{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:00:04Z","timestamp":1781812804061,"version":"3.54.5"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11596-024-2952-5","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T01:07:08Z","timestamp":1734138428000},"page":"1071-1080","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mast Cells Contribute to Pressure Overload-Induced Myocardial Hypertrophy by Upregulating TRPV4 via Histamine: Role of Ca2+\/ CnA\/NFATc3 Signaling Pathway"],"prefix":"10.1007","volume":"44","author":[{"given":"Zhi-dong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-yi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-feng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"issue":"8","key":"2952_CR1","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1161\/CIRCRESAHA.116.304937","volume":"116","author":"RC Lyon","year":"2015","unstructured":"Lyon RC, Zanella F, Omens JH, et al. Mechanotransduction in cardiac hypertrophy and failure. Circ Res, 2015,116(8):1462\u20131476","journal-title":"Circ Res"},{"issue":"3","key":"2952_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.pharmthera.2012.06.006","volume":"135","author":"J Hou","year":"2012","unstructured":"Hou J, Kang YJ. Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets. Pharmacol Ther, 2012,135(3):337\u2013354","journal-title":"Pharmacol Ther"},{"key":"2952_CR3","doi-asserted-by":"publisher","first-page":"2164017","DOI":"10.1155\/2019\/2164017","volume":"2019","author":"D Strassheim","year":"2019","unstructured":"Strassheim D, Dempsey EC, Gerasimovskaya E, et al. Role of inflammatory cell subtypes in heart failure. J Immunol Res, 2019,2019:2164017","journal-title":"J Immunol Res"},{"issue":"2","key":"2952_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1084\/jem.20111741","volume":"211","author":"H Sawada","year":"2014","unstructured":"Sawada H, Saito T, Nickel NP, et al. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension. J Exp Med, 2014,211(2):263\u2013280","journal-title":"J Exp Med"},{"issue":"5","key":"2952_CR5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","volume":"11","author":"NG Frangogiannis","year":"2014","unstructured":"Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol, 2014,11(5):255\u2013265","journal-title":"Nat Rev Cardiol"},{"key":"2952_CR6","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.3389\/fimmu.2018.02665","volume":"9","author":"C Gr\u00f6schel","year":"2018","unstructured":"Gr\u00f6schel C, Sasse A, Monecke S, et al. CD8+-T cells with specificity for a model antigen in cardiomyocytes can become activated after transverse aortic constriction but do not accelerate progression to heart failure. Front Immunol, 2018,9:2665","journal-title":"Front Immunol"},{"issue":"4","key":"2952_CR7","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1161\/CIRCHEARTFAILURE.115.002225","volume":"8","author":"T Nevers","year":"2015","unstructured":"Nevers T, Salvador AM, Grodecki-Pena A, et al. Left ventricular t-cell recruitment contributes to the pathogenesis of heart failure. Circ Hear Fail, 2015,8(4):776\u2013787","journal-title":"Circ Hear Fail"},{"issue":"1","key":"2952_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/cvr\/cvq272","volume":"89","author":"SP Levick","year":"2011","unstructured":"Levick SP, Melndez GC, Plante E, et al. Cardiac mast cells: The centrepiece in adverse myocardial remodelling. Cardiovasc Res, 2011,89(1):12\u201319","journal-title":"Cardiovasc Res"},{"key":"2952_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clim.2016.11.010","volume":"175","author":"SF Ong","year":"2017","unstructured":"Ong SF, Rose NR, \u010cih\u00e1kov\u00e1 D. Natural killer cells in inflammatory heart disease. Clin Immunol, 2017,175:26\u201333","journal-title":"Clin Immunol"},{"issue":"4","key":"2952_CR10","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","volume":"71","author":"P Kong","year":"2014","unstructured":"Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci, 2014,71(4):549\u2013574","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"2952_CR11","doi-asserted-by":"publisher","first-page":"a003962","DOI":"10.1101\/cshperspect.a003962","volume":"2","author":"M Gees","year":"2010","unstructured":"Gees M, Colsoul B, Nilius B. The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol, 2010,2(10):a003962","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2952_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ceca.2017.04.007","volume":"66","author":"M Mulier","year":"2017","unstructured":"Mulier M, Vriens J, Voets T. TRP channel pores and local calcium signals. Cell Calcium, 2017,66:19\u201324","journal-title":"Cell Calcium"},{"key":"2952_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-94-024-1088-4_1","volume":"976","author":"H Li","year":"2017","unstructured":"Li H. TRP Channel Classification. Adv Exp Med Biol, 2017,976:1\u20138","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"2952_CR14","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1172\/JCI27702","volume":"116","author":"K Kuwahara","year":"2006","unstructured":"Kuwahara K, Hill JA, Olson EN, et al. