{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:55:50Z","timestamp":1780376150512,"version":"3.54.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,8,16]],"date-time":"2014-08-16T00:00:00Z","timestamp":1408147200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s11606-014-2961-3","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T17:59:51Z","timestamp":1408125591000},"page":"1599-1606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Intensive Blood Pressure Control, Falls, and Fractures in Patients with Type 2 Diabetes: The ACCORD Trial"],"prefix":"10.1007","volume":"29","author":[{"given":"Karen L.","family":"Margolis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Palermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vittinghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal H.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Josse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra L.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Tiktin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann V.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,16]]},"reference":[{"key":"2961_CR1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","volume":"335","author":"R Collins","year":"1990","unstructured":"Collins R, Peto R, MacMahon S, Hebert P, Fiebach N, Eberlein K, Godwin J, Qizilbash N, Taylor J, Hennekens C. Blood pressure, stroke, and coronary heart disease. Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet. 1990;335:827\u201338.","journal-title":"Lancet"},{"issue":"9395","key":"2961_CR2","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","volume":"362","author":"F Turnbull","year":"2003","unstructured":"Turnbull F. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet. 2003;362(9395):1527\u201335.","journal-title":"Lancet"},{"issue":"1","key":"2961_CR3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/HJH.0b013e32834000be","volume":"29","author":"S Czernichow","year":"2011","unstructured":"Czernichow S, Zanchetti A, Turnbull F, Barzi F, Ninomiya T, Kengne AP, Lambers Heerspink HJ, Perkovic V, Huxley R, Arima H, Patel A, Chalmers J, Woodward M, MacMahon S, Neal B. The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials. J Hypertens. 2011;29(1):4\u201316.","journal-title":"J Hypertens"},{"key":"2961_CR4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2147\/CIA.S5242","volume":"4","author":"GS Stokes","year":"2009","unstructured":"Stokes GS. Management of hypertension in the elderly patient. Clin Interv Aging. 2009;4:379\u201389.","journal-title":"Clin Interv Aging"},{"issue":"11","key":"2961_CR5","first-page":"724","volume":"28","author":"EZ Riefkohl","year":"2003","unstructured":"Riefkohl EZ, Bieber HL, Burlingame MB, Lowenthal DT. Medications and falls in the elderly: a review of the evidence and practical considerations. Pharm Ther. 2003;28(11):724\u201333.","journal-title":"Pharm Ther"},{"issue":"24","key":"2961_CR6","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1001\/jama.1991.03460240051027","volume":"265","author":"SHEP Cooperative Research Group","year":"1991","unstructured":"SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991;265(24):3255\u201364.","journal-title":"JAMA"},{"key":"2961_CR7","doi-asserted-by":"crossref","first-page":"SA15","DOI":"10.1111\/j.1532-5415.1993.tb05941.x","volume":"41","author":"J Curb","year":"1993","unstructured":"Curb J, Applegate W, Vogt T, Pressel S, Lee M, Hoffmeier M, Schron R, Bearden D, Huber M, Moye L, Systolic Hypertension in the Elderly Program Cooperative Group. Antihypertensive therapy and falls and fractures in the systolic hypertension in the elderly program. J Am Geriatr Soc. 1993;41:SA15.","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"2961_CR8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/ageing\/afq071","volume":"39","author":"R Peters","year":"2010","unstructured":"Peters R, Beckett N, Burch L, de Vernejoul MC, Liu L, Duggan J, Swift C, Gil-Extremera B, Fletcher A, Bulpitt C. The effect of treatment based on a diuretic (indapamide) +\/\u2212 ACE inhibitor (perindopril) on fractures in the Hypertension in the Very Elderly Trial (HYVET). Age Ageing. 