{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:48:31Z","timestamp":1766087311501},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s11596-018-1925-y","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T07:27:03Z","timestamp":1534750023000},"page":"640-647","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polymorphism of OAS2 rs739901 C\/A Involves the Susceptibility to EV71 Infection in Chinese Children"],"prefix":"10.1007","volume":"38","author":[{"given":"Yu-xia","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-gang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao-yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"1925_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1743-422X-7-94","volume":"7","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Zhu Z, Yang W, et al. An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J, 2010, 7:94","journal-title":"Virol J"},{"issue":"4","key":"1925_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/1040841X.2011.580723","volume":"37","author":"L Yi","year":"2011","unstructured":"Yi L, Lu J, Kung HF, et al. The virology and developments toward control of human enterovirus 71. Crit Rev Microbiol, 2011, 37(4):313\u2013327","journal-title":"Crit Rev Microbiol"},{"issue":"1","key":"1925_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","volume":"26","author":"PC McMirni","year":"2002","unstructured":"McMirni PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev, 2002, 26(1):91\u2013107","journal-title":"FEMS Microbiol Rev"},{"issue":"6","key":"1925_CR4","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1586\/eri.09.45","volume":"7","author":"SM Wang","year":"2009","unstructured":"Wang SM, Liu CC. Enterovirus 71: epidemiology, pathogenesis and management. Expert Rev Anti Infect Ther, 2009, 7(6):735\u2013742","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"11","key":"1925_CR5","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","volume":"9","author":"MH Ooi","year":"2010","unstructured":"Ooi MH, Wong SC, Lewthwaite P, et al Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol, 2010, 9(11):1097\u20131105","journal-title":"Lancet Neurol"},{"issue":"4","key":"1925_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","volume":"44","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Tan XJ, Wang HY, et al. An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol, 2009, 44(4):262\u2013267","journal-title":"J Clin Virol"},{"issue":"1","key":"1925_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.virusres.2009.06.006","volume":"145","author":"NZ Ding","year":"2009","unstructured":"Ding NZ, Wang XM, Sun SW, et al. Appearance of mosaic enterovirus 71 in the 2008 outbreak of China. Virus Res, 2009, 145(1):157\u2013161","journal-title":"Virus Res"},{"issue":"6","key":"1925_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.braindev.2009.05.007","volume":"32","author":"R Tadokoro","year":"2010","unstructured":"Tadokoro R, Okumura A, Nakazawa T, et al. Acute encephalopathy with biphasic seizures and late reduced diffusion associated with hemophagocytic syndrome. Brain Dev, 2010, 32(6):477\u2013481","journal-title":"Brain Dev"},{"issue":"16","key":"1925_CR9","first-page":"2571","volume":"49","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama M, Fujita T. RIG-I: critical regulator for virus-induced innate immunity. Tanpakushitsu Kakusan Koso, 2004, 49(16):2571\u20132578","journal-title":"Tanpakushitsu Kakusan Koso"},{"issue":"5","key":"1925_CR10","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.immuni.2011.05.003","volume":"34","author":"YM Loo","year":"2011","unstructured":"Loo YM, Gale M. Immune signaling by RIG-I-like receptors. Immunity, 2011, 34(5):680\u2013692","journal-title":"Immunity"},{"issue":"3","key":"1925_CR11","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1128\/MCB.15.3.1312","volume":"15","author":"S Leung","year":"1995","unstructured":"Leung S, Qureshi SA, Kerr IM, et al. Role of STAT2 in the alpha interferon signaling pathway. Mol Cell Biol, 1995, 15(3):1312\u20131317","journal-title":"Mol Cell Biol"},{"issue":"9","key":"1925_CR12","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0198-8859(00)00167-1","volume":"61","author":"V Pravica","year":"2000","unstructured":"Pravica V, Perrey C, Stevens A, et al. