{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:07:37Z","timestamp":1782547657957,"version":"3.54.5"},"reference-count":20,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s11605-013-2250-1","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T13:24:32Z","timestamp":1372685072000},"page":"1643-1650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["An Envirogenomic Signature Is Associated with Risk of IBD-Related Surgery in a Population-Based Crohn\u2019s Disease Cohort"],"prefix":"10.1016","volume":"17","author":[{"given":"Bushra F","family":"Nasir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn R","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslam","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Barclay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B","family":"Gearry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney A","family":"Lea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s11605-013-2250-1_bb0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ibd.20352","article-title":"New global map of Crohn\u2019s disease: genetic, environmental and socioeconomic correlations","volume":"14","author":"Economou","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"10.1007\/s11605-013-2250-1_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2036.2006.03134.x","article-title":"Review article: altering the natural history of Crohn\u2019s disease\u2014evidence for and against current therapies","volume":"25","author":"Vermeire","year":"2006","journal-title":"Aliment Pharm Therap"},{"key":"10.1007\/s11605-013-2250-1_bb0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/bega.2003.0361","article-title":"Crohn\u2019s disease: step up or top down therapy","volume":"17","author":"Hanauer","year":"2003","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1007\/s11605-013-2250-1_bb0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/gene.2010.11","article-title":"Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn\u2019s disease","volume":"11","author":"Roberts","year":"2010","journal-title":"Genes Immun"},{"key":"10.1007\/s11605-013-2250-1_bb0030","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/ibd.20190","article-title":"Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population based cohort","volume":"13","author":"Gearry","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1007\/s11605-013-2250-1_bb0035","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1440-1746.2009.06140.x","article-title":"Population-based cases control study of inflammatory bowel disease risk factors","volume":"25","author":"Gearry","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1007\/s11605-013-2250-1_bb0040","doi-asserted-by":"crossref","unstructured":"Gearry R.B., Richardson A, Frampton C.M, Collette J.A, Burt M.J., Chapman B.A, Barclay M.L, \u2018High Incidence of Crohn\u2019s disease in Canterbury, New Zealand: Results of an epidemiologic study\u2019, Inflamm Bowel Dis, 2006;12:10,936\u2013943","DOI":"10.1097\/01.mib.0000231572.88806.b9"},{"key":"10.1007\/s11605-013-2250-1_bb0045","doi-asserted-by":"crossref","unstructured":"Nasir BF, Griffiths L, Nasir A et al, \u2018Perianal disease combined with NOD2 genotype predicts need for IBD-related surgery in Crohn\u2019s disease patients from a population-based cohort\u2019, J Clin Gastroenterol, 2013 (In press)","DOI":"10.1097\/MCG.0b013e318258314d"},{"issue":"28","key":"10.1007\/s11605-013-2250-1_bb0050","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.3748\/wjg.15.3504","article-title":"Perianal disease, small bowel disease, smoking, prior steroid or early azathioprine\/biological therapy are predictors of disease behavior change in patients with Crohn\u2019s disease","volume":"15","author":"Lakatos","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1007\/s11605-013-2250-1_bb0055","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1111\/j.1572-0241.2008.02212.x","article-title":"Perianal disease predicts changes in Crohn\u2019s disease phenotype\u2014results of a population-based study of inflammatory bowel disease phenotype","volume":"103","author":"Tarant","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1007\/s11605-013-2250-1_bb0060","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1751-2980.2011.00484.x","article-title":"Risk factors that predict the requirement of aggressive therapy among Chinese patients with Crohn\u2019s disease","volume":"12","author":"Yang","year":"2011","journal-title":"J Dig Dis"},{"key":"10.1007\/s11605-013-2250-1_bb0065","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/gast.2001.23231","article-title":"Smoking cessation and the course of Crohn\u2019s disease: An intervention study","volume":"120","author":"Cosnes","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-013-2250-1_bb0070","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","article-title":"Inflammatory Bowel Disease: the role of environmental factors","volume":"3","author":"Danese","year":"2004","journal-title":"Autoimmun Rev"},{"key":"10.1007\/s11605-013-2250-1_bb0075","first-page":"600","article-title":"A hospital-based study of clinical and genetic features of Crohn\u2019s disease","volume":"110","author":"Wei","year":"2011","journal-title":"JFMA"},{"key":"10.1007\/s11605-013-2250-1_bb0080","doi-asserted-by":"crossref","unstructured":"Bouguen G and Peyrin-Biroulet L, \u2018Surgery for adult Crohn\u2019s disease: what is the actual risk?\u2019, Gut, 2011;60(9):1178\u20131181","DOI":"10.1136\/gut.2010.234617"},{"key":"10.1007\/s11605-013-2250-1_bb0085","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/gut.2009.202101","article-title":"Natural history of Crohn\u2019s disease population-based cohort from Cardiff (1986\u20132003): a study of changes in medical treatment and surgical resection rates","volume":"59","author":"Ramadas","year":"2010","journal-title":"Gut"},{"key":"10.1007\/s11605-013-2250-1_bb0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/ibd.21386","article-title":"Real-time tool to display the predicted disease course and treatment response for children with Crohn\u2019s disease","volume":"17","author":"Siegel","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1007\/s11605-013-2250-1_bb0095","doi-asserted-by":"crossref","unstructured":"Lewis CM, Whitwell SCL, Forbes A et al., \u2018Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn\u2019s disease\u2019, J Med Genet, 2007:1\u201316","DOI":"10.1136\/jmg.2007.051672"},{"key":"10.1007\/s11605-013-2250-1_bb0100","first-page":"747","volume":"461","author":"Manolio","year":"2009","journal-title":"Finding the missing heritability of complex diseases\u2019, Nature"},{"key":"10.1007\/s11605-013-2250-1_bb0105","doi-asserted-by":"crossref","unstructured":"Weersma R.K., Stokkers P.C., van Bodegraven A.A, et al, \u2018Molecular prediction of disease risk and severity in a large Dutch Crohn\u2019s disease cohort\u2019, Gut, 2009;58(3):388\u201395","DOI":"10.1136\/gut.2007.144865"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-013-2250-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11605-013-2250-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23041288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23041288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-013-2250-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:40:47Z","timestamp":1761075647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X23041288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1091255X23041288"],"URL":"https:\/\/doi.org\/10.1007\/s11605-013-2250-1","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Envirogenomic Signature Is Associated with Risk of IBD-Related Surgery in a Population-Based Crohn\u2019s Disease Cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-013-2250-1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}