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This study aimed to examine the associations between non-traditional lipid indices\u2014specifically the lipoprotein combined index (LCI) and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (non-HDL-C to HDL-C ratio, NHHR)\u2014and incident sarcopenia in a Chinese population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants aged\u2009\u2265\u200945\u00a0years were enrolled from the 2011\u20132015 waves of the China Health and Retirement Longitudinal Study (CHARLS). Multivariate logistic regression was applied in cross-sectional analyses (n\u2009=\u20093,161) to assess the associations between log-transformed LCI, NHHR and sarcopenia. Longitudinal analyses (n\u2009=\u20092,898) were performed using multivariate Cox proportional hazards models, restricted cubic splines, subgroup analyses, and receiver operating characteristic (ROC) curves. Sensitivity analyses were conducted to test the robustness of the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher quartiles of lnLCI and lnNHHR were inversely associated with sarcopenia in both cross-sectional (lnLCI Q4: OR 0.58,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.015; lnNHHR Q3: OR 0.56,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) and longitudinal analyses (lnLCI Q4: HR 0.57,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001; lnNHHR Q4: HR 0.46,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002), with linear trends observed in spline models. Alcohol intake modified the association between lnNHHR and sarcopenia (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017), whereas the association of lnLCI with sarcopenia remained consistent in alcohol intake subgroup. ROC analyses showed similar predictive ability (lnLCI AUC 0.599; lnNHHR AUC 0.603). Sensitivity analyses excluding participants with hypercholesterolemia further validated the findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among Chinese adults aged\u2009\u2265\u200945\u00a0years, LCI and NHHR were inversely associated with sarcopenia, with NHHR demonstrating slightly superior diagnostic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11596-026-00193-w","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:29:30Z","timestamp":1776943770000},"page":"802-814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Non-traditional Lipid Indices and Sarcopenia: Evidence from a Prospective Chinese Cohort Study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9421-3423","authenticated-orcid":false,"given":"Rui-rong","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-xue","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-fan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"issue":"10191","key":"193_CR1","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Sayer AA. 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