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This study investigated whether subtraction iodine imaging (SII) would improve tumor delineation and measurability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Fifty-seven consecutive patients with tongue cancer, who underwent scanning with a 320-row area detector CT with contrast administration and were treated with surgical resection, were retrospectively evaluated. CT was reconstructed with single-energy projection-based metallic artifact reduction (sCT). SII was generated by subtracting the pre-contrast volume scans from the post-contrast volume scans using a high-resolution deformable registration algorithm. MRI scans were also evaluated for comparing the ability of measurements. Two radiologists visually graded the tumor delineation using a 5-point scale. Tumor size and DOI were measured wherever possible. The tumor delineation score was compared using the Wilcoxon signed-rank method. Spearman\u2019s correlations between imaging and pathological measurements were calculated. Intraclass correlation coefficients of measurements between readers were estimated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The tumor delineation score was greater on sCT-plus-SII than on sCT alone (medians: 3 and 1, respectively; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with higher number of detectable cases observed with sCT-plus-SII (36\/57 [63.2%]) than sCT alone (21\/57 [36.8%]). Tumor size and DOI measurability were higher with sCT-plus-SII (29\/57 [50.9%]) than with sCT alone (17\/57 [29.8%]). MRI had the highest detectability (52\/57 [91.2%]) and measurability (46\/57 [80.7%]). Correlation coefficients between radiological and pathological tumor size and DOI were similar for sCT (0.83\u20130.88), sCT-plus-SII (0.78\u20130.84), and MRI (0.78\u20130.90). Intraclass correlation coefficients were higher than 0.95 for each modality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>SII improves detectability and measurability of tumor size and DOI in patients with oral tongue squamous cell carcinoma, thus increasing the diagnostic potential. SII may also be beneficial for cases unevaluable on MRI due to artifacts or for patients with contraindications to MRI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11604-021-01196-4","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T14:03:41Z","timestamp":1631801021000},"page":"167-176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Subtraction iodine imaging with area detector CT to improve tumor delineation and measurability of tumor size and depth of invasion in tongue squamous cell carcinoma"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-4341","authenticated-orcid":false,"given":"Takashi","family":"Hiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4337-2782","authenticated-orcid":false,"given":"Hirofumi","family":"Kuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-8534","authenticated-orcid":false,"given":"Kotaro","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-848X","authenticated-orcid":false,"given":"So","family":"Tsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6818-2574","authenticated-orcid":false,"given":"Shioto","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-2097","authenticated-orcid":false,"given":"Tatsushi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"issue":"9","key":"1196_CR1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s11604-020-00982-w","volume":"38","author":"A Baba","year":"2020","unstructured":"Baba A, Hashimoto K, Kayama R, Yamauchi H, Ikeda K, Ojiri H. 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The other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the institutional review board of National Cancer Hospital East. The requirement for written informed consent was waived. All applicable institutional and\/or national guidelines for the care of study participants were followed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}