{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:50:35Z","timestamp":1788915035500,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s11596-020-2294-x","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T21:35:11Z","timestamp":1610400911000},"page":"1121-1127","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of CX3CL1 and CX3CR1 Expression with Liver Fibrosis in a Mouse Model of Schistosomiasis"],"prefix":"10.1007","volume":"40","author":[{"given":"Pan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-ju","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-mao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao-xiao","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"2294_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-030-18616-6_3","volume":"1154","author":"PT Loverde","year":"2019","unstructured":"Loverde PT. Schistosomiasis. Adv Exp Med Biol, 2019, 1154:45\u201370","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"2294_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","volume":"4","author":"DP Mcmanus","year":"2018","unstructured":"Mcmanus DP, Dunne DW, Sacko M, et al. Schistosomiasis. Nat Rev Dis Primers, 2018,4(1): 13","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2294_CR3","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.actatropica.2013.07.024","volume":"128","author":"MM El-Tonsy","year":"2013","unstructured":"El-Tonsy MM, Hussein HM, Helal Tel S, et al. Schistosoma mansoni infection: is it a risk factor for development of hepatocellular carcinoma?. Acta Trop, 2013,128(3): 542\u2013547","journal-title":"Acta Trop"},{"key":"2294_CR4","doi-asserted-by":"publisher","first-page":"6920","DOI":"10.1038\/ncomms7920","volume":"6","author":"PC Cook","year":"2015","unstructured":"Cook PC, Owen H, Deaton AM, et al. A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nat Commun, 2015, 6: 6920","journal-title":"Nat Commun"},{"issue":"7","key":"2294_CR5","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1242\/dmm.018242","volume":"8","author":"L Ran","year":"2015","unstructured":"Ran L, Yu Q, Zhang S, et al. Cx3cr1 deficiency in mice attenuates hepatic granuloma formation during acute schistosomiasis by enhancing the M2-type polarization of macrophages. Dis Model Mech, 2015,8(7): 691\u2013700","journal-title":"Dis Model Mech"},{"issue":"4","key":"2294_CR6","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1182\/blood-2002-12-3775","volume":"102","author":"C Hundhausen","year":"2003","unstructured":"Hundhausen C, Misztela D, Berkhout TA, et al. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood, 2003,102(4): 1186\u20131195","journal-title":"Blood"},{"key":"2294_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.2741\/3261","volume":"14","author":"R Bonecchi","year":"2009","unstructured":"Bonecchi R, Galliera E, Borroni EM, et al. Chemokines and chemokine receptors: an overview. Front Biosci (Landmark Ed), 2009,14:540\u2013551","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2294_CR8","first-page":"6941368","volume":"2018","author":"Y Shi","year":"2018","unstructured":"Shi Y, Zhang Z, Cai D, et al. Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response. J Immunol Res, 2018,2018:6941368","journal-title":"J Immunol Res"},{"key":"2294_CR9","doi-asserted-by":"publisher","first-page":"43067","DOI":"10.1038\/srep43067","volume":"7","author":"SL Roche","year":"2017","unstructured":"Roche SL, Wyse-Jackson AC, Ruiz-Lopez AM, et al. Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina. Sci Rep, 2017,7:43067","journal-title":"Sci Rep"},{"issue":"2","key":"2294_CR10","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s10620-013-2920-6","volume":"59","author":"M Sasaki","year":"2014","unstructured":"Sasaki M, Miyakoshi M, Sato Y, et al. Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis. Dig Dis Sci, 2014,59(2): 358\u2013364","journal-title":"Dig Dis Sci"},{"issue":"2","key":"2294_CR11","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/cvr\/cvu115","volume":"103","author":"S Martinez-Hervas","year":"2014","unstructured":"Martinez-Hervas S, Vinue A, Nunez L, et al. Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1\/CX3CR1 axis. Cardiovasc Res, 2014,103(2): 324\u2013336","journal-title":"Cardiovasc Res"},{"issue":"8","key":"2294_CR12","doi-asserted-by":"publisher","first-page":"844","DOI":"10.2174\/1389203720666190305165722","volume":"20","author":"Q Zhuang","year":"2019","unstructured":"Zhuang Q, Ou J, Zhang S, et al. Crosstalk between the CX3CL1\/CX3CR1 Axis and Inflammatory Signaling Pathways in Tissue Injury. Curr Protein Pept Sci, 2019,20(8): 844\u2013854","journal-title":"Curr Protein Pept Sci"},{"issue":"6","key":"2294_CR13","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.kint.2018.12.030","volume":"95","author":"A Helmke","year":"2019","unstructured":"Helmke A, Nordlohne J, Balzer MS, et al. CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis. Kidney Int, 2019,95(6): 1405\u20131417","journal-title":"Kidney Int"},{"issue":"4","key":"2294_CR14","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1002\/hep.23795","volume":"52","author":"T Aoyama","year":"2010","unstructured":"Aoyama T, Inokuchi S, Brenner DA, et al. