{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T03:53:47Z","timestamp":1772942027582,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11596-019-2086-3","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T14:02:57Z","timestamp":1564063377000},"page":"645-652","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification and Interaction Analysis of Key Genes and MicroRNAs in Systemic Sclerosis by Bioinformatics Approaches"],"prefix":"10.1007","volume":"39","author":[{"given":"Yan-hong","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-zheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"issue":"2","key":"2086_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/BOR.0b013e32834ff2e8","volume":"24","author":"J Barnes","year":"2012","unstructured":"Barnes J, Mayes MD. Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers. Curr Opin Rheumatol, 2012,24(2):165\u2013170","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"2086_CR2","doi-asserted-by":"publisher","first-page":"55","DOI":"10.7861\/clinmedicine.16-1-55","volume":"16","author":"CP Denton","year":"2016","unstructured":"Denton CP. Advances in pathogenesis and treatment of systemic sclerosis. Clin Med (Lond), 2016,16(1):55\u201360","journal-title":"Clin Med (Lond)"},{"issue":"4Suppl92","key":"2086_CR3","first-page":"S3","volume":"33","author":"CP Denton","year":"2015","unstructured":"Denton CP. Systemic sclerosis: from pathogenesis to targeted therapy. Clin Exp Rheumatol, 2015,33(4 Suppl 92):S3\u2013S7","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"2086_CR4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/cge.12946","volume":"92","author":"X Zuo","year":"2017","unstructured":"Zuo X, Zhang L, Luo H, et al. Systematic approach to understanding the pathogenesis of systemic sclerosis. Clin Genet, 2017,92(4):365\u2013371","journal-title":"Clin Genet"},{"issue":"9","key":"2086_CR5","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/rheumatology\/kes120","volume":"51","author":"T Sing","year":"2012","unstructured":"Sing T, Jinnin M, Yamane K, et al. microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. Rheumatology (Oxford), 2012,51(9):1550\u20131556","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"2086_CR6","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1007\/s10875-013-9896-z","volume":"33","author":"H Zhu","year":"2013","unstructured":"Zhu H, Luo H, Li Y, et al. MicroRNA-21 in scleroderma fibrosis and its function in TGF-beta-regulated fibrosis-related genes expression. J Clin Immunol, 2013,33(6):1100\u20131109","journal-title":"J Clin Immunol"},{"issue":"1","key":"2086_CR7","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.intimp.2015.07.042","volume":"28","author":"CG Miao","year":"2015","unstructured":"Miao CG, Xiong YY, Yu H, et al. Critical roles of microRNAs in the pathogenesis of systemic sclerosis: New advances, challenges and potential directions. Int Immunopharmacol, 2015,28(1):626\u2013633","journal-title":"Int Immunopharmacol"},{"key":"2086_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-1-4939-3578-9_5","volume":"1418","author":"E Clough","year":"2016","unstructured":"Clough E, Barrett T. The Gene Expression Omnibus Database. Methods Mol Biol, 2016,1418:93\u2013110","journal-title":"Methods Mol Biol"},{"issue":"6","key":"2086_CR9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nprot.2015.052","volume":"10","author":"J Xia","year":"2015","unstructured":"Xia J, Gill EE, Hancock RE. NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc, 2015,10(6):823\u2013844","journal-title":"Nat Protoc"},{"key":"2086_CR10","doi-asserted-by":"publisher","first-page":"D322","DOI":"10.1093\/nar\/gkj021","volume":"34","author":"C Gene Ontology","year":"2006","unstructured":"Gene Ontology C. The Gene Ontology (GO) project in 2006. Nucleic Acids Res, 2006,34(Database issue):D322\u2013326","journal-title":"Nucleic Acids Res"},{"key":"2086_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-4939-3743-1_21","volume":"1446","author":"SE Lewis","year":"2017","unstructured":"Lewis SE. The Vision and Challenges of the Gene Ontology. Methods Mol Biol, 2017,1446:291\u2013302","journal-title":"Methods Mol Biol"},{"issue":"D1","key":"2086_CR12","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","volume":"44","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa M, Sato Y, Kawashima M, et al. KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res, 2016,44(D1):D457\u2013462","journal-title":"Nucleic Acids Res"},{"key":"2086_CR13","doi-asserted-by":"publisher","first-page":"W169","DOI":"10.1093\/nar\/gkm415","volume":"35","author":"DW Huang","year":"2007","unstructured":"Huang DW, Sherman BT, Tan Q, et al. DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res, 2007,35(Web Server issue):W169\u2013175","journal-title":"Nucleic Acids Res"},{"key":"2086_CR14","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res, 2015,43(Database issue):D447\u2013452","journal-title":"Nucleic Acids Res"},{"key":"2086_CR15","doi-asserted-by":"publisher","first-page":"8.13.1","DOI":"10.1002\/0471250953.bi0813s47","volume":"47","author":"G Su","year":"2014","unstructured":"Su G, Morris JH, Demchak B, et al. Biological network exploration with Cytoscape 3. Curr Protoc Bioinformatics, 