{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:32:01Z","timestamp":1790163121281,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s11605-020-04576-9","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T09:04:12Z","timestamp":1587373452000},"page":"1386-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["\u201cSmall-for-Flow\u201d Syndrome: Concept Evolution"],"prefix":"10.1016","volume":"24","author":[{"given":"Maitane I.","family":"Orue-Echebarria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Olmedilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Garc\u00eda Sabrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM.","family":"Asencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0002-9610(75)90323-2","article-title":"Alopecia, ascites, and incomplete regeneration after 85 to 90 per cent liver resection","volume":"129","author":"Starzl","year":"1975","journal-title":"Am J Surg"},{"issue":"4","key":"10.1007\/s11605-020-04576-9_bb0015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/cld.666","article-title":"Small-for-size syndrome in LT: Small-for-Size Syndrome in LT","volume":"10","author":"Hibi","year":"2017","journal-title":"Clin Liver Dis"},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/ans.14245","article-title":"Impact of graft-to-recipient weight ratio on small-for-size syndrome following living donor liver transplantation: Small-for-size grafts in LDLT","volume":"88","author":"Bell","year":"2018","journal-title":"ANZ J Surg"},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0025","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.transproceed.2011.05.037","article-title":"Lower limit of the graft-to-recipient weight ratio can be safely reduced to 0.6% in adult-to-adult living donor liver transplantation in combination with portal pressure control","volume":"43","author":"Kaido","year":"2011","journal-title":"Transplant Proc"},{"issue":"3","key":"10.1007\/s11605-020-04576-9_bb0030","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5306\/wjco.v8.i3.190","article-title":"Multidisciplinary approach of colorectal cancer liver metastases","volume":"8","author":"Fiorentini","year":"2017","journal-title":"World J Clin Oncol."},{"issue":"2","key":"10.1007\/s11605-020-04576-9_bb0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3748\/wjg.v22.i2.567","article-title":"Preoperative selection of patients with colorectal cancer liver metastasis for hepatic resection","volume":"22","author":"Mattar","year":"2016","journal-title":"World J Gastroenterol."},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0040","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/hpb.12181","article-title":"Outcomes of extended versus limited indications for patients undergoing a liver resection for colorectal cancer liver metastases","volume":"16","author":"van Dam","year":"2014","journal-title":"HPB."},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0045","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3892\/or.2017.5531","article-title":"Current status and future perspectives on treatment of liver metastasis in colorectal cancer","volume":"37","author":"Al Bandar","year":"2017","journal-title":"Oncol Rep."},{"issue":"12","key":"10.1007\/s11605-020-04576-9_bb0050","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1245\/s10434-010-1304-9","article-title":"Patterns of referral and resection among patients with liver-only metastatic colorectal cancer (MCRC)","volume":"17","author":"Ksienski","year":"2010","journal-title":"Ann Surg Oncol."},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0055","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.jamcollsurg.2006.12.032","article-title":"Hepatic Insufficiency and Mortality in 1,059 Noncirrhotic Patients Undergoing Major Hepatectomy","volume":"204","author":"Mullen","year":"2007","journal-title":"J Am Coll Surg."},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0060","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/jhbp.97","article-title":"How to expand the safe limits in hepatic resections?","volume":"21","author":"Asencio","year":"2014","journal-title":"J Hepato-Biliary-Pancreat Sci."},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0065","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mehy.2013.01.028","article-title":"\u201cSmall-for-flow\u201d syndrome: Shifting the \u201csize\u201d paradigm","volume":"80","author":"Asencio","year":"2013","journal-title":"Med Hypotheses."