{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:38:43Z","timestamp":1777181923343,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Radiol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s11604-020-01023-2","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T12:03:54Z","timestamp":1596197034000},"page":"1197-1208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Toxicity and clinical outcomes of single-fraction high-dose-rate brachytherapy combined with external beam radiotherapy for high-\/very high-risk prostate cancer: A dosimetric analysis of toxicity"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-0667","authenticated-orcid":false,"given":"Takayuki","family":"Sakurai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Taka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Gabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"Kumano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"1023_CR1","unstructured":"Cancer Statistics in Japan, Center for Cancer Control and Information Services, National Cancer Center. 2020. Available online: https:\/\/ganjoho.jp\/reg_stat\/statistics\/stat\/summary.html. Accessed Jan 18, 2020"},{"key":"1023_CR2","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1200\/JCO.2009.26.0133","volume":"28","author":"MR Cooperberg","year":"2010","unstructured":"Cooperberg MR, Broering JM, Carroll PR. Time trends and local variation in primary treatment of localized prostate cancer. J Clin Oncol. 2010;28:1117\u201323.","journal-title":"J Clin Oncol"},{"key":"1023_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.6004\/jnccn.2016.0004","volume":"14","author":"JL Mohler","year":"2016","unstructured":"Mohler JL, Armstrong AJ, Bahnson RR, D\u2019Amico AV, Davis BJ, Eastham JA, et al. Prostate cancer, version 1. 2016. J Natl Compr Canc Netw. 2016;14:19\u201330.","journal-title":"J Natl Compr Canc Netw."},{"key":"1023_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brachy.2016.09.006","volume":"16","author":"DE Spratt","year":"2017","unstructured":"Spratt DE, Soni PD, McLaughlin PW, Merrick GS, Stock RG, Blasko JC, et al. American Brachytherapy Society Task Group Report: combination of brachytherapy and external beam radiation for high-risk prostate cancer. Brachytherapy. 2017;16:1\u201312.","journal-title":"Brachytherapy"},{"key":"1023_CR5","doi-asserted-by":"publisher","first-page":"E322","DOI":"10.3390\/cancers10090322","volume":"10","author":"H Yamazaki","year":"2018","unstructured":"Yamazaki H, Masui K, Suzuki G, Nakamura S, Shimizu D, Nishikawa T, et al. High-dose-rate brachytherapy monotherapy versus image-guided intensity-modulated radiotherapy with helical tomotherapy for patients with localized prostate cancer. Cancers (Basel). 2018;10:E322.","journal-title":"Cancers (Basel)."},{"key":"1023_CR6","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.brachy.2017.06.013","volume":"16","author":"AT Falk","year":"2017","unstructured":"Falk AT, Demontoy S, Chamorey E, Chand ME, Gautier M, Azria D, et al. High-dose-rate brachytherapy boost for prostate cancer: Comparison of three different fractionation schemes. Brachytherapy. 2017;16:993\u20139.","journal-title":"Brachytherapy"},{"key":"1023_CR7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.5114\/jcb.2013.38657","volume":"5","author":"H Hijazi","year":"2013","unstructured":"Hijazi H, Chevallier D, Gal J, Chand ME, Gautier M, Hannoun-Levi JM. Prostate cancer boost using high-dose-rate brachytherapy: early toxicity analysis of 3 different fractionation schemes. J Contemp Brachytherapy. 2013;5:203\u20139.","journal-title":"J Contemp Brachytherapy"},{"key":"1023_CR8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.5114\/jcb.2016.59216","volume":"8","author":"O Lauche","year":"2016","unstructured":"Lauche O, Delouya G, Taussky D, Menard C, B\u00e9liveau-Nadeau D, Hervieux Y, et al. Single-fraction high-dose-rate brachytherapy using real-time transrectal ultrasound based planning in combination with external beam radiotherapy for prostate cancer: dosimetrics and early clinical results. J Contemp Brachytherapy. 