{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:41:32Z","timestamp":1771036892807,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s11596-014-1278-0","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T02:48:15Z","timestamp":1403146095000},"page":"330-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fucoidan induces apoptosis of HepG2 cells by down-regulating p-Stat3"],"prefix":"10.1007","volume":"34","author":[{"given":"Sadia","family":"Roshan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Banafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-xiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-xiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-yuan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"issue":"8","key":"1278_CR1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","volume":"13","author":"B Li","year":"2008","unstructured":"Li B, Lu F, Wei XJ, et al. Fucoidan: structure and bioactivity. Molecules, 2008, 13(8):1671\u20131695","journal-title":"Molecules"},{"issue":"1\u20132","key":"1278_CR2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0008-6215(99)00148-2","volume":"320","author":"AO Chizhov","year":"1999","unstructured":"Chizhov AO, Dell A, Morris HR, et al. A study of fucoidan from the brown seaweed Chorda filum. Carbohydr Resh, 1999, 320(1\u20132):108\u2013119","journal-title":"Carbohydr Resh"},{"issue":"2","key":"1278_CR3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijbiomac.2007.10.003","volume":"42","author":"J Wang","year":"2008","unstructured":"Wang J, Zhang QB, Zhang ZS, et al. Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica. Int J Biol Macromol, 2008, 42(2): 127\u2013132","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"1278_CR4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2249.2004.02462.x","volume":"136","author":"S Matsumoto","year":"2004","unstructured":"Matsumoto S, Nagaoka M, Hara T, et al. Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the downregulation of interleukin-6 production on colonic epithelial cells. Clin Exp Immunol, 2004, 136(3):432\u2013439","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"1278_CR5","first-page":"12","volume":"53","author":"I Makarenkova","year":"2008","unstructured":"Makarenkova I, Kompanets GG, Besednova NN, et al. Inhibiting effects of fucoidans on Hantaan virus adsorption on a model of peritoneal macrophages in vitro. Vopr Virusol, 2008, 53(3):12\u201315","journal-title":"Vopr Virusol"},{"issue":"1","key":"1278_CR6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.intimp.2007.10.017","volume":"8","author":"K Hayashi","year":"2008","unstructured":"Hayashi K, Nakano T, Hashimoto M, et al. Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection. Int Immunopharmacol, 2008, 8(1):109\u2013116","journal-title":"Int Immunopharmacol"},{"issue":"20","key":"1278_CR7","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.lfs.2006.06.031","volume":"79","author":"MJ Kwon","year":"2006","unstructured":"Kwon MJ, Nam TJ. Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines. Life Sci, 2006, 79(20):1956\u20131962","journal-title":"Life Sci"},{"issue":"8","key":"1278_CR8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0008-6215(02)00053-8","volume":"337","author":"MI Bilan","year":"2002","unstructured":"Bilan MI, Grachev AA, Ustuzhanina NE, et al. Structure of a fucoidan from the brown seaweed Fucus evanescens C. Ag. Carbohydr Res, 2002, 337(8):719\u2013730","journal-title":"Carbohydr Res"},{"issue":"1","key":"1278_CR9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ajh.20182","volume":"78","author":"Y Aisa","year":"2005","unstructured":"Aisa Y, Miyakawa Y, Nakazato T, et al. Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways. Am J Hematol, 2005, 78(1):7\u201314","journal-title":"Am J Hematol"},{"issue":"3","key":"1278_CR10","first-page":"181","volume":"29","author":"A Philchenkov","year":"2007","unstructured":"Philchenkov A, Zavelevich M, Imbs T, et al. Sensitization of human malignant lymphoid cells to etoposide by fucoidan, a brown seaweed polysaccharide. Exp Oncol, 2007, 29(3):181\u2013185","journal-title":"Exp Oncol"},{"issue":"7","key":"1278_CR11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/ptr.3489","volume":"25","author":"HJ Boo","year":"2011","unstructured":"Boo HJ, Hyun JH, Kim SC, et al. Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells. Phytother Res, 2011, 25(7):1082\u20131086","journal-title":"Phytother Res"},{"issue":"3","key":"1278_CR12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/01635580802567133","volume":"61","author":"T Nagamine","year":"2009","unstructured":"Nagamine T, Hayakawa K, Kusakabe T, et al. Inhibitory effect of fucoidan on Huh7 hepatoma cells through downregulation of CXCL12. Nutr Cancer, 2009, 61(3):340\u2013347","journal-title":"Nutr Cancer"},{"issue":"10","key":"1278_CR13","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.ejca.2004.02.027","volume":"40","author":"AK Nowak","year":"2004","unstructured":"Nowak AK, Chow PK, Findlay M. Systemic therapy for advanced hepatocellular carcinoma: a review. Eur J Cancer, 2004, 40(10):1474\u20131484","journal-title":"Eur J Cancer"},{"issue":"2","key":"1278_CR14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-483X(02)00253-6","volume":"181","author":"XW Wang","year":"2002","unstructured":"Wang XW, Hussain SP, Huo TI, et al. Molecular pathogenesis of human hepatocellular carcinoma. Toxicology, 2002, 181(2):43\u201347","journal-title":"Toxicology"},{"issue":"12","key":"1278_CR15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1470-2045(03)01277-4","volume":"4","author":"W Hu","year":"2003","unstructured":"Hu W, Kavanagh JJ. Anticancer therapy targeting the apoptotic pathway. Lancet Oncol, 2003, 4(12):721\u2013729","journal-title":"Lancet Oncol"},{"issue":"4","key":"1278_CR16","first-page":"537","volume":"1","author":"S Fukahori","year":"2008","unstructured":"Fukahori S, Yano H, Akiba J, et al. Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro. Mol Med Report, 2008, 1(4):537\u2013542","journal-title":"Mol Med Report"},{"issue":"2","key":"1278_CR17","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1207\/s15327914nc5202_9","volume":"52","author":"K Haneji","year":"2005","unstructured":"Haneji K, Matsuda T, Tomita M, et al. Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. Nutr Cancer, 2005, 52(2):189\u2013201","journal-title":"Nutr Cancer"},{"issue":"3A","key":"1278_CR18","first-page":"1213","volume":"16","author":"D Riou","year":"1996","unstructured":"Riou D, Colliec-Jouault S, Pinczon du Sel D, et al. Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line. Anticancer Res, 1996, 16(3A):1213\u20131218","journal-title":"Anticancer Res"},{"issue":"4","key":"1278_CR19","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbrc.2009.02.124","volume":"381","author":"W Liu","year":"2009","unstructured":"Liu W, Huang XF, Qi Q, et al. Asparanin A induces G(2)M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochem Biophys Res Commun, 2009, 381(4): 700\u2013705","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"1278_CR20","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1016\/j.febslet.2006.05.072","volume":"580","author":"J Neuzil","year":"2006","unstructured":"Neuzil J, Wang XF, Dong LF, et al. Molecular mechanism of mitocan-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS lett, 2006, 580(22): 5125\u20135129","journal-title":"FEBS lett"},{"issue":"1","key":"1278_CR21","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fct.2009.10.021","volume":"48","author":"M Sharma","year":"2010","unstructured":"Sharma M, Agrawal SK, Sharma PR, et al. Cytotoxic and apoptotic activity of essential oil from Ocimumviride towards COLO 205 cells. Food Chem Toxicol, 2010, 48(1): 336\u2013344","journal-title":"Food Chem Toxicol"},{"issue":"6802","key":"1278_CR22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35030140","volume":"407","author":"P Huang","year":"2000","unstructured":"Huang P, Feng L, Oldham EA, et al. Superoxide dismutase as a target for the selective killing of cancer cells. Nature, 2000, 407(6802):390\u2013395","journal-title":"Nature"},{"key":"1278_CR23","volume-title":"Selective elimination of cancer cells by PEITC: biological basis and therapeutic implications","author":"D Trachootham","year":"2008","unstructured":"Trachootham D. Selective elimination of cancer cells by PEITC: biological basis and therapeutic implications. 2008."},{"key":"1278_CR24","first-page":"9","volume":"2","author":"G Dewson","year":"2010","unstructured":"Dewson G, Kluck RM. Bcl-2 family-regulated apoptosis in health and disease. Cell Health Cytoskel, 2010, 2:9\u201322","journal-title":"Cell Health Cytoskel"},{"issue":"1","key":"1278_CR25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.canlet.2008.07.033","volume":"273","author":"FJ Reyes-Zurita","year":"2009","unstructured":"Reyes-Zurita FJ, Rufino-Palomares EE, Lupianez JA, et al. Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. Cancer lett, 2009, 273(1):44\u201354","journal-title":"Cancer lett"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-014-1278-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-014-1278-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-014-1278-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T13:11:03Z","timestamp":1559394663000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-014-1278-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["1278"],"URL":"https:\/\/doi.org\/10.1007\/s11596-014-1278-0","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}