{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:01:48Z","timestamp":1784091708280,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s11596-016-1545-3","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T10:49:38Z","timestamp":1454410178000},"page":"77-81","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of BRAFV600E mutation on Na+\/I- symporter expression in papillary thyroid carcinoma"],"prefix":"10.1007","volume":"36","author":[{"given":"Hong","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-jing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-lin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,3]]},"reference":[{"issue":"3","key":"1545_CR1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.suc.2014.03.004","volume":"94","author":"DC Yoo","year":"2014","unstructured":"Yoo DC, Noto RB, Mazzaglia PJ. Controversy over radioiodine ablation in thyroid cancer: who benefits? Surg Clin North Am, 2014,94(3):573\u2013586","journal-title":"Surg Clin North Am"},{"issue":"10","key":"1545_CR2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S2213-8587(14)70051-8","volume":"2","author":"C Spitzweg","year":"2014","unstructured":"Spitzweg C, Bible KC, Hofbauer LC, et al. Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets. Lancet Diabetes Endo, 2014,2(10):830\u2013842","journal-title":"Lancet Diabetes Endo"},{"issue":"9871","key":"1545_CR3","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0140-6736(13)60109-9","volume":"381","author":"M Xing","year":"2013","unstructured":"Xing M, Haugen BR, Schlumberger M. Progress in molecular-based management of differentiated thyroid cancer. Lancet, 2013,381(9871):1058\u20131069","journal-title":"Lancet"},{"issue":"14","key":"1545_CR4","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/jama.1946.02870490016004","volume":"132","author":"SM Seidlin","year":"1946","unstructured":"Seidlin SM, Marinelli LD, Oshry E. Radioactive iodine therapy: effect on functioning metastases of adenocarcinoma of the thyroid. J Am Med Assoc, 1946,132(14): 838\u2013847","journal-title":"J Am Med Assoc"},{"issue":"10","key":"1545_CR5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrendo.2011.134","volume":"7","author":"C Reiners","year":"2011","unstructured":"Reiners C, Hanscheid H, Luster M, et al. Radioiodine for remnant ablation and therapy of metastatic disease. Nat Rev Endocr, 2011,7(10):589\u2013595","journal-title":"Nat Rev Endocr"},{"issue":"4","key":"1545_CR6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archsurg.139.4.390","volume":"139","author":"S Kim","year":"2004","unstructured":"Kim S, Wei JP, Braveman JM, et al. Predicting outcome and directing therapy for papillary thyroid carcinoma. Arch Surg, 2004,139(4):390\u2013394","journal-title":"Arch Surg"},{"issue":"2","key":"1545_CR7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ecl.2008.02.007","volume":"37","author":"AM Sawka","year":"2008","unstructured":"Sawka AM, Brierley JD, Tsang RW, et al. An updated systematic review and commentary examining the effectiveness of radioactive iodine remnant ablation in well-differentiated thyroid cancer. Endocrinol Metab Clin North Am, 2008,37(2):457\u2013480","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"11","key":"1545_CR8","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1089\/thy.2009.0455","volume":"20","author":"W Sacks","year":"2010","unstructured":"Sacks W, Fung CH, Chang JT, et al. The effectiveness of radioactive iodine for treatment of low-risk thyroid cancer: a systematic analysis of the peer-reviewed literature from 1966 to April 2008. Thyroid, 2010,20(11):1235\u20131245","journal-title":"Thyroid"},{"issue":"8","key":"1545_CR9","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1210\/jc.2005-2838","volume":"91","author":"C Durante","year":"2006","unstructured":"Durante C, Haddy N, Baudin E, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocr Metab, 2006,91(8): 2892\u20132899","journal-title":"J Clin Endocr Metab"},{"issue":"1","key":"1545_CR10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1210\/er.2012-1036","volume":"35","author":"C Portulano","year":"2014","unstructured":"Portulano C, Paroder-Belenitsky M, Carrasco