{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:53:11Z","timestamp":1776423191763,"version":"3.51.2"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s11596-011-0470-8","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T12:47:36Z","timestamp":1312634856000},"page":"441-445","source":"Crossref","is-referenced-by-count":8,"title":["Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis"],"prefix":"10.1007","volume":"31","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huawen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,8,7]]},"reference":[{"issue":"1","key":"470_CR1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.annemergmed.2006.08.021","volume":"49","author":"S. Trzeciak","year":"2007","unstructured":"Trzeciak S, Dellinger RP, Parrillo JE, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med, 2007,49(1):88\u201398","journal-title":"Ann Emerg Med"},{"issue":"2","key":"470_CR2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archsurg.1986.01400020082010","volume":"121","author":"J.L. Meakins","year":"1986","unstructured":"Meakins JL, Marshall JG. Multiple organ failure syndrome. Arch Surg, 1986,121(2):196\u2013208","journal-title":"Arch Surg"},{"issue":"6","key":"470_CR3","first-page":"403","volume":"34","author":"Y. Zhuang","year":"2007","unstructured":"Zhuang Y, Zhang YP. Progress in gut-derived sepsis. Int J Surg, 2007,34(6):403\u2013406","journal-title":"Int J Surg"},{"issue":"5","key":"470_CR4","first-page":"322","volume":"13","author":"F. Liu","year":"2004","unstructured":"Liu F, Zheng Z. The mechanisms of radix salviae miltiorrhizae in prevention of left ventricular hypertrophy in spontaneously hypertensive rats. Chin J Emerg Med (Chinese). 2004,13(5):322\u2013324","journal-title":"Chin J Emerg Med (Chinese)"},{"issue":"2","key":"470_CR5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2006.05.004","volume":"108","author":"R. Lin","year":"2006","unstructured":"Lin R, Wang WR, Liu JT, et al. Protective effect of tanshinone A on human umbilical vein II endothelial cell injured by hydrogen peroxide and its mechanism. J Ethnopharmacol, 2006,108(2):217\u2013222","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"470_CR6","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.4049\/jimmunol.178.6.3856","volume":"178","author":"W. Li","year":"2007","unstructured":"Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol, 2007,178(6):3856\u20133864","journal-title":"J Immunol"},{"issue":"5","key":"470_CR7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10875-008-9206-3","volume":"28","author":"Y. Xu","year":"2008","unstructured":"Xu Y, Feng D, Wang Y, et al. Sodium tanshinone II A sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma\/STAT1 pathways. J Clin Immunol, 2008,28(5):512\u2013519","journal-title":"J Clin Immunol"},{"issue":"2","key":"470_CR8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/abbi.1998.0641","volume":"353","author":"D. Zhou","year":"1998","unstructured":"Zhou D. Characterization of a silencer element in the human aromatase gene. Arch Biochem Biophys, 1998, 353(2):213\u2013220","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"470_CR9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/jnnp.73.3.346","volume":"73","author":"J. Kraus","year":"2002","unstructured":"Kraus J, Oschmann P, Leis S, et al. High concentrations of Svcam-1 and sICAM-1 in the cerebrospinal fluid of patients with intracerebral hemorrhage are associated with poor outcome. J Neurot Neurosurg Psychiatry, 2002,73(3):346\u2013347","journal-title":"J Neurot Neurosurg Psychiatry"},{"key":"470_CR10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1084\/jem.178.3.951","volume":"178","author":"J.E. Parrillo","year":"1993","unstructured":"Parrillo JE, Parker MM, Natanson C. Septic shock in human: advances in the understanding of prognosis, cardiovascular dysfunction and therapy. J Exp Med, 1993,178:951\u2013960","journal-title":"J Exp Med"},{"issue":"9","key":"470_CR11","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1097\/01.CCM.0000139617.88704.B9","volume":"32","author":"C. Ince","year":"2004","unstructured":"Ince C. Microcirculation in distress: a new resuscitation end point? Crit Care Med, 2004,32(9):1963\u20131964","journal-title":"Crit Care Med"},{"issue":"Suppl4","key":"470_CR12","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/cc3753","volume":"9","author":"C. Ince","year":"2005","unstructured":"Ince C. The microcirculation is the motor of sepsis. Crit Care, 2005, 9(Suppl 4): S13\u201319","journal-title":"Crit Care"},{"issue":"3","key":"470_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/tropej\/fml021","volume":"52","author":"A. Nawawy","year":"2006","unstructured":"Nawawy A, Ebrahim GJ. Strategies for the treatment of sepsis. J Trop Pediatr, 2006,52(3):153\u2013154","journal-title":"J Trop Pediatr"},{"key":"470_CR14","first-page":"7008","volume":"13","author":"J.R. O\u2019Hara","year":"2008","unstructured":"O\u2019Hara JR, Buret AG. Mechanisms of intestinal tight junctional disruption during infection. Front Biosc, 2008,13:7008\u20137021","journal-title":"Front Biosc"},{"key":"470_CR15","doi-asserted-by":"crossref","first-page":"L622","DOI":"10.1152\/ajplung.00477.2005","volume":"290","author":"S.F. Liu","year":"2006","unstructured":"Liu SF, Malik AB. NF-\u03baB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol, 2006,290:L622\u2013645","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"470_CR16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11655-008-0051-2","volume":"14","author":"J. Wang","year":"2008","unstructured":"Wang J, Qiao LF, Yang GT. Role of Shenfu injection in rats with systemic inflammatory response syndrome. Chin J Integr Med, 2008,14(1):51\u201355","journal-title":"Chin J Integr Med"},{"issue":"3","key":"470_CR17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(06)69005-3","volume":"5","author":"K.A. Brown","year":"2006","unstructured":"Brown KA, Brain SD, Pearson JD, et al. Neutrophils in development of multiple organ failure in sepsis. Lancet, 2006,5(3):157\u2013169","journal-title":"Lancet"},{"issue":"10","key":"470_CR18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1056\/NEJM200103083441009","volume":"344","author":"M.A. Matthay","year":"2001","unstructured":"Matthay MA. Severe sepsis\u2014a new treatment with both anticoagulant and antiinflammatory properties. N Engl J Med, 2001,344(10):759\u2013762","journal-title":"N Engl J Med"},{"issue":"4","key":"470_CR19","first-page":"435","volume":"21","author":"F. Zhao","year":"2008","unstructured":"Zhao F, Zheng SY, Xu JG. Tissue factor and sepsis. J Med Postgraduate, 2008,21(4):435\u2013437","journal-title":"J Med Postgraduate"},{"issue":"1\u20133","key":"470_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.04.044","volume":"542","author":"S.I. Jang","year":"2006","unstructured":"Jang SI, Kim HJ, Kin YJ, et al. Tanshinone II A inhibits LPS-induced NF-\u03baB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1\/2, p38 and JNK Pathways. Eur J Pharmacol, 2006,542(1\u20133):1\u20137","journal-title":"Eur J Pharmacol"},{"key":"470_CR21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2009.12.046","volume":"1321","author":"L. Wang","year":"2010","unstructured":"Wang L, Zhang X, Liu L, et al. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Res, 2010,1321:143\u2013151","journal-title":"Brain Res"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-011-0470-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-011-0470-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-011-0470-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T17:15:09Z","timestamp":1559409309000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-011-0470-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["470"],"URL":"https:\/\/doi.org\/10.1007\/s11596-011-0470-8","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}