2016;8:104\u20139.","journal-title":"J Contemp Brachytherapy"},{"key":"1023_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.radonc.2014.07.013","volume":"112","author":"A Boladeras","year":"2014","unstructured":"Boladeras A, Santorsa L, Gutierrez C, Martinez E, Pera J, Pino F, et al. External beam radiotherapy plus single-fraction high dose rate brachytherapy in the treatment of locally advanced prostate cancer. Radiother Oncol. 2014;112:227\u201332.","journal-title":"Radiother Oncol"},{"key":"1023_CR10","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ijrobp.2009.05.054","volume":"77","author":"GC Morton","year":"2010","unstructured":"Morton GC, Loblaw DA, Sankreacha R, Deabreu A, Zhang L, Mamedov A, et al. Single-fraction high-dose-rate brachytherapy and hypofractionated external beam radiotherapy for men with intermediate-risk prostate cancer: analysis of short- and medium-term toxicity and quality of life. Int J Radiat Oncol Biol Phys. 2010;77:811\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1023_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.brachy.2009.05.001","volume":"9","author":"F Pistis","year":"2010","unstructured":"Pistis F, Guedea F, Pera J, Gutierrez C, Ventura M, Polo A, et al. External beam radiotherapy plus high-dose-rate brachytherapy for treatment of locally advanced prostate cancer: the initial experience of the Catalan Institute of Oncology. Brachytherapy. 2010;9:15\u201322.","journal-title":"Brachytherapy"},{"key":"1023_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.radonc.2019.02.018","volume":"135","author":"D B\u00fcchser","year":"2019","unstructured":"B\u00fcchser D, Casquero F, Espinosa JM, Perez F, Minguez P, Martinez-Indart L, et al. Late toxicity after single dose HDR prostate brachytherapy and EBRT for localized prostate cancer: Clinical and dosimetric predictors in a prospective cohort study. Radiother Oncol. 2019;135:13\u20138.","journal-title":"Radiother Oncol"},{"key":"1023_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.radonc.2019.08.017","volume":"141","author":"K Martell","year":"2019","unstructured":"Martell K, Mendez LC, Chung HT, Tseng CL, Alayed Y, Cheung P, et al. Results of 15 Gy HDR-BT boost plus EBRT in intermediate-risk prostate cancer: analysis of over 500 patients. Radiother Oncol. 2019;141:149\u201355.","journal-title":"Radiother Oncol"},{"key":"1023_CR14","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.clon.2017.01.042","volume":"29","author":"N Shahid","year":"2017","unstructured":"Shahid N, Loblaw A, Chung HT, Cheung P, Szumacher E, Danjoux C, et al. Long-term toxicity and health-related quality of life after single-fraction high dose rate brachytherapy boost and hypofractionated external beam radiotherapy for intermediate-risk prostate cancer. Clin Oncol (R Coll Radiol). 2017;29:412\u201320.","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"1023_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.brachy.2017.03.002","volume":"16","author":"R Chicas-Sett","year":"2017","unstructured":"Chicas-Sett R, Farga D, Perez-Calatayud MJ, Celada F, Roldan S, et al. High-dose-rate brachytherapy boost for prostate cancer: analysis of dose-volume histogram parameters for predicting late rectal toxicity. Brachytherapy. 2017;16:511\u20137.","journal-title":"Brachytherapy"},{"key":"1023_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.brachy.2016.10.008","volume":"16","author":"B Kragelj","year":"2017","unstructured":"Kragelj B, Zlatic J, Zaletel-Kragelj L. Avoidance of late rectal toxicity after high-dose-rate brachytherapy boost treatment for prostate cancer. Brachytherapy. 2017;16:193\u2013200.","journal-title":"Brachytherapy"},{"key":"1023_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.brachy.2011.09.008","volume":"1","author":"Y Yamada","year":"2012","unstructured":"Yamada Y, Rogers L, Demanes DJ, Morton G, Prestidge BR, Pouliot J, et al. American Brachytherapy Society consensus guidelines for high-dose-rate prostate brachytherapy. Brachytherapy. 2012;1:20\u2013322.","journal-title":"Brachytherapy"},{"key":"1023_CR18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.radonc.2013.05.002","volume":"3","author":"PJ Hoskin","year":"2013","unstructured":"Hoskin PJ, Colombo A, Henry A, Niehoff P, Paulsen Hellebust T, Siebert FA, et al. GEC\/ESTRO recommendations on high dose rate afterloading brachytherapy for localised prostate cancer: an update. Radiother Oncol. 