2010;39(5):609\u201316.","journal-title":"Age Ageing"},{"issue":"17","key":"2961_CR9","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1001286","volume":"362","author":"The ACCORD Study Group","year":"2010","unstructured":"The ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362(17):1575\u201385.","journal-title":"N Engl J Med"},{"issue":"12A","key":"2961_CR10","doi-asserted-by":"crossref","first-page":"21i","DOI":"10.1016\/j.amjcard.2007.03.003","volume":"99","author":"JB Buse","year":"2007","unstructured":"Buse JB, Bigger JT, Byington RP, Cooper LS, Cushman WC, Friedewald WT, Genuth S, Gerstein HC, Ginsberg HN, Goff DC Jr, Grimm RH Jr, Margolis KL, Probstfield JL, Simons-Morton DG, Sullivan MD. Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: design and methods. Am J Cardiol. 2007;99(12A):21i\u201333i.","journal-title":"Am J Cardiol"},{"issue":"12A","key":"2961_CR11","doi-asserted-by":"crossref","first-page":"44i","DOI":"10.1016\/j.amjcard.2007.03.005","volume":"99","author":"WC Cushman","year":"2007","unstructured":"Cushman WC, Grimm RH Jr, Cutler JA, Evans GW, Capes S, Corson MA, Sadler LS, Alderman MH, Peterson K, Bertoni A, Basile JN. Rationale and design for the blood pressure intervention of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Am J Cardiol. 2007;99(12A):44i\u201355.","journal-title":"Am J Cardiol"},{"issue":"7","key":"2961_CR12","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2337\/dc11-2184","volume":"35","author":"AV Schwartz","year":"2012","unstructured":"Schwartz AV, Margolis KL, Sellmeyer DE, Vittinghoff E, Ambrosius WT, Bonds DE, Josse RG, Schnall AM, Simmons DL, Hue TF, Palermo L, Hamilton BP, Green JB, Atkinson HH, O\u2019Connor PJ, Force RW, Bauer DC. Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial. Diabetes Care. 2012;35(7):1525\u201331.","journal-title":"Diabetes Care"},{"issue":"Suppl 4","key":"2961_CR13","first-page":"1","volume":"34","author":"MJ Gibson","year":"1987","unstructured":"Gibson MJ, Andres RO, Isaacs B. The prevention of falls in later life. A report of the Kellogg International Work Group on the Prevention of Falls by the Elderly. Dan Med Bull. 1987;34(Suppl 4):1\u201324.","journal-title":"Dan Med Bull"},{"issue":"2 Suppl 1","key":"2961_CR14","first-page":"S1","volume":"39","author":"National Kidney Foundation Kidney Disease Outcomes Quality Initiative","year":"2002","unstructured":"National Kidney Foundation Kidney Disease Outcomes Quality Initiative. K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2 Suppl 1):S1\u2013246.","journal-title":"Am J Kidney Dis"},{"issue":"18","key":"2961_CR15","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1056\/NEJMoa0801369","volume":"358","author":"NS Beckett","year":"2008","unstructured":"Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, Stoyanovsky V, Antikainen RL, Nikitin Y, Anderson C, Belhani A, Forette F, Rajkumar C, Thijs L, Banya W, Bulpitt CJ. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358(18):1887\u201398.","journal-title":"N Engl J Med"},{"issue":"6","key":"2961_CR16","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI24134","volume":"115","author":"T Nijenhuis","year":"2005","unstructured":"Nijenhuis T, Vallon V, van der Kemp AW, Loffing J, Hoenderop JG, Bindels RJ. Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest. 2005;115(6):1651\u20138.","journal-title":"J Clin Invest"},{"issue":"5","key":"2961_CR17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0022-5347(17)53269-3","volume":"128","author":"D Scholz","year":"1982","unstructured":"Scholz D, Schwille PO, Sigel A. Double-blind study with thiazide in recurrent calcium lithiasis. J Urol. 1982;128(5):903\u20137.","journal-title":"J Urol"},{"issue":"7","key":"2961_CR18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7326\/0003-4819-133-7-200010030-00010","volume":"133","author":"AZ LaCroix","year":"2000","unstructured":"LaCroix AZ, Ott SM, Ichikawa L, Scholes D, Barlow WE. Low-dose hydrochlorothiazide and preservation of bone mineral density in older adults. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133(7):516\u201326.","journal-title":"Ann Intern Med"},{"issue":"5","key":"2961_CR19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0002-9343(00)00510-6","volume":"109","author":"IR Reid","year":"2000","unstructured":"Reid IR, Ames RW, Orr-Walker BJ, Clearwater JM, Horne AM, Evans MC, Murray MA, McNeil AR, Gamble GD. Hydrochlorothiazide reduces loss of cortical bone in normal postmenopausal women: a randomized controlled trial. Am J Med. 2000;109(5):362\u201370.","journal-title":"Am J Med"},{"issue":"7","key":"2961_CR20","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/jbmr.356","volume":"26","author":"DH Solomon","year":"2011","unstructured":"Solomon DH, Mogun H, Garneau K, Fischer MA. Risk of fractures in older adults using antihypertensive medications. J Bone Miner Res. 2011;26(7):1561\u20137.","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2961_CR21","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1001\/jama.292.11.1326","volume":"292","author":"RG Schlienger","year":"2004","unstructured":"Schlienger RG, Kraenzlin ME, Jick SS, Meier CR. Use of beta-blockers and risk of fractures. JAMA. 2004;292(11):1326\u201332.","journal-title":"JAMA"},{"issue":"4","key":"2961_CR22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1365-2796.2006.01695.x","volume":"260","author":"M Wiens","year":"2006","unstructured":"Wiens M, Etminan M, Gill SS, Takkouche B. Effects of antihypertensive drug treatments on fracture outcomes: a meta-analysis of observational studies. J Intern Med. 2006;260(4):350\u201362.","journal-title":"J Intern Med"},{"issue":"1","key":"2961_CR23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jbmr.5650100115","volume":"10","author":"G Jones","year":"1995","unstructured":"Jones G, Nguyen T, Sambrook PN, Eisman JA. Thiazide diuretics and fractures: can meta-analysis help? J Bone Miner Res. 1995;10(1):106\u201311.","journal-title":"J Bone Miner Res"},{"key":"2961_CR24","volume":"10","author":"K Aung","year":"2011","unstructured":"Aung K, Htay T. Thiazide diuretics and the risk of hip fracture. Cochrane Database Syst Rev. 2011;10, CD005185.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2961_CR25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00223-004-0084-2","volume":"76","author":"L Rejnmark","year":"2005","unstructured":"Rejnmark L, Vestergaard P, Mosekilde L. Reduced fracture risk in users of thiazide diuretics. Calcif Tissue Int. 2005;76(3):167\u201375.","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2961_CR26","first-page":"119","volume":"135","author":"G Lemieux","year":"1986","unstructured":"Lemieux G. Treatment of idiopathic hypercalciuria with indapamide. CMAJ. 1986;135(2):119\u201321.","journal-title":"CMAJ"},{"issue":"5","key":"2961_CR27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000138405","volume":"36","author":"L Borghi","year":"1988","unstructured":"Borghi L, Elia G, Trapassi MR, Melloni E, Amato F, Barbarese F, Novarini A. Acute effect of indapamide on urine calcium excretion in nephrolithiasis and human essential hypertension. Pharmacology. 1988;36(5):348\u201355.","journal-title":"Pharmacology"},{"issue":"6","key":"2961_CR28","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1345\/aph.1E544","volume":"39","author":"K Ceylan","year":"2005","unstructured":"Ceylan K, Topal C, Erkoc R, Sayarlioglu H, Can S, Yilmaz Y, Dogan E, Algun E, Gonulalan H. Effect of indapamide on urinary calcium excretion in patients with and without urinary stone disease. Ann Pharmacother. 2005;39(6):1034\u20138.","journal-title":"Ann Pharmacother"},{"issue":"Suppl 6","key":"2961_CR29","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1097\/00005344-199312050-00014","volume":"22","author":"L Borghi","year":"1993","unstructured":"Borghi L, Meschi T, Guerra A, Novarini A. Randomized prospective study of a nonthiazide diuretic, indapamide, in preventing calcium stone recurrences. J Cardiovasc Pharmacol. 