{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:56:36Z","timestamp":1784919396788,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Radiol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11604-020-00991-9","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T01:02:22Z","timestamp":1590541342000},"page":"997-1003","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impaired lesion detectability on gadoxetic acid-enhanced MR imaging in indocyanine green excretory defect: case series of three patients"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-6542","authenticated-orcid":false,"given":"Sota","family":"Masuoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Kitao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Saida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"issue":"Suppl 5","key":"991_CR1","doi-asserted-by":"publisher","first-page":"S975","DOI":"10.1007\/s00330-009-1624-y","volume":"19","author":"A Tanimoto","year":"2009","unstructured":"Tanimoto A, Lee JM, Murakami T, Huppertz A, Kudo M, Grazioli L. Consensus report of the 2nd international forum for liver MRI. Eur Radiol. 2009;19(Suppl 5):S975\u201389.","journal-title":"Eur Radiol"},{"key":"991_CR2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1148\/radiol.2301020269","volume":"230","author":"A Huppertz","year":"2004","unstructured":"Huppertz A, Balzer T, Blakeborough A, Breuer J, Giovagnoni A, Heinz-Peer G, et al. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology. 2004;230:266\u201375.","journal-title":"Radiology"},{"key":"991_CR3","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1111\/hepr.12646","volume":"46","author":"M Tsurusaki","year":"2016","unstructured":"Tsurusaki M, Sofue K, Murakami T. Current evidence for the diagnostic value of gadoxetic acid-enhanced magnetic resonance imaging for liver metastasis. Hepatol Res. 2016;46:853\u201361.","journal-title":"Hepatol Res"},{"key":"991_CR4","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1002\/jmri.21956","volume":"30","author":"U Motosugi","year":"2009","unstructured":"Motosugi U, Ichikawa T, Sou H, Sano K, Tominaga L, Kitamura T, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging. 2009;30:1042\u20136.","journal-title":"J Magn Reson Imaging"},{"key":"991_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3348\/kjr.2004.5.4.231","volume":"5","author":"HK Ryeom","year":"2004","unstructured":"Ryeom HK, Kim SH, Kim JY, Kim HJ, Lee JM, Chang YM, et al. Quantitative evaluation of liver function with MRI using Gd-EOB-DTPA. Korean J Radiol. 2004;5:231\u20139.","journal-title":"Korean J Radiol"},{"key":"991_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1111\/j.1872-034X.2012.01027.x","volume":"42","author":"K Kumazawa","year":"2012","unstructured":"Kumazawa K, Edamoto Y, Yanase M, Nakayama T. Liver analysis using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging: correlation with histological grading and quantitative liver evaluation prior to hepatectomy. Hepatol Res. 2012;42:1081\u20138.","journal-title":"Hepatol Res"},{"key":"991_CR7","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1136\/gut.17.8.588","volume":"17","author":"K Okuda","year":"1976","unstructured":"Okuda K, Ohkubo H, Musha H, Kotoda K, Abe H, Tanikawa K. Marked delay in indocyanine green plasma clearance with a near-normal bromosulphophthalein retention test: a constitutional abnormality? Gut. 1976;17:588\u201394.","journal-title":"Gut"},{"key":"991_CR8","first-page":"6","volume":"28","author":"T Namihisa","year":"1981","unstructured":"Namihisa T, Nambu M, Kobayashi N, Kuroda H. Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect. Hepatogastroenterology. 1981;28:6\u201312.","journal-title":"Hepatogastroenterology"},{"key":"991_CR9","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1007\/BF02389522","volume":"31","author":"M Nambu","year":"1996","unstructured":"Nambu M, Namihisa T. Hepatic transport of serum bilirubin, bromsulfophthalein, and indocyanine green in patients with congenital non-hemolytic hyperbilirubinemia and patients with constitutional indocyanine green excretory defect. J Gastroenterol. 1996;31:228\u201336.","journal-title":"J Gastroenterol"},{"key":"991_CR10","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.jhep.2010.07.047","volume":"54","author":"W de Graaf","year":"2011","unstructured":"de Graaf W, Hausler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, et al. Transporters involved in the hepatic uptake of (99\u00a0m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011;54:738\u201345.","journal-title":"J Hepatol"},{"key":"991_CR11","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1007\/s00330-011-2165-8","volume":"21","author":"A Kitao","year":"2011","unstructured":"Kitao A, Matsui O, Yoneda N, Kozaka K, Shinmura R, Koda W, et al. The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. Eur Radiol. 