},{"key":"10.1007\/s11605-020-04576-9_bb0070","doi-asserted-by":"crossref","unstructured":"Demetris AJ, Kelly DM, Eghtesad B, Fontes P, Wallis Marsh J, Tom K, et al. Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome: Am J Surg Pathol. 2006;30(8):986\u201393.","DOI":"10.1097\/00000478-200608000-00009"},{"issue":"1","key":"10.1007\/s11605-020-04576-9_bb0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.transproceed.2015.12.026","article-title":"How much portal vein flow is too much for liver remnant in a stable porcine model?","volume":"48","author":"Xiang","year":"2016","journal-title":"Transplant Proc"},{"key":"10.1007\/s11605-020-04576-9_bb0080","doi-asserted-by":"crossref","unstructured":"Asencio J, Steiner M, Garc\u00eda-Sabrido J, L\u00f3pez-Baena JA, Ferreiroa J, Morales A, et al. Early changes in small-for-flow syndrome: an experimental model. J Liver Dis Transplant. 2013;03(01).","DOI":"10.4172\/2325-9612.1000115"},{"issue":"3","key":"10.1007\/s11605-020-04576-9_bb0085","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.clinre.2015.06.024","article-title":"Small for Size and Flow (SFSF) syndrome: An alternative description for posthepatectomy liver failure","volume":"40","author":"Golriz","year":"2016","journal-title":"Clin Res Hepatol Gastroenterol."},{"issue":"1","key":"10.1007\/s11605-020-04576-9_bb0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/lt.20317","article-title":"Impact of portal venous pressure on regeneration and graft damage after living-donor liver transplantation","volume":"11","author":"Yagi","year":"2005","journal-title":"Liver Transpl"},{"issue":"11","key":"10.1007\/s11605-020-04576-9_bb0095","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s11605-019-04130-2","article-title":"Comprehensive Characterization of a Porcine Model of The \u201cSmall-for-Flow\u201d Syndrome","volume":"23","author":"Orue-Echebarria","year":"2019","journal-title":"J Gastrointest Surg."},{"issue":"11","key":"10.1007\/s11605-020-04576-9_bb0100","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s11605-015-2872-6","article-title":"Defining Post Hepatectomy Liver Insufficiency: Where do We stand?","volume":"19","author":"Lafaro","year":"2015","journal-title":"J Gastrointest Surg"},{"key":"10.1007\/s11605-020-04576-9_bb0105","doi-asserted-by":"crossref","unstructured":"Allard M-A, Adam R, Bucur P-O, Termos S, Cunha AS, Bismuth H, et al. Posthepatectomy portal vein pressure predicts liver failure and mortality after major liver resection on noncirrhotic liver: Ann Surg. noviembre de 2013;258(5):822\u201330.","DOI":"10.1097\/SLA.0b013e3182a64b38"},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0110","first-page":"10","article-title":"Small for size liver remnant following resection: prevention and management","volume":"3","author":"Eshkenazy","year":"2014","journal-title":"HepatoBiliary Surg Nutr"},{"key":"10.1007\/s11605-020-04576-9_bb0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amsu.2017.12.003","article-title":"Impact of liver volume and liver function on posthepatectomy liver failure after portal vein embolization\u2013 A multivariable cohort analysis","volume":"25","author":"Alizai","year":"2018","journal-title":"Ann Med Surg"},{"key":"10.1007\/s11605-020-04576-9_bb0120","doi-asserted-by":"crossref","unstructured":"Kohler A, Moller PW, Frey S, Tinguely P, Candinas D, Obrist D, et al. Portal hyperperfusion after major liver resection and associated sinusoidal damage is a therapeutic target to protect the remnant liver. Am J Physiol-Gastrointest Liver Physiol. 1 de septiembre de 2019;317(3):G264\u201374.","DOI":"10.1152\/ajpgi.00113.2019"},{"issue":"4","key":"10.1007\/s11605-020-04576-9_bb0125","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3748\/wjg.v20.i4.1021","article-title":"Portal inflow preservation during portal diversion in small-for-size syndrome","volume":"20","author":"Wang","year":"2014","journal-title":"World J Gastroenterol."