{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:57:44Z","timestamp":1789786664610,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s11606-014-3161-x","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T18:59:19Z","timestamp":1421089159000},"page":"692-696","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hormones and the Bone Marrow: Panhypopituitarism and Pancytopenia in a Man with a Pituitary Adenoma"],"prefix":"10.1007","volume":"30","author":[{"given":"Dianna","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"3161_CR1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/1752-1947-5-490","volume":"5","author":"M Fatma","year":"2011","unstructured":"Fatma M, Mouna E, Nabila R, Mouna M, Nadia C, Mohamed A. Sheehan\u2019s syndrome with pancytopenia: a case report and review of the literature. J Med Case Rep. 2011;5:490. doi: 10.1186\/1752-1947-5-490 .","journal-title":"J Med Case Rep"},{"issue":"3","key":"3161_CR2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00277-009-0804-9","volume":"89","author":"BA Laway","year":"2010","unstructured":"Laway BA, Bhat JR, Mir SA, Khan RS, Lone MI, Zargar AH. Sheehan\u2019s syndrome with pancytopenia\u2013complete recovery after hormone replacement (case series with review). Ann Hematol. 2010;89(3):305\u20138. doi: 10.1007\/s00277-009-0804-9 .","journal-title":"Ann Hematol"},{"issue":"5","key":"3161_CR3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00277-003-0800-4","volume":"83","author":"DY Kim","year":"2004","unstructured":"Kim DY, Kim JH, Park YJ, Jung KH, Chung HS, Shin S, et al. Case of complete recovery of pancytopenia after treatment of hypopituitarism. Ann Hematol. 2004;83(5):309\u201312. doi: 10.1007\/s00277-003-0800-4 .","journal-title":"Ann Hematol"},{"issue":"2","key":"3161_CR4","first-page":"e32","volume":"17","author":"GI Holmes","year":"2011","unstructured":"Holmes GI, Shepherd P, Walker JD. Panhypopituitarism secondary to a macroprolactinoma manifesting with pancytopenia: case report and literature review. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologists. 2011;17(2):e32\u20136. doi: 10.4158\/EP10298.CR .","journal-title":"Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologists"},{"issue":"4","key":"3161_CR5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2141.1976.tb03576.x","volume":"33","author":"E Ferrari","year":"1976","unstructured":"Ferrari E, Ascari E, Bossolo PA, Barosi G. Sheehan\u2019s syndrome with complete bone marrow aplasia: long-term results of substitution therapy with hormones. Br J Haematol. 1976;33(4):575\u201382.","journal-title":"Br J Haematol"},{"issue":"4","key":"3161_CR6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00277-006-0233-y","volume":"86","author":"A Gokmen Akoz","year":"2007","unstructured":"Gokmen Akoz A, Atmaca H, Ustundag Y, Ozdamar SO. An unusual case of pancytopenia associated with Sheehan\u2019s syndrome. Ann Hematol. 2007;86(4):307\u20138. doi: 10.1007\/s00277-006-0233-y .","journal-title":"Ann Hematol"},{"issue":"4\u20135","key":"3161_CR7","first-page":"595","volume":"15","author":"SK Kim","year":"2000","unstructured":"Kim SK, Oh YJ, Joo PY, Kim YW, Hong SB, Kim MR, Nam MS, Kim YS. A case of pancytopenia caused by Sheehan\u2019s syndrome improved with hormone replacement therapy. J Korean Soc Endocrinol. 2000;15(4\u20135):595\u20139.","journal-title":"J Korean Soc Endocrinol"},{"issue":"2","key":"3161_CR8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s11102-011-0304-5","volume":"15","author":"BA Laway","year":"2012","unstructured":"Laway BA, Mir SA, Bhat JR, Lone MI, Samoon J, Zargar AH. Hematological response of pancytopenia to glucocorticoids in patients with Sheehan\u2019s syndrome. Pituitary. 2012;15(2):184\u20137. doi: 10.1007\/s11102-011-0304-5 .","journal-title":"Pituitary"},{"issue":"11","key":"3161_CR9","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00277-010-0938-9","volume":"89","author":"AC Lee","year":"2010","unstructured":"Lee AC. Pancytopenia secondary to hypopituitarism may just be due to hypothyroidism alone. Ann Hematol. 