{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:59:20Z","timestamp":1784321960187,"version":"3.55.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s11605-019-04441-4","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T14:02:45Z","timestamp":1574172165000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Peritoneal Metastases in Colorectal Cancer: Biology and Barriers"],"prefix":"10.1016","volume":"24","author":[{"given":"Lai","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil H.","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Turaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-5005","authenticated-orcid":false,"given":"Oliver S.","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s11605-019-04441-4_bb0010","doi-asserted-by":"crossref","unstructured":"Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nature Communications 2018; 9(1). https:\/\/doi.org\/10.1038\/s41467-018-04278-6.","DOI":"10.1038\/s41467-018-04278-6"},{"issue":"29","key":"10.1007\/s11605-019-04441-4_bb0015","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1200\/JCO.2007.11.0833","article-title":"Actual 10-year survival after resection of colorectal liver metastases defines cure","volume":"25","author":"Tomlinson","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"10.1007\/s11605-019-04441-4_bb0020","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.athoracsur.2007.02.093","article-title":"Surgical Resection of Pulmonary Metastases From Colorectal Cancer: A Systematic Review of Published Series","volume":"84","author":"Pfannschmidt","year":"2007","journal-title":"Annals of Thoracic Surgery"},{"issue":"20","key":"10.1007\/s11605-019-04441-4_bb0025","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1200\/JCO.2003.04.187","article-title":"Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer","volume":"21","author":"Verwaal","year":"2003","journal-title":"Journal of Clinical Oncology"},{"issue":"9","key":"10.1007\/s11605-019-04441-4_bb0030","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1245\/s10434-008-9966-2","article-title":"8-Year follow-up of randomized trial: Cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer","volume":"15","author":"Verwaal","year":"2008","journal-title":"Annals of Surgical Oncology"},{"issue":"18_suppl","key":"10.1007\/s11605-019-04441-4_bb0035","doi-asserted-by":"crossref","first-page":"LBA3503","DOI":"10.1200\/JCO.2018.36.18_suppl.LBA3503","article-title":"A UNICANCER phase III trial of hyperthermic intra-peritoneal chemotherapy (HIPEC) for colorectal peritoneal carcinomatosis (PC): PRODIGE 7","volume":"36","author":"Quenet","year":"2018","journal-title":"Journal of Clinical Oncology"},{"issue":"6024","key":"10.1007\/s11605-019-04441-4_bb0040","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1203543","article-title":"A perspective on cancer cell metastasis","volume":"331","author":"Chaffer","year":"2011","journal-title":"Science"},{"issue":"8","key":"10.1007\/s11605-019-04441-4_bb0045","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1245\/s10434-018-6490-x","article-title":"Peritoneal Metastases in Colorectal Cancer","volume":"25","author":"Jacobson","year":"2018","journal-title":"Annals of surgical oncology"},{"issue":"1","key":"10.1007\/s11605-019-04441-4_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1200\/JCO.1995.13.1.8","article-title":"Oligometastases","volume":"13","author":"Hellman","year":"1995","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1007\/s11605-019-04441-4_bb0055","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nrclinonc.2011.44","article-title":"Oligometastases revisited","volume":"8","author":"Weichselbaum","year":"2011","journal-title":"Nature Reviews Clinical Oncology"},{"issue":"6419","key":"10.1007\/s11605-019-04441-4_bb0060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/bmj.288.6419.749","article-title":"Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts","volume":"288","author":"Tarin","year":"1984","journal-title":"Bmj"},{"key":"10.1007\/s11605-019-04441-4_bb0065","doi-asserted-by":"crossref","unstructured":"Malanchi I, Santamaria-Mart\u00ednez A, Susanto E, Peng H, Lehr H-A, Delaloye J-F, Huelsken J. