{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:08:40Z","timestamp":1785035320686,"version":"3.55.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFB830"],"award-info":[{"award-number":["2025AFB830"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Fund of Hubei Provincial Key Laboratory for Occupational Hazard Identification and Control","award":["JF2024-G17"],"award-info":[{"award-number":["JF2024-G17"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CURR MED SCI"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11596-026-00163-2","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:28:28Z","timestamp":1770208108000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epigenetic Modulation by\u00a0Vitamin C and in Prenatal Depression: Implications for Offspring Health"],"prefix":"10.1007","volume":"46","author":[{"given":"Jia-shuang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-qing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"163_CR1","doi-asserted-by":"publisher","first-page":"101932","DOI":"10.1016\/j.cpr.2020.101932","volume":"83","author":"X Yin","year":"2021","unstructured":"Yin X, Sun N, Jiang N, et al. Prevalence and associated factors of antenatal depression: Systematic reviews and meta-analyses. Clin Psychol Rev. 2021;83:101932.","journal-title":"Clin Psychol Rev"},{"issue":"23","key":"163_CR2","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.3390\/healthcare12232431","volume":"12","author":"JK Aldinger","year":"2024","unstructured":"Aldinger JK, Abele H, Kranz A. Prenatal maternal psychological stress (PMPS) and its effect on the maternal and neonatal outcome: a retrospective cohort study. Healthcare (Basel). 2024;12(23):2431.","journal-title":"Healthcare (Basel)"},{"issue":"8","key":"163_CR3","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1017\/S0033291723003604","volume":"54","author":"H Hope","year":"2024","unstructured":"Hope H, Pierce M, Gabr H, et al. The causal association between maternal depression, anxiety, and infection in pregnancy and neurodevelopmental disorders among 410,461 children: a population study using quasi-negative control cohorts and sibling analysis. Psychol Med. 2024;54(8):1693\u20131701.","journal-title":"Psychol Med"},{"issue":"4","key":"163_CR4","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3390\/antiox13040398","volume":"13","author":"Z Lu","year":"2024","unstructured":"Lu Z, Yang Y, Zhao G, et al. The association of redox regulatory drug target genes with psychiatric disorders: a mendelian randomization study. Antioxidants (Basel). 2024;13(4):398.","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"163_CR5","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.cmet.2025.01.019","volume":"37","author":"ZL Cheng","year":"2025","unstructured":"Cheng ZL, Zhang S, Wang Z, et al. Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation. Cell Metab. 2025;37(5):1137\u20131151.e5.","journal-title":"Cell Metab"},{"key":"163_CR6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bbi.2025.03.032","volume":"128","author":"M Sim","year":"2025","unstructured":"Sim M, Hong S, Jung MH, et al. Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitamin C status: a randomized, double-blind, placebo-controlled trial. Brain Behav Immun. 2025;128:179\u2013191.","journal-title":"Brain Behav Immun"},{"key":"163_CR7","doi-asserted-by":"publisher","first-page":"1234461","DOI":"10.3389\/fpsyt.2023.1234461","volume":"14","author":"R Yang","year":"2023","unstructured":"Yang R, Lin Z, Cai Y, et al. Assessing the risk of prenatal depressive symptoms in Chinese women: an integrated evaluation of serum metabolome, multivitamin supplement intake, and clinical blood indicators. Front Psychiatry. 2023;14:1234461.","journal-title":"Front Psychiatry"},{"key":"163_CR8","doi-asserted-by":"crossref","unstructured":"Pereira AGA, Molino GOG, Santos ACFF, et al. Efficacy of vitamin C supplementation during pregnancy in the prevention of preterm birth: a systematic review and meta-analysis. Rev Bras Ginecol Obstet. 