2013;3:325\u201332.","journal-title":"Radiother Oncol"},{"key":"1023_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ijrobp.2009.04.041","volume":"77","author":"RB Wilder","year":"2010","unstructured":"Wilder RB, Chittenden L, Mesa AV, Bunyapanasarn J, Agustin J, Lizarde J, et al. A prospective study of intrafraction prostate motion in the prone vs. supine position. Int J Radiat Oncol Biol Phys. 2010;77:165\u201370.","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"1023_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1093\/jrr\/rrt089","volume":"55","author":"I Ikeda","year":"2014","unstructured":"Ikeda I, Mizowaki T, Sawada Y, Nakata M, Norihisa Y, Ogura M, et al. Assessment of interfractional prostate motion in patients immobilized in the prone position using a thermoplastic shell. J Radiat Res. 2014;55:168\u201374.","journal-title":"J Radiat Res"},{"key":"1023_CR21","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ijrobp.2006.04.029","volume":"65","author":"M Roach III","year":"2006","unstructured":"Roach M III, Hanks G, Thames H Jr, Schellhammer P, Shipley WU, Sokol GH, et al. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006;65:965\u201374.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1023_CR22","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/bmt.2012.244","volume":"48","author":"Y Kanda","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 2013;48:452\u20138.","journal-title":"Bone Marrow Transplant"},{"key":"1023_CR23","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1120\/jacmp.v8i4.2415","volume":"8","author":"Y Kim","year":"2007","unstructured":"Kim Y, Hsu IC, Pouliot J. Measurement of craniocaudal catheter displacement between fractions in computed tomography-based high dose rate brachytherapy of prostate cancer. J Appl Clin Med Phys. 2007;8:2415.","journal-title":"J Appl Clin Med Phys"},{"key":"1023_CR24","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.ijrobp.2009.03.052","volume":"76","author":"A Tiong","year":"2010","unstructured":"Tiong A, Bydder S, Ebert M, Caswell N, Waterhouse D, Spry N, et al. A small tolerance for catheter displacement in high-dose rate prostate brachytherapy is necessary and feasible. Int J Radiat Oncol Biol Phys. 2010;76:1066\u201372.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1023_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brachy.2009.04.006","volume":"9","author":"K Yoshida","year":"2010","unstructured":"Yoshida K, Yamazaki H, Nose T, Shiomi H, Yoshida M, Mikami M, et al. Needle applicator displacement during high-dose-rate interstitial brachytherapy for prostate cancer. Brachytherapy. 2010;9:36\u201341.","journal-title":"Brachytherapy"},{"key":"1023_CR26","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/S0360-3016(01)01607-8","volume":"50","author":"J Fowler","year":"2001","unstructured":"Fowler J, Chappell R, Ritter M. Is alpha\/beta for prostate tumors really low? Int J Radiat Oncol Biol Phys. 2001;50:1021\u201331.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1023_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0360-3016(01)02664-5","volume":"52","author":"DJ Brenner","year":"2002","unstructured":"Brenner DJ, Martinez AA, Edmundson GK, Mitchell C, Thames HD, Armour EP. Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha\/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys. 2002;52:6\u201313.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1023_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s00066-018-1380-5","volume":"195","author":"A L\u00f6ser","year":"2019","unstructured":"L\u00f6ser A, Beyer B, Carl CO, L\u00f6ser B, Nagaraj Y, Frenzel T, et al. Toxicity and risk factors after combined high-dose-rate brachytherapy and external beam radiation therapy in men \u226575 years with localized prostate cancer. Strahlenther Onkol. 