{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:58:45Z","timestamp":1782601125818,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s11606-016-3700-8","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T14:25:17Z","timestamp":1464359117000},"page":"1061-1067","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["At-Home Versus In-Clinic INR Monitoring: A Cost\u2013Utility Analysis from The Home INR Study (THINRS)"],"prefix":"10.1007","volume":"31","author":[{"name":"writing for the THINRS Executive Committee and Site Investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran S.","family":"Phibbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan K.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Edson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pon","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Uyeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Matchar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"3700_CR1","doi-asserted-by":"crossref","first-page":"160S","DOI":"10.1378\/chest.08-0670","volume":"133","author":"J Ansell","year":"2008","unstructured":"Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:160S\u2013198S.","journal-title":"Chest"},{"key":"3700_CR2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7326\/0003-4819-157-10-201211200-00532","volume":"157","author":"SS Adam","year":"2012","unstructured":"Adam SS, McDuffie JR, Ortel TL, Williams JW Jr. Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review. Ann Intern Med. 2012;157:796\u2013807.","journal-title":"Ann Intern Med"},{"key":"3700_CR3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0002-9343(02)01131-2","volume":"113","author":"DB Matchar","year":"2002","unstructured":"Matchar DB, Samsa GP, Cohen SJ, Oddone EZ, Jurgelski AE. Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trial. Am J Med. 2002;113:42\u201351.","journal-title":"Am J Med"},{"issue":"Suppl 1","key":"3700_CR4","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1023\/A:1018722001817","volume":"9","author":"DB Matchar","year":"2000","unstructured":"Matchar DB, Samsa GP, Cohen SJ, Oddone EZ. Community impact of anticoagulation services: rationale and design of the Managing Anticoagulation Services Trial (MAST). J Thromb Thrombolysis. 2000;9(Suppl 1):S7\u201311.","journal-title":"J Thromb Thrombolysis"},{"key":"3700_CR5","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1001\/archinte.158.15.1641","volume":"158","author":"E Chiquette","year":"1998","unstructured":"Chiquette E, Amato MG, Bussey HI. Comparison of an anticoagulation clinic with usual medical care: anticoagulation control, patient outcomes, and health care costs. Arch Intern Med. 1998;158:1641\u20131647.","journal-title":"Arch Intern Med"},{"key":"3700_CR6","doi-asserted-by":"crossref","unstructured":"Garcia-Alamino JM, Ward AM, Alonso-Coello P, et al. Self-monitoring and self-management of oral anticoagulation. Cochrane Database Syst Rev. 2010:CD003839.","DOI":"10.1002\/14651858.CD003839.pub2"},{"key":"3700_CR7","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa1002617","volume":"363","author":"DB Matchar","year":"2010","unstructured":"Matchar DB, Jacobson A, Dolor R, et al. Effect of home testing of international normalized ratio on clinical events. N Engl J Med. 2010;363:1608\u20131620.","journal-title":"N Engl J Med"},{"key":"3700_CR8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijcard.2006.06.018","volume":"118","author":"TD Christensen","year":"2007","unstructured":"Christensen TD, Johnsen SP, Hjortdal VE, Hasenkam JM. Self-management of oral anticoagulant therapy: a systematic review and meta-analysis. Int J Cardiol. 2007;118:54\u201361.","journal-title":"Int J Cardiol"},{"key":"3700_CR9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0140-6736(11)61294-4","volume":"379","author":"C Heneghan","year":"2012","unstructured":"Heneghan C, Ward A, Perera R, et al. Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Lancet. 2012;379:322\u2013334.","journal-title":"Lancet"},{"key":"3700_CR10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1023\/A:1018778914477","volume":"9","author":"GP Samsa","year":"2000","unstructured":"Samsa GP, Matchar DB. Relationship between test frequency and outcomes of anticoagulation: a literature review and commentary with implications for the design of randomized trials of patient self-management. J Thromb Thrombolysis. 2000;9:283\u2013292.","journal-title":"J Thromb Thrombolysis"},{"key":"3700_CR11","doi-asserted-by":"crossref","first-page":"e152S","DOI":"10.1378\/chest.11-2295","volume":"141","author":"A Holbrook","year":"2012","unstructured":"Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e152S\u2013184S.","journal-title":"Chest"},{"key":"3700_CR12","doi-asserted-by":"crossref","unstructured":"Horseman J, Furlong W, Feeny D, Torrance G. The Health Utilities Index (HUI\u00ae): Concepts, Measurement Properties and Applications. Health and Quality of Life Outcomes (electronic journal). 