{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:01:41Z","timestamp":1762326101006,"version":"3.38.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102512"],"award-info":[{"award-number":["82102512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11596-025-00025-3","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T16:23:03Z","timestamp":1740586983000},"page":"122-136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cellular Membrane Protein GRINA is Highly Expressed and Associated with Survival Outcomes in Liver Cancer Patients"],"prefix":"10.1007","volume":"45","author":[{"given":"Jun-bo","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-shan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-lin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"15","key":"25_CR1","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","volume":"380","author":"A Villanueva","year":"2019","unstructured":"Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450\u20131462.","journal-title":"N Engl J Med."},{"issue":"1","key":"25_CR2","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","volume":"2","author":"JM Llovet","year":"2016","unstructured":"Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2(1):16018.","journal-title":"Nat Rev Dis Primers."},{"issue":"1","key":"25_CR3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","volume":"74","author":"RL Siegel","year":"2024","unstructured":"Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12\u201349.","journal-title":"CA Cancer J Clin."},{"issue":"1","key":"25_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","volume":"21","author":"C Zhang","year":"2022","unstructured":"Zhang C, Liu X, Jin S, et al. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer. 2022;21(1):47.","journal-title":"Mol Cancer."},{"issue":"8","key":"25_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12(8):599\u2013620.","journal-title":"Protein Cell."},{"issue":"1","key":"25_CR6","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13045-022-01392-3","volume":"15","author":"X Tong","year":"2022","unstructured":"Tong X, Tang R, Xiao M, et al. Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research. J Hematol Oncol. 2022;15(1):174.","journal-title":"J Hematol Oncol."},{"issue":"2","key":"25_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cac2.12250","volume":"42","author":"L Zhao","year":"2022","unstructured":"Zhao L, Zhou X, Xie F, et al. Ferroptosis in cancer and cancer immunotherapy. Cancer Commun (Lond). 2022;42(2):88\u2013116.","journal-title":"Cancer Commun (Lond)."},{"issue":"1","key":"25_CR8","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","volume":"12","author":"Y Mou","year":"2019","unstructured":"Mou Y, Wang J, Wu J, et al. Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol. 2019;12(1):34.","journal-title":"J Hematol Oncol."},{"issue":"5","key":"25_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, et al. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280\u2013296.","journal-title":"Nat Rev Clin Oncol."},{"issue":"1","key":"25_CR10","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","volume":"5","author":"D Li","year":"2020","unstructured":"Li D, Li Y. The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther. 2020;5(1):108.","journal-title":"Signal Transduct Target Ther."},{"issue":"12","key":"25_CR11","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","volume":"33","author":"LE Pope","year":"2023","unstructured":"Pope LE, Dixon SJ. Regulation of ferroptosis by lipid metabolism. Trends Cell Biol. 2023;33(12):1077\u20131087.","journal-title":"Trends Cell Biol."},{"issue":"3","key":"25_CR12","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"WS Yang","year":"2016","unstructured":"Yang WS, Stockwell BR. Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol. 2016;26(3):165\u2013176.","journal-title":"Trends Cell Biol."},{"issue":"1","key":"25_CR13","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41418-018-0173-9","volume":"26","author":"B Proneth","year":"2019","unstructured":"Proneth B, Conrad M. Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 2019;26(1):14\u201324.","journal-title":"Cell Death Differ."},{"issue":"1","key":"25_CR14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13046-017-0511-7","volume":"36","author":"Y Song","year":"2017","unstructured":"Song Y, Jang J, Shin TH, et al. Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2017;36(1):38.","journal-title":"J Exp Clin Cancer Res."},{"issue":"2","key":"25_CR15","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","volume":"79","author":"F He","year":"2023","unstructured":"He F, Zhang P, Liu J, et al. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023;79(2):362\u2013377.","journal-title":"J Hepatol."},{"issue":"2","key":"25_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203973","volume":"10","author":"B Tang","year":"2023","unstructured":"Tang B, Zhu J, Wang Y, et al. Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1\/L1 Response. Adv Sci (Weinh). 2023;10(2):e2203973.","journal-title":"Adv Sci (Weinh)."},{"issue":"1","key":"25_CR17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00726-011-0867-5","volume":"42","author":"M Conrad","year":"2012","unstructured":"Conrad M, Sato H. The oxidative stress-inducible cystine\/glutamate antiporter, system x (c) (-) : cystine supplier and beyond. Amino Acids. 2012;42(1):231\u2013246.","journal-title":"Amino Acids."