2025;47:e\u2013rbgo1.","DOI":"10.61622\/rbgo\/2025rbgo1"},{"key":"163_CR9","doi-asserted-by":"publisher","first-page":"102543","DOI":"10.1016\/j.redox.2022.102543","volume":"58","author":"QQ Han","year":"2022","unstructured":"Han QQ, Wu PF, Li YH, et al. SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene. Redox Biol. 2022;58:102543.","journal-title":"Redox Biol"},{"issue":"9","key":"163_CR10","doi-asserted-by":"publisher","first-page":"108452","DOI":"10.1016\/j.celrep.2020.108452","volume":"33","author":"T Qi","year":"2020","unstructured":"Qi T, Sun M, Zhang C, et al. Ascorbic acid promotes plasma cell differentiation through enhancing TET2\/3-mediated DNA demethylation. Cell Rep. 2020;33(9):108452.","journal-title":"Cell Rep"},{"issue":"11","key":"163_CR11","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1016\/j.jid.2025.03.040","volume":"145","author":"Y Sato","year":"2025","unstructured":"Sato Y, Sato A, Kuwano A, et al. Vitamin C promotes epidermal proliferation by promoting DNA demethylation of proliferation-related genes in human epidermal equivalents. J Investig Dermatol. 2025;145(11):2775\u20132788.e14.","journal-title":"J Investig Dermatol"},{"issue":"1","key":"163_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.2174\/1574888X16666210714152730","volume":"17","author":"X Liu","year":"2022","unstructured":"Liu X, Khan A, Li H, et al. Ascorbic acid in epigenetic reprogramming. Curr Stem Cell Res Ther. 2022;17(1):13\u201325.","journal-title":"Curr Stem Cell Res Ther"},{"key":"163_CR13","doi-asserted-by":"publisher","first-page":"108459","DOI":"10.1016\/j.jnutbio.2020.108459","volume":"85","author":"B Moritz","year":"2020","unstructured":"Moritz B, Schmitz AE, Rodrigues ALS, et al. The role of vitamin C in stress-related disorders. J Nutr Biochem. 2020;85:108459.","journal-title":"J Nutr Biochem"},{"issue":"1","key":"163_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12888-020-02730-w","volume":"20","author":"D Plevin","year":"2020","unstructured":"Plevin D, Galletly C. The neuropsychiatric effects of vitamin C deficiency: a systematic review. BMC Psychiatry. 2020;20(1):315.","journal-title":"BMC Psychiatry"},{"issue":"4","key":"163_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3390\/antiox12040941","volume":"12","author":"AC Carr","year":"2023","unstructured":"Carr AC, Bradley HA, Vlasiuk E, et al. Inflammation and vitamin C in women with prenatal depression and anxiety: effect of multinutrient supplementation. Antioxidants (Basel). 2023;12(4):941.","journal-title":"Antioxidants (Basel)"},{"issue":"1\u20132","key":"163_CR16","first-page":"29","volume":"475","author":"B Halliwell","year":"2001","unstructured":"Halliwell B. Vitamin C and genomic stability. Mutat Res. 2001;475(1\u20132):29\u201335.","journal-title":"Mutat Res"},{"issue":"11","key":"163_CR17","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/nu9111211","volume":"9","author":"A Carr","year":"2017","unstructured":"Carr A, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211.","journal-title":"Nutrients"},{"issue":"7461","key":"163_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature12362","volume":"500","author":"K Blaschke","year":"2013","unstructured":"Blaschke K, Ebata KT, Karimi MM, et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013;500(7461):222\u2013226.","journal-title":"Nature"},{"issue":"7295","key":"163_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nature09017","volume":"465","author":"M Stadtfeld","year":"2010","unstructured":"Stadtfeld M, Apostolou E, Akutsu H, et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010;465(7295):175\u2013181.","journal-title":"Nature"},{"key":"163_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ibneur.2022.12.002","volume":"14","author":"Y Rasmi","year":"2023","unstructured":"Rasmi Y, Shokati A, Hassan A, et al. The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation inhibitors as therapeutic agents for such disorders. IBRO Neurosci Rep. 2023;14:28\u201337.","journal-title":"IBRO Neurosci Rep"},{"key":"163_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41398-023-02620-1","volume":"13","author":"E Drzymalla","year":"2023","unstructured":"Drzymalla E, Crider KS, Wang A, et al. Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review. Transl Psychiatry. 2023;13:377.","journal-title":"Transl Psychiatry"},{"issue":"D1","key":"163_CR22","doi-asserted-by":"publisher","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","volume":"53","author":"S Jiang","year":"2025","unstructured":"Jiang S, Li H, Zhang L, et al. Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics. Nucleic Acids Res. 2025;53(D1): D1670\u2013D1676.","journal-title":"Nucleic Acids Res"},{"key":"163_CR23","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.freeradbiomed.2025.07.036","volume":"239","author":"R Magdalena","year":"2025","unstructured":"Magdalena R, Ferrada L, Ram\u00edrez E, et al. Dehydroascorbic acid impairs neurite growth through RIPK1-associated caspase activation. Free Radic Biol Med. 2025;239:406\u2013416.","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"163_CR24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s12031-012-9892-4","volume":"49","author":"M Moretti","year":"2013","unstructured":"Moretti M, Budni J, dos Santos DB, et al. Protective effects of ascorbic acid on behavior and oxidative status of restraint-stressed mice. J Mol Neurosci. 2013;49(1):68\u201379.","journal-title":"J Mol Neurosci"},{"key":"163_CR25","doi-asserted-by":"publisher","first-page":"932309","DOI":"10.3389\/fcimb.2022.932309","volume":"12","author":"J Song","year":"2022","unstructured":"Song J, Zhou B, Kan J, et al. Gut microbiota: Linking nutrition and perinatal depression. Front Cell Infect Microbiol. 2022;12:932309.","journal-title":"Front Cell Infect Microbiol"},{"key":"163_CR26","doi-asserted-by":"publisher","first-page":"6611169","DOI":"10.1155\/2024\/6611169","volume":"2024","author":"A Kautz","year":"2024","unstructured":"Kautz A, Meng Y, Yeh KL, et al. Dietary intake of nutrients involved in serotonin and melatonin synthesis and prenatal maternal sleep quality and affective symptoms. J Nutr Metab. 2024;2024:6611169.","journal-title":"J Nutr Metab"},{"issue":"8","key":"163_CR27","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1001\/jamapsychiatry.2019.0774","volume":"76","author":"B Leppert","year":"2019","unstructured":"Leppert B, Havdahl A, Riglin L, et al. Association of maternal neurodevelopmental risk alleles with early-life exposures. JAMA Psychiatry. 2019;76(8):834\u2013842.","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"163_CR28","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41398-024-03148-8","volume":"14","author":"S Abrishamcar","year":"2024","unstructured":"Abrishamcar S, Zhuang BC, Thomas M, et al. Association between maternal perinatal stress and depression and infant DNA methylation in the first year of life. Transl Psychiatry. 2024;14(1):445.","journal-title":"Transl Psychiatry"},{"key":"163_CR29","doi-asserted-by":"publisher","first-page":"107473","DOI":"10.1016\/j.envint.2022.107473","volume":"168","author":"G Jigeer","year":"2022","unstructured":"Jigeer G, Tao W, Zhu Q, et al. Association of residential noise exposure with maternal anxiety and depression in late pregnancy. Environ Int. 2022;168:107473.","journal-title":"Environ Int"},{"issue":"6","key":"163_CR30","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.neuron.2015.05.036","volume":"86","author":"T Klengel","year":"2015","unstructured":"Klengel T, Binder EB. Epigenetics of stress-related psychiatric disorders and gene \u00d7 environment interactions. Neuron. 