{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:08:06Z","timestamp":1789715286889,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s11605-013-2423-y","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T13:49:45Z","timestamp":1385992185000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Assessment of ISGLS Definition of Posthepatectomy Liver Failure and Its Effect on Outcome in Patients with Hepatocellular Carcinoma"],"prefix":"10.1016","volume":"18","author":[{"given":"Kenji","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Fukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kuramitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Kido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motofumi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonson","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s11605-013-2423-y_bb0010","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1007\/s11605-013-2423-y_bb0015","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S0168-8278(12)60009-9","article-title":"Management of HCC","volume":"56","author":"de Lope","year":"2012","journal-title":"J Hepatol"},{"key":"10.1007\/s11605-013-2423-y_bb0020","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1053\/j.gastro.2008.02.091","article-title":"Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma","volume":"134","author":"Ishizawa","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1007\/s11605-013-2423-y_bb0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00000658-200107000-00010","article-title":"Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10\u00a0years","volume":"234","author":"Poon","year":"2001","journal-title":"Ann Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0030","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jamcollsurg.2007.01.035","article-title":"Trends in morbidity and mortality after hepatic resection for hepatocellular carcinoma: an institute\u2019s experience with 625 patients","volume":"204","author":"Taketomi","year":"2007","journal-title":"J Am Coll Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0035","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ejso.2005.04.002","article-title":"Liver resection for hepatocellular carcinoma on cirrhosis: analysis of mortality, morbidity and survival\u2014a European single center experience","volume":"31","author":"Capussotti","year":"2005","journal-title":"Eur J Surg Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/bjs.6358","article-title":"Impact of postoperative complications on long-term outcome of curative resection for hepatocellular carcinoma","volume":"96","author":"Chok","year":"2009","journal-title":"Br J Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0045","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1245\/s10434-008-9880-7","article-title":"Short- and long-term outcomes after hepatic resection for hepatocellular carcinoma with concomitant esophageal varices in patients with cirrhosis","volume":"15","author":"Kawano","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0050","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ejso.2009.04.008","article-title":"Predictors and prognostic significance of operative complications in patients with hepatocellular carcinoma who underwent hepatic resection","volume":"35","author":"Kusano","year":"2009","journal-title":"Eur J Surg Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0055","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11605-008-0711-8","article-title":"Prognostic impact of surgical complications and preoperative serum hepatocyte growth factor in hepatocellular carcinoma patients after initial hepatectomy","volume":"13","author":"Mizuguchi","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0060","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/jso.21977","article-title":"Prognostic significance of postoperative complications after hepatectomy for hepatocellular carcinoma","volume":"104","author":"Okamura","year":"2011","journal-title":"J Surg Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0065","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s00268-011-1161-0","article-title":"Risk factors influencing postoperative outcomes of major hepatic resection of hepatocellular carcinoma for patients with underlying liver diseases","volume":"35","author":"Yang","year":"2011","journal-title":"World J Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0070","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"10.1007\/s11605-013-2423-y_bb0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bjs.7459","article-title":"Postoperative course and clinical significance of biochemical blood tests following hepatic resection","volume":"98","author":"Reissfelder","year":"2011","journal-title":"Br J Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0080","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/01.sla.0000103133.03688.3d","article-title":"Reductive surgery plus percutaneous isolated hepatic perfusion for multiple advanced hepatocellular carcinoma","volume":"239","author":"Ku","year":"2004","journal-title":"Ann Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0085","first-page":"1312","article-title":"Isolated hepatic perfusion for extensive liver cancers","author":"Ku","year":"2007"},{"key":"10.1007\/s11605-013-2423-y_bb0090","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am J Clin Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0095","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/hep.20933","article-title":"Management of hepatocellular carcinoma","volume":"42","author":"Bruix","year":"2005","journal-title":"Hepatology"},{"key":"10.1007\/s11605-013-2423-y_bb0100","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.2214\/ajr.184.5.01841510","article-title":"Determination of splenomegaly by CT: is there a place for a single measurement?","volume":"184","author":"Bezerra","year":"2005","journal-title":"AJR Am J Roentgenol"},{"key":"10.1007\/s11605-013-2423-y_bb0105","year":"2010"},{"key":"10.1007\/s11605-013-2423-y_bb0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1007\/s11605-013-2423-y_bb0115","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1007\/s11605-013-2423-y_bb0120","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1478-3231.2006.01339.x","article-title":"How to modulate inflammatory cytokines in liver diseases","volume":"26","author":"Tilg","year":"2006","journal-title":"Liver Int"},{"key":"10.1007\/s11605-013-2423-y_bb0125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver regeneration","volume":"276","author":"Michalopoulos","year":"1997","journal-title":"Science"},{"key":"10.1007\/s11605-013-2423-y_bb0130","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1038\/onc.2010.236","article-title":"The role of signaling pathways in the development and treatment of hepatocellular carcinoma","volume":"29","author":"Whittaker","year":"2010","journal-title":"Oncogene"},{"key":"10.1007\/s11605-013-2423-y_bb0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejso.2006.12.007","article-title":"Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection","volume":"34","author":"Chau","year":"2008","journal-title":"Eur J Surg Oncol"},{"key":"10.1007\/s11605-013-2423-y_bb0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000335741","article-title":"Posthepatectomy liver failure","volume":"29","author":"Schreckenbach","year":"2012","journal-title":"Dig Surg"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-013-2423-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11605-013-2423-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X2304547X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X2304547X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-013-2423-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:43:56Z","timestamp":1761075836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X2304547X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1091255X2304547X"],"URL":"https:\/\/doi.org\/10.1007\/s11605-013-2423-y","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of ISGLS Definition of Posthepatectomy Liver Failure and Its Effect on Outcome in Patients with Hepatocellular Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-013-2423-y","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}