{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T01:40:28Z","timestamp":1654220428142},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s11596-016-1539-1","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T10:49:38Z","timestamp":1454410178000},"page":"41-47","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Peroxisome proliferator-activated receptor-\u03b3 agonist pioglitazone fails to attenuate renal fibrosis caused by unilateral ureteral obstruction in mice"],"prefix":"10.1007","volume":"36","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-dan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"issue":"11","key":"1539_CR1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","volume":"21","author":"M Zeisberg","year":"2010","unstructured":"Zeisberg M, Neilson EG. Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol, 2010,21(11):1819\u20131834","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"1539_CR2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1681\/ASN.2005070757","volume":"17","author":"M Nangaku","year":"2006","unstructured":"Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol, 2006,17(1):17\u201325","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1539_CR3","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1681\/ASN.2010050510","volume":"22","author":"AC Chung","year":"2011","unstructured":"Chung AC, Lan HY. Chemokines in renal injury. J Am Soc Nephrol, 2011,22(5):802\u2013809","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"1539_CR4","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1097\/00007890-199906270-00008","volume":"67","author":"JR Piccotti","year":"1999","unstructured":"Piccotti JR, Li K, Chan SY, et al. Cytokine regulation of chronic cardiac allograft rejection: evidence against a role for Th1 in the disease process. Transplantation, 1999,67(12):1548\u20131555","journal-title":"Transplantation"},{"key":"1539_CR5","volume-title":"Transpl Res","author":"SM Kim","year":"2015","unstructured":"Kim SM, Lee SH, Lee A, et al. Targeting T helper 17 by mycophenolate mofetil attenuates diabetic nephropathy progression. Transpl Res, 2015"},{"issue":"12","key":"1539_CR6","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1681\/ASN.2015040469","volume":"26","author":"N Sakai","year":"2015","unstructured":"Sakai N, Wada T. T Helper 2 cytokine signaling in bone marrow-derived fibroblasts: A target for renal fibrosis. J Am Soc Nephrol, 2015,26(12):2896\u20132898","journal-title":"J Am Soc Nephrol"},{"issue":"1\u20132","key":"1539_CR7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cellimm.2014.04.002","volume":"289","author":"C Jun","year":"2014","unstructured":"Jun C, Ke W, Qingshu L, et al. Protective effect of CD4(+)CD25(high)CD127(low) regulatory T cells in renal ischemia-reperfusion injury. Cell Immunol, 2014,289(1\u20132):106\u2013111","journal-title":"Cell Immunol"},{"issue":"4","key":"1539_CR8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ki.2010.177","volume":"78","author":"TT Tapmeier","year":"2010","unstructured":"Tapmeier TT, Fearn A, Brown K, et al. Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int, 2010,78(4):351\u2013362","journal-title":"Kidney Int"},{"issue":"4","key":"1539_CR9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000343283","volume":"36","author":"L Liu","year":"2012","unstructured":"Liu L, Kou P, Zeng Q, et al. CD4+ T lymphocytes, especially Th2 cells, contribute to the progress of renal fibrosis. Am J Nephrol, 2012,36(4):386\u2013396","journal-title":"Am J Nephrol"},{"issue":"3","key":"1539_CR10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00365513.2011.652158","volume":"72","author":"FJ Lin","year":"2012","unstructured":"Lin FJ, Jiang GR, Shan JP, et al. Imbalance of regulatory T cells to Th17 cells in IgA nephropathy. Scand J Clin Lab Invest, 2012,72(3):221\u2013229","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"1539_CR11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7727\/wimj.2014.008","volume":"63","author":"Z Wenbin","year":"2014","unstructured":"Wenbin Z, Guojun G. Resveratrol ameliorates diabetes-induced renal damage through regulating the expression of TGF-beta1, collagen IV and Th17\/Treg-related cytokines in rats. West Indian Med J, 2014,63(1):20\u201325","journal-title":"West Indian Med J"},{"issue":"12","key":"1539_CR12","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.intimp.2011.08.015","volume":"11","author":"Y Li","year":"2011","unstructured":"Li Y, Shi Y, Huang Z, et al. CNI induced Th17\/Treg