{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T05:04:22Z","timestamp":1775970262714,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s11596-021-2364-8","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T04:05:17Z","timestamp":1622174717000},"page":"572-580","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["TLR4 Knockout Attenuates BDL-induced Liver Cholestatic Injury through Amino Acid and Choline Metabolic Pathways"],"prefix":"10.1007","volume":"41","author":[{"given":"Shou-hua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-long","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-hua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-le","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"issue":"3","key":"2364_CR1","doi-asserted-by":"publisher","first-page":"G244","DOI":"10.1152\/ajpgi.00366.2013","volume":"306","author":"S Oya","year":"2014","unstructured":"Oya S, Yokoyama Y, Kokuryo T, et al. Inhibition of Toll-like receptor 4 suppresses liver injury induced by biliary obstruction and subsequent intraportal lipopolysaccharide injection. Am J Physiol Gastrointest Liver Physiol, 2014,306(3):G244\u2013G252","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"2364_CR2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00268-003-6988-6","volume":"28","author":"K Ueno","year":"2004","unstructured":"Ueno K, Ajiki T, Watanabe H, et al. Changes in extrathymic T cells in the liver and intestinal intraepithelium in mice with obstructive jaundice. World J Surg, 2004,28(3):277\u2013282","journal-title":"World J Surg"},{"issue":"3\u20134","key":"2364_CR3","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.lfs.2011.10.021","volume":"90","author":"S Abraham","year":"2012","unstructured":"Abraham S, Hermesz E, Szabo A, et al. Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice. Life Sci, 2012,90(3\u20134):140\u2013146","journal-title":"Life Sci"},{"issue":"4","key":"2364_CR4","doi-asserted-by":"publisher","first-page":"p35","DOI":"10.1159\/000276588","volume":"114","author":"A Brandoni","year":"2010","unstructured":"Brandoni A, Di Giusto G, Franca R, et al. Expression of kidney and liver bilitranslocase in response to acute biliary obstruction. Nephron Physiol, 2010,114(4):p35\u201340","journal-title":"Nephron Physiol"},{"issue":"1\u20132","key":"2364_CR5","first-page":"39","volume":"59","author":"N Penkov","year":"2003","unstructured":"Penkov N. Pathogenetic mechanisms in biliary obstruction (literature review). Khirurgiia (Sofiia), 2003,59(1\u20132):39\u201345","journal-title":"Khirurgiia (Sofiia)"},{"key":"2364_CR6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.lfs.2017.04.025","volume":"179","author":"Z Sepehri","year":"2017","unstructured":"Sepehri Z, Kiani Z, Kohan F, et al. Toll like receptor 4 and hepatocellular carcinoma; A systematic review. Life Sci, 2017,179:80\u201387","journal-title":"Life Sci"},{"issue":"7","key":"2364_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/vim.2014.0039","volume":"27","author":"M Zare-Bidaki","year":"2014","unstructured":"Zare-Bidaki M, Tsukiyama-Kohara K, Arababadi MK. Toll-like receptor 4 and hepatitis B infection: molecular mechanisms and pathogenesis. Viral Immunol, 2014, 27(7):321\u2013326","journal-title":"Viral Immunol"},{"key":"2364_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1755-1536-3-21","volume":"3","author":"J Guo","year":"2010","unstructured":"Guo J, Friedman SL. Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis. Fibrogenesis Tissue Repair, 2010,3:21","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"3","key":"2364_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1055\/s-0030-1255353","volume":"30","author":"JP Pradere","year":"2010","unstructured":"Pradere JP, Troeger JS, Dapito DH, et al. Toll-like receptor 4 and hepatic fibrogenesis. Semin Liver Dis, 2010,30(3):232\u2013244","journal-title":"Semin Liver Dis"},{"issue":"2","key":"2364_CR10","first-page":"235","volume":"26","author":"SF Tang","year":"2017","unstructured":"Tang SF, Zhao LJ. Action and mechanism of LPS\/TLR4 signaling pathway in hepatolithiasis: recent progress. Chin J Gener Surg (Chinese), 2017,26(2):235\u2013240","journal-title":"Chin J Gener Surg (Chinese)"},{"issue":"1","key":"2364_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00210-018-1560-y","volume":"392","author":"ES Nabih","year":"2019","unstructured":"Nabih ES, El-Kharashi OA. Targeting HMGB1\/TLR4 axis and miR-21 by rosuvastatin: role in alleviating cholestatic liver injury in a rat model of bile duct ligation. Naunyn Schmiedebergs Arch Pharmacol, 2019, 392(1):37\u201343","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"2364_CR12","doi-asserted-by":"publisher","first-page":"e85694","DOI":"10.1371\/journal.pone.0085694","volume":"9","author":"DY Zhao","year":"2014","unstructured":"Zhao DY, Han LS, He ZJ, et al. Identification of the Plasma Metabolomics as Early Diagnostic Markers between Biliary Atresia and Neonatal Hepatitis Syndrome. PLoS One, 2014,9(1):e85694","journal-title":"PLoS One"},{"issue":"11","key":"2364_CR13","doi-asserted-by":"publisher","first-page":"4844","DOI":"10.1021\/acs.jproteome.5b00676","volume":"14","author":"K Zhou","year":"2015","unstructured":"Zhou K, Wang J, Xie G, et al. Distinct Plasma Bile Acid Profiles of Biliary Atresia and Neonatal Hepatitis Syndrome. J Proteome Res, 2015,14(11):4844\u20134850","journal-title":"J Proteome Res"},{"issue":"8","key":"2364_CR14","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.dld.2016.05.001","volume":"48","author":"K Zhou","year":"2016","unstructured":"Zhou K, Xie G, Wen J, et al. Histamine is correlated with liver fibrosis in biliary atresia. Dig Liver Dis, 2016,48(8):921\u2013926","journal-title":"Dig Liver Dis"},{"issue":"11","key":"2364_CR15","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.3390\/molecules23112833","volume":"23","author":"P Lee","year":"2018","unstructured":"Lee P, Park HJ, Cho N, et al. 3,5-Diethoxy-3\u2032-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury. Molecules, 2018,23(11):2833","journal-title":"Molecules"},{"issue":"30","key":"2364_CR16","doi-asserted-by":"publisher","first-page":"7444","DOI":"10.1021\/jf501744d","volume":"62","author":"B Xie","year":"2014","unstructured":"Xie B, Liu A, Zhan X, et al. Alteration of gut bacteria and metabolomes after glucaro-1,4-lactone treatment contributes to the prevention of hypercholesterolemia. J Agric Food Chem, 2014,62(30):7444\u20137451","journal-title":"J Agric Food Chem"},{"issue":"9","key":"2364_CR17","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1164\/rccm.201209-1726OC","volume":"187","author":"B Mickiewicz","year":"2013","unstructured":"Mickiewicz B, Vogel HJ, Wong HR, et al. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med, 2013,187(9):967\u2013976","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2364_CR18","doi-asserted-by":"publisher","first-page":"e89230","DOI":"10.1371\/journal.pone.0089230","volume":"9","author":"R Amathieu","year":"2014","unstructured":"Amathieu R, Triba MN, Nahon P, et al. Serum 1H-NMR metabolomic fingerprints of acute-on-chronic liver failure in intensive care unit patients with alcoholic cirrhosis. PLoS One, 2014,9(2):e89230","journal-title":"PLoS One"},{"issue":"6","key":"2364_CR19","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1515\/cclm-2017-0858","volume":"56","author":"MJ Yu","year":"2018","unstructured":"Yu MJ, Xiang TX, Wu XP, et al. Diagnosis of acute pediatric appendicitis from children with inflammatory diseases by combination of metabolic markers and inflammatory response variables. Clin Chem Lab Med, 2018,56(6):1001\u20131010","journal-title":"Clin Chem Lab Med"},{"issue":"8","key":"2364_CR20","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1039\/b820224a","volume":"5","author":"PY Yin","year":"2009","unstructured":"Yin PY, Wan DF, Zhao CX, et al. A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry. Mol Biosyst, 2009,5(8):868\u2013876","journal-title":"Mol Biosyst"},{"issue":"3","key":"2364_CR21","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1021\/pr2010082","volume":"11","author":"P Zheng","year":"2012","unstructured":"Zheng P, Gao HC, Li Q, et al. Plasma Metabonomics as a Novel Diagnostic Approach for Major Depressive Disorder. J Prot Res, 2012,11(3):1741\u20131748","journal-title":"J Prot Res"},{"issue":"44","key":"2364_CR22","doi-asserted-by":"publisher","first-page":"698","DOI":"10.4103\/0973-1296.165551","volume":"11","author":"B