR1","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3348\/kjr.2024.0307","volume":"25","author":"H Rhee","year":"2024","unstructured":"Rhee H, Park YN, Choi J-Y (2024) Advances in understanding hepatocellular carcinoma vasculature: Implications for diagnosis, prognostication, and treatment. Korean J Radiol 25(10):887\u2013901. https:\/\/doi.org\/10.3348\/kjr.2024.0307","journal-title":"Korean J Radiol"},{"issue":"1","key":"3712_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-020-00240-3","volume":"7","author":"JM Llovet","year":"2021","unstructured":"Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS (2021) Hepatocellular carcinoma. Nat Rev Dis Primers 7(1):1\u201328. https:\/\/doi.org\/10.1038\/s41572-020-00240-3","journal-title":"Nat Rev Dis Primers"},{"issue":"8","key":"3712_CR3","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.4254\/wjh.v7.i8.1054","volume":"7","author":"LS Poulou","year":"2015","unstructured":"Poulou LS, Botsa E, Thanou I, Ziakas PD, Thanos L (2015) Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma. World J Hepatol 7(8):1054\u20131063. https:\/\/doi.org\/10.4254\/wjh.v7.i8.1054","journal-title":"World J Hepatol"},{"issue":"4","key":"3712_CR4","doi-asserted-by":"publisher","first-page":"374","DOI":"10.2478\/rjim-2024-0022","volume":"62","author":"I Rey","year":"2024","unstructured":"Rey I, Darmadi D (2024) Comparative efficacy of microwave versus radiofrequency ablation in hepatocellular carcinoma: systematic review and meta-analysis of randomized-controlled trials. Rom J Intern Med 62(4):374\u2013386. https:\/\/doi.org\/10.2478\/rjim-2024-0022","journal-title":"Rom J Intern Med"},{"issue":"12","key":"3712_CR5","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1016\/j.jvir.2014.08.014","volume":"25","author":"RS Winokur","year":"2014","unstructured":"Winokur RS et al (2014) Characterization of in vivo ablation zones following percutaneous microwave ablation of the liver with two commercially available devices: are manufacturer published reference values useful? J Vasc Interv Radiol 25(12):1939\u201319461. https:\/\/doi.org\/10.1016\/j.jvir.2014.08.014","journal-title":"J Vasc Interv Radiol"},{"key":"3712_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1109\/OJEMB.2023.3345733","volume":"5","author":"F Servin","year":"2024","unstructured":"Servin F, Collins JA, Heiselman JS, Frederick-Dyer KC, Planz VB, Geevarghese SK, Brown DB, Jarnagin WR, Miga MI (2024) Simulation of image-guided microwave ablation therapy using a digital twin computational model. IEEE Open J Eng Med Biol 5:107\u2013124. https:\/\/doi.org\/10.1109\/OJEMB.2023.3345733","journal-title":"IEEE Open J Eng Med Biol"},{"issue":"11","key":"3712_CR7","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.3390\/cancers16112095","volume":"16","author":"A Heshmat","year":"2024","unstructured":"Heshmat A, O\u2019Connor CS, Silva AMJ, Paolucci I, Jones AK, Odisio BC, Brock KK (2024) Using patient-specific 3D modeling and simulations to optimize microwave ablation therapy for liver cancer. Cancers 16(11):2095","journal-title":"Cancers"},{"key":"3712_CR8","doi-asserted-by":"publisher","unstructured":"Audigier C, Meister F, Akkari FG, Tonglet A, Frings O, Duran R (2025)Retrospective evaluation of a patient-specific liver digital twin to predict thermal ablation outcomes in HCC. In: digital twin for healthcare: first international workshop, DT4H 2025, Held in Conjunction with MICCAI 2025, Daejeon, South Korea, September 23, 2025, Proceedings, pp. 47\u201357. Springer, Berlin, Heidelberg . https:\/\/doi.org\/10.1007\/978-3-032-07694-6_5","DOI":"10.1007\/978-3-032-07694-6_5"},{"issue":"6","key":"3712_CR9","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1109\/TBME.2019.2939686","volume":"67","author":"JA Collins","year":"2020","unstructured":"Collins JA, Heiselman JS, Clements LW, Weis JA, Brown DB, Miga MI (2020) Toward image data-driven predictive modeling for guiding thermal ablative therapy. IEEE Trans Biomed Eng 67(6):1548\u20131557. https:\/\/doi.org\/10.1109\/TBME.2019.2939686","journal-title":"IEEE Trans Biomed Eng"},{"key":"3712_CR10","doi-asserted-by":"publisher","unstructured":"Baumgartner C, Hasgall PA, Di Gennaro F, Neufeld E, Lloyd B, Gosselin M-C, Payne D, Klingenb\u00f6ck A, Kuster N (2025) IT\u2019IS database for thermal and electromagnetic parameters of biological tissues. https:\/\/doi.org\/10.13099\/VIP21000-05-0","DOI":"10.13099\/VIP21000-05-0"},{"issue":"4","key":"3712_CR11","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1118\/1.4942980","volume":"43","author":"G Deshazer","year":"2016","unstructured":"Deshazer G, Merck D, Hagmann M, Dupuy DE, Prakash P (2016) Physical modeling of microwave ablation zone clinical margin variance. Med Phys 43(4):1764\u20131776. https:\/\/doi.org\/10.1118\/1.4942980","journal-title":"Med Phys"},{"key":"3712_CR12","doi-asserted-by":"publisher","unstructured":"Vaidya N, Baragona M, Lavezzo V, Maessen R, Veroy K (2022) Tuning the pennes perfusion rate to model large vessel cooling effects in hepatic radiofrequency ablation. J Biomech Eng 144(8):084506. https:\/\/doi.org\/10.1115\/1.4053909","DOI":"10.1115\/1.4053909"},{"key":"3712_CR13","doi-asserted-by":"publisher","unstructured":"Tucci C, Trujillo M, Berjano E, Iasiello M, Andreozzi A, Vanoli GP (2021) Pennes\u2019 bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation. Scientific