{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:11:56Z","timestamp":1788567116893,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Hand (New York, N,Y.)"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was designed to provide comparative information on the safety and efficacy of injection with collagenase clostridium histolyticum (CCH) and fasciectomy for patients with Dupuytren's contracture (DC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single-center, retrospective, observational, longitudinal chart review was conducted of 25 patients treated with CCH injections and 21 patients undergoing fasciectomy. Patients were assessed at 1 week, monthly for 3 months and then yearly for a minimum of 2 years after treatment for changes in contracture and range of motion, time to return to work\/normal activities, patient satisfaction, and Disabilities of Arm, Shoulder and Hand (DASH) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post-procedure follow-up averaged 32 months for the injection group compared with 39 months for fasciectomy group. For the CCH group, the mean postinjection contracture was 3.6\u00b0 for the metacarpophalangeal and 17.5\u00b0 for the proximal interphalangeal joints compared with 3.7\u00b0 and 8.1\u00b0 in the fasciectomy group, respectively. Patients treated with injections returned to normal activities after a mean of 1.9 days compared with 37.4 days for fasciectomy patients ( p&lt;0.0001). DASH scores for 13 CCH and 15 fasciectomy patients were obtained. The mean DASH score was significantly lower in the injection group in the first 3 months ( p&lt;0.01). At the 2-year follow-up visit, patients were satisfied with their outcomes following either treatment (92 % and 96 % of CCH and fasciectomy patients, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCH injections are safe and effective and may be a viable alternative to fasciectomy for treating DC. It also allows earlier return to work and daily activities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11552-013-9540-7","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T09:20:05Z","timestamp":1371633605000},"page":"410-416","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Functional Outcome of Collagenase Injections Compared with Fasciectomy in Treatment of Dupuytren's Contracture"],"prefix":"10.1177","volume":"8","author":[{"given":"Nash H.","family":"Naam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"bibr1-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1007\/s12570-012-0092-z"},{"key":"bibr2-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410376286"},{"key":"bibr3-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2005.05.008"},{"key":"bibr4-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000205819.53215.52"},{"key":"bibr5-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"bibr6-s11552-013-9540-7","first-page":"116","volume":"10","author":"Denkler K.","year":"2010","journal-title":"Eplasty."},{"key":"bibr7-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2010.510509"},{"key":"bibr8-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-9053(05)80271-6"},{"key":"bibr9-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.08.007"},{"key":"bibr10-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1080\/09638280601125106"},{"key":"bibr11-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"bibr12-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-136"},{"key":"bibr13-s11552-013-9540-7","first-page":"251","volume-title":"Dupuytren's disease","author":"Mackin E.J.","year":"2010"},{"key":"bibr14-s11552-013-9540-7","first-page":"106","volume":"18","author":"Mavrogenis A.F.","year":"2009","journal-title":"J Surg Orthop Adv."},{"key":"bibr15-s11552-013-9540-7","first-page":"159","volume-title":"Green's operative hand surgery","author":"McGrouther D.A.","year":"2005","edition":"5"},{"key":"bibr16-s11552-013-9540-7","first-page":"383","volume":"6","author":"O'Gorman D.B.","year":"2010","journal-title":"Ther Clin Risk Manage."},{"key":"bibr17-s11552-013-9540-7","volume-title":"Xiaflex\u00ae (collagenase clostridium histolyticum) [prescribing information]","author":"Auxilium Pharmaceuticals, Inc.","year":"2012"},{"key":"bibr18-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200701000-00026"},{"key":"bibr19-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2008.05.027"},{"key":"bibr20-s11552-013-9540-7","unstructured":"Skrepnik N.V., Waller P., Kushner H., Nguyen D. Collagenase Clostridium histolyticum therapy for Dupuytren's contracture in Europe, Australia and US. Presented at American Academy of Orthopaedic Surgeons 2011 Annual Meeting, February 15\u201319, 2011, San Diego, CA. Abstract 4601. Available at: http:\/\/www3.aaos.org\/education\/anmeet\/anmt2011\/proceedings.pdf. Accessed July 3, 2012."},{"key":"bibr21-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S8591"},{"key":"bibr22-s11552-013-9540-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-9053(05)80272-8"},{"key":"bibr23-s11552-013-9540-7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1742-1241.1997.tb09644.x","volume":"51","author":"Wilson G.R.","year":"1997","journal-title":"Br J Clin Pract."}],"container-title":["HAND"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s11552-013-9540-7","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1007\/s11552-013-9540-7","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1007\/s11552-013-9540-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:26:02Z","timestamp":1777447562000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1007\/s11552-013-9540-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1007\/s11552-013-9540-7"],"URL":"https:\/\/doi.org\/10.1007\/s11552-013-9540-7","relation":{},"ISSN":["1558-9447","1558-9455"],"issn-type":[{"value":"1558-9447","type":"print"},{"value":"1558-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}