2015;86(6):1343\u20131357.","journal-title":"Neuron"},{"issue":"4","key":"163_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.31887\/DCNS.2019.21.4\/ebinder","volume":"21","author":"S Penner-Goeke","year":"2019","unstructured":"Penner-Goeke S, Binder EB. Epigenetics and depression?. Dialogues Clin Neurosci. 2019;21(4):397\u2013405.","journal-title":"Dialogues Clin Neurosci"},{"issue":"10","key":"163_CR32","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.3390\/antiox11101993","volume":"11","author":"A G\u0119gotek","year":"2022","unstructured":"G\u0119gotek A, Skrzydlewska E. Antioxidative and anti-inflammatory activity of ascorbic acid. Antioxidants.. 2022;11(10):1993.","journal-title":"Antioxidants"},{"key":"163_CR33","doi-asserted-by":"publisher","first-page":"1290749","DOI":"10.3389\/fnut.2023.1290749","volume":"10","author":"N Ding","year":"2023","unstructured":"Ding N, Zeng Z, Luo J, et al. The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database. Front Nutr. 2023;10:1290749.","journal-title":"Front Nutr"},{"issue":"12","key":"163_CR34","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1007\/s11010-021-04240-z","volume":"476","author":"YR Li","year":"2021","unstructured":"Li YR, Zhu H. Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine. Mol Cell Biochem. 2021;476(12):4449\u20134460.","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"163_CR35","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3947\/ic.2020.52.4.461","volume":"52","author":"M Farjana","year":"2020","unstructured":"Farjana M, Moni A, Sohag AAM, et al. Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19. Infect Chemother. 2020;52(4):461\u2013477.","journal-title":"Infect Chemother"},{"key":"163_CR36","doi-asserted-by":"publisher","first-page":"104321","DOI":"10.1016\/j.phrs.2019.104321","volume":"146","author":"SJ Ballaz","year":"2019","unstructured":"Ballaz SJ, Rebec GV. Neurobiology of vitamin C: Expanding the focus from antioxidant to endogenous neuromodulator. Pharmacol Res. 2019;146:104321.","journal-title":"Pharmacol Res"},{"issue":"36","key":"163_CR37","doi-asserted-by":"publisher","first-page":"365501","DOI":"10.1088\/1361-6528\/ad544d","volume":"35","author":"A Biswas","year":"2024","unstructured":"Biswas A, Kumar A, Kumar A, et al. High performance Pt-anchored MoS2based chemiresistive ascorbic acid sensor. Nanotechnology. 2024;35(36):365501.","journal-title":"Nanotechnology"},{"key":"163_CR38","doi-asserted-by":"publisher","first-page":"1229243","DOI":"10.3389\/fnut.2023.1229243","volume":"10","author":"VK Maurya","year":"2023","unstructured":"Maurya VK, Shakya A, McClements DJ, et al. Vitamin C fortification: need and recent trends in encapsulation technologies. Front Nutr. 2023;10:1229243.","journal-title":"Front Nutr"},{"issue":"6","key":"163_CR39","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/molecules26061562","volume":"26","author":"J Jiaranaikulwanitch","year":"2021","unstructured":"Jiaranaikulwanitch J, Pandith H, Tadtong S, et al. Novel multifunctional ascorbic triazole derivatives for amyloidogenic pathway inhibition, anti-inflammation, and neuroprotection. Molecules. 2021;26(6):1562.","journal-title":"Molecules"},{"issue":"2","key":"163_CR40","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41390-024-03674-7","volume":"98","author":"CA Gillespie","year":"2025","unstructured":"Gillespie CA, Chowdhury A, Quinn KA, et al. Fundamentals of DNA methylation in development. Pediatr Res. 2025;98(2):458\u2013469.","journal-title":"Pediatr Res"},{"key":"163_CR41","doi-asserted-by":"publisher","first-page":"966522","DOI":"10.3389\/fimmu.2022.966522","volume":"13","author":"L Wei","year":"2022","unstructured":"Wei L, Ying X, Zhai M, et al. The association between peritraumatic distress, perceived stress, depression in pregnancy, and NR3C1 DNA methylation among Chinese pregnant women who experienced COVID-19 lockdown. Front Immunol. 