imbalance and susceptibility to renal dysfunction in renal transplantation. Int Immunopharmacol, 2011,11 (12): 2033\u20132038","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"1539_CR13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.tem.2012.03.001","volume":"23","author":"B Cariou","year":"2012","unstructured":"Cariou B, Charbonnel B, Staels B. Thiazolidinediones and PPARgamma agonists: time for a reassessment. Trends Endocrinol Metab, 2012,23(5):205\u2013215","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"1539_CR14","doi-asserted-by":"crossref","first-page":"F1263","DOI":"10.1152\/ajprenal.00475.2009","volume":"298","author":"YJ Lee","year":"2010","unstructured":"Lee YJ, Han HJ. Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K\/Akt, GSK-3beta, Snail1, and beta-catenin in renal proximal tubule cells. Am J Physiol Renal Physiol, 2010,298(5):F1263\u2013F1275","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"1539_CR15","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1055\/s-0032-1314836","volume":"44","author":"F Pistrosch","year":"2012","unstructured":"Pistrosch F, Passauer J, Herbrig K, et al. Effect of thiazolidinedione treatment on proteinuria and renal hemodynamic in type 2 diabetic patients with overt nephropathy. Horm Metab Res, 2012,44(12):914\u2013918","journal-title":"Horm Metab Res"},{"issue":"4","key":"1539_CR16","first-page":"240","volume":"46","author":"KC Huang","year":"2014","unstructured":"Huang KC, Cherng YG, Chen LJ, et al. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Horm Metab Res, 2014,46(4):240\u2013244","journal-title":"Horm Metab Res"},{"issue":"1","key":"1539_CR17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1523-1755.2005.00416.x","volume":"68","author":"R Agarwal","year":"2005","unstructured":"Agarwal R, Saha C, Battiwala M, et al. A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy. Kidey Int, 2005,68(1):285\u2013292","journal-title":"Kidey Int"},{"issue":"1","key":"1539_CR18","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1681\/ASN.2007060678","volume":"19","author":"CA Schneider","year":"2008","unstructured":"Schneider CA, Ferrannini E, Defronzo R, et al. Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney disease. J Am Soc Nephrol, 2008,19(1): 182\u2013187","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"1539_CR19","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1681\/ASN.2008111138","volume":"20","author":"HC Yang","year":"2009","unstructured":"Yang HC, Deleuze S, Zuo Y, et al. The PPARgamma agonist pioglitazone ameliorates aging-related progressive renal injury. J Am Soc Nephrol, 2009,20(11): 2380\u20132388","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"1539_CR20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jat.2818","volume":"34","author":"CR Jesse","year":"2014","unstructured":"Jesse CR, Bortolatto CF, Wilhelm EA, et al. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone protects against cisplatin-induced renal damage in mice. J Appl Toxicol, 2014,34(1):25\u201332","journal-title":"J Appl Toxicol"},{"issue":"1","key":"1539_CR21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jss.2012.01.012","volume":"178","author":"H Hu","year":"2012","unstructured":"Hu H, Zou C, Xi X, et al. Protective effects of pioglitazone on renal ischemia-reperfusion injury in mice. J Surg Res, 2012,178(1):460\u2013465","journal-title":"J Surg Res"},{"issue":"3","key":"1539_CR22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1440-1797.2009.01253.x","volume":"15","author":"K Higashi","year":"2010","unstructured":"Higashi K, Oda T, Kushiyama T, et al. Additive antifibrotic effects of pioglitazone and candesartan on experimental renal fibrosis in mice. Nephrology (Carlton), 2010,15(3):327\u2013335","journal-title":"Nephrology (Carlton)"},{"issue":"1","key":"1539_CR23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3346\/jkms.2010.25.1.35","volume":"25","author":"JY Han","year":"2010","unstructured":"Han JY, Kim YJ, Kim L, et al. PPARgamma agonist and angiotensin II receptor antagonist ameliorate renal tubulointerstitial fibrosis. J Korean Med Sci, 2010,25(1):35\u201341","journal-title":"J Korean Med Sci"},{"issue":"10","key":"1539_CR24","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jacc.2008.04.055","volume":"52","author":"G Orasanu","year":"2008","unstructured":"Orasanu G, Ziouzenkova O, Devchand PR, et al. