{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:09:32Z","timestamp":1781348972722,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s11596-024-2854-6","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T04:02:39Z","timestamp":1712203359000},"page":"355-368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats"],"prefix":"10.1007","volume":"44","author":[{"given":"Shao-ze","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-han","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-kun","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-hu","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"issue":"9991","key":"2854_CR1","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"S Glyn-Jones","year":"2015","unstructured":"Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet, 2015,386(9991):376\u2013387","journal-title":"Lancet"},{"issue":"10134","key":"2854_CR2","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","volume":"391","author":"R Barnett","year":"2018","unstructured":"Barnett R. Osteoarthritis. Lancet, 2018,391(10134):1985","journal-title":"Lancet"},{"issue":"10182","key":"2854_CR3","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet, 2019,393(10182):1745\u20131759","journal-title":"Lancet"},{"issue":"1","key":"2854_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","volume":"7","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol, 2011,7(1):33\u201342","journal-title":"Nat Rev Rheumatol"},{"issue":"8","key":"2854_CR5","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1080\/17425247.2016.1182487","volume":"13","author":"B Armend\u00e1riz-Barrag\u00e1n","year":"2016","unstructured":"Armend\u00e1riz-Barrag\u00e1n B, Zafar N, Badri W, et al. Plant extracts: from encapsulation to application. Expert Opin Drug Deliv, 2016,13(8):1165\u201375","journal-title":"Expert Opin Drug Deliv"},{"key":"2854_CR6","doi-asserted-by":"publisher","first-page":"108193","DOI":"10.1016\/j.intimp.2021.108193","volume":"101","author":"D Liu","year":"2021","unstructured":"Liu D, Zhang C, Hu M, et al. Scutellarein relieves the death and inflammation of tubular epithelial cells in ischemic kidney injury by degradation of COX-2 protein. Int Immunopharmacol, 2021,101(Pt A):108193","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"2854_CR7","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.3390\/molecules27123782","volume":"27","author":"MY Park","year":"2022","unstructured":"Park MY, Ha SE, Kim HH, et al. Scutellarein Inhibits LPS-Induced Inflammation through NF-\u03baB\/MAPKs Signaling Pathway in RAW264.7 Cells. Molecules, 2022,27(12):3782","journal-title":"Molecules"},{"issue":"10","key":"2854_CR8","doi-asserted-by":"publisher","first-page":"e22870","DOI":"10.1002\/jbt.22870","volume":"35","author":"X Lang","year":"2021","unstructured":"Lang X, Chen Z, Yang X, et al. Scutellarein induces apoptosis and inhibits proliferation, migration, and invasion in ovarian cancer via inhibition of EZH2\/FOXO1 signaling. J Biochem Mol Toxicol, 2021,35(10):e22870","journal-title":"J Biochem Mol Toxicol"},{"issue":"16","key":"2854_CR9","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1080\/14786419.2018.1440230","volume":"33","author":"F Guo","year":"2019","unstructured":"Guo F, Yang F, Zhu YH. Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. Nat Prod Res, 2019,33(16):2372\u20132375","journal-title":"Nat Prod Res"},{"issue":"2","key":"2854_CR10","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/nu11020263","volume":"11","author":"SE Ha","year":"2019","unstructured":"Ha SE, Kim SM, Lee HJ, et al. Scutellarein Induces Fas-Mediated Extrinsic Apoptosis and G2\/M Cell Cycle Arrest in Hep3B Hepatocellular Carcinoma Cells. Nutrients, 2019,11(2):263","journal-title":"Nutrients"},{"issue":"1","key":"2854_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12950-023-00339-w","volume":"20","author":"Q Ding","year":"2023","unstructured":"Ding Q, Zhang R, Sheng G, et al. Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study. J Inflamm (Lond), 2023,20(1):14","journal-title":"J Inflamm (Lond)"},{"issue":"WebServerissue","key":"2854_CR12","doi-asserted-by":"publisher","first-page":"W609","DOI":"10.1093\/nar\/gkq300","volume":"38","author":"X Liu","year":"2010","unstructured":"Liu X, Ouyang S, Yu B, et al. PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach. Nucleic Acids Res, 2010,38(Web Server issue):W609\u2013W614","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2854_CR13","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","volume":"15","author":"P Bardou","year":"2014","unstructured":"Bardou P, Mariette J, Escudi\u00e9 F, et al. Jvenn: an interactive Venn diagram viewer. BMC Bioinformatics, 2014,15(1):293","journal-title":"BMC Bioinformatics"},{"issue":"19","key":"2854_CR14","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","volume":"30","author":"Z Gu","year":"2014","unstructured":"Gu Z, Gu L, Eils R, et al. circlize implements and enhances circular visualization in R. Bioinformatics, 2014,30(19):2811\u20132812","journal-title":"Bioinformatics"},{"issue":"1","key":"2854_CR15","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systemslevel datasets. Nat Commun, 2019,10(1):1523","journal-title":"Nat Commun"},{"issue":"5","key":"2854_CR16","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3892\/ijmm.2013.1318","volume":"31","author":"X Chu","year":"2013","unstructured":"Chu X, You H, Yuan X, et al. Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis. Int J Mol Med, 2013,31(5):1222\u20131228","journal-title":"Int J Mol Med"},{"key":"2854_CR17","doi-asserted-by":"publisher","first-page":"153387","DOI":"10.1016\/j.phymed.2020.153387","volume":"80","author":"K Sun","year":"2021","unstructured":"Sun K, Luo J, Jing X, et al. Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study. Phytomedicine, 2021,80:153387","journal-title":"Phytomedicine"},{"issue":"4","key":"2854_CR18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1302\/2046-3758.124.BJR-2022-0384.R1","volume":"12","author":"R Lu","year":"2023","unstructured":"Lu R, Wang YG, Qu Y, et al. Dihydrocaffeic acid improves IL-1\u03b2-induced inflammation and cartilage degradation via inhibiting NF-\u03baB and MAPK signalling pathways. Bone Joint Res, 2023,12(4):259\u2013273","journal-title":"Bone Joint Res"},{"issue":"3","key":"2854_CR19","first-page":"205","volume":"18","author":"MB Aydelotte","year":"1988","unstructured":"Aydelotte MB, Kuettner KE. Differences between subpopulations of cultured bovine articular chondrocytes. I. Morphology and cartilage matrix production. Connect Tissue Res, 1988,18(3):205\u2013222","journal-title":"I. Morphology and cartilage matrix production. Connect Tissue Res"},{"issue":"7","key":"2854_CR20","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3390\/ijms21072358","volume":"21","author":"YA Rim","year":"2020","unstructured":"Rim YA, Nam Y, Ju JH. The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression. Int J Mol Sci, 2020,21(7):2358","journal-title":"Int J Mol Sci"},{"key":"2854_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fphar.2019.00041","volume":"10","author":"C Tu","year":"2019","unstructured":"Tu C, Huang X, Xiao Y, et al. Schisandrin A Inhibits the IL-1\u03b2-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-\u03baB Signal Pathways in Rat Chondrocytes. Front Pharmacol, 2019,10:41","journal-title":"Front Pharmacol"},{"issue":"2","key":"2854_CR22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/00913847.2016.1168272","volume":"44","author":"MM Richards","year":"2016","unstructured":"Richards MM, Maxwell JS, Weng L, et al. Intraarticular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed, 2016,44(2):101\u2013108","journal-title":"Phys Sportsmed"},{"issue":"Suppl 1","key":"2854_CR23","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1111\/pme.12252","volume":"14","author":"JA Katz","year":"2013","unstructured":"Katz JA. COX-2 inhibition: what we learned\u2014a controversial update on safety data. Pain Med, 2013,14(Suppl1):S29\u2013S34","journal-title":"Pain Med"},{"key":"2854_CR24","doi-asserted-by":"publisher","first-page":"109582","DOI":"10.1016\/j.intimp.2022.109582","volume":"115","author":"S Lin","year":"2023","unstructured":"Lin S, Lu J, Chen Q, et al. Plantamajoside suppresses the activation of NF-\u03baB and MAPK and ameliorates the development of osteoarthritis. Int Immunopharmacol, 2023,115:109582","journal-title":"Int Immunopharmacol"},{"key":"2854_CR25","doi-asserted-by":"publisher","first-page":"109624","DOI":"10.1016\/j.intimp.2022.109624","volume":"115","author":"X Wang","year":"2023","unstructured":"Wang X, Guo Z, Lin J, et al. Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-\u03baB pathways. Int Immunopharmacol, 2023,115:109624","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"2854_CR26","first-page":"5581","volume":"17","author":"XW Huang","year":"2019","unstructured":"Huang XW, Xu Y, Sui X, et al. Scutellarein suppresses A\u03b2-induced memory impairment via inhibition of the NF-\u03baB pathway in vivo and in vitro. Oncol Lett, 2019,17(6):5581\u20135589","journal-title":"Oncol Lett"},{"issue":"7","key":"2854_CR27","doi-asserted-by":"publisher","first-page":"11951","DOI":"10.1002\/jcp.27888","volume":"234","author":"F Fu","year":"2019","unstructured":"Fu F, Shao S, Wang Z, et al. Scutellarein inhibits RANKL-induced osteoclast formation in vitro and prevents LPS-induced bone loss in vivo. J Cell Physiol, 2019,234(7):11951\u201311959","journal-title":"J