{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:08:39Z","timestamp":1781719719665,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFF0509200"],"award-info":[{"award-number":["2024YFF0509200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017689","name":"Guangdong Provincial People\u2019s Hospital","doi-asserted-by":"crossref","award":["KY0120211130"],"award-info":[{"award-number":["KY0120211130"]}],"id":[{"id":"10.13039\/501100017689","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Medical Science Research Foundation","award":["B2023023"],"award-info":[{"award-number":["B2023023"]}]},{"name":"Guangdong Medical Science Research Foundation","award":["B2025335"],"award-info":[{"award-number":["B2025335"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502392"],"award-info":[{"award-number":["82502392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Radiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s11604-025-01876-5","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T05:28:50Z","timestamp":1759123730000},"page":"156-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physiological biodistribution of 68Ga-Pentixafor: PET\/CT evaluation and implications for CXCR4 imaging"],"prefix":"10.1007","volume":"44","author":[{"given":"Jingyun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9479-132X","authenticated-orcid":false,"given":"Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"1876_CR1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nri3049","volume":"11","author":"A Zlotnik","year":"2011","unstructured":"Zlotnik A, Burkhardt AM, Homey B. Homeostatic chemokine receptors and organ-specific metastasis. Nat Rev Immunol. 2011;11:597\u2013606.","journal-title":"Nat Rev Immunol"},{"key":"1876_CR2","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc1388","volume":"4","author":"F Balkwill","year":"2004","unstructured":"Balkwill F. Cancer and the chemokine network. Nat Rev Cancer. 2004;4:540\u201350.","journal-title":"Nat Rev Cancer"},{"key":"1876_CR3","doi-asserted-by":"publisher","first-page":"618","DOI":"10.7150\/thno.11251","volume":"5","author":"HJ Wester","year":"2015","unstructured":"Wester HJ, Keller U, Schottelius M, et al. Disclosing the CXCR4 expression in lymphoproliferative diseases by targeted molecular imaging. Theranostics. 2015;5:618\u201330.","journal-title":"Theranostics"},{"key":"1876_CR4","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1007\/s00259-020-04722-0","volume":"47","author":"J Ding","year":"2020","unstructured":"Ding J, Zhang Y, Wen J, et al. Imaging CXCR4 expression in patients with suspected primary hyperaldosteronism. Eur J Nucl Med Mol Imaging. 2020;47:2656\u201365.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1876_CR5","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1097\/RLU.0000000000004244","volume":"47","author":"J Ding","year":"2022","unstructured":"Ding J, Tong A, Hacker M, Feng M, Huo L, Li X. Usefulness of 68 Ga-Pentixafor PET\/CT on diagnosis and management of Cushing syndrome. Clin Nucl Med. 2022;47:669\u201376.","journal-title":"Clin Nucl Med"},{"key":"1876_CR6","doi-asserted-by":"publisher","first-page":"741","DOI":"10.2967\/jnumed.115.161034","volume":"57","author":"T Vag","year":"2016","unstructured":"Vag T, Gerngross C, Herhaus P, et al. First experience with chemokine receptor CXCR4-targeted PET imaging of patients with solid cancers. J Nucl Med. 2016;57:741\u20136.","journal-title":"J Nucl Med"},{"key":"1876_CR7","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1097\/RLU.0000000000005374","volume":"49","author":"Y Chen","year":"2024","unstructured":"Chen Y, Yuan H, Tan X, et al. CXCR4-targeted 68 Ga-Pentixafor PET\/CT imaging in inflammatory bowel disease. Clin Nucl Med. 2024;49:817\u201321.","journal-title":"Clin Nucl Med"},{"key":"1876_CR8","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00259-023-06547-z","volume":"51","author":"N Dreher","year":"2024","unstructured":"Dreher N, Hahner S, Fuss CT, et al. CXCR4-directed PET\/CT with [(68) Ga]Ga-Pentixafor in solid tumors\u2014a comprehensive analysis of imaging findings and comparison with histopathology. Eur J Nucl Med Mol Imaging. 2024;51:1383\u201394.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1876_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1161\/HYPERTENSIONAHA.117.09975","volume":"71","author":"B Heinze","year":"2018","unstructured":"Heinze B, Fuss CT, Mulatero P, et al. Targeting CXCR4 (CXC chemokine receptor type 4) for molecular imaging of aldosterone-producing adenoma. Hypertension. 2018;71:317\u201325.","journal-title":"Hypertension"},{"key":"1876_CR10","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","volume":"12","author":"JJ Campbell","year":"2000","unstructured":"Campbell JJ, Butcher EC. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol. 2000;12:336\u201341.","journal-title":"Curr Opin Immunol"},{"key":"1876_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.7150\/thno.16576","volume":"7","author":"C Lapa","year":"2017","unstructured":"Lapa C, Schreder M, Schirbel A, et al. [(68)Ga]Pentixafor-PET\/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma\u2014comparison to [(18)F]FDG and laboratory values. Theranostics. 