{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:46:27Z","timestamp":1791927987951,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Jpn J Radiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate whether changes in diffusion-based total lesion volume (\u0394tDV) on whole-body MRI correlate with changes in serum prostate-specific antigen (\u0394PSA) after therapy, and to assess reproducibility of \u0394tDV measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective study included 20 prostate cancer patients who underwent whole-body MRI before and after treatment. Changes in total lesion volume (\u0394tDV), mean apparent diffusion coefficient (\u0394mADC), and PSA (\u0394PSA) were calculated. Correlations between \u0394tDV and \u0394PSA, as well as between \u0394mADC and \u0394PSA, were evaluated using Spearman\u2019s rank correlation coefficient.<\/jats:p>\n                    <jats:p>Image interpretation was independently performed by two readers blinded to clinical information. One reader conducted two separate reading sessions with an approximately one-year washout period. Inter-observer and intra-observer agreement for \u0394tDV measurements was assessed using Bland\u2013Altman analysis and intraclass correlation coefficients (ICCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u0394tDV demonstrated a strong positive correlation with \u0394PSA across all three reader sessions, with Spearman correlation coefficients exceeding 0.7 and significant p values (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In contrast, \u0394mADC showed a weak negative correlation with \u0394PSA, which did not reach statistical significance.\n                    <\/jats:p>\n                    <jats:p>Bland\u2013Altman analysis showed mean biases of \u22123.1\u00a0mL for inter-observer measurements and 1.4\u00a0mL for intra-observer measurements, with 95% limits of agreement of \u221222.6 to 16.5\u00a0mL and \u221219.0 to 21.9\u00a0mL, respectively. The inter- and intra-observer ICCs were 0.916 and 0.911, respectively, indicating excellent agreement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changes in diffusion-based total lesion volume on whole-body MRI show a strong and reproducible association with PSA changes after therapy, suggesting that \u0394tDV may serve as a robust quantitative imaging biomarker for treatment response in prostate cancer bone metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11604-026-02077-4","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:07:58Z","timestamp":1790140078000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reproducibility of a quantitative body diffusion score derived from whole-body diffusion-weighted imaging (DWIBS) for assessment of bone metastases in prostate cancer"],"prefix":"10.1007","author":[{"given":"Katsuyuki","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenari","family":"Hongyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mio","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Kashiwagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Nagahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2077_CR1","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s00256-024-04723-2","volume":"53","author":"FE Lecouvet","year":"2024","unstructured":"Lecouvet FE, Chabot C, Taihi L, Kirchgesner T, Triqueneaux P, Malghem J. 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