2010;89(11):1181. doi: 10.1007\/s00277-010-0938-9 .","journal-title":"Ann Hematol"},{"issue":"5","key":"3161_CR10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1368-5031.2004.00059.x","volume":"58","author":"M Ozdogan","year":"2004","unstructured":"Ozdogan M, Yazicioglu G, Karadogan I, Cevikol C, Karayalcin U, Undar L. Sheehan\u2019s syndrome associated with pancytopenia due to marrow aplasia; full recovery with hormone replacement therapy. Int J Clin Pract. 2004;58(5):533\u20135.","journal-title":"Int J Clin Pract"},{"issue":"3","key":"3161_CR11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/(SICI)1096-8652(199811)59:3<230::AID-AJH8>3.0.CO;2-2","volume":"59","author":"R Fonseca","year":"1998","unstructured":"Fonseca R, Rajkumar SV, White WL, Tefferi A, Hoagland HC. Anemia after orchiectomy. Am J Hematol. 1998;59(3):230\u20133.","journal-title":"Am J Hematol"},{"issue":"6","key":"3161_CR12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2265.2001.01417.x","volume":"55","author":"M Sohmiya","year":"2001","unstructured":"Sohmiya M, Kato Y. Effect of long-term administration of recombinant human growth hormone (rhGH) on plasma erythropoietin (EPO) and haemoglobin levels in anaemic patients with adult GH deficiency. Clin Endocrinol. 2001;55(6):749\u201354.","journal-title":"Clin Endocrinol"},{"issue":"3","key":"3161_CR13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2141.1988.tb02480.x","volume":"70","author":"S Merchav","year":"1988","unstructured":"Merchav S, Tatarsky I, Hochberg Z. Enhancement of erythropoiesis in vitro by human growth hormone is mediated by insulin-like growth factor I. Br J Haematol. 1988;70(3):267\u201371.","journal-title":"Br J Haematol"},{"issue":"1","key":"3161_CR14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3181\/00379727-96-23397","volume":"96","author":"HA Meineke","year":"1957","unstructured":"Meineke HA, Crafts RC. Effect of combined thyroxin-cortisone-growth hormone therapy on hematopoiesis in hypophysectomized rats. Proc Soc Exp Biol Med Soc Exp Biol Med. 1957;96(1):74\u20139.","journal-title":"Proc Soc Exp Biol Med Soc Exp Biol Med"},{"issue":"4","key":"3161_CR15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2141.1989.tb06302.x","volume":"71","author":"E Nagy","year":"1989","unstructured":"Nagy E, Berczi I. Pituitary dependence of bone marrow function. Br J Haematol. 1989;71(4):457\u201362.","journal-title":"Br J Haematol"},{"issue":"23","key":"3161_CR16","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1093\/emboj\/16.23.6926","volume":"16","author":"ND Horseman","year":"1997","unstructured":"Horseman ND, Zhao W, Montecino-Rodriguez E, Tanaka M, Nakashima K, Engle SJ, et al. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J. 1997;16(23):6926\u201335. doi: 10.1093\/emboj\/16.23.6926 .","journal-title":"EMBO J"},{"issue":"4566","key":"3161_CR17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/bmj.2.4566.75","volume":"2","author":"A Bloom","year":"1948","unstructured":"Bloom A, Bryson CC. Aplastic anaemia in Simmonds\u2019s disease; report of a case. Br Med J. 1948;2(4566):75\u20137.","journal-title":"Br Med J"},{"key":"3161_CR18","author":"P Dharmshaktu","year":"2013","unstructured":"Dharmshaktu P, Bhowmick J, Manglani D, Dhanwal DK. Recurrent symptomatic hypoglycaemia with pancytopenia as a delayed presentation of Sheehan\u2019s syndrome with complete recovery after hormone replacement. BMJ Case Rep. 2013. doi: 10.1136\/bcr-2013-009014 .","journal-title":"BMJ Case Rep"},{"key":"3161_CR19","first-page":"P151","volume":"16","author":"H Atmaca","year":"2008","unstructured":"Atmaca H, Bayraktaroglu T, Gokmen Akoz A, Koyuncu BU. Two unusual cases with pancytopenia associated with Sheehan\u2019s syndrome. Endocr Abstr. 2008;16:P151.","journal-title":"Endocr Abstr"},{"issue":"11","key":"3161_CR20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1157\/13092780","volume":"127","author":"PJ Pines Corrales","year":"2006","unstructured":"Pines Corrales PJ, Anton Bravo T, Zurita Sepulveda P. Pancytopenia and acquired factor IX deficiency in patient with Sheehan\u2019s syndrome. Med Clin. 2006;127(11):439.","journal-title":"Med Clin"},{"issue":"1","key":"3161_CR21","first-page":"73","volume":"80","author":"S Anfuso","year":"2009","unstructured":"Anfuso S, Patrelli TS, Soncini E, Chiodera P, Fadda GM, Nardelli GB. A case report of Sheehan\u2019s syndrome with acute onset, hyponatremia and severe anemia. Acta Biomed Atenei Parmensis. 