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 2011; 481:85. https:\/\/doi.org\/10.1038\/nature10694 Accessed.","DOI":"10.1038\/nature10694"},{"issue":"118","key":"10.1007\/s11605-019-04441-4_bb0070","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/newbio242148a0","article-title":"Selection of successive tumour lines for metastasis","volume":"242","author":"Fidler","year":"1973","journal-title":"Nature New Biology"},{"key":"10.1007\/s11605-019-04441-4_bb0075","doi-asserted-by":"crossref","unstructured":"Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, Weichselbaum RR. STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. PLoS ONE 2009; 4(6). https:\/\/doi.org\/10.1371\/journal.pone.0005821.","DOI":"10.1371\/journal.pone.0005821"},{"issue":"5","key":"10.1007\/s11605-019-04441-4_bb0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ccr.2012.08.013","article-title":"Dependency of colorectal cancer on a TGF-\u03b2-driven program in stromal cells for metastasis initiation","volume":"22","author":"Calon","year":"2012","journal-title":"Cancer cell"},{"issue":"7586","key":"10.1007\/s11605-019-04441-4_bb0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature17038","article-title":"Metastatic colonization by circulating tumour cells","volume":"529","author":"Massagu\u00e9","year":"2016","journal-title":"Nature"},{"issue":"4","key":"10.1007\/s11605-019-04441-4_bb0090","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2006.11.001","article-title":"Cancer Metastasis: Building a Framework","volume":"127","author":"Gupta","year":"2006","journal-title":"Cell"},{"key":"10.1007\/s11605-019-04441-4_bb0095","unstructured":"The deleted in colorectal cancer (DCC) gene: A candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules. Cancer Surveys 1995; 24:3\u201317."},{"issue":"4","key":"10.1007\/s11605-019-04441-4_bb0100","first-page":"187","article-title":"A role for WISP2 in colorectal cancer cell invasion and motility","volume":"10","author":"Frewer","year":"2013","journal-title":"Cancer Genomics and Proteomics"},{"issue":"4_suppl","key":"10.1007\/s11605-019-04441-4_bb0105","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1200\/JCO.2019.37.4_suppl.498","article-title":"Molecular comparison of primary colorectal cancer (pCRC) with peritoneal metastases (PM)","volume":"37","author":"Stein","year":"2019","journal-title":"Journal of Clinical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0110","doi-asserted-by":"crossref","unstructured":"Mlecnik B, Bindea G, Kirilovsky A, Angell HK, Obenauf AC, Tosolini M, Church SE, Maby P, Vasaturo A, Angelova M, Fredriksen T, Mauger S, Waldner M, Berger A, Speicher MR, Pag\u00e8s F, Valge-Archer V, Galon J. The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Science Translational Medicine 2016; 8(327). https:\/\/doi.org\/10.1126\/scitranslmed.aad6352.","DOI":"10.1126\/scitranslmed.aad6352"},{"key":"10.1007\/s11605-019-04441-4_bb0115","doi-asserted-by":"crossref","unstructured":"Carmignani CP, Sugarbaker TA, Bromley CM, Sugarbaker PH. Intraperitoneal cancer dissemination: Mechanisms of the patterns of spread. Cancer and Metastasis Reviews 2003.","DOI":"10.1023\/A:1023791229361"},{"issue":"3","key":"10.1007\/s11605-019-04441-4_bb0120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/annonc\/mdt591","article-title":"Metastatic pattern in colorectal cancer is strongly influenced by histological subtype","volume":"25","author":"Hugen","year":"2014","journal-title":"Annals of Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0125","doi-asserted-by":"crossref","unstructured":"Gendler SJ. MUC1, The renaissance molecule. Journal of Mammary Gland Biology and Neoplasia 2001.","DOI":"10.1023\/A:1011379725811"},{"key":"10.1007\/s11605-019-04441-4_bb0130","doi-asserted-by":"crossref","unstructured":"Wei X, Xu H, Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 2005. https:\/\/doi.org\/10.1016\/j.ccr.2005.01.008.","DOI":"10.1016\/j.ccr.2005.01.008"},{"key":"10.1007\/s11605-019-04441-4_bb0135","doi-asserted-by":"crossref","unstructured":"Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ. MUC1 alters \u03b2-catenin-dependent tumor formation and promotes cellular invasion. Oncogene 2003. https:\/\/doi.org\/10.1038\/sj.onc.1206291.","DOI":"10.1038\/sj.onc.1206291"},{"issue":"12","key":"10.1007\/s11605-019-04441-4_bb0140","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1245\/s10434-007-9557-7","article-title":"Site-specific gene expression profiles and novel molecular prognostic factors in patients with lower gastrointestinal adenocarcinoma diffusely metastatic to liver or peritoneum","volume":"14","author":"Varghese","year":"2007","journal-title":"Annals of Surgical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0145","doi-asserted-by":"crossref","unstructured":"Lemoine L, Sugarbaker P, Van Der Speeten K. Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum. World Journal of Gastroenterology 2016.","DOI":"10.3748\/wjg.v22.i34.7692"},{"issue":"26","key":"10.1007\/s11605-019-04441-4_bb0150","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1056\/NEJMra0805239","article-title":"Molecular Basis of Metastasis","volume":"359","author":"Chiang","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"10.1007\/s11605-019-04441-4_bb0155","doi-asserted-by":"crossref","unstructured":"Naxerova K, Reiter JG, Brachtel E, Lennerz JK, Van De Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science 2017; 357(6346). https:\/\/doi.org\/10.1126\/science.aai8515.","DOI":"10.1126\/science.aai8515"},{"issue":"2","key":"10.1007\/s11605-019-04441-4_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1245\/s10434-008-0234-2","article-title":"Evaluation of preoperative computed tomography in estimating peritoneal cancer index in colorectal peritoneal carcinomatosis","volume":"16","author":"Koh","year":"2009","journal-title":"Annals of Surgical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0165","doi-asserted-by":"crossref","unstructured":"Dresen RC, De Vuysere S, De Keyzer F, Van Cutsem E, Prenen H, Vanslembrouck R, De Hertogh G, Wolthuis A, D\u2019Hoore A, Vandecaveye V. Whole-body diffusion-weighted MRI for operability assessment in patients with colorectal cancer and peritoneal metastases. Cancer Imaging 2019; 19(1). https:\/\/doi.org\/10.1186\/s40644-018-0187-z.","DOI":"10.1186\/s40644-018-0187-z"},{"issue":"6","key":"10.1007\/s11605-019-04441-4_bb0170","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S1470-2045(17)30336-4","article-title":"Under-representation of peritoneal metastases in published clinical trials of metastatic colorectal cancer","volume":"18","author":"Tseng","year":"2017","journal-title":"The Lancet Oncology"},{"issue":"3","key":"10.1007\/s11605-019-04441-4_bb0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1200\/JCO.2011.37.1039","article-title":"Treatment of colorectal peritoneal carcinomatosis with systemic chemotherapy: A pooled analysis of North Central Cancer Treatment Group phase III trials N9741 and N9841","volume":"30","author":"Franko","year":"2012","journal-title":"Journal of Clinical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0180","doi-asserted-by":"crossref","unstructured":"Jacquet P, Sugarbaker PH. Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis. In: 1996:359\u2013374.","DOI":"10.1007\/978-1-4613-1247-5_23"},{"issue":"1","key":"10.1007\/s11605-019-04441-4_bb0185","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1245\/s10434-015-4627-8","article-title":"Linear Relationship of Peritoneal Cancer Index and Survival in Patients with Peritoneal Metastases from Colorectal Cancer","volume":"23","author":"Faron","year":"2016","journal-title":"Annals of Surgical Oncology"},{"issue":"1","key":"10.1007\/s11605-019-04441-4_bb0190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1245\/s10434-018-7005-5","article-title":"Narrow-Band Imaging Improves Detection of Colorectal Peritoneal Metastases: A Clinical Study Comparing Advanced Imaging Techniques","volume":"26","author":"Sluiter","year":"2019","journal-title":"Annals of Surgical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0195","unstructured":"Surgical treatment of peritoneal carcinomatosis: 1988 Du Pont lecture. Canadian Journal of Surgery 1989; 32(3):164\u2013170."