{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T14:08:30Z","timestamp":1788703710058,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jgisurgery.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gastrointestinal Surgery"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s11605-020-04729-w","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T16:02:47Z","timestamp":1595520167000},"page":"1815-1827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparative Outcomes of Adenosquamous Carcinoma of the Gallbladder: an Analysis of the National Cancer Database"],"prefix":"10.1016","volume":"25","author":[{"given":"Gilbert","family":"Murimwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Hester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio M.","family":"Polanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Porembka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Herbert J.","family":"Zeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Yopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1479-666X(08)80073-X","article-title":"Gallbladder cancer--a comprehensive review","volume":"6","author":"Lai","year":"2008","journal-title":"Surgeon."},{"issue":"1","key":"10.1007\/s11605-020-04729-w_bb0015","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin."},{"issue":"5","key":"10.1007\/s11605-020-04729-w_bb0020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-006-0075-x","article-title":"Diagnosis and surgical management of gallbladder cancer: a review","volume":"11","author":"Reid","year":"2007","journal-title":"J Gastrointest Surg."},{"issue":"3","key":"10.1007\/s11605-020-04729-w_bb0025","first-page":"E71","article-title":"Cholecystic adenosquamous carcinoma mimicking Mirizzi syndrome","volume":"52","author":"Horio","year":"2009","journal-title":"Can J Surg."},{"issue":"4","key":"10.1007\/s11605-020-04729-w_bb0030","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1349-7006.1994.tb02372.x","article-title":"Adenosquamous carcinoma of the gallbladder: a clinicopathological, immunohistochemical and flow-cytometric study of twenty cases","volume":"85","author":"Nishihara","year":"1994","journal-title":"Jpn J Cancer Res."},{"issue":"3","key":"10.1007\/s11605-020-04729-w_bb0035","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1440-1827.1995.tb03450.x","article-title":"Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium","volume":"45","author":"Nishihara","year":"1995","journal-title":"Pathol Int."},{"issue":"1","key":"10.1007\/s11605-020-04729-w_bb0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00428-006-0171-z","article-title":"Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder","volume":"449","author":"Noske","year":"2006","journal-title":"Virchows Arch."},{"issue":"11","key":"10.1007\/s11605-020-04729-w_bb0045","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1002\/cncr.10578","article-title":"Adenosquamous carcinoma of the gallbladder warrants resection only if curative resection is feasible","volume":"94","author":"Oohashi","year":"2002","journal-title":"Cancer."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0050","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0899-7071(97)00079-X","article-title":"MRI findings in adenosquamous carcinoma of the gallbladder","volume":"22","author":"Wagreich","year":"1998","journal-title":"Clin Imaging."},{"issue":"1","key":"10.1007\/s11605-020-04729-w_bb0055","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12253-017-0314-3","article-title":"DDR2 and IFITM1 Are Prognostic Markers in Gallbladder Squamous Cell\/Adenosquamous Carcinomas and Adenocarcinomas","volume":"25","author":"Li","year":"2019","journal-title":"Pathol Oncol Res."},{"issue":"1","key":"10.1007\/s11605-020-04729-w_bb0060","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s13277-012-0557-2","article-title":"ILK and PRDX1 are prognostic markers in squamous cell\/adenosquamous carcinomas and adenocarcinoma of gallbladder","volume":"34","author":"Li","year":"2013","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12253-013-9693-2","article-title":"Squamous cell\/adenosquamous carcinomas and adenocarcinomas of the gallbladder: an immunohistochemistry study of prognostic markers","volume":"20","author":"Li","year":"2014","journal-title":"Pathol Oncol Res."},{"issue":"3","key":"10.1007\/s11605-020-04729-w_bb0070","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12253-015-0019-4","article-title":"The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance","volume":"22","author":"Liu","year":"2016","journal-title":"Pathol Oncol Res."},{"issue":"7","key":"10.1007\/s11605-020-04729-w_bb0075","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/his.12341","article-title":"Paxillin and carbonic anhydrase IX are prognostic markers in gallbladder squamous cell\/adenosquamous carcinomas and adenocarcinomas","volume":"64","author":"Liu","year":"2014","journal-title":"Histopathology."},{"issue":"5","key":"10.1007\/s11605-020-04729-w_bb0080","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.3892\/mmr.2016.5851","article-title":"MCM2 and TIP30 are prognostic markers in squamous cell\/adenosquamous carcinoma and adenocarcinoma of the gallbladder","volume":"14","author":"Liu","year":"2016","journal-title":"Mol Med Rep."