},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0130","doi-asserted-by":"crossref","first-page":"420","DOI":"10.20344\/amp.10892","article-title":"Portal venous pressure variation during hepatectomy: a prospective study","volume":"32","author":"Carrapita","year":"2019","journal-title":"Acta M\u00e9dica Port"},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0135","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejso.2014.01.018","article-title":"Splenic artery ligation for severe oxaliplatin induced portal hypertension: A way to improve postoperative course and allow adjuvant chemotherapy for colorectal liver metastases","volume":"40","author":"Schwarz","year":"2014","journal-title":"Eur J Surg Oncol EJSO"},{"issue":"39","key":"10.1007\/s11605-020-04576-9_bb0140","first-page":"831","article-title":"Splenic arterial ligation prevents liver injury after a major hepatectomy by a reduction of surplus portal hypertension in hepatocellular carcinoma patients with cirrhosis","volume":"48","author":"Sato","year":"2001","journal-title":"Hepatogastroenterology"},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0145","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1097\/SLA.0000000000002601","article-title":"Portal Inflow Modulation by Somatostatin After Major Liver Resection: A Pilot Study","volume":"267","author":"Rhaiem","year":"2018","journal-title":"Ann Surg"},{"issue":"2","key":"10.1007\/s11605-020-04576-9_bb0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12029-015-9701-8","article-title":"Small-for-Size Liver Syndrome: a Case Series with a Proposal for Management Based on Portal Flow Modulation","volume":"46","author":"Famularo","year":"2015","journal-title":"J Gastrointest Cancer"},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0155","first-page":"2065","article-title":"Methods to Increase Future Liver Remnant Volume in Patients with Primarily Unresectable Colorectal Liver Metastases: Current State and Future Perspectives","volume":"36","author":"Treska","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1007\/s11605-020-04576-9_bb0160","doi-asserted-by":"crossref","unstructured":"Hwang S, Lee S-G, Ko G-Y, Kim B-S, Sung K-B, Kim M-H, et al. Sequential preoperative ipsilateral hepatic vein embolization after portal vein embolization to induce further liver regeneration in patients with hepatobiliary malignancy: Ann Surg. 2009;249(4):608\u201316.","DOI":"10.1097\/SLA.0b013e31819ecc5c"},{"issue":"5","key":"10.1007\/s11605-020-04576-9_bb0165","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jviscsurg.2018.03.005","article-title":"Liver hypertrophy: Underlying mechanisms and promoting procedures before major hepatectomy","volume":"155","author":"Le Roy","year":"2018","journal-title":"J Visc Surg"},{"issue":"10","key":"10.1007\/s11605-020-04576-9_bb0170","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ejso.2018.06.005","article-title":"The HPB controversy of the decade: 2007\u20132017 \u2013 Ten years of ALPPS","volume":"44","author":"Olthof","year":"2018","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"10.1007\/s11605-020-04576-9_bb0175","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0168-8278(02)00088-0","article-title":"Improved functional reserve of hypertrophied contra lateral liver after portal vein ligation in rats","volume":"37","author":"Nagano","year":"2002","journal-title":"J Hepatol"},{"issue":"4930","key":"10.1007\/s11605-020-04576-9_bb0180","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1126\/science.2683075","article-title":"G1 events and regulation of cell proliferation","volume":"246","author":"Pardee","year":"1989","journal-title":"Science"},{"issue":"6","key":"10.1007\/s11605-020-04576-9_bb0185","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.surg.2016.12.003","article-title":"Preconditioning by portal vein embolization modulates hepatic hemodynamics and improves liver function in pigs with extended hepatectomy","volume":"161","author":"Asencio","year":"2017","journal-title":"Surgery."},{"key":"10.1007\/s11605-020-04576-9_bb0190","doi-asserted-by":"crossref","unstructured":"Lozano P, Mart\u00edn L, Orue-Echebarria M, Asencio JM, Sharma H, L\u00f3pez-Baena JA. Purpose of the measurement of intraoperative hepatic hemodynamics in liver transplant surgery. Arch Organ Transplant. 22 de marzo de 2019;001\u20134.","DOI":"10.17352\/2640-7973.000011"},{"key":"10.1007\/s11605-020-04576-9_bb0195","doi-asserted-by":"crossref","unstructured":"Bogner A, Reissfelder C, Striebel F, Mehrabi A, Ghamarnejad O, Rahbari M, et al. Intraoperative Increase of Portal Venous Pressure is an Immediate Predictor of Posthepatectomy Liver Failure After Major Hepatectomy: A Prospective Study. Ann Surg. 2019;Epub ahead of print.","DOI":"10.1097\/SLA.0000000000003496"},{"key":"10.1007\/s11605-020-04576-9_bb0200","doi-asserted-by":"crossref","unstructured":"Smyrniotis VE, Kostopanagiotou G, Theodoraki K, Gamaletsos E, Kondi-Pafiti A, Mystakidou K, et al. Effect of mesocaval shunt on