2022;13:966522.","journal-title":"Front Immunol"},{"key":"163_CR42","doi-asserted-by":"publisher","first-page":"251686572093214","DOI":"10.1177\/2516865720932146","volume":"13","author":"V Stonawski","year":"2020","unstructured":"Stonawski V, Roetner J, Goecke TW, et al. Genome-wide DNA methylation patterns in children exposed to nonpharmacologically treated prenatal depressive symptoms: results from 2 independent cohorts. Genet Epigenet. 2020;13:2516865720932146.","journal-title":"Genet Epigenet"},{"key":"163_CR43","doi-asserted-by":"publisher","first-page":"e10603","DOI":"10.48101\/ujms.v129.10603","volume":"129","author":"RTA Castro","year":"2024","unstructured":"Castro RTA, Gardini E, Iliadis SI, et al. Personality vulnerability to depression, resilience, and depressive symptoms: epigenetic markers among perinatal women. Ups J Med Sci. 2024;129:e10603.","journal-title":"Ups J Med Sci"},{"key":"163_CR44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.jad.2023.01.079","volume":"327","author":"JH Zhu","year":"2023","unstructured":"Zhu JH, Bo HH, Liu BP, et al. The associations between DNA methylation and depression: a systematic review and meta-analysis. J Affect Disord. 2023;327:439\u2013450.","journal-title":"J Affect Disord"},{"issue":"1","key":"163_CR45","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13148-021-01054-0","volume":"13","author":"TK Kallak","year":"2021","unstructured":"Kallak TK, Br\u00e4nn E, Fransson E, et al. DNA methylation in cord blood in association with prenatal depressive symptoms. Clin Epigenetics. 2021;13(1):78.","journal-title":"Clin Epigenetics"},{"issue":"4","key":"163_CR46","doi-asserted-by":"publisher","first-page":"409","DOI":"10.4161\/epi.19551","volume":"7","author":"JW Schroeder","year":"2012","unstructured":"Schroeder JW, Smith AK, Brennan PA, et al. DNA methylation in neonates born to women receiving psychiatric care. Epigenetics. 2012;7(4):409\u2013414.","journal-title":"Epigenetics"},{"issue":"4","key":"163_CR47","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.biopsych.2016.08.017","volume":"81","author":"A Torres-Berr\u00edo","year":"2017","unstructured":"Torres-Berr\u00edo A, Lopez JP, Bagot RC, et al. DCC confers susceptibility to depression-like behaviors in humans and mice and is regulated by miR-218. Biol Psychiatry. 2017;81(4):306\u2013315.","journal-title":"Biol Psychiatry"},{"issue":"38","key":"163_CR48","doi-asserted-by":"publisher","first-page":"23280","DOI":"10.1073\/pnas.1820842116","volume":"117","author":"N Proven\u00e7al","year":"2020","unstructured":"Proven\u00e7al N, Arloth J, Cattaneo A, et al. Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. Proc Natl Acad Sci U S A. 2020;117(38):23280\u201323285.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"163_CR49","doi-asserted-by":"publisher","first-page":"105769","DOI":"10.1016\/j.psyneuen.2022.105769","volume":"141","author":"ACI Rodriguez","year":"2022","unstructured":"Rodriguez ACI, Smith L, Harris R, et al. Oxytocin modulates sensitivity to acculturation and discrimination stress in pregnancy. Psychoneuroendocrinology. 2022;141:105769.","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"163_CR50","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.cell.2017.07.032","volume":"170","author":"L Cimmino","year":"2017","unstructured":"Cimmino L, Dolgalev I, Wang Y, et al. Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell. 2017;170(6):1079\u20131095.e20.","journal-title":"Cell"},{"issue":"1","key":"163_CR51","doi-asserted-by":"publisher","first-page":"2211361","DOI":"10.1080\/15592294.2023.2211361","volume":"18","author":"A Keshawarz","year":"2023","unstructured":"Keshawarz A, Joehanes R, Ma J, et al. Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis. Epigenetics. 