2009;80(1):73\u20136.","journal-title":"Acta Biomed Atenei Parmensis"},{"issue":"5","key":"3161_CR22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00277-008-0607-4","volume":"88","author":"D Gokalp","year":"2009","unstructured":"Gokalp D, Tuzcu A, Bahceci M, Arikan S, Bahceci S, Pasa S. Sheehan\u2019s syndrome as a rare cause of anaemia secondary to hypopituitarism. Ann Hematol. 2009;88(5):405\u201310. doi: 10.1007\/s00277-008-0607-4 .","journal-title":"Ann Hematol"},{"issue":"7","key":"3161_CR23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-0029-1190185","volume":"40","author":"M Simmonds","year":"1914","unstructured":"Simmonds M. \u00dcber Hypophysisschwund mit t\u00f6dlichem Ausgang. Dtsch Med Wochenschr. 1914;40(7):322\u20133.","journal-title":"Dtsch Med Wochenschr"},{"issue":"3\u20134","key":"3161_CR24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11102-006-6039-z","volume":"8","author":"MO Aken van","year":"2005","unstructured":"van Aken MO, Lamberts SW. Diagnosis and treatment of hypopituitarism: an update. Pituitary. 2005;8(3\u20134):183\u201391. doi: 10.1007\/s11102-006-6039-z .","journal-title":"Pituitary"},{"issue":"5","key":"3161_CR25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/MAJ.0b013e3181f8c6df","volume":"340","author":"AH Tessnow","year":"2010","unstructured":"Tessnow AH, Wilson JD. The changing face of Sheehan\u2019s syndrome. Am J Med Sci. 2010;340(5):402\u20136. doi: 10.1097\/MAJ.0b013e3181f8c6df .","journal-title":"Am J Med Sci"},{"issue":"2","key":"3161_CR26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/09513590009167667","volume":"14","author":"YY Huang","year":"2000","unstructured":"Huang YY, Ting MK, Hsu BR, Tsai JS. Demonstration of reserved anterior pituitary function among patients with amenorrhea after postpartum hemorrhage. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2000;14(2):99\u2013104.","journal-title":"Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol"},{"issue":"2","key":"3161_CR27","first-page":"229","volume":"14","author":"MA Badawi","year":"2008","unstructured":"Badawi MA, Salih F, Al-Humaidi AA, El Khalifa MY, Elhadd TA. Bone marrow hypoplasia responsive to testosterone therapy in a patient with panhypopituitarism: need for adherence to androgen replacement. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologists. 2008;14(2):229\u201332. doi: 10.4158\/EP.14.2.229 .","journal-title":"Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologists"},{"issue":"1","key":"3161_CR28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF03324902","volume":"21","author":"L Foppiani","year":"2009","unstructured":"Foppiani L, Ruelle A, Quilici P, Del Monte P. Hypopituitarism in the elderly: two case-reports with heterogeneous presentation. Aging Clin Exp Res. 2009;21(1):76\u201381.","journal-title":"Aging Clin Exp Res"},{"issue":"4","key":"3161_CR29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3803\/EnM.2012.27.4.308","volume":"27","author":"JH Koh","year":"2012","unstructured":"Koh JH, Lee YJ, Kang JH, Choi BK, Jeon YK, Kim SS, et al. Pancytopenia associated with hypopituitarism in an acromegaly patient: a case report and a review of the literature. Endocrinol Metab. 2012;27(4):308\u201313.","journal-title":"Endocrinol Metab"},{"issue":"1","key":"3161_CR30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000205075","volume":"15","author":"SA Killmann","year":"1956","unstructured":"Killmann SA. A case of pancytopenia in hypopituitarism; with a review of the hematological changes in clinical and experimental pituitary insufficiency. Acta Haematol. 1956;15(1):34\u201345.","journal-title":"Acta Haematol"}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-014-3161-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11606-014-3161-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-014-3161-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T17:49:13Z","timestamp":1559411353000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11606-014-3161-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,13]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["3161"],"URL":"https:\/\/doi.org\/10.1007\/s11606-014-3161-x","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,13]]}}}