Mamtimin","year":"2015","unstructured":"Mamtimin B, Xia G, Mijit M, et al. Metabolic differentiation and classification of abnormal Savda Munziq\u2019s pharmacodynamic role on rat models with different diseases by nuclear magnetic resonance-based metabonomics. Pharmacogn Mag, 2015,11(44):698\u2013706","journal-title":"Pharmacogn Mag"},{"issue":"3","key":"2364_CR23","first-page":"224","volume":"18","author":"M Li","year":"2010","unstructured":"Li M, Yin L, Liu P, et al. LPS increases the liver injury viaTLR4 dependent manner in mice with acute obstructive jaundice. J Hepatobiliary Surg, 2010,18(3):224\u2013227","journal-title":"J Hepatobiliary Surg"},{"key":"2364_CR24","doi-asserted-by":"crossref","unstructured":"Zhu J, Lu T, Chen F, et al. Choline Protects Against Intestinal Failure-Associated Liver Disease in Parenteral Nutrition-Fed Immature Rats. JPEN J Parenter Enteral Nutr, 2016:148607116677048","DOI":"10.1177\/0148607116677048"},{"issue":"5","key":"2364_CR25","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/jhbp.333","volume":"23","author":"H Yamamoto","year":"2016","unstructured":"Yamamoto H, Kanno K, Ikuta T, et al. Enhancing hepatic fibrosis in spontaneously hypertensive rats fed a choline-deficient diet: a follow-up report on long-term effects of oxidative stress in non-alcoholic fatty liver disease. J Hepatobiliary Pancreat Sci, 2016,23(5):260\u2013269","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"1","key":"2364_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3945\/an.114.007955","volume":"7","author":"JL Sherriff","year":"2016","unstructured":"Sherriff JL, O\u2019Sullivan TA, Properzi C, et al. Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. Adv Nutr, 2016,7(1):5\u201313","journal-title":"Adv Nutr"},{"key":"2364_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.lfs.2019.03.008","volume":"222","author":"D Mikami","year":"2019","unstructured":"Mikami D, Kobayashi M, Uwada J, et al. \u03b2-Hydroxy-butyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells. Life Sci, 2019,222:125\u2013132","journal-title":"Life Sci"},{"issue":"12","key":"2364_CR28","doi-asserted-by":"publisher","first-page":"11 175","DOI":"10.3168\/jds.2018-15120","volume":"101","author":"X Du","year":"2018","unstructured":"Du X, Liu G, Loor JJ, et al. Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function. J Dairy Sci, 2018,101(12):11 175\u201311 185","journal-title":"J Dairy Sci"},{"key":"2364_CR29","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fcimb.2018.00174","volume":"8","author":"Z Chang","year":"2018","unstructured":"Chang Z, Wang H, Li B, et al. Metabolic Characterization of Peripheral Host Responses to Drainage-Resistant Klebsiella pneumoniae Liver Abscesses by Serum 1H-NMR Spectroscopy. Front Cell Infect Microbiol, 2018,8:174","journal-title":"Front Cell Infect Microbiol"},{"key":"2364_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.metabol.2018.01.007","volume":"83","author":"RJ Lamontagne","year":"2018","unstructured":"Lamontagne RJ, Casciano JC, Bouchard MJ. A broad investigation of the HBV-mediated changes to primary hepatocyte physiology reveals HBV significantly alters metabolic pathways. Metabolism, 2018,83:50\u201359","journal-title":"Metabolism"},{"issue":"1","key":"2364_CR31","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/13880209.2018.1525414","volume":"56","author":"W Yang","year":"2018","unstructured":"Yang W, Zhou G, Zou S, et al. Metabonomics of d-glucaro-1,4-lactone in preventing diethylnitrosamine-induced liver cancer in rats. Pharm Biol, 2018,56(1):643\u2013648","journal-title":"Pharm Biol"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-021-2364-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-021-2364-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-021-2364-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T17:13:51Z","timestamp":1626023631000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-021-2364-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,28]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2364"],"URL":"https:\/\/doi.org\/10.1007\/s11596-021-2364-8","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,28]]},"assertion":[{"value":"22 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}