2023;18(1):2211361.","journal-title":"Epigenetics"},{"issue":"1","key":"163_CR52","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1021\/acschembio.3c00567","volume":"19","author":"W He","year":"2024","unstructured":"He W, Yin X, Xu C, et al. Ascorbic acid reprograms epigenome and epitranscriptome by reducing Fe(III) in the catalytic cycle of dioxygenases. ACS Chem Biol. 2024;19(1):129\u2013140.","journal-title":"ACS Chem Biol"},{"issue":"1","key":"163_CR53","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41467-021-21061-2","volume":"12","author":"W Li","year":"2021","unstructured":"Li W, Zhang T, Sun M, et al. Molecular mechanism for vitamin C-derived C5-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun. 2021;12(1):744.","journal-title":"Nat Commun"},{"key":"163_CR54","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13072-017-0143-3","volume":"10","author":"KT Ebata","year":"2017","unstructured":"Ebata KT, Mesh K, Liu S, et al. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a\/b. Epigenetics Chromatin. 2017;10:36.","journal-title":"Epigenetics Chromatin"},{"key":"163_CR55","doi-asserted-by":"publisher","first-page":"1373499","DOI":"10.3389\/fnut.2024.1373499","volume":"11","author":"NY Noronha","year":"2024","unstructured":"Noronha NY, Noma IHY, Fernandes Ferreira R, et al. Association between the relative abundance of Phyla Actinobacteria, vitamin C consumption, and DNA methylation of genes linked to immune response pathways. Front Nutr. 2024;11:1373499.","journal-title":"Front Nutr"},{"issue":"1","key":"163_CR56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13148-022-01404-6","volume":"15","author":"A Taira","year":"2023","unstructured":"Taira A, Palin K, Kuosmanen A, et al. Vitamin C boosts DNA demethylation in TET2 germline mutation carriers. Clin Epigenetics. 2023;15(1):7.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"163_CR57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13148-024-01644-8","volume":"16","author":"LE Shorey-Kendrick","year":"2024","unstructured":"Shorey-Kendrick LE, McEvoy CT, Milner K, et al. Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age. Clin Epigenetics. 2024;16(1):35.","journal-title":"Clin Epigenetics"},{"issue":"4","key":"163_CR58","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1192\/bjp.2019.260","volume":"216","author":"H Burger","year":"2020","unstructured":"Burger H, Verbeek T, Aris-Meijer JL, et al. Effects of psychological treatment of mental health problems in pregnant women to protect their offspring: randomised controlled trial. Br J Psychiatry. 2020;216(4):182\u2013188.","journal-title":"Br J Psychiatry"},{"issue":"8","key":"163_CR59","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1177\/07067437241248070","volume":"69","author":"M Talib","year":"2024","unstructured":"Talib M, Rachdi M, Papazova A, et al. The Role of Dietary Patterns and Nutritional Supplements in the Management of Mental Disorders in Children and Adolescents: an Umbrella Review of Meta-Analyses: Le r\u00f4le des habitudes alimentaires et des suppl\u00e9ments nutritionnels dans la prise en charge des troubles mentaux chez les enfants et les adolescents: une m\u00e9ta-revue de m\u00e9ta-analyses. Can J Psychiatry. 2024;69(8):567\u2013589.","journal-title":"Can J Psychiatry"},{"issue":"9","key":"163_CR60","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1002\/aur.2988","volume":"16","author":"LA Avalos","year":"2023","unstructured":"Avalos LA, Chandran A, Churchill ML, et al. Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program. Autism Res. 2023;16(9):1825\u20131835.","journal-title":"Autism Res"},{"issue":"6","key":"163_CR61","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jaac.2023.08.018","volume":"63","author":"LM Chen","year":"2024","unstructured":"Chen LM, Pokhvisneva I, Lahti-Pulkkinen M, et al. Independent prediction of child psychiatric symptoms by maternal mental health and child polygenic risk scores. J Am Acad Child Adolesc Psychiatry. 2024;63(6):640\u2013651.