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Study involving patient data and the subsequent experimental procedures were approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (IORG No: IORG0003571; Ethics Approval No. [2020] S261). Because the study used only pre-existing clinical data and did not affect patient management, the requirement for informed consent was waived by the ethics committee. Moreover, as this was a retrospective observational study with no prospective assignment to health-related interventions, trial registration was not required. All experimental procedures were implemented following the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals. Moreover, all animal experiments were conducted in compliance with the ARRIVE guidelines.","order":2,"name":"Ethics","label":"Ethics Approval and Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}