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Of them, 30,595 included outpatients had 6-month eGFR test and 27,698 included outpatients had 1-year eGFR test. The outpatients were further divided into two groups based on initial eGFR: between 30 and 59 and\u2009\u2265\u200960\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. Impaired renal function was defined as eGFR declined to below 30\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. The comorbidities with P values less than 0.1 identified in univariable logistic regression models were entered into the multivariable analysis with backward selection, thereby identifying comorbidities that increased the risk of eGFR decline at 6-month and 1-year follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Outpatients with initial eGFR between 30 and 59\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> were 175.94 times more likely to have eGFR decline at 6\u00a0months, and were 94.10 times more likely to have eGFR decline at 1\u00a0year, compared with their corresponding initial eGFR\u2009\u2265\u200960 counterparts. Multivariable logistic regression analyses disclosed that chronic kidney disease, hypertension, and heart failure were independent risk factors for eGFR decline in outpatients with initial eGFR between 30 and 59\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Outpatients with initial eGFR\u2009\u2265\u200960\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> might not need routine eGFR test prior to contrast-enhanced CT scan for 1\u00a0year. In addition, chronic kidney disease, hypertension, and heart failure increased the risk of declined renal function, particularly, in outpatients with initial eGFR between 30 and 59\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11604-023-01425-y","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T07:04:41Z","timestamp":1681196681000},"page":"994-1006","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in renal function over time in outpatients with eGFR\u2009\u2265\u200930\u00a0mL\/min\/1.73 m2: implication for timing of renal function testing before contrast-enhanced CT imaging"],"prefix":"10.1007","volume":"41","author":[{"given":"Yoshiki","family":"Kuwatsuru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Yumi","family":"Ishisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Sokooshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1960-6400","authenticated-orcid":false,"given":"Ryohei","family":"Kuwatsuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"1425_CR1","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1007\/s00330-017-5246-5","volume":"28","author":"AJ van der Molen","year":"2018","unstructured":"van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, et al. 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