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"163_CR62","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jad.2023.01.103","volume":"327","author":"Q Wei","year":"2023","unstructured":"Wei Q, Zou J, Ma X, et al. Prospective associations between various prenatal exposures to maternal psychological stress and neurodevelopment in children within 24 months after birth. J Affect Disord. 2023;327:101\u2013110.","journal-title":"J Affect Disord"},{"issue":"1\u20132","key":"163_CR63","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/pr.2016.197","volume":"81","author":"D Scheinost","year":"2017","unstructured":"Scheinost D, Sinha R, Cross SN, et al. Does prenatal stress alter the developing connectome? Pediatr Res. 2017;81(1\u20132):214\u2013226.","journal-title":"Pediatr Res"},{"issue":"3","key":"163_CR64","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3390\/nu16030369","volume":"16","author":"SJ Coker","year":"2024","unstructured":"Coker SJ, Berry MJ, Vissers MCM, et al. Maternal vitamin C intake during pregnancy influences long-term offspring growth with timing- and sex-specific effects in guinea pigs. Nutrients. 2024;16(3):369.","journal-title":"Nutrients"},{"issue":"1","key":"163_CR65","doi-asserted-by":"publisher","first-page":"25486","DOI":"10.1038\/s41598-024-73005-7","volume":"14","author":"LE Shorey-Kendrick","year":"2024","unstructured":"Shorey-Kendrick LE, McEvoy CT, O\u2019Sullivan SM, et al. Vitamin C supplementation improves placental function and alters placental gene expression in smokers. Sci Rep. 2024;14(1):25486.","journal-title":"Sci Rep"},{"issue":"6","key":"163_CR66","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.3390\/nu17061077","volume":"17","author":"MQ Nguyen","year":"2025","unstructured":"Nguyen MQ, Munakata K, Natsume M, et al. The influence of maternal diet in late pregnancy on malondialdehyde and Cortisol levels in maternal and cord blood. Nutrients. 2025;17(6):1077.","journal-title":"Nutrients"},{"issue":"1","key":"163_CR67","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12884-018-1798-x","volume":"18","author":"F Fan","year":"2018","unstructured":"Fan F, Zou Y, Zhang Y, et al. The relationship between maternal anxiety and Cortisol during pregnancy and birth weight of Chinese neonates. BMC Pregnancy Childbirth. 2018;18(1):265.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"163_CR68","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00213-010-1870-3","volume":"211","author":"DO Kennedy","year":"2010","unstructured":"Kennedy DO, Veasey R, Watson A, et al. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology. 2010;211(1):55\u201368.","journal-title":"Psychopharmacology"},{"key":"163_CR69","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.genhosppsych.2021.04.006","volume":"71","author":"S Yosaee","year":"2021","unstructured":"Yosaee S, Keshtkaran Z, Abdollahi S, et al. The effect of vitamin C supplementation on mood status in adults: a systematic review and meta-analysis of randomized controlled clinical trials. Gen Hosp Psychiatry. 2021;71:36\u201342.","journal-title":"Gen Hosp Psychiatry"}],"container-title":["Current Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-026-00163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11596-026-00163-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11596-026-00163-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:03:20Z","timestamp":1772193800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11596-026-00163-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["163"],"URL":"https:\/\/doi.org\/10.1007\/s11596-026-00163-2","relation":{},"ISSN":["2096-5230","2523-899X"],"issn-type":[{"value":"2096-5230","type":"print"},{"value":"2523-899X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"10 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflicts of interest\u00a0related to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This article is a review of existing literature and does not involve original human or animal research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}