Reports 11, 5272 :https:\/\/doi.org\/10.1038\/s41598-021-84546-6","DOI":"10.1038\/s41598-021-84546-6"},{"issue":"2","key":"3712_CR14","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1152\/jappl.1948.1.2.93","volume":"1","author":"HH Pennes","year":"1948","unstructured":"Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1(2):93\u2013122. https:\/\/doi.org\/10.1152\/jappl.1948.1.2.93","journal-title":"J Appl Physiol"},{"issue":"8","key":"3712_CR15","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1088\/0031-9155\/60\/8\/3287","volume":"60","author":"M Cavagnaro","year":"2015","unstructured":"Cavagnaro M, Pinto R, Lopresto V (2015) Numerical models to evaluate the temperature increase induced by ex vivo microwave thermal ablation. Phys Med Biol 60(8):3287\u20133311. https:\/\/doi.org\/10.1088\/0031-9155\/60\/8\/3287","journal-title":"Phys Med Biol"},{"issue":"17","key":"3712_CR16","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aad9c5","volume":"63","author":"M Ge","year":"2018","unstructured":"Ge M, Jiang H, Huang X, Zhou Y, Zhi D, Zhao G, Chen Y, Wang L, Qiu B (2018) A multi-slot coaxial microwave antenna for liver tumor ablation. Phys Med Biol 63(17):175011. https:\/\/doi.org\/10.1088\/1361-6560\/aad9c5","journal-title":"Phys Med Biol"},{"issue":"2","key":"3712_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/15368378.2020.1741383","volume":"39","author":"S Singh","year":"2020","unstructured":"Singh S, Melnik R (2020) Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions. Electromagn Biol Med 39(2):49\u201388. https:\/\/doi.org\/10.1080\/15368378.2020.1741383","journal-title":"Electromagn Biol Med"},{"issue":"7","key":"3712_CR18","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3109\/02656736.2015.1058429","volume":"31","author":"B Zhang","year":"2015","unstructured":"Zhang B, Moser MAJ, Zhang EM, Luo Y, Zhang W (2015) Numerical analysis of the relationship between the area of target tissue necrosis and the size of target tissue in liver tumours with pulsed radiofrequency ablation. Int J Hyperth 31(7):715\u2013725. https:\/\/doi.org\/10.3109\/02656736.2015.1058429","journal-title":"Int J Hyperth"},{"key":"3712_CR19","series-title":"Robotic interventions, and modeling","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1117\/12.3007856","volume-title":"Medical imaging 2024: image-guided procedures","author":"A Heshmat","year":"2024","unstructured":"Heshmat A, O\u2019Connor CS, Hong J, Silva JAM, Paolucci I, Jones AK, Odisio BC, Brock KK (2024) Comprehensive examination of personalized microwave ablation: exploring the effects of blood perfusion rate and metabolic heat on treatment responses. Medical imaging 2024: image-guided procedures, vol 12928. Robotic interventions, and modeling. SPIE, Bellingham, WA, USA, pp 514\u2013519. https:\/\/doi.org\/10.1117\/12.3007856"},{"issue":"1","key":"3712_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12880-015-0068-x","volume":"15","author":"AA Taha","year":"2015","unstructured":"Taha AA, Hanbury A (2015) Metrics for evaluating 3D medical image segmentation: analysis, selection, and tool. BMC Med Imaging 15(1):29. https:\/\/doi.org\/10.1186\/s12880-015-0068-x","journal-title":"BMC Med Imaging"},{"issue":"9","key":"3712_CR21","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1016\/j.ejrad.2011.07.003","volume":"81","author":"T Kanda","year":"2012","unstructured":"Kanda T, Yoshikawa T, Ohno Y, Kanata N, Koyama H, Takenaka D, Sugimura K (2012) CT hepatic perfusion measurement: comparison of three analytic methods. Eur J Radiol 81(9):2075\u20132079. https:\/\/doi.org\/10.1016\/j.ejrad.2011.07.003","journal-title":"Eur J Radiol"},{"issue":"Pt 2","key":"3712_CR22","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/11866763_47","volume":"9","author":"T Kr\u00f6ger","year":"2006","unstructured":"Kr\u00f6ger T, Altrogge I, Preusser T, Pereira PL, Schmidt D, Weihusen A, Peitgen H-O (2006) Numerical simulation of radio frequency ablation with state dependent material parameters in three space dimensions. Int Conf Med Image Comput Computer-Assist Int MICCAI 9(Pt 2):380\u2013388. https:\/\/doi.org\/10.1007\/11866763_47","journal-title":"Int Conf Med Image Comput Computer-Assist Int MICCAI"}],"container-title":["International Journal of Computer Assisted Radiology and Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-026-03712-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11548-026-03712-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11548-026-03712-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:19:49Z","timestamp":1786108789000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11548-026-03712-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["3712"],"URL":"https:\/\/doi.org\/10.1007\/s11548-026-03712-1","relation":{},"ISSN":["1861-6429"],"issn-type":[{"value":"1861-6429","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Francesco Dettori, Ilias Nahmed, Michel Duprez, Juan Verde, Pablo Alvarez, and St\u00e9phane Cotin declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were conducted at the Institut Hospitalo-Univesrsitaire (IHU) of Strasbourg with the approval of the local ethics committee.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors. Therefore, informed consent was not required.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}