{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:30:43Z","timestamp":1781620243232,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1007\/s11605-006-0021-y","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T10:22:17Z","timestamp":1169029337000},"page":"16-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cytokine Network in Chronic Perianal Crohn\u2019s Disease and Indeterminate Colitis After Colectomy"],"prefix":"10.1016","volume":"11","author":[{"given":"Cesare","family":"Ruffolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Faggian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Romanato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnnaMaria","family":"De Pellegrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Prando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Polese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Scopelliti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pilon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Frego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide Francesco","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imerio","family":"Angriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s11605-006-0021-y_bb0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF02058706","article-title":"Perianal Crohn\u2019s disease. Results of local surgical treatment","volume":"39","author":"Sangwan","year":"1996","journal-title":"Dis Colon Rectum"},{"key":"10.1007\/s11605-006-0021-y_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0039-6109(05)70279-6","article-title":"Anorectal Crohn\u2019s disease","volume":"81","author":"McClane","year":"2001","journal-title":"Surg clin North Am"},{"key":"10.1007\/s11605-006-0021-y_bb0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF02603444","article-title":"Anal complications in Crohn\u2019s disease","volume":"24","author":"Williams","year":"1981","journal-title":"Dis Colon Rectum"},{"key":"10.1007\/s11605-006-0021-y_bb0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF01648416","article-title":"Current status and influence of operation on perianal Crohn\u2019s disease","volume":"1","author":"Keighley","year":"1986","journal-title":"Int J Colorectal Dis"},{"key":"10.1007\/s11605-006-0021-y_bb0030","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1136\/gut.52.8.1133","article-title":"Genotype\u2013phenotype analysis of the Crohn\u2019s disease susceptibility haplotype on chromosome 5q31","volume":"52","author":"Armuzzi","year":"2003","journal-title":"Gut"},{"key":"10.1007\/s11605-006-0021-y_bb0035","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.gastro.2003.08.025","article-title":"American Gastroenterological Association Clinical Practice Committee. AGA technical review on perianal Crohn\u2019s disease","volume":"125","author":"Sandborn","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-006-0021-y_bb0040","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.4049\/jimmunol.159.12.6276","article-title":"A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn\u2019s disease","volume":"159","author":"Plevy","year":"1997","journal-title":"J Immunol"},{"key":"10.1007\/s11605-006-0021-y_bb0045","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM199710093371502","article-title":"A short-term study of chimeric monoclonal antibody cA2 to tumour necrosis factor alpha for Crohn\u2019s disease. Crohn\u2019s Disease cA2 Study Group","volume":"337","author":"Targan","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1007\/s11605-006-0021-y_bb0050","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1053\/gast.2001.24042","article-title":"CDP571 Crohn\u2019s Disease Study Group. An engineered human antibody to TNF (CDP571) for active Crohn\u2019s disease: A randomized double-blind placebo-controlled trial","volume":"120","author":"Sandborn","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-006-0021-y_bb0055","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJM199905063401804","article-title":"Infliximab for the treatment of fistulas in patients with Crohn\u2019s disease","volume":"340","author":"Present","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1007\/s11605-006-0021-y_bb0060","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1111\/j.1572-0241.2000.03366.x","article-title":"Clinical experience with infliximab therapy in 100 patients with Crohn\u2019s disease","volume":"95","author":"Farrell","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1007\/s11605-006-0021-y_bb0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10350-004-6111-6","article-title":"Endosonographic evidence of persistence of Crohn\u2019s disease-associated fistulas after infliximab treatment, irrespective of clinical response","volume":"45","author":"van Bodegraven","year":"2002","journal-title":"Dis Colon Rectum"},{"key":"10.1007\/s11605-006-0021-y_bb0070","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0002-9270(02)05909-9","article-title":"Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn\u2019s disease","volume":"98","author":"Van Assche","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1007\/s11605-006-0021-y_bb0075","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1056\/NEJMoa033402","article-title":"Anti-interleukin-12 antibody for active Crohn\u2019s disease","volume":"351","author":"Mannon","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1007\/s11605-006-0021-y_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00004836-199501000-00008","article-title":"Usual therapy improves perianal Crohn\u2019s disease as measured by a new disease activity index. McMaster IBD Study Group","volume":"20","author":"Irvine","year":"1995","journal-title":"J Clin