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology, 2010,52(4): 1390\u20131400","journal-title":"Hepatology"},{"issue":"1","key":"2294_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1365-3024.2009.01161.x","volume":"32","author":"P Liu","year":"2010","unstructured":"Liu P, Li J, Yang X, et al. Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process. Parasite Immunol, 2010,32(1): 57\u201366","journal-title":"Parasite Immunol"},{"issue":"10","key":"2294_CR16","doi-asserted-by":"publisher","first-page":"e0005094","DOI":"10.1371\/journal.pntd.0005094","volume":"10","author":"S Zhou","year":"2016","unstructured":"Zhou S, Jin X, Li Y, et al. Blockade of PD-1 Signaling Enhances Th2 Cell Responses and Aggravates Liver Immunopathology in Mice with Schistosomiasis japonica. PLoS Negl Trop Dis, 2016,10(10): e0005094","journal-title":"PLoS Negl Trop Dis"},{"issue":"11","key":"2294_CR17","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","volume":"31","author":"ZA Andrade","year":"2009","unstructured":"Andrade ZA. Schistosomiasis and liver fibrosis. Parasite Immunol, 2009,31(11):656\u2013663","journal-title":"Parasite Immunol"},{"issue":"1","key":"2294_CR18","doi-asserted-by":"publisher","first-page":"16833","DOI":"10.1038\/s41598-017-17007-8","volume":"7","author":"Y Ishida","year":"2017","unstructured":"Ishida Y, Kimura A, Nosaka M, et al. Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration. Sci Rep, 2017, 7(1):16833","journal-title":"Sci Rep"},{"issue":"1","key":"2294_CR19","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0168-8278(02)00065-X","volume":"37","author":"E Efsen","year":"2002","unstructured":"Efsen E, Grappone C, Defranco RM, et al. Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans. J Hepatol, 2002,37(1): 39\u201347","journal-title":"J Hepatol"},{"issue":"2","key":"2294_CR20","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jhep.2007.09.008","volume":"48","author":"HE Wasmuth","year":"2008","unstructured":"Wasmuth HE, Zaldivar MM, Berres ML, et al. The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection. J Hepatol, 2008,48(2): 208\u2013215","journal-title":"J Hepatol"},{"issue":"3","key":"2294_CR21","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1002\/hep.20582","volume":"41","author":"K Isse","year":"2005","unstructured":"Isse K, Harada K, Zen Y, et al. Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology, 2005,41(3): 506\u2013516","journal-title":"Hepatology"},{"issue":"1","key":"2294_CR22","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s13071-019-3542-4","volume":"12","author":"ZY Li","year":"2019","unstructured":"Li ZY, Xiao L, Lin G, et al. Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL-33\/ST2 expression. Parasit Vectors, 2019,12(1): 302","journal-title":"Parasit Vectors"},{"issue":"6","key":"2294_CR23","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.4049\/jimmunol.180.6.4283","volume":"180","author":"P Lu","year":"2008","unstructured":"Lu P, Li L, Kuno K, et al. Protective roles of the fractalkine\/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression. J Immunol, 2008, 180(6):4283\u20134291","journal-title":"J Immunol"},{"issue":"1","key":"2294_CR24","first-page":"3","volume":"28","author":"E Rossi","year":"2007","unstructured":"Rossi E, Adams LA, Bulsara M, et al. Assessing liver fibrosis with serum marker models. Clin Biochem Rev, 2007,28(1): 3\u201310","journal-title":"Clin Biochem Rev"},{"issue":"4","key":"2294_CR25","doi-asserted-by":"publisher","first-page":"658","DOI":"10.4269\/ajtmh.1999.60.658","volume":"60","author":"S Ricard-Blum","year":"1999","unstructured":"Ricard-Blum S, Hartmann DJ, Grenard P, et al. Relationships between several markers of extracellular matrix turn-over and ultrasonography in human Schistosomiasis mansoni. Am J Trop Med Hyg, 1999, 60(4):658\u2013663","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"2294_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1590\/S0074-02762010000400020","volume":"105","author":"CC Marinho","year":"2010","unstructured":"Marinho CC, Bretas T, Voieta I, et al. Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil. Mem Inst Oswaldo Cruz, 2010,105(4): 471\u2013478","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"5","key":"2294_CR27","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1002\/hep.23894","volume":"52","author":"KR Karlmark","year":"2010","unstructured":"Karlmark KR, Zimmermann HW, Roderburg C, et al. The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology, 2010,52(5): 1769\u20131782","journal-title":"Hepatology"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-020-2294-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11596-020-2294-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-020-2294-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T12:33:08Z","timestamp":1615984388000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11596-020-2294-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2294"],"URL":"https:\/\/doi.org\/10.1007\/s11596-020-2294-x","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"16 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}