1993;22(Suppl 6):S78\u201386.","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"2961_CR30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1359\/jbmr.2001.16.2.361","volume":"16","author":"A Lalande","year":"2001","unstructured":"Lalande A, Roux S, Denne MA, Stanley ER, Schiavi P, Guez D, De Vernejoul MC. Indapamide, a thiazide-like diuretic, decreases bone resorption in vitro. J Bone Miner Res. 2001;16(2):361\u201370.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2961_CR31","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00198-007-0354-8","volume":"18","author":"C Meisinger","year":"2007","unstructured":"Meisinger C, Heier M, Lang O, Doring A. Beta-blocker use and risk of fractures in men and women from the general population: the MONICA\/KORA Augsburg cohort study. Osteoporos Int. 2007;18(9):1189\u201395.","journal-title":"Osteoporos Int"},{"issue":"5","key":"2961_CR32","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bone.2007.01.006","volume":"40","author":"N Bonnet","year":"2007","unstructured":"Bonnet N, Gadois C, McCloskey E, Lemineur G, Lespessailles E, Courteix D, Benhamou CL. Protective effect of beta blockers in postmenopausal women: influence on fractures, bone density, micro and macroarchitecture. Bone. 2007;40(5):1209\u201316.","journal-title":"Bone"},{"issue":"1","key":"2961_CR33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1359\/jbmr.0301214","volume":"19","author":"JA Pasco","year":"2004","unstructured":"Pasco JA, Henry MJ, Sanders KM, Kotowicz MA, Seeman E, Nicholson GC. Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study. J Bone Miner Res. 2004;19(1):19\u201324.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2961_CR34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/01.hjh.0000203845.26690.cb","volume":"24","author":"L Rejnmark","year":"2006","unstructured":"Rejnmark L, Vestergaard P, Mosekilde L. Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: a nationwide case\u2013control study. J Hypertens. 2006;24(3):581\u20139.","journal-title":"J Hypertens"},{"issue":"6","key":"2961_CR35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/pds.1318","volume":"16","author":"F Vries de","year":"2007","unstructured":"de Vries F, Pouwels S, Bracke M, Leufkens HG, Cooper C, Lammers JW, van Staa TP. Use of beta-2 agonists and risk of hip\/femur fracture: a population-based case\u2013control study. Pharmacoepidemiol Drug Saf. 2007;16(6):612\u20139.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"3","key":"2961_CR36","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1532-5415.2005.53178_7.x","volume":"53","author":"R Levasseur","year":"2005","unstructured":"Levasseur R, Dargent-Molina P, Sabatier JP, Marcelli C, Breart G. Beta-blocker use, bone mineral density, and fracture risk in older women: results from the Epidemiologie de l\u2019Osteoporose prospective study. J Am Geriatr Soc. 2005;53(3):550\u20132.","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"2961_CR37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1359\/JBMR.041202","volume":"20","author":"IR Reid","year":"2005","unstructured":"Reid IR, Gamble GD, Grey AB, Black DM, Ensrud KE, Browner WS, Bauer DC. Beta-Blocker use, BMD, and fractures in the study of osteoporotic fractures. J Bone Miner Res. 2005;20(4):613\u20138.","journal-title":"J Bone Miner Res"},{"issue":"9183","key":"2961_CR38","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(99)01437-3","volume":"354","author":"FP Cappuccio","year":"1999","unstructured":"Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA. High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet. 1999;354(9183):971\u20135.","journal-title":"Lancet"},{"issue":"2","key":"2961_CR39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/01.HYP.2.2.162","volume":"2","author":"DA McCarron","year":"1980","unstructured":"McCarron DA, Pingree PA, Rubin RJ, Gaucher SM, Molitch M, Krutzik S. Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak. Hypertension. 