},{"issue":"2","key":"25_CR18","first-page":"245","volume":"1836","author":"AA Alkhateeb","year":"2013","unstructured":"Alkhateeb AA, Connor JR. The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis. Biochim Biophys Acta. 2013;1836(2):245\u2013254.","journal-title":"Biochim Biophys Acta."},{"issue":"22","key":"25_CR19","doi-asserted-by":"publisher","first-page":"22240","DOI":"10.1021\/acsnano.3c01199","volume":"17","author":"Y Gao","year":"2023","unstructured":"Gao Y, Tong M, Wong TL, et al. Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation. ACS Nano. 2023;17(22):22240\u201322258.","journal-title":"ACS Nano."},{"issue":"6","key":"25_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202663","volume":"12","author":"Y Su","year":"2023","unstructured":"Su Y, Zhang Z, Lee LTO, et al. Amphiphilic Dendrimer Doping Enhanced pH-Sensitivity of Liposomal Vesicle for Effective Co-delivery toward Synergistic Ferroptosis-Apoptosis Therapy of Hepatocellular Carcinoma. Adv Healthc Mater. 2023;12(6):e2202663.","journal-title":"Adv Healthc Mater."},{"issue":"3","key":"25_CR21","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"J Chen","year":"2022","unstructured":"Chen J, Li X, Ge C, et al. The multifaceted role of ferroptosis in liver disease. Cell Death Differ. 2022;29(3):467\u2013480.","journal-title":"Cell Death Differ."},{"issue":"5","key":"25_CR22","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1158\/1078-0432.CCR-16-0968","volume":"23","author":"L Seifert","year":"2017","unstructured":"Seifert L, Miller G. Molecular Pathways: The Necrosome-A Target for Cancer Therapy. Clin Cancer Res. 2017;23(5):1132\u20131136.","journal-title":"Clin Cancer Res."},{"issue":"1","key":"25_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188848","volume":"1878","author":"Y Huang","year":"2023","unstructured":"Huang Y, Wang S, Ke A, et al. Ferroptosis and its interaction with tumor immune microenvironment in liver cancer. Biochim Biophys Acta Rev Cancer. 2023;1878(1):188848.","journal-title":"Biochim Biophys Acta Rev Cancer."},{"key":"25_CR24","doi-asserted-by":"publisher","first-page":"1285540","DOI":"10.3389\/fimmu.2023.1285540","volume":"14","author":"S Chen","year":"2023","unstructured":"Chen S, Zhou Z, Li Y, et al. Application of single-cell sequencing to the research of tumor microenvironment. Front Immunol. 2023;14:1285540.","journal-title":"Front Immunol."},{"issue":"9","key":"25_CR25","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s12276-020-0422-0","volume":"52","author":"J Fan","year":"2020","unstructured":"Fan J, Slowikowski K, Zhang F. Single-cell transcriptomics in cancer: computational challenges and opportunities. Experimental & Molecular Medicine. 2020;52(9):1452\u20131465.","journal-title":"Experimental &amp; Molecular Medicine."},{"key":"25_CR26","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.","journal-title":"BMC Bioinformatics."},{"issue":"6","key":"25_CR27","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1177\/0272989X06295361","volume":"26","author":"AJ Vickers","year":"2006","unstructured":"Vickers AJ, Elkin EB. Decision Curve Analysis: A Novel Method for Evaluating Prediction Models. Medical Decision Making. 2006;26(6):565\u2013574.","journal-title":"Medical Decision Making."},{"issue":"11","key":"25_CR28","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.3390\/antiox11112269","volume":"11","author":"R Pap","year":"2022","unstructured":"Pap R, Pandur E, J\u00e1nosa G, et al. Lutein Decreases Inflammation and Oxidative Stress and Prevents Iron Accumulation and Lipid Peroxidation at Glutamate-Induced Neurotoxicity. Antioxidants (Basel). 2022;11(11):2269.","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"25_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jhep.2021.09.035","volume":"76","author":"B Scheiner","year":"2022","unstructured":"Scheiner B, Pomej K, Kirstein MM, et al. Prognosis of patients with hepatocellular carcinoma treated with immunotherapy - development and validation of the CRAFITY score. J Hepatol. 2022;76(2):353\u2013363.","journal-title":"J Hepatol."},{"issue":"1","key":"25_CR30","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s12072-023-10593-y","volume":"18","author":"Y Mo","year":"2024","unstructured":"Mo Y, Zou Z, Chen E. Targeting ferroptosis in hepatocellular carcinoma. Hepatol Int. 2024;18(1):32\u201349.","journal-title":"Hepatol Int."},{"issue":"3","key":"25_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41571-021-00573-2","volume":"19","author":"JM Llovet","year":"2022","unstructured":"Llovet JM, Castet F, Heikenwalder M, et al. Immunotherapies for hepatocellular carcinoma. Nat Rev Clin Oncol. 2022;19(3):151\u2013172.","journal-title":"Nat Rev Clin Oncol."},{"issue":"5","key":"25_CR32","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1002\/hep.32740","volume":"77","author":"R Donne","year":"2023","unstructured":"Donne R, Lujambio A. The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma. Hepatology. 2023;77(5):1773\u20131796.","journal-title":"Hepatology."},{"issue":"1","key":"25_CR33","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12072-021-10248-w","volume":"16","author":"S Wan","year":"2022","unstructured":"Wan S, Lei Y, Li M, et al. A prognostic model for hepatocellular carcinoma patients based on signature ferroptosis-related genes. Hepatol Int. 2022;16(1):112\u2013124.","journal-title":"Hepatol Int."