2019;195:374\u201382.","journal-title":"Strahlenther Onkol"},{"key":"1023_CR29","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/iju.12050","volume":"20","author":"R Tanimoto","year":"2013","unstructured":"Tanimoto R, Bekku K, Katayama N, Kobayashi Y, Ebara S, Araki M, et al. Predictive factors for acute and late urinary toxicity after permanent interstitial brachytherapy in Japanese patients. Int J Urol. 2013;20:812\u20137.","journal-title":"Int J Urol"},{"key":"1023_CR30","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00345-013-1188-y","volume":"32","author":"X Li","year":"2014","unstructured":"Li X, Fang D, Cooperberg MR, Whitson JM, Lue TF, Zhou L, et al. Long-term follow-up of International Prostate Symptom Score (IPSS) in men following prostate brachytherapy. World J Urol. 2014;32:1061\u20136.","journal-title":"World J Urol"},{"key":"1023_CR31","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12894-017-0251-1","volume":"17","author":"M Miyake","year":"2017","unstructured":"Miyake M, Tanaka N, Asakawa I, Hori S, Morizawa Y, Tatsumi Y, et al. Assessment of lower urinary symptom flare with overactive bladder symptom score and International Prostate Symptom Score in patients treated with iodine-125 implant brachytherapy: long-term follow-up experience at a single institute. BMC Urol. 2017;17:62.","journal-title":"BMC Urol"},{"key":"1023_CR32","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.brachy.2019.02.003","volume":"18","author":"N Sanmamed","year":"2019","unstructured":"Sanmamed N, Chung P, Berlin A, Adleman J, Borg J, Lao B, et al. Dose to the bladder neck in MRI-guided high-dose-rate prostate brachytherapy: impact on acute urinary toxicity and health-related quality of life. Brachytherapy. 2019;18:477\u201383.","journal-title":"Brachytherapy"},{"key":"1023_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.eururo.2007.04.020","volume":"52","author":"A Heidenreich","year":"2007","unstructured":"Heidenreich A, Ohlmann CH, Polyakov S. Anatomical extent of pelvic lymphadenectomy in patients undergoing radical prostatecomy. Eur Urol. 2007;52:29\u201337.","journal-title":"Eur Urol"},{"key":"1023_CR34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.radonc.2013.06.046","volume":"110","author":"P Dirix","year":"2014","unstructured":"Dirix P, Joniau S, Van den Bergh L, Isebaert S, Oyen R, Deroose CM, et al. The role of elective pelvic radiotherapy in clinically node-negative prostate cancer: a systematic review. Radiother Oncol. 2014;110:45\u2013544.","journal-title":"Radiother Oncol"},{"key":"1023_CR35","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.ijrobp.2019.09.044","volume":"106","author":"H Tharmalingam","year":"2020","unstructured":"Tharmalingam H, Tsang Y, Choudhury A, Alonzi R, Wylie J, Ahmed I, et al. External beam radiation therapy (EBRT) and high-dose-rate (HDR) brachytherapy for intermediate and high-risk prostate cancer: the impact of EBRT volume. Int J Radiat Oncol Biol Phys. 2020;106:525\u201333.","journal-title":"Int J Radiat Oncol Biol Phys"}],"updated-by":[{"DOI":"10.1007\/s11604-020-01073-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000}}],"container-title":["Japanese Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-020-01023-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11604-020-01023-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-020-01023-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T01:18:08Z","timestamp":1627694288000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11604-020-01023-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1023"],"URL":"https:\/\/doi.org\/10.1007\/s11604-020-01023-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11604-020-01073-6","asserted-by":"object"}]},"ISSN":["1867-1071","1867-108X"],"issn-type":[{"value":"1867-1071","type":"print"},{"value":"1867-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"assertion":[{"value":"27 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original publication, Toshifumi Gabata should be listed the final author.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standard"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study. This retrospective study was approved by the institutional review board of Kanazawa university hospital [approval: # 2016-326 (2074)]. All applicable institutional and\/or national guidelines for the care were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}