N. The Na+\/I-symporter (NIS): Mechanism and medical impact. Endocr Rev, 2014,35(1):106\u2013149","journal-title":"Endocr Rev"},{"issue":"6","key":"1545_CR11","first-page":"363","volume":"5","author":"A Lakshmanan","year":"2014","unstructured":"Lakshmanan A, Scarberry D, Shen DH, et al. Modulation of sodium iodide symporter in thyroid cancer. HormCancer, 2014,5(6):363\u2013373","journal-title":"HormCancer"},{"issue":"1","key":"1545_CR12","first-page":"97","volume":"9","author":"G Vita De","year":"1998","unstructured":"De Vita G, Zannini M, Cirafici AM, et al. Expression of the RET\/PTC1 oncogene impairs the activity of TTF-1 and Pax-8 thyroid transcription factors. Cell Growth Differ, 1998,9(1):97\u2013103","journal-title":"Cell Growth Differ"},{"issue":"9","key":"1545_CR13","first-page":"421","volume":"11","author":"G Portella","year":"1999","unstructured":"Portella G, Vitagliano D, Borselli C, et al. Human N-ras, TRK-T1, and RET\/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells. Oncol Res, 1999,11(9):421\u2013427","journal-title":"Oncol Res"},{"issue":"7","key":"1545_CR14","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1210\/jc.2006-2707","volume":"92","author":"C Durante","year":"2007","unstructured":"Durante C, Puxeddu E, Ferretti E, et al. BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism. J Clin Endocrinol Metab, 2007,92(7): 2840\u20132843","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1545_CR15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1677\/erc.1.01119","volume":"13","author":"G Riesco-Eizaguirre","year":"2006","unstructured":"Riesco-Eizaguirre G, Gutierrez-Martinez P, Garcia-Cabezas MA, et al. The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+\/I-targeting to the membrane. Endocr Relat Cancer, 2006,13(1):257\u2013269","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"1545_CR16","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3892\/ol.2012.947","volume":"5","author":"S Wang","year":"2013","unstructured":"Wang S, Liang J, Lin Y, et al. Differential expression of the Na+\/I-symporter protein in thyroid cancer and adjacent normal and nodular goiter tissues. Oncol Lett, 2013,5(1):368\u2013372","journal-title":"Oncol Lett"},{"issue":"1","key":"1545_CR17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jss.2012.08.053","volume":"182","author":"DA Kleiman","year":"2013","unstructured":"Kleiman DA, Buitrago D, Crowley MJ, et al. Thyroid stimulating hormone increases iodine uptake by thyroid cancer cells during BRAF silencing. J Surg Res, 2013,182(1):85\u201393","journal-title":"J Surg Res"},{"key":"1545_CR18","first-page":"43","volume":"35","author":"L Wang","year":"2014","unstructured":"Wang L, Gang F, Liu S. The correlation study of sodium\/ iodide symporter in autoimmune thyroid diseases. China Foreign Med Treat, 2014(35):43\u201344","journal-title":"China Foreign Med Treat"},{"issue":"21","key":"1545_CR19","doi-asserted-by":"crossref","first-page":"8317","DOI":"10.1158\/0008-5472.CAN-09-1248","volume":"69","author":"G Riesco-Eizaguirre","year":"2009","unstructured":"Riesco-Eizaguirre G, Rodriguez I, De la Vieja A, et al. The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. Cancer Res, 2009,69(21):8317\u20138325","journal-title":"Cancer Res"},{"issue":"1","key":"1545_CR20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1684\/ecn.2013.0331","volume":"24","author":"I Manolova","year":"2013","unstructured":"Manolova I, Gerenova J, Ivanova M. Serum levels of transforming growth factor-beta1 (TGF-beta1) in patients with systemic lupus erythematosus and Hashimoto's thyroiditis. Eur Cytokine Netw, 2013,24(1):69\u201374","journal-title":"Eur Cytokine Netw"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1545-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-016-1545-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1545-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T20:30:57Z","timestamp":1600115457000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-016-1545-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["1545"],"URL":"https:\/\/doi.org\/10.1007\/s11596-016-1545-3","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}