},{"issue":"6","key":"10.1007\/s11605-020-04729-w_bb0085","doi-asserted-by":"crossref","first-page":"557","DOI":"10.5301\/tj.5000519","article-title":"The clinicopathological significance of Jagged1 and DLL4 in gallbladder cancer","volume":"103","author":"Luo","year":"2017","journal-title":"Tumori."},{"issue":"14","key":"10.1007\/s11605-020-04729-w_bb0090","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.3748\/wjg.v23.i14.2601","article-title":"Comparative study of ROR2 and WNT5a expression in squamous\/adenosquamous carcinoma and adenocarcinoma of the gallbladder","volume":"23","author":"Wu","year":"2017","journal-title":"World J Gastroenterol."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10147-013-0550-9","article-title":"A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell\/adenosquamous carcinomas and adenocarcinoma of the gallbladder","volume":"19","author":"Yang","year":"2014","journal-title":"Int J Clin Oncol."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0100","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3109\/07357907.2012.756113","article-title":"CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell\/adenosquamous carcinomas and adenocarcinomas of gallbladder","volume":"31","author":"Yang","year":"2013","journal-title":"Cancer Invest."},{"issue":"3","key":"10.1007\/s11605-020-04729-w_bb0105","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.7314\/APJCP.2014.15.3.1441","article-title":"EphB1 and Ephrin-B, new potential biomarkers for squamous cell\/adenosquamous carcinomas and adenocarcinomas of the gallbladder","volume":"15","author":"Yuan","year":"2014","journal-title":"Asian Pac J Cancer Prev."},{"key":"10.1007\/s11605-020-04729-w_bb0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1477-7819-11-143","article-title":"Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous\/adenosquamous carcinoma and gallbladder adenocarcinoma","volume":"11","author":"Zou","year":"2013","journal-title":"World J Surg Oncol."},{"issue":"8","key":"10.1007\/s11605-020-04729-w_bb0115","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/modpathol.2011.68","article-title":"Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas","volume":"24","author":"Roa","year":"2011","journal-title":"Mod Pathol."},{"issue":"3","key":"10.1007\/s11605-020-04729-w_bb0120","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jso.21813","article-title":"Clinicopathologic analysis of adenosquamous\/squamous cell carcinoma of the gallbladder","volume":"103","author":"Kim","year":"2011","journal-title":"J Surg Oncol."},{"issue":"6","key":"10.1007\/s11605-020-04729-w_bb0125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jso.24065","article-title":"Squamous\/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma","volume":"112","author":"Song","year":"2015","journal-title":"J Surg Oncol."},{"key":"10.1007\/s11605-020-04729-w_bb0130","doi-asserted-by":"crossref","unstructured":"Akce M, Zakka K, Penley M, Jiang R, Alese OB, Shaib WL, et al. Clinicopathological features and survival outcomes of rare histologic variants of gallbladder cancer. J Surg Oncol. 2019.","DOI":"10.1002\/jso.25781"},{"issue":"6","key":"10.1007\/s11605-020-04729-w_bb0135","doi-asserted-by":"crossref","first-page":"e0198809","DOI":"10.1371\/journal.pone.0198809","article-title":"Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study","volume":"13","author":"Samuel","year":"2018","journal-title":"PLoS One."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/jso.20576","article-title":"Adenosquamous\/squamous cell carcinoma of the gallbladder","volume":"95","author":"Chan","year":"2007","journal-title":"J Surg Oncol."},{"issue":"4","key":"10.1007\/s11605-020-04729-w_bb0145","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0014-2964(71)90073-9","article-title":"Relation between the pathological nature and the growth rate of human tumors","volume":"7","author":"Charbit","year":"1971","journal-title":"Eur J Cancer."},{"key":"10.1007\/s11605-020-04729-w_bb0150","unstructured":"Surgeons ACo. American College of Surgeons: National Cancer Database. [Available from: https:\/\/www-facs-org.foyer.swmed.edu\/quality-programs\/cancer\/ncdb."},{"key":"10.1007\/s11605-020-04729-w_bb0155","unstructured":"Fritz AG. International classification of diseases for oncology : ICD-O. 3rd ed. Geneva: World Health Organization; 2000. vii, 240 p. p."},{"key":"10.1007\/s11605-020-04729-w_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13000-015-0375-0","article-title":"CD109 is a novel marker for squamous cell\/adenosquamous carcinomas of the gallbladder","volume":"10","author":"Dong","year":"2015","journal-title":"Diagn Pathol."},{"issue":"12","key":"10.1007\/s11605-020-04729-w_bb0165","doi-asserted-by":"crossref","first-page":"19467","DOI":"10.18632\/oncotarget.14444","article-title":"The clinical significance and underlying correlation of pStat-3 and integrin alphavbeta6 expression in gallbladder cancer","volume":"8","author":"Enyu","year":"2017","journal-title":"Oncotarget."},{"issue":"8","key":"10.1007\/s11605-020-04729-w_bb0170","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.prp.2017.05.004","article-title":"Adenosquamous gallbladder carcinoma: Multigene hotspot mutational profiling reveals a monoclonal origin of the two components","volume":"213","author":"Galuppini","year":"2017","journal-title":"Pathol Res Pract."