{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:01:37Z","timestamp":1790604097206,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11596-021-2405-3","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T10:03:41Z","timestamp":1629194621000},"page":"737-745","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term Therapeutic Outcome and Prognostic Factors of Patients with Nasopharyngeal Carcinoma Receiving Intensity-modulated Radiotherapy: An Analysis of 608 Patients from Low-endemic Regions of China"],"prefix":"10.1007","volume":"41","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-yuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-wen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"issue":"3","key":"2405_CR1","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.radonc.2013.10.020","volume":"110","author":"X Sun","year":"2014","unstructured":"Sun X, Su S, Chen C, et al. Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: an analysis of survival and treatment toxicities. Radiother Oncol, 2014,110(3):398\u2013403","journal-title":"Radiother Oncol"},{"issue":"1","key":"2405_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1471-2407-10-39","volume":"10","author":"S Lin","year":"2010","unstructured":"Lin S, Lu JJ, Han L, et al. Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: experience of 370 consecutive cases. BMC Cancer, 2010,10(1):39","journal-title":"BMC Cancer"},{"issue":"35","key":"2405_CR3","doi-asserted-by":"publisher","first-page":"38 381","DOI":"10.18632\/oncotarget.5420","volume":"6","author":"X Ou","year":"2015","unstructured":"Ou X, Zhou X, Shi Q, et al. Treatment outcomes and late toxicities of 869 patients with nasopharyngeal carcinoma treated with definitive intensity modulated radiation therapy: new insight into the value of total dose of cisplatin and radiation boost. Oncotarget, 2015,6(35):38 381\u201338 397","journal-title":"Oncotarget"},{"issue":"17","key":"2405_CR4","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1016\/j.ejca.2015.08.006","volume":"51","author":"MX Zhang","year":"2015","unstructured":"Zhang MX, Li J, Shen GP, et al. Intensity-modulated radiotherapy prolongs the survival of patients with nasopharyngeal carcinoma compared with conventional two-dimensional radiotherapy: A 10-year experience with a large cohort and long follow-up. Eur J Cancer, 2015,51(17):2587\u20132595","journal-title":"Eur J Cancer"},{"issue":"9","key":"2405_CR5","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.oraloncology.2012.03.001","volume":"48","author":"LN Zhao","year":"2012","unstructured":"Zhao LN, Zhou B, Shi M, et al. Clinical outcome for nasopharyngeal carcinoma with predominantly WHO II histology treated with intensity-modulated radiation therapy in non-endemic region of China. Oral Oncol, 2012,48(9):864\u2013869","journal-title":"Oral Oncol"},{"issue":"3","key":"2405_CR6","first-page":"1","volume":"155","author":"D Parkin","year":"2002","unstructured":"Parkin D, Whelan S, Ferlay J, et al. Cancer incidence in five continents. IARC Sci Publications, 2002,155(3):1\u2013781","journal-title":"IARC Sci Publications"},{"issue":"2","key":"2405_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1177\/014556130608500201","volume":"85","author":"L Thompson","year":"2006","unstructured":"Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J, 2006,85(2):74","journal-title":"Ear Nose Throat J"},{"issue":"2","key":"2405_CR8","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1002\/cncr.28049","volume":"119","author":"Y Chen","year":"2013","unstructured":"Chen Y, Sun Y, Liang SB, et al. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China. Cancer, 2013,119(2):2230\u20132238","journal-title":"Cancer"},{"issue":"1","key":"2405_CR9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12885-015-1288-8","volume":"15","author":"Y Chen","year":"2015","unstructured":"Chen Y, Hu XF, Wang Y, et al. Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy? BMC Cancer, 2015,15(1):305","journal-title":"BMC Cancer"},{"issue":"5","key":"2405_CR10","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/S0360-3016(98)00164-3","volume":"41","author":"JM Hwang","year":"1998","unstructured":"Hwang JM, Fu KK, Phillips TL. Results and prognostic factors in the retreatment of locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys, 1998,41(5):1099\u20131111","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"2405_CR11","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","volume":"16","author":"M Al-Sarraf","year":"1998","unstructured":"Al-Sarraf M, LeBlanc M, Giri PG, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol, 1998,16(4):1310\u20131317","journal-title":"J Clin Oncol"},{"issue":"3","key":"2405_CR12","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0360-3016(01)01509-7","volume":"50","author":"SH Cheng","year":"2001","unstructured":"Cheng SH, Yen KL, Jian JJ, et al. Examining prognostic factors and patterns of failure in nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy: impact on future clinical trials. Int J Radiat Oncol Biol Phys, 2001,50(3):717\u2013726","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"5","key":"2405_CR13","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.oraloncology.2011.11.017","volume":"48","author":"F Cheung","year":"2012","unstructured":"Cheung F, Chan O, Ng WT, et al. The prognostic value of histological typing in nasopharyngeal carcinoma. Oral Oncology, 2012,48(5):429\u2013433","journal-title":"Oral Oncology"},{"issue":"7","key":"2405_CR14","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1001\/archotol.129.7.794","volume":"129","author":"TP Farias","year":"2003","unstructured":"Farias TP, Dias FL, Lima RA, et al. Prognostic factors and outcome for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg, 2003,129(7):794\u2013799","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"10","key":"2405_CR15","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO;2-S","volume":"86","author":"DM Heng","year":"1999","unstructured":"Heng DM, Wee J, Fong KW, et al. Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer, 1999,86(10):1912\u20131920","journal-title":"Cancer"},{"issue":"2","key":"2405_CR16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0360-3016(92)90741-Y","volume":"23","author":"CA Perez","year":"1992","unstructured":"Perez CA, Devineni VR, Marcial-Vega V, et al. Carcinoma of the nasopharynx: factors affecting prognosis. Int J Radiat Oncol Biol Phys, 1992,23(2):271\u2013280","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2405_CR17","unstructured":"Shanmugaratnam K. Histological typing of nasopharyngeal carcinoma. IARC Sci Publ, 1978, (20):3\u201312"},{"issue":"1","key":"2405_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40880-016-0103-5","volume":"35","author":"HY Wang","year":"2016","unstructured":"Wang HY, Chang YL, To KF, et al. A new prognostic histopathologic classification of nasopharyngeal carcinoma. Chin J Cancer, 2016,35(1):41","journal-title":"Chin J Cancer"},{"issue":"2","key":"2405_CR19","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin, 2011,61(2):69\u201390","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"2405_CR20","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/hed.21557","volume":"33","author":"KP Chang","year":"2011","unstructured":"Chang KP, Chang YT, Wu CC, et al. Multiplexed immunobead-based profiling of cytokine markers for detection of nasopharyngeal carcinoma and prognosis of patient survival. Head Neck, 2011,33(6):886\u2013897","journal-title":"Head Neck"},{"issue":"3","key":"2405_CR21","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1158\/1078-0432.CCR-09-2796","volume":"16","author":"WY Wang","year":"2010","unstructured":"Wang WY, Twu CW, Chen HH, et al. Plasma EBV DNA Clearance Rate as a Novel Prognostic Marker for Metastatic\/Recurrent Nasopharyngeal Carcinoma. Clinical Cancer Research, 2010,16(3):1016\u20131024","journal-title":"Clinical Cancer Research"},{"issue":"3","key":"2405_CR22","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.radonc.2011.10.009","volume":"104","author":"L Chen","year":"2012","unstructured":"Chen L, Mao YP, Xie FY, et al. The seventh edition of the UICC\/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China. Radiother Oncol, 2012,104(3):331\u2013337","journal-title":"Radiother Oncol"},{"issue":"3","key":"2405_CR23","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.oraloncology.2014.10.012","volume":"51","author":"J Zong","year":"2015","unstructured":"Zong J, Lin S, Lin J, et al. Impact of intensity-modulated radiotherapy on nasopharyngeal carcinoma: Validation of the 7th edition AJCC staging system. Oral Oncology, 2015,51(3):254\u2013259","journal-title":"Oral Oncology"},{"issue":"2","key":"2405_CR24","first-page":"346","volume":"7","author":"M Kang","year":"2017","unstructured":"Kang M, Zhou P, Wei T, et al. A new T staging system for nasopharyngeal carcinoma based on intensity-modulated radiation therapy: results from a prospective multicentric clinical study. Am J Cancer Res, 2017,7(2):346\u2013356","journal-title":"Am J Cancer Res"},{"issue":"2","key":"2405_CR25","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3322\/caac.21389","volume":"67","author":"A E Giuliano","year":"2017","unstructured":"Giuliano A E, Connolly J L, Edge SB, et al. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin, 2017,67(2):122\u2013137","journal-title":"CA Cancer J Clin"},{"issue":"41","key":"2405_CR26","doi-asserted-by":"publisher","first-page":"70586","DOI":"10.18632\/oncotarget.19829","volume":"8","author":"M Kang","year":"2017","unstructured":"Kang M, Zhou P, Li G, et al. Validation of the 8th edition of the UICC\/AJCC staging system for nasopharyngeal carcinoma treated with intensity-modulated radiotherapy. Oncotarget, 2017,8(41):70586\u201370594","journal-title":"Oncotarget"},{"issue":"3","key":"2405_CR27","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.ijrobp.2010.03.024","volume":"80","author":"SZ Lai","year":"2011","unstructured":"Lai SZ, Li WF, Chen L, et al. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients? Int J Radiat Oncol Biol Phys, 2011,80(3):661\u2013668","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"2405_CR28","doi-asserted-by":"publisher","first-page":"15252","DOI":"10.18632\/oncotarget.7553","volume":"7","author":"M Kang","year":"2016","unstructured":"Kang M, Long J, Li G, et al. A new staging system for nasopharyngeal carcinoma based on intensity-modulated radiation therapy: results of a prospective multicentric clinical study. Oncotarget, 2016,7(12):15252\u201315261","journal-title":"Oncotarget"},{"key":"2405_CR29","first-page":"1419676","volume":"2017","author":"Q Zhou","year":"2017","unstructured":"Zhou Q, He Y, Zhao Y, et al. A Study of 358 Cases of Locally Advanced Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiation Therapy: Improving the Seventh Edition of the American Joint Committee on Cancer T-Staging System. Biomed Res Int, 2017,2017:1419676","journal-title":"Biomed Res Int"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-021-2405-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-021-2405-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-021-2405-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T10:36:54Z","timestamp":1629196614000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-021-2405-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["2405"],"URL":"https:\/\/doi.org\/10.1007\/s11596-021-2405-3","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"28 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}},{"value":"Author Gang WU is a member of the Editorial Board for Current Medical Science. The paper was handled by the other editor and has undergone rigrous peer review process. Author Gang WU was not involved in the journal\u2019s review of, or decisions related to, this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}