{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:15:58Z","timestamp":1775632558469,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s11596-018-1889-y","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T01:17:40Z","timestamp":1525051060000},"page":"379-385","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Thrombophilia Caused by Beta2-Glycoprotein I Deficiency: In Vitro Study of a Rare Mutation in APOH Gene"],"prefix":"10.1007","volume":"38","author":[{"given":"Xiao-ping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"issue":"11","key":"1889_CR1","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1161\/ATVBAHA.114.304488","volume":"34","author":"GE Raskob","year":"2014","unstructured":"Raskob GE, Angchaisuksiri P, Blanco AN, et al. Thrombosis: A major contributor to global disease burden. Arterioscler Thromb Vasc Biol, 2014,34(11):2363\u20132371","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1889_CR2","doi-asserted-by":"crossref","unstructured":"The Lancet-Haematology. Thromboembolism: an under appreciated cause of death. Lancet Haematol, 2015,2(10):e393","DOI":"10.1016\/S2352-3026(15)00202-1"},{"issue":"16","key":"1889_CR3","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1056\/NEJM200104193441607","volume":"344","author":"U Seligsohn","year":"2001","unstructured":"Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med, 2001,344(16): 1222\u20131231","journal-title":"N Engl J Med"},{"issue":"11","key":"1889_CR4","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1001\/jama.299.11.1306","volume":"299","author":"ID Bezemer","year":"2008","unstructured":"Bezemer ID, Bare LA, Doggen CJ, et al. Gene variants associated with deep vein thrombosis. JAMA, 2008,299(11):1306\u20131314","journal-title":"JAMA"},{"issue":"1","key":"1889_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1182\/blood-2005-08-3249","volume":"108","author":"J Corral","year":"2006","unstructured":"Corral J, Gonzalez-Conejero R, Soria JM, et al. A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis. Blood, 2006,108(1):177\u2013183","journal-title":"Blood"},{"issue":"2","key":"1889_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ajhg.2012.12.013","volume":"92","author":"L Tang","year":"2013","unstructured":"Tang L, Wang HF, Lu X, et al. Common genetic risk factors for venous thrombosis in the Chinese population. Am J Hum Genet, 2013,92(2):177\u2013187","journal-title":"Am J Hum Genet"},{"issue":"10","key":"1889_CR7","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1111\/j.1538-7836.2012.04862.x","volume":"10","author":"L Tang","year":"2012","unstructured":"Tang L, Lu X, Yu JM, et al. PROC c.574_576del polymorphism: a common genetic risk factor for venous thrombosis in the Chinese population. J Thromb Haemost, 2012,10(10):2019\u20132026","journal-title":"J Thromb Haemost"},{"issue":"7","key":"1889_CR8","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1055\/s-0034-1390003","volume":"40","author":"W Lim","year":"2014","unstructured":"Lim W. Thrombotic risk in the antiphospholipid syndrome. Semin Thromb Hemost, 2014,40(7):741\u2013746","journal-title":"Semin Thromb Hemost"},{"issue":"11","key":"1889_CR9","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1056\/NEJMra1112830","volume":"368","author":"B Giannakopoulos","year":"2013","unstructured":"Giannakopoulos B, Krilis SA. The pathogenesis of the antiphospholipid syndrome. N Engl J Med, 2013,368(11):1033\u20131044","journal-title":"N Engl J Med"},{"issue":"43","key":"1889_CR10","doi-asserted-by":"publisher","first-page":"13833","DOI":"10.1021\/bi960657q","volume":"35","author":"GM Willems","year":"1996","unstructured":"Willems GM, Janssen MP, Pelsers MM, et al. Role of divalency in the high-affinity binding of anticardiolipin antibody-beta 2-glycoprotein I complexes to lipid membranes. Biochemistry, 1996,35(43):13833\u201313842","journal-title":"Biochemistry"},{"issue":"7","key":"1889_CR11","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/j.1538-7836.2011.04327.x","volume":"9","author":"PG Groot de","year":"2011","unstructured":"de Groot PG, Meijers JC. Beta(2)-glycoprotein I: evolution, structure and function. J Thromb Haemost, 2011,9(7):1275\u20131284","journal-title":"J Thromb Haemost"},{"issue":"5","key":"1889_CR12","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1182\/blood-2006-10-053199","volume":"110","author":"JJ Hulstein","year":"2007","unstructured":"Hulstein JJ, Lenting PJ, de Laat B, et al. Beta2-glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation. Blood, 2007,110(5):1483\u20131491","journal-title":"Blood"},{"issue":"5","key":"1889_CR13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V66.5.1086.1086","volume":"66","author":"I Schousboe","year":"1985","unstructured":"Schousboe I. Beta 2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood, 1985,66(5):1086\u20131091","journal-title":"Blood"},{"issue":"6","key":"1889_CR14","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1111\/jth.12238","volume":"11","author":"N Pozzi","year":"2013","unstructured":"Pozzi N, Acquasaliente L, Frasson R, et al. Beta2 -glycoprotein I binds to thrombin and selectively inhibits the enzyme procoagulant