{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:07:05Z","timestamp":1784826425695,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11596-024-2919-6","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T05:02:07Z","timestamp":1722661327000},"page":"692-697","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Monocyte to High-density Lipoprotein Cholesterol Ratio as a Predictor of Nonalcoholic Fatty Liver Disease in Childhood Obesity"],"prefix":"10.1007","volume":"44","author":[{"given":"Jun-feng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-qing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-cai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"issue":"1","key":"2919_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.28431","volume":"64","author":"ZM Younossi","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, 2016,64(1):73\u201384","journal-title":"Hepatology"},{"issue":"3","key":"2919_CR2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/gutjnl-2019-318813","volume":"69","author":"ZM Younossi","year":"2020","unstructured":"Younossi ZM, Stepanova M, Younossi Y, et al. Epidemiology of chronic liver diseases in the USA in the past three decades. Gut, 2020,69(3):564\u2013568","journal-title":"Gut"},{"issue":"10","key":"2919_CR3","doi-asserted-by":"publisher","first-page":"e0140908","DOI":"10.1371\/journal.pone.0140908","volume":"10","author":"EL Anderson","year":"2015","unstructured":"Anderson EL, Howe LD, Jones HE, et al. The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis. PLoS One, 2015,10(10):e0140908","journal-title":"PLoS One"},{"issue":"5","key":"2919_CR4","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/17474124.2019.1595589","volume":"13","author":"L Draijer","year":"2019","unstructured":"Draijer L, Benninga M, Koot B. Pediatric NAFLD: an overview and recent developments in diagnostics and treatment. Expert Rev Gastroenterol Hepatol, 2019,13(5):447\u2013461","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"2","key":"2919_CR5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/hep.29797","volume":"68","author":"C Caussy","year":"2018","unstructured":"Caussy C, Reeder SB, Sirlin CB, et al. Noninvasive, Quantitative Assessment of Liver Fat by MRI-PDFF as an Endpoint in NASH Trials. Hepatology, 2018,68(2):763\u2013772","journal-title":"Hepatology"},{"issue":"8","key":"2919_CR6","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","volume":"65","author":"E Buzzetti","year":"2016","unstructured":"Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of nonalcoholic fatty liver disease (NAFLD). Metabolism, 2016,65(8):1038\u20131048","journal-title":"Metabolism"},{"issue":"7","key":"2919_CR7","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1080\/17461391.2019.1571114","volume":"19","author":"P Farzanegi","year":"2019","unstructured":"Farzanegi P, Dana A, Ebrahimpoor Z, et al. Mechanisms of beneficial effects of exercise training on nonalcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. Eur J Sport Sci, 2019,19(7):994\u20131003","journal-title":"Eur J Sport Sci"},{"issue":"8","key":"2919_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-018-0014-9","volume":"15","author":"VW Wong","year":"2018","unstructured":"Wong VW, Adams LA, de L\u00e9dinghen V, et al. Noninvasive biomarkers in NAFLD and NASH - current progress and future promise. Nat Rev Gastroenterol Hepatol, 2018,15(8):461\u2013478","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"2919_CR9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","volume":"11","author":"C Shi","year":"2011","unstructured":"Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol, 2011,11(11):762\u2013774","journal-title":"Nat Rev Immunol"},{"key":"2919_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.plipres.2017.05.001","volume":"67","author":"S Ganjali","year":"2017","unstructured":"Ganjali S, Momtazi AA, Banach M, et al. HDL abnormalities in familial hypercholesterolemia: Focus on biological functions. Progr Lipid Res, 2017,67:16\u201326","journal-title":"Progr Lipid Res"},{"issue":"5","key":"2919_CR11","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1177\/1076029617741362","volume":"24","author":"AU Uslu","year":"2018","unstructured":"Uslu AU, Sekin Y, Tarhan G, et al. Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome. Clin Appl Thromb Hemost, 2018,24(5):828\u2013833","journal-title":"Clin Appl Thromb Hemost"},{"issue":"4","key":"2919_CR12","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1080\/09273948.2019.1611876","volume":"28","author":"Z Katipoglu","year":"2020","unstructured":"Katipoglu Z, Mirza E, Oltulu R, et al. May Monocyte\/HDL Cholesterol Ratio (MHR) and Neutrophil\/Lymphocyte Ratio (NLR) Be an Indicator of Inflammation and Oxidative Stress in Patients with Keratoconus? Ocul Immunol Inflamm, 2020,28(4):632\u2013636","journal-title":"Ocul Immunol Inflamm"},{"issue":"8","key":"2919_CR13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.5603\/GP.a2020.0191","volume":"92","author":"D Herkiloglu","year":"2021","unstructured":"Herkiloglu D, Gokce S. Correlation of monocyte\/HDL ratio (MHR) with inflammatory parameters in obese patients diagnosed with polycystic ovary syndrome. Ginekol Lol, 2021,92(8):537\u2013543","journal-title":"Ginekol Lol"},{"issue":"2","key":"2919_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3390\/nu14020347","volume":"14","author":"C De Matteis","year":"2022","unstructured":"De Matteis C, Crudele L, Cariello M, et al. Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects. Nutrients, 2022,14(2):347","journal-title":"Nutrients"},{"issue":"7","key":"2919_CR15","first-page":"493","volume":"47","author":"H Li","year":"2009","unstructured":"Li H, Ji CY, Zong XN, et al. Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years. Zhonghua er ke za zhi (Chinese), 2009,47(7):493\u2013498","journal-title":"Zhonghua er ke za zhi (Chinese)"},{"issue":"4","key":"2919_CR16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/1751-2980.12685","volume":"20","author":"JG Fan","year":"2019","unstructured":"Fan JG, Wei L, Zhuang H. Guidelines of prevention and treatment of nonalcoholic fatty liver disease (2018, China). J Digest Dis, 2019,20(4):163\u2013173","journal-title":"J Digest Dis"},{"issue":"6","key":"2919_CR17","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2337\/diacare.27.6.1487","volume":"27","author":"TM Wallace","year":"2004","unstructured":"Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care, 2004,27(6):1487\u20131495","journal-title":"Diabetes Care"},{"issue":"11","key":"2919_CR18","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1161\/ATVBAHA.108.168690","volume":"28","author":"AJ Murphy","year":"2008","unstructured":"Murphy AJ, Woollard KJ, Hoang A, et al. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol, 2008,28(11):2071\u20132077","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"2919_CR19","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/j.amjcard.2015.08.036","volume":"116","author":"H Kundi","year":"2015","unstructured":"Kundi H, Gok M, Kiziltunc E, et al. Relation Between Monocyte to High-Density Lipoprotein Cholesterol Ratio With Presence and Severity of Isolated Coronary Artery Ectasia. Am J Cardiol, 2015,116(11):1685\u20131689","journal-title":"Am J Cardiol"},{"issue":"5","key":"2919_CR20","first-page":"505","volume":"23","author":"SK A\u00e7\u0131kg\u00f6z","year":"2016","unstructured":"A\u00e7\u0131kg\u00f6z SK, A\u00e7\u0131kg\u00f6z E, \u015eensoy B, et al. Monocyte to high-density lipoprotein cholesterol ratio is predictive of in-hospital and five-year mortality in ST-segment elevation myocardial infarction. Cardiol J, 2016,23(5):505\u2013512","journal-title":"Cardiol J"},{"key":"2919_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.vph.2018.12.002","volume":"113","author":"AK Vlacil","year":"2019","unstructured":"Vlacil AK, Schuett J, Schieffer B, et al. Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesis. Vasc Pharmacol, 2019,113:9\u201319","journal-title":"Vasc Pharmacol"},{"key":"2919_CR22","doi-asserted-by":"publisher","first-page":"777822","DOI":"10.3389\/fcvm.2022.777822","volume":"9","author":"M Lee-Rueckert","year":"2022","unstructured":"Lee-Rueckert M, Lappalainen J, Kovanen PT, et al. Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View. Front Cardiovasc Med, 2022,9:777822","journal-title":"Front Cardiovasc Med"},{"key":"2919_CR23","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.3389\/fimmu.2019.02852","volume":"10","author":"D van der Heide","year":"2019","unstructured":"van der Heide D, Weiskirchen R, Bansal R. Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases. Front Immunol, 2019,10:2852","journal-title":"Front Immunol"},{"issue":"3","key":"2919_CR24","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/hep.22404","volume":"48","author":"S Cl\u00e9ment","year":"2008","unstructured":"Cl\u00e9ment S, Juge-Aubry C, Sgroi A, et al. Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes. Hepatology, 2008,48(3):799\u2013807","journal-title":"Hepatology"},{"issue":"9","key":"2919_CR25","doi-asserted-by":"publisher","first-page":"e107265","DOI":"10.1371\/journal.pone.0107265","volume":"9","author":"KA Negrin","year":"2014","unstructured":"Negrin KA, Roth Flach RJ, DiStefano MT, et al. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PloS One, 2014,9(9):e107265","journal-title":"PloS One"},{"issue":"1","key":"2919_CR26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/hep.22950","volume":"50","author":"KR Karlmark","year":"2009","unstructured":"Karlmark KR, Weiskirchen R, Zimmermann HW, et al. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology, 2009,50(1):261\u2013274","journal-title":"Hepatology"},{"issue":"12","key":"2919_CR27","doi-asserted-by":"publisher","first-page":"9237","DOI":"10.1002\/jcp.27028","volume":"233","author":"S Ganjali","year":"2018","unstructured":"Ganjali S, Gotto AM Jr, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic marker in cardiovascular diseases. J Cell Physiol, 2018,233(12):9237\u20139246","journal-title":"J Cell Physiol"},{"issue":"7","key":"2919_CR28","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","volume":"24","author":"SL Friedman","year":"2018","unstructured":"Friedman SL, Neuschwander-Tetri BA, Rinella M, et al. Mechanisms of NAFLD development and therapeutic strategies. Nat Med, 2018,24(7):908\u2013922","journal-title":"Nat Med"},{"issue":"10290","key":"2919_CR29","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","volume":"397","author":"EE Powell","year":"2021","unstructured":"Powell EE, Wong VW, Rinella M. Nonalcoholic fatty liver disease. Lancet, 2021,397(10290):2212\u20132224","journal-title":"Lancet"},{"issue":"1","key":"2919_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/archdischild-2019-318063","volume":"106","author":"M Shaunak","year":"2021","unstructured":"Shaunak M, Byrne CD, Davis N, et al. Nonalcoholic fatty liver disease and childhood obesity. Arch Dis Child, 2021,106(1):3\u20138","journal-title":"Arch Dis Child"},{"issue":"5","key":"2919_CR31","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nrm2391","volume":"9","author":"A Guilherme","year":"2008","unstructured":"Guilherme A, Virbasius JV, Puri V, et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol, 2008,9(5):367\u2013377","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2919_CR32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cld.2009.07.009","volume":"13","author":"K Cusi","year":"2009","unstructured":"Cusi K. Role of insulin resistance and lipotoxicity in nonalcoholic steatohepatitis. Clin Liver Dis, 2009,13(4):545\u2013563","journal-title":"Clin Liver Dis"},{"issue":"1","key":"2919_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.cld.2017.08.010","volume":"22","author":"D Kim","year":"2018","unstructured":"Kim D, Touros A, Kim WR. Nonalcoholic Fatty Liver Disease and Metabolic Syndrome. Clin Liv Dis, 2018,22(1):133\u2013140","journal-title":"Clin Liv Dis"},{"key":"2919_CR34","doi-asserted-by":"publisher","first-page":"6642246","DOI":"10.1155\/2021\/6642246","volume":"2021","author":"H Huang","year":"2021","unstructured":"Huang H, Wang Q, Shi X, et al. Association between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study. Mediators Inflamm, 2021,2021:6642246","journal-title":"Mediators Inflamm"},{"key":"2919_CR35","doi-asserted-by":"publisher","first-page":"898931","DOI":"10.3389\/fmed.2022.898931","volume":"9","author":"L Wang","year":"2022","unstructured":"Wang L, Dong J, Xu M, et al. Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study. Front Med, 2022,9:898931","journal-title":"Front Med"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2919-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-024-2919-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2919-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T22:14:07Z","timestamp":1733868847000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-024-2919-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["2919"],"URL":"https:\/\/doi.org\/10.1007\/s11596-024-2919-6","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"1 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no competing interests to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}