2014,47:8.13.1\u201324","journal-title":"Curr Protoc Bioinformatics"},{"issue":"W1","key":"2086_CR16","doi-asserted-by":"publisher","first-page":"W514","DOI":"10.1093\/nar\/gky510","volume":"46","author":"G Zhou","year":"2018","unstructured":"Zhou G, Xia J. OmicsNet: a web-based tool for creation and visual analysis of biological networks in 3D space. Nucleic Acids Res, 2018,46(W1):W514\u2013W522","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2086_CR17","first-page":"e235","volume":"169","author":"G Elia","year":"2018","unstructured":"Elia G, Guglielmi G. CXCL9 chemokine in ulcerative colitis. Clin Ter, 2018,169(5):e235\u2013e241","journal-title":"Clin Ter"},{"issue":"11","key":"2086_CR18","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1002\/cam4.934","volume":"5","author":"Q Ding","year":"2016","unstructured":"Ding Q, Lu P, Xia Y, et al. CXCL9: evidence and contradictions for its role in tumor progression. Cancer Med, 2016,5(11):3246\u20133259","journal-title":"Cancer Med"},{"issue":"2","key":"2086_CR19","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.cyto.2015.04.015","volume":"74","author":"GV Duarte","year":"2015","unstructured":"Duarte GV, Boeira V, Correia T, et al. Osteopontin, CCL5 and CXCL9 are independently associated with psoriasis, regardless of the presence of obesity. Cytokine, 2015,74(2):287\u2013292","journal-title":"Cytokine"},{"key":"2086_CR20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/1465-9921-14-121","volume":"14","author":"R Su","year":"2013","unstructured":"Su R, Nguyen ML, Agarwal MR, et al. Interferon-inducible chemokines reflect severity and progression in sarcoidosis. Respir Res, 2013,14:121","journal-title":"Respir Res"},{"issue":"5","key":"2086_CR21","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1111\/j.1600-0625.2007.00556.x","volume":"16","author":"J Wenzel","year":"2007","unstructured":"Wenzel J, Tuting T. Identification of type I interferon-associated inflammation in the pathogenesis of cutaneous lupus erythematosus opens up options for novel therapeutic approaches. Exp Dermatol, 2007,16(5):454\u2013463","journal-title":"Exp Dermatol"},{"issue":"8","key":"2086_CR22","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.jid.2017.04.008","volume":"137","author":"JC O\u2019Brien","year":"2017","unstructured":"O\u2019Brien JC, Rainwater YB, Malviya N, et al. Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea. J Invest Dermatol, 2017,137(8):1663\u20131670","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2086_CR23","doi-asserted-by":"publisher","first-page":"R18","DOI":"10.1186\/ar3242","volume":"13","author":"BJ Rabquer","year":"2011","unstructured":"Rabquer BJ, Tsou PS, Hou Y, et al. Dysregulated expression of MIG\/CXCL9, IP-10\/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Arthritis Res Ther, 2011,13(1):R18","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"2086_CR24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10067-010-1610-4","volume":"30","author":"M Hasegawa","year":"2011","unstructured":"Hasegawa M, Fujimoto M, Matsushita T, et al. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Clin Rheumatol, 2011,30(2):231\u2013237","journal-title":"Clin Rheumatol"},{"issue":"6","key":"2086_CR25","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3109\/s10165-012-0795-6","volume":"23","author":"M Hasegawa","year":"2013","unstructured":"Hasegawa M, Asano Y, Endo H, et al. Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study. Mod Rheumatol, 2013,23(6):1076\u20131084","journal-title":"Mod Rheumatol"},{"key":"2086_CR26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fmed.2018.00271","volume":"5","author":"PT Kuo","year":"2018","unstructured":"Kuo PT, Zeng Z, Salim N, et al. The Role of CXCR3 and Its Chemokine Ligands in Skin Disease and Cancer. Front Med (Lausanne), 2018,5:271","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"2086_CR27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.immuni.2009.03.003","volume":"30","author":"N Fazilleau","year":"2009","unstructured":"Fazilleau N, Mark L, McHeyzer-Williams LJ, et al. Follicular helper T cells: lineage and location. Immunity, 2009,30(3):324\u2013335","journal-title":"Immunity"},{"issue":"11","key":"2086_CR28","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1172\/JCI200422325","volume":"114","author":"HW Lim","year":"2004","unstructured":"Lim HW, Hillsamer P, Kim CH. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest, 2004,114(11):1640\u20131649","journal-title":"J Clin Invest"},{"issue":"1","key":"2086_CR29","doi-asserted-by":"publisher","first-page":"650","DOI":"10.4049\/jimmunol.166.1.650","volume":"166","author":"K Shi","year":"2001","unstructured":"Shi K, Hayashida K, Kaneko M, et al. Lymphoid Chemokine B Cell-Attracting Chemokine-1 (CXCL13) Is Expressed in Germinal Center of Ectopic Lymphoid Follicles within the Synovium of Chronic Arthritis Patients. J Immunol, 2001,166(1):650\u2013655","journal-title":"J Immunol"},{"issue":"12","key":"2086_CR30","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1084\/jem.193.12.1393","volume":"193","author":"S Ishikawa","year":"2001","unstructured":"Ishikawa S, Sato T, Abe M, et al. Aberrant high expression of B lymphocyte chemokine (BLC\/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. J Exp Med, 