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFNgamma production. Hum Immunol, 2000, 61(9):863\u2013866","journal-title":"Hum Immunol"},{"issue":"7","key":"1925_CR13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nri2314","volume":"8","author":"AJ Sadler","year":"2008","unstructured":"Sadler AJ, Williams BR. Interferon-inducible antiviral effectors. Nat Rev Immunol, 2008, 8(7):559\u2013568","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"1925_CR14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.pharmthera.2004.07.007","volume":"103","author":"SN Sarkar","year":"2004","unstructured":"Sarkar SN, Sen GC. Novel functions of proteins encoded by viral stress-inducible genes. Pharmacol Ther, 2004, 103(3):245\u2013259","journal-title":"Pharmacol Ther"},{"issue":"14","key":"1925_CR15","doi-asserted-by":"publisher","first-page":"7009","DOI":"10.1128\/JVI.00489-06","volume":"80","author":"MA Samuel","year":"2006","unstructured":"Samuel MA, Whitby K, Keller BC, et al. PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol, 2006, 80(14):7009\u20137019","journal-title":"J Virol"},{"issue":"7053","key":"1925_CR16","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/nature04078","volume":"436","author":"M Gale","year":"2005","unstructured":"Gale M, Foy EM. Evasion of intracellular host defence by hepatitis \u0421 virus. Nature, 2005, 436(7053): 939\u2013945","journal-title":"Nature"},{"issue":"5\u20136","key":"1925_CR17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.cytogfr.2007.06.003","volume":"18","author":"AG Hovanessian","year":"2007","unstructured":"Hovanessian AG. On the discovery of interferoninducible, double-stranded RNA activated enzymes: the 2\u2032\u20135\u2032 oligoadenylate synthetases and the protein kinase PKR. Cytokine Growth Factor Rev, 2007, 18(5\u20136):351\u2013361","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4498","key":"1925_CR18","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1126\/science.6165080","volume":"212","author":"G Floyd-Smith","year":"1981","unstructured":"Floyd-Smith G, Slattery E, Lengyel P. Interferon action: RNA cleavage pattern of a (2\u2032\u20135\u2032) oligoadenylate\u2014dependent endonuclease. Science, 1981, 212(4498):1030\u20131032","journal-title":"Science"},{"issue":"1","key":"1925_CR19","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.virol.2008.10.021","volume":"384","author":"AC Br\u00e9hin","year":"2009","unstructured":"Br\u00e9hin AC, Casad\u00e9mont I, Frenkiel MP, et al. The large form of human 2, 5\u2032-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus. Virology, 2009, 384(1):216\u2013222","journal-title":"Virology"},{"issue":"6148","key":"1925_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/330587a0","volume":"330","author":"J Chebath","year":"1987","unstructured":"Chebath J, Benech P, Revel M, et al. Constitutive expression of (2,\u20135, ) oligo A synthetase confers resistance to Picornavirus infection. Nature, 1987, 330(6148):587\u2013588","journal-title":"Nature"},{"key":"1925_CR21","volume-title":"J Gen Virol","author":"J Marques","year":"2008","unstructured":"Marques J, Anwar J, Eskildsen-Larsen S, et al. The p59 oligoadenylate synthetase-like protein possesses antiviral activity thatrequires the C-terminal ubiquitinlike domain. J Gen Virol, 2008, 89(Ptll):2767\u20132772"},{"issue":"5","key":"1925_CR22","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/iji.12134","volume":"41","author":"Y Cai","year":"2014","unstructured":"Cai Y, Chen Q, Zhou W, et al. Association analysis of polymorphisms in OAS1 with susceptibility and severity of hand, foot and mouth disease. Int J Immunogenet, 2014, 41(5):384\u2013392","journal-title":"Int J Immunogenet"},{"issue":"8","key":"1925_CR23","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1007\/s00705-017-3381-6","volume":"162","author":"Y Tan","year":"2017","unstructured":"Tan Y, Yang T, Liu P, et al. Association of the OAS3 rsl859330 G\/A genetic polymorphism with severity of enterovirus-71 infection in Chinese Han children. Arch Virol, 2017, 162(8):2305\u20132313","journal-title":"Arch Virol"},{"issue":"24","key":"1925_CR24","first-page":"1473","volume":"30","author":"China MoHotPRo.","year":"2010","unstructured":"China MoHotPRo. A guidebook of HFMD diagnosis and treatment (2010 edition). Int J Respir, 2010, 30(24):1473\u20131475","journal-title":"Int J Respir"},{"issue":"3","key":"1925_CR25","doi-asserted-by":"publisher","first-page":"e32405","DOI":"10.1371\/journal.pone.0032405","volume":"7","author":"X Wang","year":"2012","unstructured":"Wang X, Zhu C, Bao W, et al. Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China. PLoS One, 2012, 7(3):e32405","journal-title":"PLoS One"},{"issue":"4","key":"1925_CR26","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s10753-013-9629-8","volume":"36","author":"T Lv","year":"2013","unstructured":"Lv T, Li J, Han Z, et al. Association of interleukin-17F gene polymorphism with enterovirus 71 encephalitis in patients with hand, foot, and mouth disease. Inflammation, 2013, 36(4):977\u2013981","journal-title":"Inflammation"},{"issue":"10","key":"1925_CR27","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1097\/INF.0000000000000368","volume":"33","author":"J Hu","year":"2014","unstructured":"Hu J, Chen Z, Liu X, et al. Association of CPTII gene with risk of acute encephalitis in Chinese children. Pediatr Infect Dis J, 2014, 33(10):1077\u20131082","journal-title":"Pediatr Infect Dis J"},{"issue":"7","key":"1925_CR28","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00011-014-0724-6","volume":"63","author":"JA Li","year":"2014","unstructured":"Li JA, Chen ZB, Lv TG, et al. Genetic polymorphism of CCL2-2518, CXCL10-201, IL8+781 and susceptibility to severity of Enterovirus-71 infection in a Chinese population. Inflamm Res, 2014, 63(7):549\u2013556","journal-title":"Inflamm Res"},{"issue":"6","key":"1925_CR29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3109\/00365548.2011.649490","volume":"44","author":"J Yang","year":"2012","unstructured":"Yang J, Zhao N, Su NL, et al. Association of interleukin 10 and interferon gamma gene polymorphisms with enterovirus 71 encephalitis in patients with hand, foot and mouth disease. Scand J Infect Dis, 2012, 44(6):465\u2013469","journal-title":"Scand J Infect Dis"},{"issue":"4","key":"1925_CR30","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00705-015-2356-8","volume":"160","author":"F Li","year":"2015","unstructured":"Li F, Liu XP, Li JA, et al. Correlation of an interleukin-4 gene polymorphism with susceptibility to severe enterovirus 71 infection in Chinese children. Arch Virol, 2015, 160(4):1035\u20131042","journal-title":"Arch Virol"},{"issue":"2","key":"1925_CR31","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s10753-014-9983-1","volume":"38","author":"A Yuan","year":"2015","unstructured":"Yuan A, Li J, Liu P, et al. Association of interleukin-6-572C\/G gene polymorphism and serum or cerebrospinal fluid interleukin-6 level with enterovirus 71 encephalitis in Chinese Han patients with hand, foot, and mouth disease. Inflammation, 2015, 38(2):728\u2013735","journal-title":"Inflammation"},{"issue":"6","key":"1925_CR32","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3109\/00365548.2015.1007473","volume":"47","author":"J Li","year":"2015","unstructured":"Li J, Lin A, Yu C, et al. Association of enterovirus 71 encephalitis with the interleukin-8 gene region in Chinese children. Infect Dis (Lond), 2015, 47(6):418\u2013422","journal-title":"Infect Dis (Lond)"},{"issue":"9","key":"1925_CR33","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1007\/s00705-014-2082-7","volume":"159","author":"ZL Han","year":"2014","unstructured":"Han ZL, Li JA, Chen ZB. Genetic polymorphism of CCL2-2510 and susceptibility to enterovirus 71 encephalitis in a Chinese population. Arch Virol, 2014, 159(9):2503\u20132507","journal-title":"Arch Virol"},{"key":"1925_CR34","first-page":"1261","volume":"125","author":"H Zhou","year":"2012","unstructured":"Zhou H, Guo SZ, Zhou H, etal. Clinical characteristics of hand, foot and mouth disease in Harbin and the prediction of severe cases. Chin Med J (Engl), 2012, 125(7):1261\u20131265","journal-title":"Chin Med J (Engl)"},{"issue":"7","key":"1925_CR35","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1086\/591462","volume":"198","author":"SM Wang","year":"2008","unstructured":"Wang SM, Lei HY, Yu CK, et al. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J Infect Dis, 2008, 198(7):1002\u20131006","journal-title":"J Infect Dis"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-018-1925-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-018-1925-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-018-1925-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T10:03:53Z","timestamp":1659089033000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-018-1925-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["1925"],"URL":"https:\/\/doi.org\/10.1007\/s11596-018-1925-y","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"28 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}