1980;2(2):162\u20138.","journal-title":"Hypertension"},{"issue":"2","key":"2961_CR40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00223-008-9198-2","volume":"84","author":"P Vestergaard","year":"2009","unstructured":"Vestergaard P, Rejnmark L, Mosekilde L. Hypertension is a risk factor for fractures. Calcif Tissue Int. 2009;84(2):103\u201311.","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2961_CR41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00198-012-2053-3","volume":"24","author":"SD Berry","year":"2013","unstructured":"Berry SD, Zhu Y, Choi H, Kiel DP, Zhang Y. Diuretic initiation and the acute risk of hip fracture. Osteoporos Int. 2013;24(2):689\u201395.","journal-title":"Osteoporos Int"},{"key":"2961_CR42","first-page":"1","volume":"19","author":"DA Butt","year":"2012","unstructured":"Butt DA, Mamdani M, Austin PC, Tu K, Gomes T, Glazier RH. The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med. 2012;19:1\u20136.","journal-title":"Arch Intern Med"},{"issue":"1","key":"2961_CR43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/jhh.2008.81","volume":"23","author":"P Hiitola","year":"2009","unstructured":"Hiitola P, Enlund H, Kettunen R, Sulkava R, Hartikainen S. Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older. J Hum Hypertens. 2009;23(1):33\u20139.","journal-title":"J Hum Hypertens"},{"issue":"5","key":"2961_CR44","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1291\/hypres.31.897","volume":"31","author":"JS Wu","year":"2008","unstructured":"Wu JS, Yang YC, Lu FH, Wu CH, Chang CJ. Population-based study on the prevalence and correlates of orthostatic hypotension\/hypertension and orthostatic dizziness. Hypertens Res. 2008;31(5):897\u2013904.","journal-title":"Hypertens Res"},{"issue":"10","key":"2961_CR45","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1532-5415.2008.01946.x","volume":"56","author":"GC Verwoert","year":"2008","unstructured":"Verwoert GC, Mattace-Raso FU, Hofman A, Heeringa J, Stricker BH, Breteler MM, Witteman JC. Orthostatic hypotension and risk of cardiovascular disease in elderly people: the Rotterdam study. J Am Geriatr Soc. 2008;56(10):1816\u201320.","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"2961_CR46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/ageing\/afp192","volume":"39","author":"S Kamaruzzaman","year":"2010","unstructured":"Kamaruzzaman S, Watt H, Carson C, Ebrahim S. The association between orthostatic hypotension and medication use in the British Women\u2019s Heart and Health Study. Age Ageing. 2010;39(1):51\u20136.","journal-title":"Age Ageing"},{"issue":"21","key":"2961_CR47","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1161\/01.CIR.98.21.2290","volume":"98","author":"KH Masaki","year":"1998","unstructured":"Masaki KH, Schatz IJ, Burchfiel CM, Sharp DS, Chiu D, Foley D, Curb JD. Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation. 1998;98(21):2290\u20135.","journal-title":"Circulation"},{"issue":"4","key":"2961_CR48","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2796.2004.01313.x","volume":"255","author":"H Luukinen","year":"2004","unstructured":"Luukinen H, Koski K, Laippala P, Airaksinen KE. Orthostatic hypotension and the risk of myocardial infarction in the home-dwelling elderly. J Intern Med. 2004;255(4):486\u201393.","journal-title":"J Intern Med"},{"issue":"1","key":"2961_CR49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/eurheartj\/ehp329","volume":"31","author":"A Fedorowski","year":"2010","unstructured":"Fedorowski A, Stavenow L, Hedblad B, Berglund G, Nilsson PM, Melander O. Orthostatic hypotension predicts all-cause mortality and coronary events in middle-aged individuals (The Malmo Preventive Project). Eur Heart J. 2010;31(1):85\u201391.","journal-title":"Eur Heart J"},{"issue":"1","key":"2961_CR50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2337\/dc08-1389","volume":"32","author":"JS Wu","year":"2009","unstructured":"Wu JS, Yang YC, Lu FH, Wu CH, Wang RH, Chang CJ. Population-based study on the prevalence and risk factors of orthostatic hypotension in subjects with pre-diabetes and diabetes. Diabetes Care. 2009;32(1):69\u201374.","journal-title":"Diabetes Care"},{"issue":"4","key":"2961_CR51","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1525-8610(04)70128-0","volume":"5","author":"MS Maurer","year":"2004","unstructured":"Maurer MS, Cohen S, Cheng H. The degree and timing of orthostatic blood pressure changes in relation to falls in nursing home residents. J Am Med Dir Assoc. 