{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:44:47Z","timestamp":1774035887779,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s11605-009-0951-2","type":"journal-article","created":{"date-parts":[[2009,7,3]],"date-time":"2009-07-03T07:01:34Z","timestamp":1246604494000},"page":"1707-1716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat"],"prefix":"10.1016","volume":"13","author":[{"given":"G.","family":"Karadeniz Cakmak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Irkorucu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.H.","family":"Ucan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.U.","family":"Emre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bahadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Demirtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Tascilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Karakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Acikgoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kertis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ankarali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Pasaoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Comert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1007\/s11605-009-0951-2_bb0010","first-page":"166","article-title":"Colorectal cancer and hypercholesterolemia: review of current research","volume":"27","author":"Herbey","year":"2005","journal-title":"Exp Oncol"},{"key":"10.1007\/s11605-009-0951-2_bb0015","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/82219","article-title":"Statins as a newly recognized type of immunomodulator","volume":"6","author":"Kwak","year":"2000","journal-title":"Nat Med"},{"key":"10.1007\/s11605-009-0951-2_bb0020","first-page":"2104","article-title":"Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha toxin","volume":"15","author":"Pruefer","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1007\/s11605-009-0951-2_bb0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCULATIONAHA.104.502195","article-title":"Statin treatment after onset of sepsis in a murine model improves survival","volume":"112","author":"Merx","year":"2005","journal-title":"Circulation"},{"issue":"9","key":"10.1007\/s11605-009-0951-2_bb0030","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/pds.1599","article-title":"Chronic statin therapy and the risk of colorectal cancer","volume":"17","author":"Yang","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"3","key":"10.1007\/s11605-009-0951-2_bb0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/FJC.0b013e3180a72606","article-title":"Simvastatin reverses target organ damage and oxidative stress in angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine","volume":"50","author":"Rugale","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"10.1007\/s11605-009-0951-2_bb0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejvs.2003.09.014","article-title":"The role of statins in vascular disease","volume":"27","author":"Laws","year":"2004","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1007\/s11605-009-0951-2_bb0045","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1056\/NEJMoa043792","article-title":"Statins and the risk of colorectal cancer","volume":"352","author":"Poynter","year":"2005","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1007\/s11605-009-0951-2_bb0050","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/ijc.22796","article-title":"Individual and joint use of statins and low-dose aspirin and risk of colorectal cancer: a population-based case-control study","volume":"121","author":"Hoffmeister","year":"2007","journal-title":"Int J Cancer"},{"issue":"9","key":"10.1007\/s11605-009-0951-2_bb0055","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/bjs.5054","article-title":"Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer","volume":"92","author":"McArdle","year":"2005","journal-title":"Br J Surg"},{"key":"10.1007\/s11605-009-0951-2_bb0060","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0015-0282(16)43693-9","article-title":"Classification of adnexal adhesions: a proposal and evaluation of its prognostic value","volume":"41","author":"Hulka","year":"1978","journal-title":"Fertil Steril"},{"key":"10.1007\/s11605-009-0951-2_bb0065","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"15","author":"Jamall","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1007\/s11605-009-0951-2_bb0070","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/BF00988606","article-title":"Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients","volume":"10","author":"Hunter","year":"1985","journal-title":"Neurochem Res"},{"key":"10.1007\/s11605-009-0951-2_bb0075","first-page":"1126","article-title":"The human serum paraoxanase\/arylesterase polymorphism","volume":"35","author":"Eckerson","year":"1983","journal-title":"Hum Genet"},{"key":"10.1007\/s11605-009-0951-2_bb0080","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch Surg"},{"key":"10.1007\/s11605-009-0951-2_bb0085","first-page":"465","article-title":"Evolution anatomo-pathologique des anastomoses digestives bord a bord en un plan. Etude de 210 anastomoses coliques chez le rat de 2e and 180e jour","volume":"7","author":"Houdart","year":"1983","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1007\/s11605-009-0951-2_bb0090","first-page":"75","article-title":"Wundheilung nach laser und rotlichtbestralung","volume":"13","author":"Hutschenreiter","year":"1980","journal-title":"Z Exp Chir"},{"key":"10.1007\/s11605-009-0951-2_bb0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0009-739X(02)71981-7","article-title":"Modificacio\u2019n de los mediadores inflamatorios en isquemia\u2013reperfusio\u2019n intestinal en unmodelo de diabetes tipo II","volume":"71","author":"Garcia","year":"2002","journal-title":"Cir Esp"},{"key":"10.1007\/s11605-009-0951-2_bb0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.sla.0000133186.81222.08","article-title":"Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer","volume":"240","author":"Walker","year":"2004","journal-title":"Ann