Gastroenterol"},{"key":"10.1007\/s11605-006-0021-y_bb0085","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn\u2019s disease activity index. National Cooperative Crohn\u2019s Disease Study","volume":"70","author":"Best","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-006-0021-y_bb0090","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0016-5085(79)90383-4","article-title":"National Cooperative Crohn\u2019s Disease Study: Study design and conduct of the study","volume":"77","author":"Winship","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-006-0021-y_bb0095","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jcp.46.3.198","article-title":"International Council for Standardization in Haematology (Expert Panel on Blood Rheology)","volume":"46","author":"ICSH recommendations for measurement of erythrocyte sedimentation rate","year":"1993","journal-title":"J Clin Pathol"},{"key":"10.1007\/s11605-006-0021-y_bb0100","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jcla.20038","article-title":"Measurement of C-reactive protein: two high sensitivity methods compared","volume":"18","author":"Dominici","year":"2004","journal-title":"J Clin Lab Anal"},{"key":"10.1007\/s11605-006-0021-y_bb0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1006\/abio.1995.1186","article-title":"A comparison of methods for determining total body protein","volume":"226","author":"Brooks","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1007\/s11605-006-0021-y_bb0110","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1046\/j.1365-2036.2003.01535.x","article-title":"Infliximab in refractory pouchitis complicated by fistulae following ileo-anal pouch for ulcerative colitis","volume":"17","author":"Viscido","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1007\/s11605-006-0021-y_bb0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.dld.2005.01.019","article-title":"Italian multicentric study group on infliximab. Infliximab in the treatment of Crohn\u2019s disease: predictors of response in an Italian multicentric open study","volume":"37","author":"Orlando","year":"2005","journal-title":"Dig Liver Dis"},{"key":"10.1007\/s11605-006-0021-y_bb0120","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.gastro.2005.05.013","article-title":"Characteristics of intestinal dendritic cells in inflammatory bowel diseases","volume":"129","author":"Hart","year":"2005","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1007\/s11605-006-0021-y_bb0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01.MIB.0000194183.92671.b6","article-title":"Both IL-12p70 and IL-23 are synthesized during active Crohn\u2019s disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody","volume":"12","author":"Fuss","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"10.1007\/s11605-006-0021-y_bb0130","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/00365520310000672","article-title":"Upregulation of interleukin-12 and -17 in active inflammatory bowel disease","volume":"38","author":"Nielsen","year":"2003","journal-title":"Scand J Gastroenterol"},{"key":"10.1007\/s11605-006-0021-y_bb0135","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.ajog.2005.05.039","article-title":"Insulin-like growth factor and interleukin-1beta levels and subsequent fetal size response to chronic Porphyromonas gingivalis exposure in the pregnant rabbit","volume":"193","author":"Boggess","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1007\/s11605-006-0021-y_bb0140","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1080\/00365520510023774","article-title":"Saliva Interleukin-6 in patients with inflammatory bowel disease","volume":"40","author":"Aleksandra","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1007\/s11605-006-0021-y_bb0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/gut.35.1.77","article-title":"Interrelations between interleukin-6, interleukin-1beta, plasma C-reactive protein values, and in vitro C-reactive protein generation in patients with inflammatory bowel disease","volume":"35","author":"Mazlam","year":"1994","journal-title":"Gut"},{"key":"10.1007\/s11605-006-0021-y_bb0150","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00054725-200409000-00026","article-title":"C-reactive protein as a marker for inflammatory bowel disease","volume":"10","author":"Vermeire","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"10.1007\/s11605-006-0021-y_bb0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1385\/CRIAI:28:3:187","article-title":"Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer","volume":"28","author":"Atreya","year":"2005","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1007\/s11605-006-0021-y_bb0160","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2004.01.012","article-title":"A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn\u2019s disease","volume":"126","author":"Ito","year":"2004","journal-title":"Gastroenterology"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-006-0021-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11605-006-0021-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23077995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23077995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-006-0021-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:27:14Z","timestamp":1761074834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X23077995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S1091255X23077995"],"URL":"https:\/\/doi.org\/10.1007\/s11605-006-0021-y","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine Network in Chronic Perianal Crohn\u2019s Disease and Indeterminate Colitis After Colectomy","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-006-0021-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}