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After portal vein embolization, DECT was performed after injecting iodinated contrast medium into the portal vein, allowing the quantification of iodine concentration and iodine content in the FLR. Liver volumes were assessed before and after portal vein embolization to calculate the degree of hypertrophy and kinetic growth rate of the FLR. Correlations between iodine content and hypertrophy indices, such as degree of hypertrophy and kinetic growth rate, were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post-portal vein embolization volumetric CT for FLR hypertrophy evaluation was performed at a median of 25\u00a0days (21\u201330\u00a0days). Early-phase iodine content of the left hepatic lobe on DECT was significantly correlated with both the degree of hypertrophy (DH; r\u2009=\u20090.380,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) and the kinetic growth rate (KGR; r\u2009=\u20090.401,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), as determined using Pearson\u2019s correlation analysis. Likewise, late-phase iodine content of the left hepatic lobe was significantly correlated with DH (r\u2009=\u20090.403,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and KGR (r\u2009=\u20090.337,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher iodine content in the FLR was associated with greater FLR hypertrophy after portal vein embolization. However, because the correlation observed in this study was modest, the predictive ability of this parameter could not be established. Nevertheless, DECT-based iodine quantification may provide complementary information on FLR function and warrants further investigation as a potential biomarker in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11604-025-01906-2","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T05:04:23Z","timestamp":1762751063000},"page":"572-583","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between intrahepatic iodine quantity after portal vein embolization and future liver remnant hypertrophy"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-1429","authenticated-orcid":false,"given":"Tomohiro","family":"Komada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Tamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-0734","authenticated-orcid":false,"given":"Takashi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-7050","authenticated-orcid":false,"given":"Tomoki","family":"Ebata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-613X","authenticated-orcid":false,"given":"Shinji","family":"Naganawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"1906_CR1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.annonc.2022.10.506","volume":"34","author":"A Vogel","year":"2023","unstructured":"Vogel A, Bridgewater J, Edeline J, Kelley RK, Kl\u00fcmpen HJ, Malka D, et al. 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All other authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The Ethics Review Committee of Nagoya University Graduate School of Medicine (Nagoya, Japan) approved this prospective single-center study (approval no. 2021\u20130299).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent for both research and intervention was obtained from all patients in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}