Cell Physiol"},{"issue":"22","key":"2854_CR28","doi-asserted-by":"publisher","first-page":"13104","DOI":"10.1111\/jcmm.15915","volume":"24","author":"S Sun","year":"2020","unstructured":"Sun S, Yan Z, Shui X, et al. Astilbin prevents osteoarthritis development through the TLR4\/MD-2 pathway. J Cell Mol Med, 2020, 24(22):13104\u201313114","journal-title":"J Cell Mol Med"},{"issue":"5","key":"2854_CR29","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","volume":"13","author":"A Mobasheri","year":"2017","unstructured":"Mobasheri A, Rayman MP, Gualillo O, et al. The role of metabolism in the pathogenesis of osteoarthritis. Nat Rev Rheumatol, 2017,13(5):302\u2013311","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"2854_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","volume":"64","author":"F Motta","year":"2023","unstructured":"Motta F, Barone E, Sica A, et al. Inflammaging and Osteoarthritis. Clin Rev Allergy Immunol, 2023,64(2):222\u2013238","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"2854_CR31","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12951-023-02050-7","volume":"21","author":"J Wan","year":"2023","unstructured":"Wan J, He Z, Peng R, et al. Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy. J Nanobiotechnology, 2023,21(1):284","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"2854_CR32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41419-020-03341-9","volume":"12","author":"Q Guo","year":"2021","unstructured":"Guo Q, Chen X, Chen J, et al. STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-\u03baB signaling pathway. Cell Death Dis, 2021,12(1):13","journal-title":"Cell Death Dis"},{"issue":"1","key":"2854_CR33","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13075-022-02859-x","volume":"24","author":"Y Liu","year":"2022","unstructured":"Liu Y, Zhang Z, Li T, et al. Senescence in osteoarthritis: from mechanism to potential treatment. Arthritis Res Ther, 2022,24(1):174","journal-title":"Arthritis Res Ther"},{"key":"2854_CR34","doi-asserted-by":"publisher","first-page":"106926","DOI":"10.1016\/j.compbiomed.2023.106926","volume":"160","author":"Y Qu","year":"2023","unstructured":"Qu Y, Wang Y, Wang S, et al. A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis. Comput Biol Med, 2023,160:106926","journal-title":"Comput Biol Med"},{"issue":"3","key":"2854_CR35","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.maturitas.2014.12.003","volume":"80","author":"A Mobasheri","year":"2015","unstructured":"Mobasheri A, Matta C, Z\u00e1k\u00e1ny R, et al. Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis. Maturitas, 2015,80(3):237\u2013244","journal-title":"Maturitas"},{"issue":"18","key":"2854_CR36","doi-asserted-by":"publisher","first-page":"6741","DOI":"10.1128\/MCB.20.18.6741-6754.2000","volume":"20","author":"V Duli\u0107","year":"2000","unstructured":"Duli\u0107 V, Beney GE, Frebourg G, et al. Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol, 2000,20(18):6741\u20136754","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2854_CR37","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1080\/21691401.2019.1699803","volume":"48","author":"B Chai","year":"2020","unstructured":"Chai B, Zheng ZH, Liao X, et al. The protective role of omentin-1 in IL-1\u03b2-induced chondrocyte senescence. Artif Cells Nanomed Biotechnol, 2020,48(1):8\u201314","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"2854_CR38","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.biopha.2018.06.154","volume":"106","author":"H Huang","year":"2018","unstructured":"Huang H, Lei H, Yang F, et al. Activation of the bile acid receptor GPBAR1 (TGR5) ameliorates interleukin-1\u03b2 (IL-1\u03b2)-induced chondrocytes senescence. Biomed Pharmacother, 2018,106:1713\u20131719","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"2854_CR39","doi-asserted-by":"publisher","first-page":"26035","DOI":"10.3390\/ijms161125943","volume":"16","author":"HS Hwang","year":"2015","unstructured":"Hwang HS, Kim HA. Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis. Int J Mol Sci, 2015,16(11):26035\u201326054","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2854_CR40","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage, 2013,21(1):16\u201321","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2854-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-024-2854-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2854-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T09:18:23Z","timestamp":1713604703000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-024-2854-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2854"],"URL":"https:\/\/doi.org\/10.1007\/s11596-024-2854-6","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}