Surg"},{"issue":"23","key":"10.1007\/s11605-009-0951-2_bb0105","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1200\/JCO.2007.10.8936","article-title":"Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million patients","volume":"25","author":"Bonovas","year":"2007","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1007\/s11605-009-0951-2_bb0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/jnci\/djk003","article-title":"Statin use and risk of colorectal cancer","volume":"99","author":"Coogan","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1007\/s11605-009-0951-2_bb0115","first-page":"95","article-title":"Cholesterol production inhibitor (statin) increased bone healing in surgically created femoral defect in an animal model","volume":"43","author":"Adah","year":"2007","journal-title":"Biomed Sci Instrum"},{"issue":"1","key":"10.1007\/s11605-009-0951-2_bb0120","first-page":"187","article-title":"New addition to the statin\u2019s effect","volume":"63","author":"Serin-Kilicoglu","year":"2007","journal-title":"J Trauma"},{"key":"10.1007\/s11605-009-0951-2_bb0125","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/79510","article-title":"The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals","volume":"6","author":"Kureishi","year":"2000","journal-title":"Nat Med"},{"key":"10.1007\/s11605-009-0951-2_bb0130","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/hc0602.103393","article-title":"Statins have biphasic effects on angiogenesis","volume":"105","author":"Weis","year":"2002","journal-title":"Circulation"},{"issue":"12","key":"10.1007\/s11605-009-0951-2_bb0135","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nrc1751","article-title":"Statins and cancer prevention","volume":"5","author":"Demierre","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"1\u20132","key":"10.1007\/s11605-009-0951-2_bb0140","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cca.2007.10.027","article-title":"Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in hypercholesterolemic patients and induces pro-angiogenic cytokine IL-8 secretion from monocytes","volume":"388","author":"Park","year":"2008","journal-title":"Clin Chim Acta"},{"issue":"1","key":"10.1007\/s11605-009-0951-2_bb0145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0006-291X(02)03014-0","article-title":"Simvastatin stimulates VEGF release via p44\/p42 MAP kinase in vascular smooth muscle cells","volume":"301","author":"Takenaka","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1007\/s11605-009-0951-2_bb0150","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0039-6109(05)70568-5","article-title":"Healing in the gastrointestinal tract","volume":"77","author":"Thornton","year":"1997","journal-title":"Surg Clin North Am"},{"issue":"2","key":"10.1007\/s11605-009-0951-2_bb0155","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jss.2006.11.021","article-title":"Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury","volume":"141","author":"Cowled","year":"2007","journal-title":"J Surg Res"},{"issue":"6","key":"10.1007\/s11605-009-0951-2_bb0160","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.athoracsur.2007.07.022","article-title":"Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model","volume":"84","author":"Shao","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1007\/s11605-009-0951-2_bb0165","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1365-2168.2001.01649.x","article-title":"Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model","volume":"88","author":"Syk","year":"2001","journal-title":"Br J Surg"},{"key":"10.1007\/s11605-009-0951-2_bb0170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00384-002-0418-3","article-title":"The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat","volume":"17","author":"de Hingh","year":"2002","journal-title":"Int J Colorectal Dis"},{"issue":"5","key":"10.1007\/s11605-009-0951-2_bb0175","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/ATVBAHA.107.139881","article-title":"Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation","volume":"27","author":"Ferri","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1007\/s11605-009-0951-2_bb0180","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000090339","article-title":"HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veins","volume":"37","author":"Nomura","year":"2005","journal-title":"Eur Surg Res"},{"key":"10.1007\/s11605-009-0951-2_bb0185","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1096\/fj.04-2852fje","article-title":"Simvastatin inhibitsMMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA\/ROCK pathway and reducing MMP-9 mRNA levels","volume":"19","author":"Turner","year":"2005","journal-title":"FASEB J"},{"issue":"4","key":"10.1007\/s11605-009-0951-2_bb0190","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/147323000703500412","article-title":"Effects of simvastatin on lung injury induced by ischaemia\u2013reperfusion of the hind limbs in rats","volume":"35","author":"Sun","year":"2007","journal-title":"J Int Med Res"},{"issue":"2","key":"10.1007\/s11605-009-0951-2_bb0195","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.sla.0000236627.07927.7c","article-title":"Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity","volume":"245","author":"Aarons","year":"2007","journal-title":"Ann Surg"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-009-0951-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11605-009-0951-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X2305552X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X2305552X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-009-0951-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:31:40Z","timestamp":1761075100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X2305552X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S1091255X2305552X"],"URL":"https:\/\/doi.org\/10.1007\/s11605-009-0951-2","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-009-0951-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}