2001,193(12):1393\u20131402","journal-title":"J Exp Med"},{"issue":"5","key":"2086_CR31","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1189\/jlb.0113036","volume":"94","author":"JM Kramer","year":"2013","unstructured":"Kramer JM, Klimatcheva E, Rothstein TL. CXCL13 is elevated in Sjogren\u2019s syndrome in mice and humans and is implicated in disease pathogenesis. J Leukoc Biol, 2013,94(5):1079\u20131089","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2086_CR32","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/bjd.12411","volume":"169","author":"N Wutte","year":"2013","unstructured":"Wutte N, Kovacs G, Berghold A, et al. CXCL13 and B-cell activating factor as putative biomarkers in systemic sclerosis. Br J Dermatol, 2013,169(3):723\u2013725","journal-title":"Br J Dermatol"},{"issue":"9","key":"2086_CR33","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/exd.13724","volume":"27","author":"T Taniguchi","year":"2018","unstructured":"Taniguchi T, Miyagawa T, Toyama S, et al. CXCL13 produced by macrophages due to Fli1 deficiency may contribute to the development of tissue fibrosis, vasculopathy and immune activation in systemic sclerosis. Exp Dermatol, 2018,27(9):1030\u20131037","journal-title":"Exp Dermatol"},{"issue":"41","key":"2086_CR34","doi-asserted-by":"publisher","first-page":"14776","DOI":"10.1073\/pnas.1416498111","volume":"111","author":"M Ammirante","year":"2014","unstructured":"Ammirante M, Shalapour S, Kang Y, et al. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci USA, 2014,111(41):14776\u201314781","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"2086_CR35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00262-017-2083-y","volume":"67","author":"Y Wei","year":"2018","unstructured":"Wei Y, Lin C, Li H, et al. CXCL13 expression is prognostic and predictive for postoperative adjuvant chemotherapy benefit in patients with gastric cancer. Cancer Immunol Immunother, 2018,67(2):261\u2013269","journal-title":"Cancer Immunol Immunother"},{"issue":"1-2","key":"2086_CR36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s11010-014-2285-y","volume":"400","author":"Z Zhu","year":"2015","unstructured":"Zhu Z, Zhang X, Guo H, et al. CXCL13-CXCR5 axis promotes the growth and invasion of colon cancer cells via PI3K\/AKT pathway. Mol Cell Biochem, 2015,400(1-2):287\u2013295","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"2086_CR37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","volume":"7","author":"Y Cai","year":"2009","unstructured":"Cai Y, Yu X, Hu S, et al. A brief review on the mechanisms of miRNA regulation. Genomics, Proteomics Bioinformatics, 2009,7(4):147\u2013154","journal-title":"Genomics, Proteomics Bioinformatics"},{"issue":"1","key":"2086_CR38","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.intimp.2015.07.042","volume":"28","author":"CG Miao","year":"2015","unstructured":"Miao CG, Xiong YY, Yu H, et al. Critical roles of microRNAs in the pathogenesis of systemic sclerosis: New advances, challenges and potential directions. Int Immunopharmacol, 2015,28(1):626\u2013633","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"2086_CR39","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.prp.2018.07.025","volume":"214","author":"CM Jia","year":"2018","unstructured":"Jia CM, Tian YY, Quan LN, et al. miR-26b-5p suppresses proliferation and promotes apoptosis in multiple myeloma cells by targeting JAG1. Pathol Res Pract, 2018,214(9):1388\u20131394","journal-title":"Pathol Res Pract"},{"issue":"1","key":"2086_CR40","first-page":"386","volume":"15","author":"F Fan","year":"2018","unstructured":"Fan F, Lu J, Yu W, et al. MicroRNA-26b-5p regulates cell proliferation, invasion and metastasis in human intrahepatic cholangiocarcinoma by targeting S100A7. Oncol Lett, 2018,15(1):386\u2013392","journal-title":"Oncol Lett"},{"key":"2086_CR41","doi-asserted-by":"publisher","first-page":"40342","DOI":"10.1038\/srep40342","volume":"7","author":"CM Tang","year":"2017","unstructured":"Tang CM, Zhang M, Huang L, et al. CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep, 2017,7:40342","journal-title":"Sci Rep"},{"key":"2086_CR42","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jaut.2017.12.015","volume":"89","author":"E Chouri","year":"2018","unstructured":"Chouri E, Servaas NH, Bekker CPJ, et al. Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis. J Autoimmun, 2018,89:162\u2013170","journal-title":"J Autoimmun"},{"issue":"9","key":"2086_CR43","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nri887","volume":"2","author":"A Richmond","year":"2002","unstructured":"Richmond A. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol, 2002,2(9):664\u2013674","journal-title":"Nat Rev Immunol"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-019-2086-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-019-2086-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-019-2086-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T13:51:42Z","timestamp":1596117102000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-019-2086-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2086"],"URL":"https:\/\/doi.org\/10.1007\/s11596-019-2086-3","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"8 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}