2011;21:2056\u201366.","journal-title":"Eur Radiol"},{"key":"991_CR12","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1148\/radiol.10092214","volume":"256","author":"A Kitao","year":"2010","unstructured":"Kitao A, Zen Y, Matsui O, Gabata T, Kobayashi S, Koda W, et al. Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging\u2013correlation with molecular transporters and histopathologic features. Radiology. 2010;256:817\u201326.","journal-title":"Radiology"},{"key":"991_CR13","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1097\/RCT.0b013e31821a02aa","volume":"35","author":"Y Nakamura","year":"2011","unstructured":"Nakamura Y, Date S, Toyota N, Tani C, Honda Y, Komoto D, et al. Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans. J Comput Assist Tomogr. 2011;35:351\u20132.","journal-title":"J Comput Assist Tomogr"},{"key":"991_CR14","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1476-5381.2009.00430.x","volume":"158","author":"A Kalliokoski","year":"2009","unstructured":"Kalliokoski A, Niemi M. Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009;158:693\u2013705.","journal-title":"Br J Pharmacol"},{"key":"991_CR15","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1124\/dmd.104.001909","volume":"33","author":"T Nozawa","year":"2005","unstructured":"Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I. Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms. Drug Metab Dispos. 2005;33:434\u20139.","journal-title":"Drug Metab Dispos"},{"key":"991_CR16","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1148\/radiol.11101840","volume":"261","author":"K Sano","year":"2011","unstructured":"Sano K, Ichikawa T, Motosugi U, Sou H, Muhi AM, Matsuda M, et al. Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging. Radiology. 2011;261:834\u201344.","journal-title":"Radiology"},{"key":"991_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s40792-016-0216-8","volume":"2","author":"S Imada","year":"2016","unstructured":"Imada S, Kobayashi T, Kitao A, Matsui O, Hashimoto M, Ide K, et al. Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter. Surg Case Rep. 2016;2:89.","journal-title":"Surg Case Rep"},{"key":"991_CR18","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1148\/radiol.12112061","volume":"264","author":"A Nassif","year":"2012","unstructured":"Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, et al. Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Radiology. 2012;264:741\u201350.","journal-title":"Radiology"},{"key":"991_CR19","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1007\/s00261-015-0503-z","volume":"40","author":"N Yoneda","year":"2015","unstructured":"Yoneda N, Matsui O, Ikeno H, Inoue D, Yoshida K, Kitao A, et al. Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome. Abdom Imaging. 2015;40:3099\u2013103.","journal-title":"Abdom Imaging"},{"key":"991_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/hepr.12128","volume":"44","author":"Y Kimura","year":"2014","unstructured":"Kimura Y, Sato S, Hitomi E, Ohyama M, Adachi K, Inagaki Y, et al. Coexpression of organic anion-transporting polypeptides 1B3 and multidrug-resistant proteins 2 increases the enhancement effect of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid on hepatocellular carcinoma in magnetic resonance imaging. Hepatol Res. 2014;44:327\u201337.","journal-title":"Hepatol Res"},{"key":"991_CR21","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1148\/radiol.10092065","volume":"256","author":"N Tsuda","year":"2010","unstructured":"Tsuda N, Matsui O. Cirrhotic rat liver: reference to transporter activity and morphologic changes in bile canaliculi\u2013gadoxetic acid-enhanced MR imaging. Radiology. 2010;256:767\u201373.","journal-title":"Radiology"}],"container-title":["Japanese Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-020-00991-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11604-020-00991-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-020-00991-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T15:02:48Z","timestamp":1640962968000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11604-020-00991-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["991"],"URL":"https:\/\/doi.org\/10.1007\/s11604-020-00991-9","relation":{},"ISSN":["1867-1071","1867-108X"],"issn-type":[{"value":"1867-1071","type":"print"},{"value":"1867-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"assertion":[{"value":"15 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}