{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:59:08Z","timestamp":1791644348076,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11596-023-2721-x","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T10:40:05Z","timestamp":1680691205000},"page":"399-408","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production"],"prefix":"10.1007","volume":"43","author":[{"given":"Shu-min","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-ya","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-chun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"issue":"9997","key":"2721_CR1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","volume":"386","author":"W Boehncke","year":"2015","unstructured":"Boehncke W, Sch\u00f6n MP. Psoriasis. Lancet, 2015,386 (9997):983\u2013994","journal-title":"Lancet"},{"issue":"19","key":"2721_CR2","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. JAMA, 2020,323(19):1945\u20131960","journal-title":"JAMA"},{"issue":"6","key":"2721_CR3","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","volume":"20","author":"A Rendon","year":"2019","unstructured":"Rendon A, Sch\u00e4kel K. Psoriasis Pathogenesis and Treatment. Int J Mol Sci, 2019,20(6):1475","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2721_CR4","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1038\/jid.2010.103","volume":"130","author":"BB Davidovici","year":"2010","unstructured":"Davidovici BB, Sattar N, Prinz J, et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Invest Dermatol, 2010,130(7):1785\u20131796","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2721_CR5","first-page":"169","volume":"22","author":"R Sales","year":"2014","unstructured":"Sales R, Torres T. Psoriasis and metabolic syndrome. Acta Dermatovenerol Croat, 2014,22(3):169\u2013174","journal-title":"Acta Dermatovenerol Croat"},{"issue":"12","key":"2721_CR6","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1080\/1744666X.2016.1201423","volume":"12","author":"A Chiricozzi","year":"2016","unstructured":"Chiricozzi A, Raimondo A, Lembo S, et al. Crosstalk between skin inflammation and adipose tissue-derived products: pathogenic evidence linking psoriasis to increased adiposity. Expert Rev Clin Immunol, 2016,12(12):1299\u20131308","journal-title":"Expert Rev Clin Immunol"},{"issue":"2","key":"2721_CR7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.advms.2021.05.002","volume":"66","author":"M Acewicz","year":"2021","unstructured":"Acewicz M, Kasacka I. Chemerin activity in selected pathological states of human body \u2014 A systematic review. Adv Med Sci, 2021,66(2):270\u2013278","journal-title":"Adv Med Sci"},{"issue":"1","key":"2721_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/1523-1747.ep12276660","volume":"109","author":"S Nagpal","year":"1997","unstructured":"Nagpal S, Patel S, Jacobe H, et al. Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. J Invest Dermatol, 1997,109(1):91\u201395","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2721_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/iub.1242","volume":"66","author":"A Mattern","year":"2014","unstructured":"Mattern A, Zellmann T, Beck-Sickinger AG. Processing, signaling, and physiological function of chemerin. IUBMB Life, 2014,66(1):19\u201326","journal-title":"IUBMB Life"},{"key":"2721_CR10","doi-asserted-by":"publisher","first-page":"517820","DOI":"10.1155\/2014\/517820","volume":"2014","author":"M Kukla","year":"2014","unstructured":"Kukla M, Adamek B, Waluga M, et al. Hepatic chemerin and chemokine-like receptor 1 expression in patients with chronic hepatitis C. Biomed Res Int, 2014,2014:517820","journal-title":"Biomed Res Int"},{"issue":"4","key":"2721_CR11","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/crj.12164","volume":"9","author":"B Boyuk","year":"2015","unstructured":"Boyuk B, Guzel EC, Atalay H, et al. Relationship between plasma chemerin levels and disease severity in COPD patients. Clin Respir J, 2015,9(4):468\u2013474","journal-title":"Clin Respir J"},{"issue":"5","key":"2721_CR12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.dld.2011.06.020","volume":"44","author":"K Adrych","year":"2012","unstructured":"Adrych K, Stojek M, Smoczynski M, et al. Increased serum chemerin concentration in patients with chronic pancreatitis. Dig Liver Dis, 2012,44(5):393\u2013397","journal-title":"Dig Liver Dis"},{"issue":"4","key":"2721_CR13","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/cmi.2014.14","volume":"11","author":"C Buechler","year":"2014","unstructured":"Buechler C. Chemerin, a novel player in inflammatory bowel disease. Cell Mol Immunol, 2014,11(4):315\u2013316","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"2721_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1530\/EJE-09-0380","volume":"161","author":"M Lehrke","year":"2009","unstructured":"Lehrke M, Becker A, Greif M, et al. Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis. Eur J Endocrinol, 2009,161(2):339\u2013344","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2721_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00011-014-0792-7","volume":"64","author":"F Mariani","year":"2015","unstructured":"Mariani F, Roncucci L. Chemerin\/chemR23 axis in inflammation onset and resolution. Inflamm Res, 2015,64(2):85\u201395","journal-title":"Inflamm Res"},{"issue":"9","key":"2721_CR16","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1182\/blood-2006-08-038844","volume":"109","author":"S Parolini","year":"2007","unstructured":"Parolini S, Santoro A, Marcenaro E, et al. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood, 2007, 109(9):3625\u20133632","journal-title":"Blood"},{"issue":"7","key":"2721_CR17","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1515\/hsz-2021-0409","volume":"403","author":"TF Fischer","year":"2022","unstructured":"Fischer TF, Beck-Sickinger AG. Chemerin-exploring a versatile adipokine. Biol Chem, 2022,403(7):625\u2013642","journal-title":"Biol Chem"},{"issue":"1","key":"2721_CR18","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.18632\/oncotarget.22260","volume":"9","author":"F Bai","year":"2018","unstructured":"Bai F, Zheng W, Dong Y, et al. Serum levels of adipokines and cytokines in psoriasis patients: a systematic review and meta-analysis. Oncotarget, 2018,9(1):1266\u20131278","journal-title":"Oncotarget"},{"issue":"4","key":"2721_CR19","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/bjd.12118","volume":"168","author":"P Gisondi","year":"2013","unstructured":"Gisondi P, Lora V, Bonauguri C, et al. Serum chemerin is increased in patients with chronic plaque psoriasis and normalizes following treatment with infliximab. Br J Dermatol, 2013,168(4):749\u2013755","journal-title":"Br J Dermatol"},{"issue":"2","key":"2721_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.bbrc.2009.01.071","volume":"380","author":"J Skrzeczynska-Moncznik","year":"2009","unstructured":"Skrzeczynska-Moncznik J, Wawro K, Stefanska A, et al. Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin. Biochem Biophys Res Commun, 2009,380(2):323\u2013327","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2721_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1084\/jem.20080129","volume":"206","author":"C Albanesi","year":"2009","unstructured":"Albanesi C, Scarponi C, Pallotta S, et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med, 2009,206(1):249\u2013258","journal-title":"J Exp Med"},{"issue":"2","key":"2721_CR22","doi-asserted-by":"publisher","first-page":"e117830","DOI":"10.1371\/journal.pone.0117830","volume":"10","author":"M Banas","year":"2015","unstructured":"Banas M, Zegar A, Kwitniewski M, et al. The expression and regulation of chemerin in the epidermis. PLoS One, 2015,10(2):e117830","journal-title":"PLoS One"},{"issue":"2","key":"2721_CR23","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1631\/jzus.B2100392","volume":"23","author":"C Gao","year":"2022","unstructured":"Gao C, Shi J, Zhang J, et al. Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1. J Zhejiang Univ Sci B, 2022,23(2):164\u2013170","journal-title":"J Zhejiang Univ Sci B"},{"issue":"6","key":"2721_CR24","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.4049\/jimmunol.174.6.3695","volume":"174","author":"K Boniface","year":"2005","unstructured":"Boniface K, Bernard FX, Garcia M, et al. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol, 2005,174(6):3695\u20133702","journal-title":"J Immunol"},{"issue":"6","key":"2721_CR25","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1038\/mi.2016.24","volume":"9","author":"ME Mulcahy","year":"2016","unstructured":"Mulcahy ME, Leech JM, Renauld JC, et al. Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa. Mucosal Immunol, 2016,9(6):1429\u20131441","journal-title":"Mucosal Immunol"},{"issue":"5","key":"2721_CR26","doi-asserted-by":"publisher","first-page":"R158","DOI":"10.1186\/ar3475","volume":"13","author":"K Kaneko","year":"2011","unstructured":"Kaneko K, Miyabe Y, Takayasu A, et al. Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis. Arthritis Res Ther, 2011,13(5):R158","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"2721_CR27","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1002\/jcb.27936","volume":"120","author":"Y Wang","year":"2019","unstructured":"Wang Y, Huo J, Zhang D, et al. Chemerin\/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-\u03baB signaling. J Cell Biochem, 2019,120(4):6459\u20136470","journal-title":"J Cell Biochem"},{"issue":"8","key":"2721_CR28","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/sj.jid.5700280","volume":"126","author":"JS Arthur","year":"2006","unstructured":"Arthur JS, Darragh J. Signaling downstream of p38 in psoriasis. J Invest Dermatol, 2006,126(8):1689\u20131691","journal-title":"J Invest Dermatol"},{"key":"2721_CR29","doi-asserted-by":"publisher","first-page":"43310","DOI":"10.1038\/srep43310","volume":"7","author":"Y Sun","year":"2017","unstructured":"Sun Y, Zhang J, Zhai T, et al. CCN1 promotes IL-1beta production in keratinocytes by activating p38 MAPK signaling in psoriasis. Sci Rep, 2017,7:43310","journal-title":"Sci Rep"},{"issue":"31","key":"2721_CR30","doi-asserted-by":"publisher","first-page":"8299","DOI":"10.1021\/acs.jafc.8b02524","volume":"66","author":"G Yang","year":"2018","unstructured":"Yang G, Li S, Yang Y, et al. Nobiletin and 5-Hydroxy-6,7,8,3\u2032,4\u2032-pentamethoxyflavone Ameliorate 12-O-Te-tradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4(+) T Cells through Mitogen-Activated Protein Kinase Signaling Pathways. J Agric Food Chem, 2018,66(31):8299\u20138306","journal-title":"J Agric Food Chem"},{"issue":"6","key":"2721_CR31","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/j.1365-2133.2010.09706.x","volume":"162","author":"L Soegaard-Madsen","year":"2010","unstructured":"Soegaard-Madsen L, Johansen C, Iversen L, et al. Adalimumab therapy rapidly inhibits p38 mitogen-activated protein kinase activity in lesional psoriatic skin preceding clinical improvement. Br J Dermatol, 2010,162(6):1216\u20131223","journal-title":"Br J Dermatol"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-023-2721-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-023-2721-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-023-2721-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T13:18:28Z","timestamp":1682515108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-023-2721-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["2721"],"URL":"https:\/\/doi.org\/10.1007\/s11596-023-2721-x","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"16 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}