{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:18:54Z","timestamp":1774970334144,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J. Huazhong Univ. Sci. Technol. [Med. Sci.]"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s11596-016-1574-y","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T09:19:43Z","timestamp":1460625583000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Knockdown of ezrin suppresses the migration and angiogenesis of human umbilical vein endothelial cells in vitro"],"prefix":"10.1007","volume":"36","author":[{"given":"Liang-ping","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-qi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-cheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"issue":"6","key":"1574_CR1","first-page":"1","volume":"28","author":"Y Sun","year":"2015","unstructured":"Sun Y, Huang J, Yang Z. The roles of ADAMTS in angiogenesis and cancer. Tumour Biol, 2015,28(6):1\u201313","journal-title":"Tumour Biol"},{"issue":"3","key":"1574_CR2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","volume":"86","author":"D Hanahan","year":"1996","unstructured":"Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 1996,86(3):353\u2013364","journal-title":"Cell"},{"issue":"4","key":"1574_CR3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/B:AGEN.0000029415.62384.ba","volume":"6","author":"YH Kusumanto","year":"2003","unstructured":"Kusumanto YH, Dam WA, Hospers GA, et al. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis, 2003,6(4):283\u2013287","journal-title":"Angiogenesis"},{"issue":"3","key":"1574_CR4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<310::AID-PATH525>3.0.CO;2-P","volume":"190","author":"FW Orr","year":"2000","unstructured":"Orr FW, Wang HW, Lafrenie RM, et al. Interactions between cancer cells and the endothelium in metastasis. J Pathol, 2000,190(3):310\u2013329","journal-title":"J Pathol"},{"issue":"3","key":"1574_CR5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ar.10159","volume":"268","author":"GE Davis","year":"2002","unstructured":"Davis GE, Mavila A, Bayless K. Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices. Anat Rec, 2002,268(3):252\u2013275","journal-title":"Anat Rec"},{"issue":"3","key":"1574_CR6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10456-014-9428-3","volume":"17","author":"SJ Mentzer","year":"2014","unstructured":"Mentzer SJ, Konerding MA. Intussusceptive angiogenesis: expansion and remodeling of microvascular networks. Angiogenesis, 2014,17(3):499\u2013509","journal-title":"Angiogenesis"},{"issue":"4","key":"1574_CR7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.exer.2006.01.011","volume":"84","author":"VL Bonilha","year":"2007","unstructured":"Bonilha VL. Focus on molecules: Ezrin. Exp Eye Res, 2007,84(4):613\u2013614","journal-title":"Exp Eye Res"},{"issue":"10","key":"1574_CR8","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/ijc.24734","volume":"125","author":"B Daria","year":"2009","unstructured":"Daria B, Stefano F. The Janus-faced role of ezrin in \u201clinking\u201d cells to either normal or metastatic phenotype. Int J Cancer, 2009,125(10):2239\u20132245","journal-title":"Int J Cancer"},{"issue":"4","key":"1574_CR9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ceb.2011.04.011","volume":"23","author":"LN Amanda","year":"2011","unstructured":"Amanda LN, Richard GF. Ezrin, Radixin and Moesin: key regulators of membrane-cortex interactions and signaling. Current Opinion in Cell Biology, 2011,23(4): 377\u2013382","journal-title":"Current Opinion in Cell Biology"},{"key":"1574_CR10","first-page":"28","volume-title":"Molecular cloning: A laboratory Manual","author":"G Michael","year":"2013","unstructured":"Michael G, Joseph S. Molecular cloning: A laboratory Manual. 4th ed. American: Cold Spring Harbor Laboratory Press. 2013,28"},{"issue":"1","key":"1574_CR11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-010-0411-z","volume":"340","author":"Y Peng","year":"2010","unstructured":"Peng Y, Li J, Geng M. The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of beta-1,6-GlcNAc branching on HUVEC conformation. Mol Cell Biochem, 2010,340(1-2):143\u2013152","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"1574_CR12","first-page":"1147","volume":"15","author":"LP Zhao","year":"2006","unstructured":"Zhao LP, Xu G, Zhou JF, et al. The effect of RhoA on human umbilical vein endothelial cell migration and angiogenesis in vitro. Oncology Reports, 2006,15(5):1147\u20131152","journal-title":"Oncology Reports"},{"issue":"19","key":"1574_CR13","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1242\/jcs.112.19.3249","volume":"112","author":"K Thomas","year":"1999","unstructured":"Thomas K, Hellmut GA. Tensional forces in fibrillar extracellular matrices control directional capillary spouting. J Cell Sci, 1999,112(19):3249\u20133258","journal-title":"J Cell Sci"},{"issue":"2","key":"1574_CR14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/01.RES.0000028149.15986.4C","volume":"91","author":"HJ Park","year":"2002","unstructured":"Park HJ, Kong D, Iruela-Arispe L, et al. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ Res, 2002,91(2):143\u2013150","journal-title":"Circ Res"},{"issue":"10","key":"1574_CR15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.abb.2014.01.013","volume":"545","author":"S Vega de","year":"2014","unstructured":"de Vega S, Suzuki N, Nonaka R. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. Arch Biochem Biophys, 2014,545(10):148\u2013153","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"1574_CR16","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nprot.2010.6","volume":"5","author":"I Arnaoutova","year":"2010","unstructured":"Arnaoutova I, Kleinman HK. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat Protoc, 2010,5(4):628\u2013635","journal-title":"Nat Protoc"},{"issue":"6","key":"1574_CR17","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1128\/MCB.01054-12","volume":"33","author":"S Evellin","year":"2013","unstructured":"Evellin S, Galvagni F, Zippo A. FOSL1 controls the a\u00dfsembly of endothelial cells into capillary tubes by direct repression of av and \u00df3 integrin transcription. Mol Cell Biol, 2013,33(6):1198\u20131209","journal-title":"Mol Cell Biol"},{"issue":"3","key":"1574_CR18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ar.10159","volume":"268","author":"GE Davis","year":"2002","unstructured":"Davis GE, Mavila A, Bayless K. Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices. Anat Rec, 2002,268(3):252\u2013275","journal-title":"Anat Rec"},{"issue":"11","key":"1574_CR19","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1177\/002215549904701101","volume":"47","author":"CJ Drake","year":"1999","unstructured":"Drake CJ, Little CD. VEGF and vascular fusion: implications for normal and pathological vessels. J Histochem Cytochem, 1999,47(11):1351\u20131356","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"1574_CR20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biocel.2007.02.012","volume":"40","author":"V Niggli","year":"2008","unstructured":"Niggli V, Rossy J. Ezrin\/radixin\/moesin: versatile controllers of signaling molecules and of the cortical cytoskeleton. Int J Biochem Cell Biol, 2008,40(3):344\u2013349","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"1574_CR21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/BJ20121642","volume":"452","author":"S Moleirinho","year":"2013","unstructured":"Moleirinho S, Tilston-Lunel A, Angus L, et al. The expanding family of FERM proteins. Biochem J, 2013,452(2):183\u2013193","journal-title":"Biochem J"},{"issue":"2","key":"1574_CR22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4161\/cam.5.2.15081","volume":"5","author":"M Arpin","year":"2011","unstructured":"Arpin M, Chirivino D, Naba A, et al. Emerging role for ERM proteins in cell adhesion and migration. Cell Adh Migr, 2011,5(2): 199\u2013206","journal-title":"Cell Adh Migr"},{"issue":"4","key":"1574_CR23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrm2866","volume":"11","author":"RG Fehon","year":"2010","unstructured":"Fehon RG, McClatchey AI, Bretscher A. Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol, 2010,11(4): 276\u2013287","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"1574_CR24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijmm.2014.1775","volume":"34","author":"DC Bosanquet","year":"2014","unstructured":"Bosanquet DC, Ye L, Harding KG, et al. FERM family proteins and their importance in cellular movements and wound healing. Int J Mol Med, 2014,34(1):3\u201312","journal-title":"Int J Mol Med"},{"issue":"9","key":"1574_CR25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/molehr\/gas019","volume":"18","author":"QY Jiang","year":"2012","unstructured":"Jiang QY, Xia JM, Ding HG, et al. RNAi-mediated blocking of ezrin reduces migration of ectopic endometrial cells in endometriosis. Mol Hum Reprod, 2012,18(9):435\u2013441","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"1574_CR26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/ajpcell.00268.2007","volume":"294","author":"M Rasmussen","year":"2008","unstructured":"Rasmussen M, Alexander RT, Darborg BV, et al. Osmotic cell shrinkage activates ezrin\/radixin\/moesin (ERM) proteins: activation mechanisms and physiological implications. Am J Physiol Cell Physiol, 2008,294(1):197\u2013212","journal-title":"Am J Physiol Cell Physiol"},{"issue":"17","key":"1574_CR27","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1093\/emboj\/19.17.4449","volume":"19","author":"K Hamada","year":"2000","unstructured":"Hamada K, Shimizu T, Matsui T, et al. Structural basis of the membrane-targeting and unmasking mechanisms of the radixin ferm domain. EMBO J, 2000,19(17):4449\u20134462","journal-title":"EMBO J"},{"issue":"1","key":"1574_CR28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.biochi.2012.09.033","volume":"95","author":"O Maniti","year":"2013","unstructured":"Maniti O, Carvalho K, Picart C. Model membranes to shed light on the biochemical and physical properties of ezrin\/radixin\/moesin. Biochimie, 2013,95(1):3\u201311","journal-title":"Biochimie"},{"issue":"6","key":"1574_CR29","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.bbalip.2014.10.011","volume":"1851","author":"K Tsujita","year":"2015","unstructured":"Tsujita K, Itoh T. Phosphoinositides in the regulation of actin cortex and cell migration. Biochim Biophys Acta, 2015,1851(6):824\u2013831","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"1574_CR30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4103\/1008-682X.146103","volume":"17","author":"NE Gungor-Ordueri","year":"2015","unstructured":"Gungor-Ordueri NE, Celik-Ozenci C, Cheng CY. Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis. Asian J Androl, 2015,17(4):653\u2013658","journal-title":"Asian J Androl"},{"issue":"15","key":"1574_CR31","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1242\/jcs.098343","volume":"127","author":"AI McClatchey","year":"2014","unstructured":"McClatchey AI. ERM proteins at a glance. J Cell Sci, 2014,127(15):3199\u20133204","journal-title":"J Cell Sci"},{"issue":"3","key":"1574_CR32","doi-asserted-by":"crossref","first-page":"e90629","DOI":"10.1371\/journal.pone.0090629","volume":"9","author":"A V\u00e1squez-Limeta","year":"2014","unstructured":"V\u00e1squez-Limeta A, Wagstaff KM, Ortega A, et al. Nuclear import of \u00df-dystroglycan is facilitated by ezrinmediated cytoskeleton reorganization. PLoS One, 2014,9(3):e90629","journal-title":"PLoS One"}],"container-title":["Journal of Huazhong University of Science and Technology [Medical Sciences]"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1574-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-016-1574-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-016-1574-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T20:14:23Z","timestamp":1655496863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-016-1574-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["1574"],"URL":"https:\/\/doi.org\/10.1007\/s11596-016-1574-y","relation":{},"ISSN":["1672-0733","1993-1352"],"issn-type":[{"value":"1672-0733","type":"print"},{"value":"1993-1352","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}