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Inclusion criteria required studies evaluating MRI (the combination of T2-weighted imaging and at least one additional sequence (diffusion-weighted imaging and\/or contrast-enhanced imaging)) in patients with myometrial masses suspicious for sarcoma, with diagnostic performance assessable by 2\u2009\u00d7\u20092 contingency tables. The reference standard was histopathology for malignant lesions, whereas benign diagnoses could be established by histopathology or by clinical\/imaging follow-up. Data extraction and Quality Assessment of Diagnostic Accuracy Studies-2 quality assessment were performed independently. Pooled sensitivity and specificity were estimated using a random-effects model, and the hierarchical summary receiver operating characteristic (HSROC) curve was generated to estimate the area under the curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Evidence synthesis<\/jats:title>\n                    <jats:p>\n                      Twelve studies met the inclusion criteria. All were retrospective, and substantial heterogeneity existed in patient selection and MRI protocols. The pooled sensitivity of MRI for diagnosing sarcoma was 84.2% (95% confidence interval (CI), 76.3\u201389.9%), and the pooled specificity was 89.1% (95% CI, 78.1\u201394.9%). The HSROC-derived AUC was 0.916 (95% CI, 0.876\u20130.941), indicating high overall diagnostic accuracy. Considerable statistical heterogeneity was noted (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200966.3% for sensitivity and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u200995.8% for specificity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRI demonstrates high diagnostic accuracy in differentiating sarcoma from leiomyoma. However, substantial heterogeneity in study design, imaging protocols, and diagnostic criteria limits overall consistency across studies. Standardized MRI protocols and diagnostic criteria are essential to improve diagnostic uniformity and clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11604-026-01952-4","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T05:22:19Z","timestamp":1770873739000},"page":"976-986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MRI for diagnosing uterine sarcoma: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-7375","authenticated-orcid":false,"given":"Tsukasa","family":"Saida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-3619","authenticated-orcid":false,"given":"Takahiro","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8778-2710","authenticated-orcid":false,"given":"Maho","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-1099","authenticated-orcid":false,"given":"Mariko","family":"Kumazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-431X","authenticated-orcid":false,"given":"Fuki","family":"Shitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-0396","authenticated-orcid":false,"given":"Shinya","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"1952_CR1","unstructured":"Japan Radiological Society. 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