2017;7:205\u201312.","journal-title":"Theranostics"},{"key":"1876_CR12","doi-asserted-by":"publisher","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","volume":"16","author":"BA Teicher","year":"2010","unstructured":"Teicher BA, Fricker SP. CXCL12 (SDF-1)\/CXCR4 pathway in cancer. Clin Cancer Res. 2010;16:2927\u201331.","journal-title":"Clin Cancer Res"},{"key":"1876_CR13","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2967\/jnumed.114.151647","volume":"56","author":"K Herrmann","year":"2015","unstructured":"Herrmann K, Lapa C, Wester HJ, et al. Biodistribution and radiation dosimetry for the chemokine receptor CXCR4-targeting probe 68Ga-Pentixafor. J Nucl Med. 2015;56:410\u20136.","journal-title":"J Nucl Med"},{"key":"1876_CR14","doi-asserted-by":"publisher","first-page":"248","DOI":"10.2967\/jnumed.115.167361","volume":"57","author":"K Herrmann","year":"2016","unstructured":"Herrmann K, Schottelius M, Lapa C, et al. First-in-human experience of CXCR4-directed endoradiotherapy with 177Lu- and 90Y-labeled Pentixather in advanced-stage multiple myeloma with extensive intra- and extramedullary disease. J Nucl Med. 2016;57:248\u201351.","journal-title":"J Nucl Med"},{"key":"1876_CR15","first-page":"280","volume":"3","author":"J Gui","year":"2012","unstructured":"Gui J, Mustachio LM, Su DM, Craig RW. Thymus size and age-related thymic involution: early programming, sexual dimorphism, progenitors and stroma. Aging Dis. 2012;3:280\u201390.","journal-title":"Aging Dis"},{"key":"1876_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-nutr-071715-050901","volume":"36","author":"BJ Gheller","year":"2016","unstructured":"Gheller BJ, Riddle ES, Lem MR, Thalacker-Mercer AE. Understanding age-related changes in skeletal muscle metabolism: differences between females and males. Annu Rev Nutr. 2016;36:129\u201356.","journal-title":"Annu Rev Nutr"},{"key":"1876_CR17","doi-asserted-by":"publisher","first-page":"949532","DOI":"10.3389\/fcell.2022.949532","volume":"10","author":"AS Shams","year":"2022","unstructured":"Shams AS, Arpke RW, Gearhart MD, et al. The chemokine receptor CXCR4 regulates satellite cell activation, early expansion, and self-renewal, in response to skeletal muscle injury. Front Cell Dev Biol. 2022;10:949532.","journal-title":"Front Cell Dev Biol"},{"key":"1876_CR18","doi-asserted-by":"publisher","first-page":"e57356","DOI":"10.7554\/eLife.57356","volume":"10","author":"I Lahmann","year":"2021","unstructured":"Lahmann I, Griger J, Chen JS, Zhang Y, Schuelke M, Birchmeier C. Met and Cxcr4 cooperate to protect skeletal muscle stem cells against inflammation-induced damage during regeneration. Elife. 2021;10:e57356.","journal-title":"Elife"},{"key":"1876_CR19","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/(SICI)1521-4141(199906)29:06<1823::AID-IMMU1823>3.0.CO;2-B","volume":"29","author":"A Aiuti","year":"1999","unstructured":"Aiuti A, Tavian M, Cipponi A, et al. Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human lympho-hematopoietic progenitors. Eur J Immunol. 1999;29:1823\u201331.","journal-title":"Eur J Immunol"},{"key":"1876_CR20","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nature09262","volume":"466","author":"S Mendez-Ferrer","year":"2010","unstructured":"Mendez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466:829\u201334.","journal-title":"Nature"},{"key":"1876_CR21","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1148\/rg.295085247","volume":"29","author":"A Shammas","year":"2009","unstructured":"Shammas A, Lim R, Charron M. Pediatric FDG PET\/CT: physiologic uptake, normal variants, and benign conditions. Radiographics. 2009;29:1467\u201386.","journal-title":"Radiographics"},{"key":"1876_CR22","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00259-012-2298-2","volume":"40","author":"A Afshar-Oromieh","year":"2013","unstructured":"Afshar-Oromieh A, Malcher A, Eder M, et al. PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging. 2013;40:486\u201395.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1876_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.2967\/jnumed.119.233015","volume":"61","author":"TL Andersen","year":"2020","unstructured":"Andersen TL, Baun C, Olsen BB, Dam JH, Thisgaard H. Improving contrast and detectability: imaging with [(55)Co]Co-DOTATATE in comparison with [(64)Cu]Cu-DOTATATE and [(68)Ga]Ga-DOTATATE. J Nucl Med. 2020;61:228\u201333.","journal-title":"J Nucl Med"}],"container-title":["Japanese Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-025-01876-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11604-025-01876-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11604-025-01876-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:33:42Z","timestamp":1767591222000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11604-025-01876-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1876"],"URL":"https:\/\/doi.org\/10.1007\/s11604-025-01876-5","relation":{},"ISSN":["1867-1071","1867-108X"],"issn-type":[{"value":"1867-1071","type":"print"},{"value":"1867-108X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"23 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}