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol, 2008,52(10):869\u2013881","journal-title":"J Am Coll Cardiol"},{"issue":"13","key":"1539_CR25","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/eurheartj\/ehl079","volume":"27","author":"FM Martens","year":"2006","unstructured":"Martens FM, Rabelink TJ, Op TRJ, et al. TNF-alpha induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR-gamma agonist pioglitazone. Eur Heart J, 2006,27(13):1605\u20131609","journal-title":"Eur Heart J"},{"issue":"2","key":"1539_CR26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1183\/09031936.00187812","volume":"43","author":"S Lea","year":"2014","unstructured":"Lea S, Plumb J, Metcalfe H, et al. The effect of peroxisome proliferator-activated receptor-gamma ligands on in vitro and in vivo models of COPD. Eur Respir J, 2014,43(2):409\u2013420","journal-title":"Eur Respir J"},{"issue":"7404","key":"1539_CR27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","volume":"486","author":"D Cipolletta","year":"2012","unstructured":"Cipolletta D, Feuerer M, Li A, et al. PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature, 2012,486(7404):549\u2013553","journal-title":"Nature"},{"issue":"2","key":"1539_CR28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00262-012-1324-3","volume":"62","author":"SK Bunt","year":"2013","unstructured":"Bunt SK, Mohr AM, Bailey JM, et al. Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. Cancer Immunol Immunother, 2013,62(2):225\u2013236","journal-title":"Cancer Immunol Immunother"},{"issue":"3","key":"1539_CR29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/01.MIB.0000160770.94199.9b","volume":"11","author":"KL Schaefer","year":"2005","unstructured":"Schaefer KL, Denevich S, Ma C, et al. Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor-gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms. Inflamm Bowel Dis, 2005,11(3):244\u2013252","journal-title":"Inflamm Bowel Dis"},{"key":"1539_CR30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2014.02.023","volume":"730","author":"P Ochodnicky","year":"2014","unstructured":"Ochodnicky P, Mesarosova L, Cernecka H, et al. Pioglitazone, a PPARgamma agonist, provides comparable protection to angiotensin converting enzyme inhibitor ramipril against adriamycin nephropathy in rat. Eur J Pharmacol, 2014,730:51\u201360","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"1539_CR31","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1681\/ASN.V961008","volume":"9","author":"S Shappell","year":"1998","unstructured":"Shappell S, Gurpinar T, Lechago J, et al. Chronic obstructive uropathy in severe combined immunodeficient (SCID) mice: lymphocyte infiltration is not required for progressive tubulointerstitial injury. J Am Soc Nephrol, 1998,9(6):1008\u20131017","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"1539_CR32","first-page":"5388","volume":"8","author":"P Cheng","year":"2015","unstructured":"Cheng P, Zhang Y, Huang H, et al. Association between CCR6 and rheumatoid arthritis: a meta-analysis. Int J Clin Exp Med, 2015,8(4):5388\u20135396","journal-title":"Int J Clin Exp Med"},{"key":"1539_CR33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2045-3701-5-5","volume":"5","author":"P Cheng","year":"2015","unstructured":"Cheng P, Sun XY, Yin DL, et al. Nanog down-regulates the Wnt signaling pathway via \u03b2-catenin phosphorylation during epidermal stem cell proliferation and differentiation. Cell Biosci, 2015,5:5","journal-title":"Cell Biosci"},{"issue":"2","key":"1539_CR34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4049\/jimmunol.169.2.929","volume":"169","author":"S Henri","year":"2002","unstructured":"Henri S, Chevillard C, Mergani A, et al. Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease. J Immunol, 2002,169(2):929\u2013936","journal-title":"J Immunol"},{"issue":"2","key":"1539_CR35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000073718","volume":"132","author":"A Saito","year":"2003","unstructured":"Saito A, Okazaki H, Sugawara I, et al. Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol, 2003,132(2): 168\u2013176","journal-title":"Int Arch Allergy Immunol"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1539-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-016-1539-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1539-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T01:08:25Z","timestamp":1654218505000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-016-1539-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["1539"],"URL":"https:\/\/doi.org\/10.1007\/s11596-016-1539-1","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}