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest, 2006,116(12):3114\u20133126","journal-title":"J Clin Invest"},{"issue":"10","key":"2952_CR15","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1096\/fj.05-5560com","volume":"20","author":"H Nakayama","year":"2006","unstructured":"Nakayama H, Wilkin BJ, Bodi I, et al. Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart. FASEB J, 2006,20(10):1660\u20131670","journal-title":"FASEB J"},{"issue":"2","key":"2952_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1161\/CIRCRESAHA.110.225888","volume":"108","author":"P Eder","year":"2011","unstructured":"Eder P, Molkentin JD. TRPC channels as effectors of cardiac hypertrophy. Circ Res, 2011,108(2):265\u2013272","journal-title":"Circ Res"},{"issue":"12","key":"2952_CR17","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1111\/jcmm.13880","volume":"22","author":"Q Zhang","year":"2018","unstructured":"Zhang Q, Qi H, Cao Y, et al. Activation of transient receptor potential vanilloid 3 channel (TRPV3) aggravated pathological cardiac hypertrophy via calcineurin\/NFATc3 pathway in rats. J Cell Mol Med, 2018,22(12):6055\u20136067","journal-title":"J Cell Mol Med"},{"key":"2952_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ebiom.2018.08.022","volume":"36","author":"Z Wang","year":"2018","unstructured":"Wang Z, Xu Y, Wang M, et al. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice. EBioMedicine, 2018,36:54\u201362.","journal-title":"EBioMedicine"},{"issue":"5","key":"2952_CR19","doi-asserted-by":"publisher","first-page":"e28282017","DOI":"10.1038\/cddis.2017.227","volume":"8","author":"QF Wu","year":"2017","unstructured":"Wu QF, Qian C, Zhao N, et al. Activation of transient receptor potential vanilloid 4 involves in hypoxia\/reoxygenation injury in cardiomyocytes. Cell Death Dis, 2017,8(5):e28282017","journal-title":"Cell Death Dis"},{"key":"2952_CR20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1196\/annals.1341.008","volume":"1047","author":"DM Bers","year":"2005","unstructured":"Bers DM, Guo TAO. Calcium Signaling in Cardiac Ventricular Myocytes. Ann N Y Acad Sci, 2005,1047:86\u201398","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"2952_CR21","doi-asserted-by":"publisher","first-page":"H792","DOI":"10.1152\/ajpheart.00017.2014","volume":"307","author":"W Ding","year":"2014","unstructured":"Ding W, Dong M, Deng J, et al. Polydatin attenuates cardiac hypertrophy through modulation of cardiac Ca2+ handling and calcineurin-NFAT signaling pathway. Am J Physiol Hear Circ Physiol, 2014,307(5):H792\u2013H802","journal-title":"Am J Physiol Hear Circ Physiol"},{"issue":"44","key":"2952_CR22","doi-asserted-by":"publisher","first-page":"33487","DOI":"10.1074\/jbc.M605536200","volume":"281","author":"EW Bush","year":"2006","unstructured":"Bush EW, Hood DB, Papst PJ, et al. Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. J Biol Chem, 2006,281(44):33487\u201333496","journal-title":"J Biol Chem"},{"issue":"6","key":"2952_CR23","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.yjmcc.2008.08.009","volume":"45","author":"SS Palaniyandi","year":"2008","unstructured":"Palaniyandi SS, Inagaki K, Mochly-Rosen D. Mast cells and epsilonPKC: A role in cardiac remodeling in hypertension-induced heart failure. J Mol Cell Cardiol, 2008,45(6):779\u2013786","journal-title":"J Mol Cell Cardiol"},{"key":"2952_CR24","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3389\/fimmu.2019.00580","volume":"10","author":"SA Legere","year":"2019","unstructured":"Legere SA, Haidl ID, L\u00e9gar\u00e9 JF, et al. Mast cells in cardiac fibrosis: New insights suggest opportunities for intervention. Front Immunol, 2019,10:580","journal-title":"Front Immunol"},{"issue":"1","key":"2952_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/FJC.0000000000000385","volume":"68","author":"H Wang","year":"2016","unstructured":"Wang H, Da Silva J, Alencar A, et al. Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 \u00d7 Brown Norway Rats. J Cardiovasc Pharmacol, 2016,68(1):49\u201357","journal-title":"J Cardiovasc Pharmacol"},{"key":"2952_CR26","doi-asserted-by":"publisher","first-page":"659666","DOI":"10.3389\/fcell.2021.659666","volume":"9","author":"X Liu","year":"2021","unstructured":"Liu X, Shi GP, Guo J. Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling. Front Cell Dev Biol, 2021,9:659666","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"2952_CR27","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1161\/HYPERTENSIONAHA.108.123158","volume":"53","author":"SP Levick","year":"2009","unstructured":"Levick SP, McLarty JL, Murray DB, et al. Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart. Hypertension, 2009,53(6):1041\u20131047","journal-title":"Hypertension"},{"issue":"3","key":"2952_CR28","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cardiores.2005.10.020","volume":"69","author":"JS Janicki","year":"2006","unstructured":"Janicki JS, Brower GL, Gardner JD, et al. Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload. Cardiovasc Res, 2006,69(3):657\u2013665","journal-title":"Cardiovasc Res"},{"key":"2952_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1600-065X.2007.00519.x","volume":"217","author":"TC Theoharides","year":"2007","unstructured":"Theoharides TC, Kempuraj D, Tagen M, et al. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev, 2007,217:65\u201378","journal-title":"Immunol Rev"},{"key":"2952_CR30","doi-asserted-by":"publisher","first-page":"850688","DOI":"10.3389\/fcvm.2022.850688","volume":"9","author":"X Xiong","year":"2022","unstructured":"Xiong X, Li J, Zhang S, et al. Involvement of Polyamines From Cardiac Mast Cells in Myocardial Remodeling Induced by Pressure Overload Through Mitochondrial Permeability Transition Pore Opening. Front Cardiovasc Med, 2022,9:850688","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"2952_CR31","doi-asserted-by":"publisher","first-page":"e003718","DOI":"10.1161\/JAHA.116.003718","volume":"5","author":"M Chen","year":"2016","unstructured":"Chen M, Xin J, Liu B, et al. Mitogen-Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation-Induced Cardiac Hypertrophy. J Am Heart Assoc, 2016,5(8):e003718","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"2952_CR32","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1097\/HJH.0000000000001213","volume":"35","author":"SE Koch","year":"2017","unstructured":"Koch SE, Mann A, Jones S, et al. Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation. J Hypertens, 2017,35(3):602\u2013611","journal-title":"J Hypertens"},{"key":"2952_CR33","doi-asserted-by":"publisher","first-page":"14257","DOI":"10.1038\/srep14257","volume":"5","author":"RJ Thoppil","year":"2015","unstructured":"Thoppil RJ, Adapala RK, Cappelli HC, et al. TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation. Sci Rep, 2015,5:14257","journal-title":"Sci Rep"},{"issue":"4","key":"2952_CR34","doi-asserted-by":"publisher","first-page":"244","DOI":"10.2174\/1573403X15666190307112326","volume":"15","author":"AS Gorbunov","year":"2019","unstructured":"Gorbunov AS, Maslov LN, Jaggi AS, et al. Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart. Curr Cardiol Rev, 2019,15(4):244\u2013251","journal-title":"Curr Cardiol Rev"},{"key":"2952_CR35","doi-asserted-by":"publisher","first-page":"e74519","DOI":"10.7554\/eLife.74519","volume":"11","author":"Y Zou","year":"2022","unstructured":"Zou Y, Zhang M, Wu Q, et al. Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy. Elife, 2022,11:e74519","journal-title":"Elife"},{"issue":"15","key":"2952_CR36","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1161\/CIRCULATIONAHA.114.006185","volume":"130","author":"MM Kreusser","year":"2014","unstructured":"Kreusser MM, Lehmann LH, Keranov S, et al. Cardiac CaM kinase II genes \u03b4 and \u03b3 contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation, 2014,130(15):1262\u2013127","journal-title":"Circulation"},{"issue":"3","key":"2952_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1093\/cvr\/cvt208","volume":"100","author":"E Chung","year":"2013","unstructured":"Chung E, Yeung F, Leinwand LA. Calcineurin activity is required for cardiac remodelling in pregnancy. Cardiovasc Res, 2013,100(3):402\u2013410","journal-title":"Cardiovasc Res"},{"issue":"12","key":"2952_CR38","doi-asserted-by":"publisher","first-page":"11795","DOI":"10.1007\/s11033-022-07985-y","volume":"49","author":"IG Lunde","year":"2022","unstructured":"Lunde IG, Aronsen JM, Melleby AO, et al. Cardiomyocyte-specific overexpression of syndecan-4 in mice results in activation of calcineurin-NFAT signalling and exacerbated cardiac hypertrophy. Mol Biol Rep, 2022,49(12):11795\u201311809","journal-title":"Mol Biol Rep"},{"issue":"12","key":"2952_CR39","doi-asserted-by":"publisher","first-page":"e0168446","DOI":"10.1371\/journal.pone.0168446","volume":"11","author":"N Kirschmer","year":"2016","unstructured":"Kirschmer N, Bandleon S, Von Ehrlich-Treuenst\u00e4 Tt V, et al. TRPC4\u03b1 and TRPC4\u03b2 similarly affect neonatal cardiomyocyte survival during chronic GPCR stimulation. PLoS One, 2016,11(12):e0168446","journal-title":"PLoS One"},{"issue":"4","key":"2952_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00395-015-0501-x","volume":"110","author":"M Kecsk\u00e9s","year":"2015","unstructured":"Kecsk\u00e9s M, Jacobs G, Kerselaers S, et al. The Ca2+-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy. Basic Res Cardiol, 2015,110(4):43","journal-title":"Basic Res Cardiol"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2952-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-024-2952-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-024-2952-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:22:28Z","timestamp":1734956548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-024-2952-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["2952"],"URL":"https:\/\/doi.org\/10.1007\/s11596-024-2952-5","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"25 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there are no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest Statement"}}]}}