{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:29:38Z","timestamp":1772148578541,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273628"],"award-info":[{"award-number":["82273628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s11596-025-00113-4","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:26:31Z","timestamp":1758291991000},"page":"1148-1159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Protective Effects of Quercetin on Ferritinophagy in Alcoholic-Induced Liver Iron Overload"],"prefix":"10.1007","volume":"45","author":[{"given":"You","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-mei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"issue":"10","key":"113_CR1","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/add.14234","volume":"113","author":"A Peacock","year":"2018","unstructured":"Peacock A, Leung J, Larney S, et al. Global statistics on alcohol, tobacco and illicit drug use: 2017 status report. Addiction. 2018;113(10):1905\u20131926.","journal-title":"Addiction."},{"key":"113_CR2","doi-asserted-by":"crossref","unstructured":"GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392(10152): 1015\u20131035.","DOI":"10.1016\/S0140-6736(18)31310-2"},{"issue":"2","key":"113_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/jama.2021.7683","volume":"326","author":"AK Singal","year":"2021","unstructured":"Singal AK, Mathurin P. Diagnosis and Treatment of Alcohol-Associated Liver Disease. JAMA. 2021;326(2):165\u2013176.","journal-title":"JAMA."},{"issue":"4","key":"113_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00018-022-04239-9","volume":"79","author":"LX Li","year":"2022","unstructured":"Li LX, Guo FF, Liu H, et al. Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets. Cell Mol Life Sci. 2022;79(4):201.","journal-title":"Cell Mol Life Sci."},{"issue":"1","key":"113_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cld.2018.09.011","volume":"23","author":"PD Axley","year":"2019","unstructured":"Axley PD, Richardson CT, Singal AK. Epidemiology of Alcohol Consumption and Societal Burden of Alcoholism and Alcoholic Liver Disease. Clin Liver Dis. 2019;23(1):39\u201350.","journal-title":"Clin Liver Dis."},{"issue":"1","key":"113_CR6","doi-asserted-by":"publisher","first-page":"7172","DOI":"10.1038\/s41467-021-27385-3","volume":"12","author":"Y Duan","year":"2021","unstructured":"Duan Y, Chu H, Brandl K, et al. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021;12(1):7172.","journal-title":"Nat Commun."},{"issue":"1","key":"113_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1182\/blood-2018-06-815894","volume":"133","author":"CY Wang","year":"2019","unstructured":"Wang CY, Babitt JL. Liver iron sensing and body iron homeostasis. Blood. 2019;133(1):18\u201329.","journal-title":"Blood."},{"issue":"1","key":"113_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biom7010009","volume":"7","author":"F Magdaleno","year":"2017","unstructured":"Magdaleno F, Blajszczak C, Nieto N. Key Events Participating in the Pathogenesis of Alcoholic Liver Disease. Biomolecules. 2017;7(1):9.","journal-title":"Biomolecules."},{"issue":"6","key":"113_CR9","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3889\/oamjms.2018.251","volume":"6","author":"MP Radicheva","year":"2018","unstructured":"Radicheva MP, Andonova AN, Milcheva HT, et al. Serum Markers of Iron Metabolism in Chronic Liver Diseases. Open Access Maced J Med Sci. 2018;6(6):1010\u20131016.","journal-title":"Open Access Maced J Med Sci."},{"issue":"7498","key":"113_CR10","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105\u2013109.","journal-title":"Nature."},{"issue":"4","key":"113_CR11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10308","volume":"5","author":"JD Mancias","year":"2015","unstructured":"Mancias JD, Pontano Vaites L, Nissim S, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. Elife. 2015;5:4:e10308.","journal-title":"Elife."},{"key":"113_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bcmd.2017.09.009","volume":"69","author":"MS Ryu","year":"2018","unstructured":"Ryu MS, Duck KA, Philpott CC. Ferritin iron regulators, PCBP1 and NCOA4, respond to cellular iron status in developing red cells. Blood Cells Mol Dis. 2018;69:75\u201381.","journal-title":"Blood Cells Mol Dis."},{"issue":"13","key":"113_CR13","doi-asserted-by":"publisher","first-page":"e00191","DOI":"10.1128\/JVI.00191-18","volume":"92","author":"Y Sun","year":"2018","unstructured":"Sun Y, Bao Q, Xuan B, et al. Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism. J Virol. 2018;92(13):e00191\u201318.","journal-title":"J Virol."},{"issue":"2","key":"113_CR14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3892\/or.2023.8482","volume":"49","author":"H Yang","year":"2023","unstructured":"Yang H, Sun WS, Bi T, et al. The PTBP1\u2011NCOA4 axis promotes ferroptosis in liver cancer cells. Oncol Rep. 2023;49(2):45.","journal-title":"Oncol Rep."