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Subjects were grouped into childhood (5\u201311 years) and adolescence (&gt;\u200912 years). Using 1.5 T MRI, mean L1-L4 signal intensity, VBQ score, and signal intensity per unit volume were calculated. MRI findings were compared using t-tests and ANOVA; diagnostic accuracy was assessed via ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the childhood group, all MRI parameters significantly differed between low bone mineral density and control subjects (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In adolescents, only mean signal intensity and signal intensity per unit volume were significant. The new parameter demonstrated the highest diagnostic value, with AUCs of 0.792 and 0.836 in childhood and adolescence groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MRI signal intensity per unit vertebral volume showed superior performance in detecting low BMD compared to existing MRI-based indices. This parameter offers a radiation-free, size-adjusted alternative to DXA, particularly valuable in pediatric patients requiring long-term monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11604-026-01967-x","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:01:59Z","timestamp":1773457319000},"page":"1231-1245","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MRI signal intensity per vertebral volume: a novel biomarker in pediatric osteoporosis"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3912-1024","authenticated-orcid":false,"given":"Ahmet Faruk","family":"G\u00fcrb\u00fcz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-8586","authenticated-orcid":false,"given":"Ay\u015fe","family":"Keven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6897-6796","authenticated-orcid":false,"given":"\u0130smail","family":"\u00d6zg\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-6462","authenticated-orcid":false,"given":"Sadi","family":"Elasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1425","authenticated-orcid":false,"given":"Mesut","family":"Parlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-0254","authenticated-orcid":false,"given":"Can","family":"\u00c7evikol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"1967_CR1","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1007\/S00431-022-04455-2","volume":"181","author":"S Ciancia","year":"2002","unstructured":"Ciancia S, van Rijn RR, H\u00f6gler W, et al. 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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The study protocol was approved by the local ethics committee. The study protocol was approved by the Akdeniz University\u2019s ethics committee (Approval Date: 27.03.2025, Approval No: 311).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Approval from the Institutional Review Board was obtained and in keeping with the policies for a retrospective review; informed consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}