survival of small-for-size liver grafts: experimental study in pigs: Transplantation. mayo de 2003;75(10):1737\u201340.","DOI":"10.1097\/01.TP.0000062558.71657.E9"},{"key":"10.1007\/s11605-020-04576-9_bb0205","doi-asserted-by":"crossref","unstructured":"Kelly DM, Zhu X, Shiba H, Irefin S, Trenti L, Cocieru A, et al. Adenosine restores the hepatic artery buffer response and improves survival in a porcine model of small-for-size syndrome. Liver Transpl. noviembre de 2009;15(11):1448\u201357.","DOI":"10.1002\/lt.21863"},{"key":"10.1007\/s11605-020-04576-9_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2009\/835965","article-title":"Influence of Portosystemic Shunt on Liver Regeneration after Hepatic Resection in Pigs","volume":"2009","author":"Ladurner","year":"2009","journal-title":"HPB Surg."},{"issue":"10","key":"10.1007\/s11605-020-04576-9_bb0215","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.dld.2011.05.018","article-title":"Early effects of portal flow modulation after extended liver resection in rat","volume":"43","author":"Di Domenico","year":"2011","journal-title":"Dig Liver Dis. octubre de"},{"issue":"3","key":"10.1007\/s11605-020-04576-9_bb0220","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3748\/wjg.v21.i3.888","article-title":"Should temporary extracorporeal continuous portal diversion replace meso\/porta-caval shunts in \u201csmall-for-size\u201d syndrome in porcine hepatectomy?","volume":"21","author":"Wang","year":"2015","journal-title":"World J Gastroenterol."},{"issue":"2","key":"10.1007\/s11605-020-04576-9_bb0225","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.amjsurg.2016.01.043","article-title":"Successful modulation of portal inflow by somatostatin in a porcine model of small-for-size syndrome","volume":"212","author":"Mohkam","year":"2016","journal-title":"Am J Surg."},{"key":"10.1007\/s11605-020-04576-9_bb0230","doi-asserted-by":"crossref","unstructured":"Carrapita J, Abrantes AM, Campelos S, Gon\u00e7alves AC, Cardoso D, Sarmento-Ribeiro AB, et al. Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability. Sci Rep. diciembre de 2016;6(1):34731.","DOI":"10.1038\/srep34731"},{"key":"10.1007\/s11605-020-04576-9_bb0235","doi-asserted-by":"crossref","unstructured":"Bucur PO, Bekheit M, Audebert C, Othman A, Hammad S, Sebagh M, et al. Modulating Portal Hemodynamics With Vascular Ring Allows Efficient Regeneration After Partial Hepatectomy in a Porcine Model: Ann Surg. febrero de 2017;1.","DOI":"10.1097\/SLA.0000000000002146"},{"key":"10.1007\/s11605-020-04576-9_bb0240","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jss.2016.09.002","article-title":"The beneficial role of simultaneous splenectomy after extended hepatectomy: experimental study in pigs","volume":"208","author":"Athanasiou","year":"2017","journal-title":"J Surg Res. febrero de"},{"key":"10.1007\/s11605-020-04576-9_bb0245","doi-asserted-by":"crossref","unstructured":"Song Z, Humar B, Gupta A, Maurizio E, Borgeaud N, Graf R, et al. Exogenous melatonin protects small-for-size liver grafts by promoting monocyte infiltration and releases interleukin-6. J Pineal Res. agosto de 2018;65(1):e12486.","DOI":"10.1111\/jpi.12486"},{"key":"10.1007\/s11605-020-04576-9_bb0250","doi-asserted-by":"crossref","unstructured":"Takamatsu Y, Hori T, Machimoto T, Hata T, Kadokawa Y, Ito T, et al. Intentional Modulation of Portal Venous Pressure by Splenectomy Saves the Patient with Liver Failure and Portal Hypertension After Major Hepatectomy: Is Delayed Splenectomy an Acceptable Therapeutic Option for Secondary Portal Hypertension? Am J Case Rep. 7 de febrero de 2018;19:137\u201344.","DOI":"10.12659\/AJCR.907178"}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-020-04576-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11605-020-04576-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23015937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23015937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-020-04576-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:00:13Z","timestamp":1761076813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X23015937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1091255X23015937"],"URL":"https:\/\/doi.org\/10.1007\/s11605-020-04576-9","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u201cSmall-for-Flow\u201d Syndrome: Concept Evolution","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-020-04576-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}