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Detailed procedures (e.g., anesthesia with isoflurane, postoperative analgesia, euthanasia methods) are described in the Materials and Methods section.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"All human gene expression data analyzed in this study were obtained from publicly available datasets (GSE36961, GSE5406, GSE160997, GSE26887) in the Gene Expression Omnibus (GEO) database. As these data were de-identified and retrospectively collected from previously published studies, no additional ethics approval or informed consent was required for this secondary analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human Ethics"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that they have no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}