2004;5(4):233\u20138.","journal-title":"J Am Med Dir Assoc"},{"issue":"2","key":"2961_CR52","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0002-9343(99)00425-8","volume":"108","author":"WL Ooi","year":"2000","unstructured":"Ooi WL, Hossain M, Lipsitz LA. The association between orthostatic hypotension and recurrent falls in nursing home residents. Am J Med. 2000;108(2):106\u201311.","journal-title":"Am J Med"},{"issue":"3","key":"2961_CR53","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1532-5415.2011.03317.x","volume":"59","author":"A Gangavati","year":"2011","unstructured":"Gangavati A, Hajjar I, Quach L, Jones RN, Kiely DK, Gagnon P, Lipsitz LA. Hypertension, orthostatic hypotension, and the risk of falls in a community-dwelling elderly population: the maintenance of balance, independent living, intellect, and zest in the elderly of Boston study. J Am Geriatr Soc. 2011;59(3):383\u20139.","journal-title":"J Am Geriatr Soc"},{"issue":"8","key":"2961_CR54","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/pds.2176","volume":"20","author":"J Gribbin","year":"2011","unstructured":"Gribbin J, Hubbard R, Gladman J, Smith C, Lewis S. Risk of falls associated with antihypertensive medication: self-controlled case series. Pharmacoepidemiol Drug Saf. 2011;20(8):879\u201384.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"2961_CR55","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/jamainternmed.2013.14764","volume":"174","author":"ME Tinetti","year":"2014","unstructured":"Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, Zhou B, Lin H. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014;174(4):588\u201395.","journal-title":"JAMA Intern Med"},{"issue":"1","key":"2961_CR56","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1532-5415.1999.tb01899.x","volume":"47","author":"RM Leipzig","year":"1999","unstructured":"Leipzig RM, Cumming RG, Tinetti ME. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc. 1999;47(1):40\u201350.","journal-title":"J Am Geriatr Soc"},{"issue":"21","key":"2961_CR57","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1001\/archinternmed.2009.357","volume":"169","author":"JC Woolcott","year":"2009","unstructured":"Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, Marra CA. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952\u201360.","journal-title":"Arch Intern Med"},{"issue":"16","key":"2961_CR58","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1056\/NEJM198904203201606","volume":"320","author":"ME Tinetti","year":"1989","unstructured":"Tinetti ME, Speechley M. Prevention of falls among the elderly. N Engl J Med. 1989;320(16):1055\u20139.","journal-title":"N Engl J Med"},{"key":"2961_CR59","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2458-5-86","volume":"5","author":"LA Talbot","year":"2005","unstructured":"Talbot LA, Musiol RJ, Witham EK, Metter EJ. Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury. BMC Public Health. 2005;5:86.","journal-title":"BMC Public Health"},{"issue":"1","key":"2961_CR60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s001980050113","volume":"9","author":"LJ Melton 3rd","year":"1999","unstructured":"Melton LJ 3rd, Crowson CS, O\u2019Fallon WM. Fracture incidence in Olmsted County, Minnesota: comparison of urban with rural rates and changes in urban rates over time. Osteoporos Int. 1999;9(1):29\u201337.","journal-title":"Osteoporos Int"}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-014-2961-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11606-014-2961-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-014-2961-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T14:01:28Z","timestamp":1717250488000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11606-014-2961-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,16]]},"references-count":60,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2961"],"URL":"https:\/\/doi.org\/10.1007\/s11606-014-2961-3","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,16]]}}}