},{"issue":"4","key":"10.1007\/s11605-020-04729-w_bb0175","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/cncr.31850","article-title":"Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations","volume":"125","author":"Narayan","year":"2019","journal-title":"Cancer."},{"issue":"6","key":"10.1007\/s11605-020-04729-w_bb0180","doi-asserted-by":"crossref","first-page":"698","DOI":"10.4149\/neo_2013_089","article-title":"Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell\/adenosquamous carcinomas and adenocarcinoma of gallbladder","volume":"60","author":"Yuan","year":"2013","journal-title":"Neoplasma."},{"issue":"8","key":"10.1007\/s11605-020-04729-w_bb0185","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1200\/JCO.18.00050","article-title":"Gemcitabine and Oxaliplatin Chemotherapy or Surveillance in Resected Biliary Tract Cancer (PRODIGE 12-ACCORD 18-UNICANCER GI): A Randomized Phase III Study","volume":"37","author":"Edeline","year":"2019","journal-title":"J Clin Oncol."},{"issue":"5","key":"10.1007\/s11605-020-04729-w_bb0190","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1470-2045(18)30915-X","article-title":"Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study","volume":"20","author":"Primrose","year":"2019","journal-title":"Lancet Oncol."},{"issue":"9","key":"10.1007\/s11605-020-04729-w_bb0195","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S1470-2045(15)00040-6","article-title":"Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial","volume":"16","author":"Shapiro","year":"2015","journal-title":"Lancet Oncol."},{"issue":"10","key":"10.1007\/s11605-020-04729-w_bb0200","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bjs.5506","article-title":"Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer","volume":"93","author":"Bujko","year":"2006","journal-title":"Br J Surg."},{"issue":"24","key":"10.1007\/s11605-020-04729-w_bb0205","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1200\/JCO.2005.08.144","article-title":"Swedish Rectal Cancer Trial: long lasting benefits from radiotherapy on survival and local recurrence rate","volume":"23","author":"Folkesson","year":"2005","journal-title":"J Clin Oncol."},{"issue":"31","key":"10.1007\/s11605-020-04729-w_bb0210","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1200\/JCO.2012.42.9597","article-title":"Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04","volume":"30","author":"Ngan","year":"2012","journal-title":"J Clin Oncol."},{"issue":"6","key":"10.1007\/s11605-020-04729-w_bb0215","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1007\/s11605-020-04729-w_bb0220","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/00365521.2016.1273383","article-title":"Adenosquamous carcinoma in the biliary tract: association of the proliferative ability of the squamous component with its proportion and tumor progression","volume":"52","author":"Hoshimoto","year":"2017","journal-title":"Scand J Gastroenterol."},{"issue":"5","key":"10.1007\/s11605-020-04729-w_bb0225","first-page":"339","article-title":"Squamous cell carcinoma of the stomach: report of three cases","volume":"81","author":"Mori","year":"1986","journal-title":"Am J Gastroenterol."},{"issue":"12","key":"10.1007\/s11605-020-04729-w_bb0230","first-page":"1879","article-title":"Squamous cell carcinoma of the gallbladder associated with squamous metaplasia and adenocarcinoma in situ of the mucosal columnar epithelium","volume":"36","author":"Hanada","year":"1986","journal-title":"Acta Pathol Jpn."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0235","first-page":"299","article-title":"Squamous cell carcinoma of gallbladder--report of two cases and review of literature","volume":"31","author":"Karasawa","year":"1981","journal-title":"Acta Pathol Jpn."},{"issue":"2","key":"10.1007\/s11605-020-04729-w_bb0240","first-page":"512","article-title":"EphA10 and EphB3 are prognostic markers in gallbladder squamous cell\/adenosquamous carcinomas and adenocarcinomas","volume":"11","author":"Yan","year":"2018","journal-title":"Int J Clin Exp Pathol."}],"container-title":["Journal of Gastrointestinal Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-020-04729-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11605-020-04729-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23011447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091255X23011447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11605-020-04729-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:04:39Z","timestamp":1761077079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091255X23011447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1091255X23011447"],"URL":"https:\/\/doi.org\/10.1007\/s11605-020-04729-w","relation":{},"ISSN":["1091-255X"],"issn-type":[{"value":"1091-255X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Outcomes of Adenosquamous Carcinoma of the Gallbladder: an Analysis of the National Cancer Database","name":"articletitle","label":"Article Title"},{"value":"Journal of Gastrointestinal Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s11605-020-04729-w","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 Society for Surgery of the Alimentary Tract. Published by ELSEVIER INC. All rights reserved. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}