},{"key":"10.1007\/s11605-019-04441-4_bb0200","doi-asserted-by":"crossref","unstructured":"Sugarbaker PH. Peritonectomy procedures. In: Peritoneal Carcinomatosis: A Multidisciplinary Approach; 2007:247\u2013264.","DOI":"10.1007\/978-0-387-48993-3_15"},{"key":"10.1007\/s11605-019-04441-4_bb0205","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Trigo V, Stuart OA, Stephens AD, Hoover LD, Sugarbaker PH. Surgically directed chemotherapy: Heated intraperitoneal lavage with mitomycin C. In: 2011:51\u201361.","DOI":"10.1007\/978-1-4613-1245-1_6"},{"issue":"16","key":"10.1007\/s11605-019-04441-4_bb0210","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1002\/cncr.25116","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis","volume":"116","author":"Franko","year":"2010","journal-title":"Cancer"},{"issue":"5","key":"10.1007\/s11605-019-04441-4_bb0215","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1200\/JCO.2008.19.7160","article-title":"Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin","volume":"27","author":"Elias","year":"2009","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"10.1007\/s11605-019-04441-4_bb0220","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/SLA.0b013e31827e9289","article-title":"Is there a possibility of a cure in patients with colorectal peritoneal carcinomatosis amenable to complete cytoreductive surgery and intraperitoneal chemotherapy?","volume":"257","author":"Go\u00e9r\u00e9","year":"2013","journal-title":"Annals of Surgery"},{"key":"10.1007\/s11605-019-04441-4_bb0225","doi-asserted-by":"crossref","unstructured":"Cashin PH, Mahteme H, Sp\u00e5ng N, Syk I, Fr\u00f6din JE, Torkzad M, Glimelius B, Graf W. Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases: A randomised trial. European Journal of Cancer 2016. https:\/\/doi.org\/10.1016\/j.ejca.2015.09.017.","DOI":"10.1016\/j.ejca.2015.09.017"},{"issue":"12","key":"10.1007\/s11605-019-04441-4_bb0230","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): Long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"The Lancet Oncology"},{"issue":"3","key":"10.1007\/s11605-019-04441-4_bb0235","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.amjsurg.2013.09.021","article-title":"Peritoneal Surface Disease Severity Score as a predictor of resectability in the treatment of peritoneal surface malignancies","volume":"207","author":"Yoon","year":"2014","journal-title":"American Journal of Surgery"},{"issue":"12","key":"10.1007\/s11605-019-04441-4_bb0240","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.ejso.2018.07.003","article-title":"The current practice of cytoreductive surgery and HIPEC for colorectal peritoneal metastases: Results of a worldwide web-based survey of the Peritoneal Surface Oncology Group International (PSOGI)","volume":"44","author":"Bushati","year":"2018","journal-title":"European Journal of Surgical Oncology"},{"issue":"5","key":"10.1007\/s11605-019-04441-4_bb0245","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1245\/s10434-013-3061-z","article-title":"Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States","volume":"21","author":"Turaga","year":"2014","journal-title":"Annals of Surgical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0250","doi-asserted-by":"crossref","unstructured":"D\u00e9solneux G, Mazi\u00e8re C, Vara J, Brouste V, Fonck M, B\u00e9chade D, B\u00e9couarn Y, Evrard S. Cytoreductive surgery of colorectal peritoneal metastases: Outcomes after complete cytoreductive surgery and systemic chemotherapy only. PLoS ONE 2015. https:\/\/doi.org\/10.1371\/journal.pone.0122816.","DOI":"10.1371\/journal.pone.0122816"},{"issue":"15_suppl","key":"10.1007\/s11605-019-04441-4_bb0255","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1200\/JCO.2018.36.15_suppl.3531","article-title":"Results of a randomized phase 3 study evaluating the potential benefit of a second-look surgery plus HIPEC in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP- NTC01226394)","volume":"36","author":"Goere","year":"2018","journal-title":"Journal of Clinical Oncology"},{"issue":"4_suppl","key":"10.1007\/s11605-019-04441-4_bb0260","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1200\/JCO.2019.37.4_suppl.482","article-title":"Adjuvant HIPEC in patients with colon cancer at high risk of peritoneal metastases: Primary outcome of the COLOPEC multicenter randomized trial","volume":"37","author":"Klaver","year":"2019","journal-title":"Journal of Clinical Oncology"},{"key":"10.1007\/s11605-019-04441-4_bb0265","doi-asserted-by":"crossref","unstructured":"Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, De La Chapelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA. PD-1 blockade in tumors with mismatch-repair deficiency. New England Journal of Medicine 2015. https:\/\/doi.org\/10.1056\/NEJMoa1500596.","DOI":"10.1056\/NEJMoa1500596"},{"key":"10.1007\/s11605-019-04441-4_bb0270","doi-asserted-by":"crossref","unstructured":"Overman MJ, McDermott R, Leach JL, Lonardi S, Lenz HJ, Morse MA, Desai J, Hill A, Axelson M, Moss RA, Goldberg M V., Cao ZA, Ledeine JM, Maglinte GA, Kopetz S, Andr\u00e9 T. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. The Lancet Oncology 2017. https:\/\/doi.org\/10.1016\/S1470-2045(17)30422-9.","DOI":"10.1016\/S1470-2045(17)30422-9"},{"key":"10.1007\/s11605-019-04441-4_bb0275","doi-asserted-by":"crossref","unstructured":"Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D\u2019Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM, McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 2017. https:\/\/doi.org\/10.1038\/nature22079.","DOI":"10.1038\/nature22079"},{"key":"10.1007\/s11605-019-04441-4_bb0280","doi-asserted-by":"crossref","unstructured":"Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ. Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers. British Journal of Cancer 2016. https:\/\/doi.org\/10.1038\/bjc.2016.161.","DOI":"10.1038\/bjc.2016.161"},{"key":"10.1007\/s11605-019-04441-4_bb0285","doi-asserted-by":"crossref","unstructured":"Tran B, Kopetz S, Tie J, Gibbs P, Jiang ZQ, Lieu CH, Agarwal A, Maru DM, Sieber O, Desai J. Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer 2011. https:\/\/doi.org\/10.1002\/cncr.26086.","DOI":"10.1002\/cncr.26086"},{"key":"10.1007\/s11605-019-04441-4_bb0290","doi-asserted-by":"crossref","unstructured":"Grass F, Vuagniaux A, Teixeira-Farinha H, Lehmann K, Demartines N, H\u00fcbner M. Systematic review of pressurized intraperitoneal aerosol chemotherapy for the treatment of advanced peritoneal carcinomatosis. British Journal of Surgery 2017.","DOI":"10.1002\/bjs.10521"},{"key":"10.1007\/s11605-019-04441-4_bb0295","doi-asserted-by":"crossref","unstructured":"Demtr\u00f6der C, Solass W, Zieren J, Strumberg D, Giger-Pabst U, Reymond MA. Pressurized intraperitoneal aerosol chemotherapy with oxaliplatin in colorectal peritoneal metastasis. Colorectal Disease 2016. https:\/\/doi.org\/10.1111\/codi.13130.","DOI":"10.1111\/codi.13130"},{"key":"10.1007\/s11605-019-04441-4_bb0300","doi-asserted-by":"crossref","unstructured":"Williamson SK, Johnson GA, Maulhardt HA, Moore KM, McMeekin DS, Schulz TK, Reed GA, Roby KF, MacKay CB, Smith HJ, Weir SJ, Wick JA, Markman M, Dizerega GS, Baltezor MJ, Espinosa J, Decedue CJ. A phase i study of intraperitoneal nanoparticulate paclitaxel (Nanotax\u00ae) in patients with peritoneal malignancies. Cancer Chemotherapy and Pharmacology 2015. https:\/\/doi.org\/10.1007\/s00280-015-2737-4.","DOI":"10.1007\/s00280-015-2737-4"},{"key":"10.1007\/s11605-019-04441-4_bb0305","doi-asserted-by":"crossref","unstructured":"Harrison LE, Bryan M, Pliner L, Saunders T. Phase I trial of pegylated liposomal doxorubicin with hyperthermic intraperitoneal chemotherapy in patients undergoing cytoreduction for advanced intra-abdominal malignancy. Annals of Surgical Oncology 2008. https:\/\/doi.org\/10.1245\/s10434-007-9718-8.","DOI":"10.1245\/s10434-007-9718-8"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-019-04441-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11605-019-04441-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23014142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23014142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-019-04441-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T19:58:06Z","timestamp":1761076686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X23014142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1091255X23014142"],"URL":"https:\/\/doi.org\/10.1007\/s11605-019-04441-4","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peritoneal Metastases in Colorectal Cancer: Biology and Barriers","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-019-04441-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}