{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:09:32Z","timestamp":1762160972619},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s11596-012-0062-2","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T08:50:46Z","timestamp":1339145446000},"page":"358-363","source":"Crossref","is-referenced-by-count":8,"title":["Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian cancer cells by down-regulating Akt phosphorylation"],"prefix":"10.1007","volume":"32","author":[{"given":"Xiangyi","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danfeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kezhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongrui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,9]]},"reference":[{"issue":"1","key":"62_CR1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2005.10.034","volume":"124","author":"S.S. Foo","year":"2006","unstructured":"Foo SS, Turner CJ, Adams S, et al. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell, 2006,124(1):161\u2013173","journal-title":"Cell"},{"issue":"1","key":"62_CR2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1182\/blood-2008-02-140020","volume":"113","author":"J.S. Scehnet","year":"2009","unstructured":"Scehnet JS, Ley EJ, Krasnoperov V, et al. The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. Blood, 2009, 113(1):254\u2013263","journal-title":"Blood"},{"issue":"15","key":"62_CR3","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1073\/pnas.0401381101","volume":"101","author":"N.K. Noren","year":"2004","unstructured":"Noren NK, Lu M, Freeman AL, et al. Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci USA, 2004, 101(15):5583\u20135588","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"62_CR4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjc.6604216","volume":"98","author":"S.M. Alam","year":"2008","unstructured":"Alam SM, Fujimoto J, Jahan I, et al. Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers. Br J Cancer, 2008,98(4):845\u2013851","journal-title":"Br J Cancer"},{"issue":"12","key":"62_CR5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ncb2122","volume":"12","author":"J.W. Astin","year":"2010","unstructured":"Astin JW, Batson J, Kadir S, et al. Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells. Nat Cell Biol, 2010,12(12):1194\u20131204","journal-title":"Nat Cell Biol"},{"issue":"2","key":"62_CR6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0002-9440(10)62998-7","volume":"167","author":"M. Nakada","year":"2005","unstructured":"Nakada M, Niska JA, Tran NL, et al. EphB2\/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am J Pathol, 2005,167(2):565\u2013576","journal-title":"Am J Pathol"},{"issue":"20","key":"62_CR7","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1073\/pnas.211430998","volume":"98","author":"J.R. Testa","year":"2001","unstructured":"Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA, 2001,98(20): 10983\u201310985","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"62_CR8","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1158\/1535-7163.MCT-10-0200","volume":"9","author":"W.A. Spannuth","year":"2010","unstructured":"Spannuth WA, Mangala LS, Stone RL, et al. Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma. Mol Cancer Ther, 2010,9(8):2377\u20132388","journal-title":"Mol Cancer Ther"},{"issue":"20","key":"62_CR9","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1021\/jm9009444","volume":"52","author":"K. Lafleur","year":"2009","unstructured":"Lafleur K, Huang D, Zhou T, et al. Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem, 2009, 52(20):6433\u20136446","journal-title":"J Med Chem"},{"issue":"18","key":"62_CR10","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1158\/0008-5472.CAN-09-0706","volume":"69","author":"H. Dopeso","year":"2009","unstructured":"Dopeso H, Mateo-Lozano S, Mazzolini R, et al. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res, 2009, 69(18):7430\u20137438","journal-title":"Cancer Res"},{"issue":"9","key":"62_CR11","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1182\/blood-2009-01-201954","volume":"114","author":"A. Pennisi","year":"2009","unstructured":"Pennisi A, Ling W, Li X, et al. The ephrinB2\/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth. Blood, 2009,114(9):1803\u20131812","journal-title":"Blood"},{"issue":"1","key":"62_CR12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2005.11.034","volume":"102","author":"Q. Wu","year":"2006","unstructured":"Wu Q, Suo Z, Kristensen GB, et al. The prognostic impact of EphB2\/B4 expression on patients with advanced ovarian carcinoma. Gynecol Oncol, 2006,102(1):15\u201321","journal-title":"Gynecol Oncol"},{"issue":"5","key":"62_CR13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/sj.onc.1209108","volume":"25","author":"G. Xia","year":"2006","unstructured":"Xia G, Kumar SR, Stein JP, et al. EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival. Oncogene, 2006,25(5):769\u2013780","journal-title":"Oncogene"},{"issue":"46","key":"62_CR14","doi-asserted-by":"crossref","first-page":"43830","DOI":"10.1074\/jbc.M207221200","volume":"277","author":"J.J. Steinle","year":"2002","unstructured":"Steinle JJ, Meininger CJ, Forough R, et al. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway. J Biol Chem, 2002,277(46):43830\u201343835","journal-title":"J Biol Chem"},{"issue":"19","key":"62_CR15","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/sj.onc.1203598","volume":"19","author":"Z.Q. Yuan","year":"2000","unstructured":"Yuan ZQ, Sun M, Feldman RI, et al. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase\/Akt pathway in human ovarian cancer. Oncogene, 2000,19(19):2324\u20132330","journal-title":"Oncogene"},{"issue":"10","key":"62_CR16","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","volume":"23","author":"I. Hers","year":"2011","unstructured":"Hers I, Vincent EE, Tavar\u00e9 JM. Akt signalling in health and disease. Cell Signal, 2011,23(10):1515\u20131527","journal-title":"Cell Signal"},{"issue":"19","key":"62_CR17","doi-asserted-by":"crossref","first-page":"9267","DOI":"10.1073\/pnas.89.19.9267","volume":"89","author":"J.Q. Cheng","year":"1992","unstructured":"Cheng JQ, Godwin AK, Bellacosa A, et al. AKT2, a putative oncogene encoding a member of a subfamily of proteinserine\/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA, 1992,89(19):9267\u20139271","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"62_CR18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1074\/jbc.M601698200","volume":"282","author":"J. Radeff-Huang","year":"2007","unstructured":"Radeff-Huang J, Seasholtz TM, Chang JW, et al. TNF-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent AKT activation and cyclin D expression. J Biol Chem, 2007,282(2): 863\u2013870","journal-title":"J Biol Chem"},{"issue":"24","key":"62_CR19","doi-asserted-by":"crossref","first-page":"23371","DOI":"10.1074\/jbc.M413839200","volume":"280","author":"J.P. Huddleson","year":"2005","unstructured":"Huddleson JP, Ahmad N, Srinivasan S, et al. Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a phosphatidylinositol 3-kinase-dependent chromatin-remodeling pathway. J Biol Chem, 2005,280(24):23371\u201323379","journal-title":"J Biol Chem"},{"key":"62_CR20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1465-9921-7-101","volume":"27","author":"Q. Tong","year":"2006","unstructured":"Tong Q, Zheng L, Lin L, et al. Participation of the PI-3K\/Akt-NF-kappaB signaling pathways in hypoxia-induced mitogenic factor-stimulated Flk-1 expression in endothelial cells. Respir Res, 2006,27:101","journal-title":"Respir Res"},{"issue":"6","key":"62_CR21","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1074\/jbc.M608487200","volume":"282","author":"C. Wu","year":"2007","unstructured":"Wu C, Huang J. PI3 kinase-AKT-mTOR pathway is essential for neuroendocrine differentiation of prostate cancer. J Biol Chem, 2007,282(6):3571\u20133583","journal-title":"J Biol Chem"},{"issue":"4","key":"62_CR22","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/sj.onc.1208099","volume":"24","author":"Y. Chen","year":"2005","unstructured":"Chen Y, Rodrik V, Foster DA. Alternative phospholipase D\/mTOR survival signal in human breast cancer cells. Oncogene, 2005,24(4):672\u2013679","journal-title":"Oncogene"},{"issue":"2","key":"62_CR23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1152\/ajpcell.00422.2003","volume":"287","author":"N. Gao","year":"2004","unstructured":"Gao N, Flynn DC, Zhang Z, et al. G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K\/AKT\/mTOR\/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol, 2004,287(2): 281\u2013291","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"62_CR24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/ijc.21932","volume":"119","author":"C.S. Beevers","year":"2006","unstructured":"Beevers CS, Li F, Liu L, et al. Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer, 2006,119(4): 757\u2013764","journal-title":"Int J Cancer"},{"issue":"13","key":"62_CR25","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/sj.onc.1209990","volume":"26","author":"X. Wan","year":"2007","unstructured":"Wan X, Harkavy B, Shen N, et al. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene, 2007,26(13): 1932\u20131940","journal-title":"Oncogene"},{"issue":"1","key":"62_CR26","first-page":"275","volume":"14","author":"X. Ma","year":"2005","unstructured":"Ma X, Wang S, Zhou J, et al. Induction of apoptosis in human ovarian epithelial cancer cells by antisurvivin oligonucleotides. Oncol Rep, 2005,14(1):275\u2013279","journal-title":"Oncol Rep"},{"issue":"22","key":"62_CR27","doi-asserted-by":"crossref","first-page":"23166","DOI":"10.1074\/jbc.M401238200","volume":"279","author":"D. Shegogue","year":"2004","unstructured":"Shegogue D, Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem 2004,279(22):23166\u201323175","journal-title":"J Biol Chem"},{"issue":"13","key":"62_CR28","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/nar\/28.13.2597","volume":"28","author":"M.J. Lehmann","year":"2000","unstructured":"Lehmann MJ, Patzel V, Sczakiel G. Theoretical design of antisense genes with statistically increased efficacy. Nucleic Acids Res, 2000,28(13):2597\u20132604","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"62_CR29","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1158\/1535-7163.MCT-05-0453","volume":"5","author":"D. Koul","year":"2006","unstructured":"Koul D, Shen R, Bergh S, et al. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. Mol Cancer Ther, 2006 5(3):637\u2013644","journal-title":"Mol Cancer Ther"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-012-0062-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-012-0062-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-012-0062-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T13:15:13Z","timestamp":1559394913000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-012-0062-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["62"],"URL":"https:\/\/doi.org\/10.1007\/s11596-012-0062-2","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}