},{"key":"25_CR34","doi-asserted-by":"publisher","first-page":"1076045","DOI":"10.3389\/fimmu.2022.1076045","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu Z, Wang J, Li S, et al. Prognostic prediction and immune infiltration analysis based on ferroptosis and EMT state in hepatocellular carcinoma. Front Immunol. 2022;13:1076045.","journal-title":"Front Immunol."},{"key":"25_CR35","doi-asserted-by":"publisher","first-page":"1090895","DOI":"10.3389\/fphar.2023.1090895","volume":"14","author":"L Dong","year":"2023","unstructured":"Dong L, Zhou S, Bai X, et al. Construction of a prognostic model for HCC based on ferroptosis-related lncRNAs expression and its potential to predict the response and irAEs of immunotherapy. Front Pharmacol. 2023;14:1090895.","journal-title":"Front Pharmacol."},{"issue":"1","key":"25_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s12672-023-00677-4","volume":"14","author":"Q Wu","year":"2023","unstructured":"Wu Q, Tan Z, Xiong Y, et al. Comprehensive analysis of ferroptosis-related genes for clinical and biological significance in hepatocellular carcinoma. Discov Oncol. 2023;14(1):69.","journal-title":"Discov Oncol."},{"key":"25_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.719175","volume":"12","author":"Z Xu","year":"2021","unstructured":"Xu Z, Peng B, Liang Q, et al. Construction of a Ferroptosis-Related Nine-lncRNA Signature for Predicting Prognosis and Immune Response in Hepatocellular Carcinoma. Front Immunol. 2021;12:719175.","journal-title":"Front Immunol."},{"issue":"1","key":"25_CR38","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12957-021-02354-8","volume":"19","author":"J Cai","year":"2021","unstructured":"Cai J, Zhou M, Xu J. N6-methyladenosine (m6A) RNA methylation regulator SNRPC is a prognostic biomarker and is correlated with immunotherapy in hepatocellular carcinoma. World J Surg Oncol. 2021;19(1):241.","journal-title":"World J Surg Oncol."},{"issue":"8","key":"25_CR39","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/art.40849","volume":"71","author":"SJ Rice","year":"2019","unstructured":"Rice SJ, Tselepi M, Sorial AK, et al. Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci. Arthritis Rheumatol. 2019;71(8):1285\u20131296.","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"25_CR40","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/cdd.2011.189","volume":"19","author":"D Rojas-Rivera","year":"2012","unstructured":"Rojas-Rivera D, Armisen R, Colombo A, et al. TMBIM3\/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012;19(6):1013\u20131026.","journal-title":"Cell Death Differ."},{"issue":"1","key":"25_CR41","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1186\/s13046-018-0974-1","volume":"37","author":"DH Xu","year":"2018","unstructured":"Xu DH, Li Q, Hu H, et al. Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer. J Exp Clin Cancer Res. 2018;37(1):308.","journal-title":"J Exp Clin Cancer Res."},{"key":"25_CR42","first-page":"1","volume":"6","author":"P Yu","year":"2015","unstructured":"Yu P, Zhang M, Ding H, et al. Effect of Glutamate on Brain Iron Metabolism and the Regulation Mechanism. J Drug Metab Toxicol. 2015;6:1\u201310.","journal-title":"Journal of Drug Metabolism and Toxicology."},{"key":"25_CR43","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1111\/ejn.14583","volume":"51","author":"A Burger","year":"2020","unstructured":"Burger A, Kotze M, Stein D, et al. The relationship between measurement of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults. Eur J Neur. 2020;51:984\u2013990.","journal-title":"European Journal of Neuroscience."},{"issue":"12","key":"25_CR44","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1111\/jipb.12985","volume":"62","author":"M Cui","year":"2020","unstructured":"Cui M, Gu M, Lu Y, et al. Glutamate synthase 1 is involved in iron-deficiency response and long-distance transportation in Arabidopsis. J Integr Plant Biol. 2020;62(12):1925\u20131941.","journal-title":"J Integr Plant Biol"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-025-00025-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-025-00025-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-025-00025-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:01:03Z","timestamp":1741852863000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-025-00025-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["25"],"URL":"https:\/\/doi.org\/10.1007\/s11596-025-00025-3","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"type":"print","value":"2096-5230"},{"type":"electronic","value":"2523-899X"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"26 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm that they have no known competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Human subjects research was approved by the Ethics Committee of Xijing Hospital, part of the Air Force Medical University. Local regulatory standards and the hospital protocol were strictly adhered to throughout the study. Written informed consent was obtained from all participants prior to their inclusion in the research activities. This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Xijing Hospital, part of the Air Force Medical University. All procedures involving human participants were performed in compliance with local regulatory standards and institutional protocols.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}