},{"issue":"1","key":"113_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1002\/ptr.7309","volume":"36","author":"A Di Petrillo","year":"2021","unstructured":"Di Petrillo A, Orr\u00f9 G, Fais A, et al. Quercetin and its derivates as antiviral potentials: A comprehensive review. Phytother Res. 2021;36(1):266\u2013278.","journal-title":"Phytother Res."},{"key":"113_CR16","doi-asserted-by":"crossref","unstructured":"Yu X, Xu YY, Zhang SS, et al. Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy. Nutrients. 2016;5;8(1):27.","DOI":"10.3390\/nu8010027"},{"key":"113_CR17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.fct.2018.12.028","volume":"125","author":"H Zeng","year":"2019","unstructured":"Zeng H, Guo X, Zhou F, et al. Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy. Food Chem Toxicol. 2019;125:21\u201328.","journal-title":"Food Chem Toxicol."},{"key":"113_CR18","doi-asserted-by":"crossref","unstructured":"Gryzik M, Srivastava A, Longhi G, et al. Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4). Bioch Biophysa Acta Gen Subj. 2017;1861(11 Pt A):2710\u20132716.","DOI":"10.1016\/j.bbagen.2017.07.015"},{"key":"113_CR19","doi-asserted-by":"crossref","unstructured":"Ohshima T, Yamamoto H, Sakamaki Y, et al. NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy. J Cell Biol. 2022;3;221(10):e202203102.","DOI":"10.1083\/jcb.202203102"},{"key":"113_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2016.12.016","volume":"103","author":"Y He","year":"2017","unstructured":"He Y, Cao X, Guo P, et al. Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia. Free Radic Biol Med. 2017;103:165\u2013176.","journal-title":"Free Radic Biol Med."},{"issue":"7","key":"113_CR21","first-page":"601","volume":"44","author":"J Wang","year":"2017","unstructured":"Wang J, Zhou J, Mo WC, et al. Accumulation of simulated pathological level of formaldehyde decreases cell viability and adhesive morphology in neuronal cells. Prog Biochem Biophys. 2017;44(7):601\u2013614.","journal-title":"Prog Biochem Biophys."},{"issue":"2","key":"113_CR22","doi-asserted-by":"publisher","first-page":"16066","DOI":"10.1038\/cddiscovery.2016.66","volume":"3","author":"L Liu","year":"2016","unstructured":"Liu L, Tao Z, Zheng LD, et al. FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes. Cell Death Discov. 2016;3:2:16066.","journal-title":"Cell Death Discov."},{"issue":"1","key":"113_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","volume":"70","author":"SK Asrani","year":"2019","unstructured":"Asrani SK, Devarbhavi H, Eaton J, et al. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151\u2013171.","journal-title":"J Hepatol."},{"issue":"3","key":"113_CR24","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.jhep.2016.11.004","volume":"66","author":"T Ramirez","year":"2017","unstructured":"Ramirez T, Li YM, Yin S, et al. Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression. J Hepatol. 2017;66(3):601\u2013609.","journal-title":"J Hepatol."},{"key":"113_CR25","doi-asserted-by":"crossref","unstructured":"Lamas-Paz A, Hao F, Nelson LJ, et al. Alcoholic liver disease: Utility of animal models. World J Gastroenterol. 2018;7;24(45):5063\u20135075.","DOI":"10.3748\/wjg.v24.i45.5063"},{"issue":"1","key":"113_CR26","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/S2468-2667(18)30230-5","volume":"4","author":"RF Simpson","year":"2019","unstructured":"Simpson RF, Hermon C, Liu B, et al. Alcohol drinking patterns and liver cirrhosis risk: analysis of the prospective UK Million Women Study. Lancet Public Health. 2019;4(1):e41\u2013e48.","journal-title":"Lancet Public Health."},{"key":"113_CR27","doi-asserted-by":"crossref","unstructured":"Li S, Cao H, Shen D, et al. Quercetin protects against ox\u2011LDL\u2011induced injury via regulation of ABCAl, LXR\u2011\u03b1 and PCSK9 in RAW264. 7 macrophages. Mol Med Rep. 2018;18(1):799\u2013806.","DOI":"10.3892\/mmr.2018.9048"},{"key":"113_CR28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.biopha.2016.12.044","volume":"86","author":"J Roslan","year":"2017","unstructured":"Roslan J, Giribabu N, Karim K, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2017;86:570\u2013582.","journal-title":"Biomed Pharmacother."},{"key":"113_CR29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.biopha.2018.03.057","volume":"102","author":"CFS Guazelli","year":"2018","unstructured":"Guazelli CFS, Staurengo-Ferrari L, Zarpelon AC, et al. Quercetin attenuates zymosan-induced arthritis in mice. Biomed Pharmacother. 2018;102:175\u2013184.","journal-title":"Biomed Pharmacother."},{"key":"113_CR30","doi-asserted-by":"crossref","unstructured":"Liu S, Tian L, Chai G, et al. Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation. Food Funct. 2018;15;9(8):4184\u20134193.","DOI":"10.1039\/C8FO00650D"},{"key":"113_CR31","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.fct.2018.02.022","volume":"114","author":"L Xiao","year":"2018","unstructured":"Xiao L, Luo G, Tang Y, et al. Quercetin and iron metabolism: What we know and what we need to know. Food Chem Toxicol. 2018;114:190\u2013203.","journal-title":"Food Chem Toxicol."},{"issue":"21","key":"113_CR32","first-page":"8023840","volume":"2018","author":"AA El-Sheikh","year":"2018","unstructured":"El-Sheikh AA, Ameen SH, Abdel-Fatah SS. Ameliorating Iron Overload in Intestinal Tissue of Adult Male Rats: Quercetin vs Deferoxamine. J Toxicol. 2018;21:2018:8023840.","journal-title":"J Toxicol."},{"issue":"6","key":"113_CR33","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/iub.1621","volume":"69","author":"P Arosio","year":"2017","unstructured":"Arosio P, Elia L, Poli M. Ferritin, cellular iron storage and regulation. IUBMB Life. 2017;69(6):414\u2013422.","journal-title":"IUBMB Life."},{"issue":"3","key":"113_CR34","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bbagen.2018.12.013","volume":"1863","author":"P Gupta","year":"2019","unstructured":"Gupta P, Singh P, Pandey HS, et al. Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation. Biochim Biophys Acta Gen Subj. 2019;1863(3):547\u2013564.","journal-title":"Biochim Biophys Acta Gen Subj."},{"issue":"1","key":"113_CR35","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1021\/pr060439b","volume":"6","author":"C Melle","year":"2006","unstructured":"Melle C, Ernst G, Scheibner O, et al. Identification of Specific Protein Markers in Microdissected Hepatocellular Carcinoma. J Proteome Res. 2006;6(1):306\u2013315.","journal-title":"J Proteome Res."},{"issue":"11","key":"113_CR36","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/ncb3053","volume":"16","author":"WE Dowdle","year":"2014","unstructured":"Dowdle WE, Nyfeler B, Nagel J, et al. Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Nat Cell Biol. 2014;16(11):1069\u20131079.","journal-title":"Nat Cell Biol."},{"key":"113_CR37","doi-asserted-by":"crossref","unstructured":"Bellelli R, Federico G, Matte\u2019 A, et al. NCOA4 Deficiency Impairs Systemic Iron Homeostasis. Cell Rep. 2016;14(3):411\u2013421.","DOI":"10.1016\/j.celrep.2015.12.065"},{"issue":"2","key":"113_CR38","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00394-018-1713-2","volume":"58","author":"Z Yao","year":"2018","unstructured":"Yao Z, Gu Y, Zhang Q, et al. Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults. Eur J Nutr. 2018;58(2):819\u2013830.","journal-title":"Eur J Nutr."},{"issue":"2","key":"113_CR39","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/liv.12893","volume":"36","author":"SK Das","year":"2015","unstructured":"Das SK, Desaulniers J, Dyck JR B, et al. Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron\u2010overload. Liver Int. 2015;36(2):246\u2013257.","journal-title":"Liver Int."},{"key":"113_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","volume":"14","author":"S Masaldan","year":"2018","unstructured":"Masaldan S, Clatworthy SA, Gamell C, et al. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis. Redox biol. 2018;14:100\u2013115.","journal-title":"Redox biol."},{"issue":"28","key":"113_CR41","doi-asserted-by":"publisher","first-page":"5073420","DOI":"10.1155\/2018\/5073420","volume":"2018","author":"Y Huang","year":"2018","unstructured":"Huang Y, Chen Y, Shaw AM, et al. Enhancing TFEB\u2010Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin. Oxid Med Cell Longev. 2018;28:2018:5073420.","journal-title":"Oxid Med Cell Longev."}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-025-00113-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-025-00113-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-025-00113-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:02:40Z","timestamp":1762290160000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-025-00113-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["113"],"URL":"https:\/\/doi.org\/10.1007\/s11596-025-00113-4","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]},"assertion":[{"value":"6 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All other authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}},{"value":"Not applicable.\u00a0","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"This study was conducted according to the Declaration of Helsinki statement.\u00a0The protocol for the animal experiments was approved by the Institutional Animal Care and Use Committee, Huazhong University of Science and Technology (No. 2024-4500).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval\u00a0and Consent to Participate"}}]}}