functions. J Thromb Haemost, 2013,11(6):1093\u20131102","journal-title":"J Thromb Haemost"},{"issue":"6","key":"1889_CR15","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1111\/jth.12566","volume":"12","author":"KA Taylor","year":"2014","unstructured":"Taylor KA, Wright JR, Vial C, et al. Amplification of human platelet activation by surface pannexin-1 channels. J Thromb Haemost, 2014,12(6):987\u2013998","journal-title":"J Thromb Haemost"},{"issue":"5","key":"1889_CR16","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1309\/AJCPAGOR4Q2IIKUG","volume":"140","author":"NM Heikal","year":"2013","unstructured":"Heikal NM, Murphy KK, Crist RA, et al. Elevated factor IX activity is associated with an increased odds ratio for both arterial and venous thrombotic events. Am J Clin Pathol, 2013,140(5):680\u2013685","journal-title":"Am J Clin Pathol"},{"issue":"1","key":"1889_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1309\/QCUUNRMVJY8MWPPL","volume":"119","author":"LL Graf","year":"2003","unstructured":"Graf LL, Welsh CH, Qamar Z, et al. Activated protein C resistance assay detects thrombotic risk factors other than factor V Leiden. Am J Clin Pathol, 2003,119(1): 52\u201360","journal-title":"Am J Clin Pathol"},{"issue":"39","key":"1889_CR18","first-page":"1944","volume":"138","author":"FR Rosendaal","year":"1994","unstructured":"Rosendaal FR. Recently discovered frequent cause of venous thrombosis: factor V Leiden, a mutated factor V, resistant against protein C inactivation. Ned Tijdschr Geneeskd, 1994,138(39):1944\u20131948","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"1","key":"1889_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1309\/7A33-8EQ4-QT98-3TPX","volume":"116","author":"R Marcucci","year":"2001","unstructured":"Marcucci R, Brunelli T, Giusti B, et al. The role of cysteine and homocysteine in venous and arterial thrombotic disease. Am J Clin Pathol, 2001,116(1):56\u201360","journal-title":"Am J Clin Pathol"},{"issue":"5","key":"1889_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.7326\/0003-4819-135-5-200109040-00013","volume":"135","author":"KA Bauer","year":"2001","unstructured":"Bauer KA. The thrombophilias: well-defined risk factors with uncertain therapeutic implications. Ann Intern Med, 2001,135(5):367\u2013373","journal-title":"Ann Intern Med"},{"issue":"8","key":"1889_CR21","doi-asserted-by":"publisher","first-page":"e71402","DOI":"10.1371\/journal.pone.0071402","volume":"8","author":"L Pelkmans","year":"2013","unstructured":"Pelkmans L, Kelchtermans H, de Groot PG, et al. Variability in exposure of epitope G40-R43 of domain i in commercial anti-beta2-glycoprotein I IgG ELISAs. PLoS One, 2013,8(8): e71402","journal-title":"PLoS One"},{"issue":"7","key":"1889_CR22","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1001\/archderm.1992.01680170077010","volume":"128","author":"P Stern","year":"1992","unstructured":"Stern P, Levine N. Controlled localized heat therapy in cutaneous warts. Arch Dermatol, 1992,128(7): 945\u2013948","journal-title":"Arch Dermatol"},{"issue":"8","key":"1889_CR23","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1182\/blood-2009-12-260976","volume":"116","author":"C Agar","year":"2010","unstructured":"Agar C, van Os GM, Morgelin M, et al. Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome. Blood, 2010,116(8): 1336\u20131343","journal-title":"Blood"},{"issue":"12","key":"1889_CR24","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1002\/art.30633","volume":"63","author":"B Laat de","year":"2011","unstructured":"de Laat B, van Berkel M, Urbanus RT, et al. Immune responses against domain I of beta(2)-glycoprotein I are driven by conformational changes: domain I of beta(2)-glycoprotein I harbors a cryptic immunogenic epitope. Arthritis Rheum, 2011,63(12): 3960\u20133968","journal-title":"Arthritis Rheum"},{"issue":"4","key":"1889_CR25","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1093\/rheumatology\/keu360","volume":"54","author":"C Pericleous","year":"2015","unstructured":"Pericleous C, Ruiz-Limon P, Romay-Penabad Z, et al. Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of beta2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis. Rheumatology (Oxford), 2015,54(4): 722\u2013727","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"1889_CR26","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1177\/0961203312437439","volume":"21","author":"L d Pelkmans","year":"2012","unstructured":"Pelkmans L, de Laat B. Antibodies against domain I of beta2-glycoprotein I: the one and only? Lupus, 2012,21(7):769\u2013772","journal-title":"Lupus"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-018-1889-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-018-1889-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-018-1889-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T06:15:39Z","timestamp":1571292939000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-018-1889-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["1889"],"URL":"https:\/\/doi.org\/10.1007\/s11596-018-1889-y","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"21 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}