{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:01:10Z","timestamp":1771473670354,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11596-022-2536-1","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T06:03:12Z","timestamp":1643349792000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice"],"prefix":"10.1007","volume":"42","author":[{"given":"Di","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"issue":"7","key":"2536_CR1","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jcmg.2015.12.018","volume":"9","author":"YJ Hong","year":"2016","unstructured":"Hong YJ, Kim TK, Hong D, et al. Myocardial Characterization Using Dual-Energy CT in Doxorubicin-Induced DCM: Comparison With CMR T1-Mapping and Histology in a Rabbit Model. JACC Cardiovasc Imaging, 2016,9(7):836\u2013845","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"2536_CR2","first-page":"383","volume":"116","author":"G Milano","year":"2020","unstructured":"Milano G, Biemmi V, Lazzarini E, et al. Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin\/trastuzumab-induced cardiac toxicity. Cardiovasc Res, 2020,116(2): 383\u2013392","journal-title":"Cardiovasc Res"},{"issue":"6","key":"2536_CR3","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","volume":"165","author":"N Kubben","year":"2016","unstructured":"Kubben N, Zhang W, Wang L, et al. Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell, 2016,165(6):1361\u20131374","journal-title":"Cell"},{"key":"2536_CR4","first-page":"748524","volume":"2014","author":"S Li","year":"2014","unstructured":"Li S, Wang W, Niu T, et al. Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction. Oxid Med Cell Longev, 2014,2014:748524","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"2536_CR5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/term.3053","volume":"14","author":"Z Guo","year":"2020","unstructured":"Guo Z, Mo Z. Keap1-Nrf2 signaling pathway in angiogenesis and vascular diseases. J Tissue Eng Regen Med, 2020,14(6):869\u2013883","journal-title":"J Tissue Eng Regen Med"},{"issue":"2","key":"2536_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s11596-018-1872-7","volume":"38","author":"MY Zhao","year":"2018","unstructured":"Zhao MY, Wang LM, Liu J, et al. MiR-21 Suppresses Anoikis through Targeting PDCD4 and PTEN in Human Esophageal Adenocarcinoma. Curr Med Sci, 2018,38(2):245\u2013251","journal-title":"Curr Med Sci"},{"issue":"4","key":"2536_CR7","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s11596-018-1917-y","volume":"38","author":"D Yang","year":"2018","unstructured":"Yang D, Li JS, Xu QY, et al. Inhibitory Effect of MiR-449b on Cancer Cell Growth and Invasion through LGR4 in Non-Small-Cell Lung Carcinoma. Curr Med Sci, 2018,38(4):582\u2013589","journal-title":"Curr Med Sci"},{"issue":"22","key":"2536_CR8","doi-asserted-by":"publisher","first-page":"4569","DOI":"10.1007\/s00018-019-03290-3","volume":"76","author":"MJ Kang","year":"2019","unstructured":"Kang MJ, Park SY, Han JS. MicroRNA-24-3p regulates neuronal differentiation by controlling hippocalcin expression. Cell Mol Life Sci, 2019,76(22):4569\u20134580","journal-title":"Cell Mol Life Sci"},{"key":"2536_CR9","doi-asserted-by":"crossref","first-page":"7042105","DOI":"10.1155\/2018\/7042105","volume":"2018","author":"X Xiao","year":"2018","unstructured":"Xiao X, Lu Z, Lin V, et al. MicroRNA miR-24-3p Reduces Apoptosis and Regulates Keap1-Nrf2 Pathway in Mouse Cardiomyocytes Responding to Ischemia\/Reperfusion Injury. Oxid Med Cell Longev, 2018,2018: 7042105","journal-title":"Oxid Med Cell Longev"},{"key":"2536_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.yjmcc.2017.10.008","volume":"114","author":"YP Yuan","year":"2018","unstructured":"Yuan YP, Ma ZG, Zhang X, et al. CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1. J Mol Cell Cardiol, 2018,114:38\u201347","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"2536_CR11","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1159\/000486026","volume":"44","author":"D Fan","year":"2017","unstructured":"Fan D, Yang Z, Liu FY, et al. Sesamin Protects Against Cardiac Remodeling Via Sirt3\/ROS Pathway. Cell Physiol Biochem, 2017,44(6):2212\u20132227","journal-title":"Cell Physiol Biochem"},{"issue":"7","key":"2536_CR12","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/s41419-019-1718-7","volume":"10","author":"FY Liu","year":"2019","unstructured":"Liu FY, Fan D, Yang Z, et al. TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis. Cell Death Dis, 2019,10(7):480","journal-title":"Cell Death Dis"},{"issue":"8","key":"2536_CR13","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1039\/C7FO00204A","volume":"8","author":"D Fan","year":"2017","unstructured":"Fan D, Yang Z, Yuan Y, et al. Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-kappaB pathways. Food Funct, 2017,8(8):2875\u20132885","journal-title":"Food Funct"},{"issue":"2","key":"2536_CR14","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3892\/etm.2020.8743","volume":"20","author":"Y Jiang","year":"2020","unstructured":"Jiang Y, Zhang Q. Catalpol ameliorates doxorubicin-induced inflammation and oxidative stress in H9C2 cells through PPAR-gamma activation. Exp Ther Med, 2020,20(2):1003\u20131011","journal-title":"Exp Ther Med"},{"issue":"2","key":"2536_CR15","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41418-019-0372-z","volume":"27","author":"X Zhang","year":"2020","unstructured":"Zhang X, Hu C, Kong CY, et al. FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT. Cell Death Differ, 2020,27(2):540\u2013555","journal-title":"Cell Death Differ"},{"issue":"13","key":"2536_CR16","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.7150\/ijbs.47180","volume":"16","author":"D Yang","year":"2020","unstructured":"Yang D, Liu HQ, Liu FY, et al. The Roles of Noncardiomyocytes in Cardiac Remodeling. Int J Biol Sci, 2020,16(13):2414\u20132429","journal-title":"Int J Biol Sci"},{"issue":"3","key":"2536_CR17","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1172\/JCI95710","volume":"128","author":"X Zhang","year":"2018","unstructured":"Zhang X, Yoon JY, Morley M, et al. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. J Clin Invest, 2018,128(3):1154\u20131163","journal-title":"J Clin Invest"},{"issue":"7","key":"2536_CR18","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCRESAHA.112.277418","volume":"111","author":"M Xu","year":"2012","unstructured":"Xu M, Wu HD, Li RC, et al. Mir-24 regulates junctophilin-2 expression in cardiomyocytes. Circ Res, 2012,111(7):837\u2013841","journal-title":"Circ Res"},{"key":"2536_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2018.08.032","volume":"129","author":"D Liu","year":"2018","unstructured":"Liu D, Ma Z, Di S, et al. AMPK\/PGC1alpha activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med, 2018,129:59\u201372","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"2536_CR20","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/s11596-020-2197-x","volume":"40","author":"WL Gao","year":"2020","unstructured":"Gao WL, Li XH, Dun XP, et al. Grape Seed Proanthocyanidin Extract Ameliorates Streptozotocin-induced Cognitive and Synaptic Plasticity Deficits by Inhibiting Oxidative Stress and Preserving AKT and ERK Activities. Curr Med Sci, 2020,40(3):434\u2013443","journal-title":"Curr Med Sci"},{"issue":"Suppl 1","key":"2536_CR21","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.33549\/physiolres.933403","volume":"65","author":"M Barancik","year":"2016","unstructured":"Barancik M, Gresova L, Bartekova M, et al. Nrf2 as a key player of redox regulation in cardiovascular diseases. Physiol Res, 2016,65 Suppl 1:S1\u2013S10","journal-title":"Physiol Res"},{"issue":"4","key":"2536_CR22","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1161\/01.RES.0000237661.18885.f6","volume":"99","author":"CA Pacak","year":"2006","unstructured":"Pacak CA, Mah CS, Thattaliyath BD, et al. Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res, 2006,99(4):e3\u20139","journal-title":"Circ Res"},{"issue":"3","key":"2536_CR23","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nm1358","volume":"12","author":"CS Manno","year":"2006","unstructured":"Manno CS, Pierce GF, Arruda VR, et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med, 2006,12(3):342\u2013347","journal-title":"Nat Med"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-022-2536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-022-2536-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-022-2536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:53:18Z","timestamp":1726581198000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-022-2536-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["2536"],"URL":"https:\/\/doi.org\/10.1007\/s11596-022-2536-1","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]},"assertion":[{"value":"4 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}