2003;1.","DOI":"10.1186\/1477-7525-1-54"},{"key":"3700_CR13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11239-014-1128-8","volume":"40","author":"DB Matchar","year":"2015","unstructured":"Matchar DB, Love SR, Jacobson AK, et al. The impact of frequency of patient self-testing of prothrombin time on time in target range within VA Cooperative Study #481: The Home INR Study (THINRS), a randomized, controlled trial. J Thromb Thrombolysis. 2015;40:17\u201325.","journal-title":"J Thromb Thrombolysis"},{"key":"3700_CR14","doi-asserted-by":"crossref","unstructured":"Matchar DB, Jacobson AK, Edson RG, et al. The Impact of Patient Self-Testing of Prothrombin Time for Managing Anticoagulation: Rationale and Design of VA Cooperative Study #481-The Home INR Study (THINRS). J Thromb Thrombolysis. 2005;19:163\u2013172.","DOI":"10.1007\/s11239-005-1452-0"},{"key":"3700_CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11239-010-0499-8","volume":"30","author":"RJ Dolor","year":"2010","unstructured":"Dolor RJ, Ruybalid RL, Uyeda L, et al. An evaluation of patient self-testing competency of prothrombin time for managing anticoagulation: pre-randomization results of VA Cooperative Study #481--The Home INR Study (THINRS). J Thromb Thrombolysis. 2010;30:263\u2013275.","journal-title":"J Thromb Thrombolysis"},{"key":"3700_CR16","unstructured":"CPI Tables. www.bls.gov\/cpi\/#tables . Accessed 3 February 2016."},{"key":"3700_CR17","unstructured":"Amazon.com: INR meter. http:\/\/www.amazon.com\/s\/ref=nb_sb_noss_2?url=search-alias%3Daps&field-keywords=INR+meter . Accessed 3 February 2016."},{"key":"3700_CR18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1477-7525-2-22","volume":"2","author":"G Samsa","year":"2004","unstructured":"Samsa G, Matchar DB, Dolor RJ, et al. A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation. Health Qual Life Outcomes. 2004;2:22.","journal-title":"Health Qual Life Outcomes"},{"key":"3700_CR19","doi-asserted-by":"crossref","DOI":"10.1201\/9781420035438","volume-title":"Design and Analysis of Quality of Life Studies in Clinical Trials","author":"D Fairclough","year":"2002","unstructured":"Fairclough D. Design and Analysis of Quality of Life Studies in Clinical Trials. Boca Raton, FL: Chapman & Hall\/CRC; 2002."},{"key":"3700_CR20","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1001\/jama.1996.03540150055031","volume":"276","author":"MC Weinstein","year":"1996","unstructured":"Weinstein MC, Siegel JE, Gold MR, Kamlet MS, Russell LB. Recommendations of the Panel on Cost-effectiveness in Health and Medicine. J Am Med Assoc. 1996;276:1253\u20131258.","journal-title":"J Am Med Assoc"},{"key":"3700_CR21","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1001\/jama.1996.03540160061034","volume":"276","author":"JE Siegel","year":"1996","unstructured":"Siegel JE, Weinstein MC, Russell LB, Gold MR. Recommendations for reporting cost-effectiveness analyses. Panel on Cost-Effectiveness in Health and Medicine. J Am Med Assoc. 1996;276:1339\u20131341.","journal-title":"J Am Med Assoc"},{"key":"3700_CR22","unstructured":"Glick H. Web Resources for Economic Evaluation in Clinical Trials. 2012; http:\/\/www.uphs.upenn.edu\/dgimhsr\/eeinct.htm. Accessed 3 February 2016."},{"key":"3700_CR23","volume-title":"Economic evaluation in clinical trials","author":"H Glick","year":"2007","unstructured":"Glick H, Doshi J, Sonnad S, Polsky D. Economic evaluation in clinical trials. Oxford, UK: Oxford University Press; 2007."},{"key":"3700_CR24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/07853890109002088","volume":"33","author":"M Drummond","year":"2001","unstructured":"Drummond M. Introducing economic and quality of life measurements into clinical studies. Ann Med. 2001;33:344\u2013349.","journal-title":"Ann Med"},{"key":"3700_CR25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2165\/00019053-199915020-00003","volume":"15","author":"G Samsa","year":"1999","unstructured":"Samsa G, Edelman D, Rothman ML, Williams GR, Lipscomb J, Matchar D. Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II. PharmacoEconomics. 1999;15:141\u2013155.","journal-title":"PharmacoEconomics"},{"key":"3700_CR26","unstructured":"Table: Threshold values for intervention cost-effectiveness by Region. http:\/\/www.who.int\/choice\/costs\/CER_levels\/en\/index.html . Accessed 3 February 2016."},{"key":"3700_CR27","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1097\/MLR.0b013e31819bc077","volume":"47","author":"LB Russell","year":"2009","unstructured":"Russell LB. Completing costs: patients' time. Med Care. 2009;47:S89\u201393.","journal-title":"Med Care"},{"key":"3700_CR28","unstructured":"Holder KA. The Educational Attainment of Veterans: 2007. 2009; https:\/\/www.census.gov\/hhes\/veterans\/files\/veteranseducation.pdf. Accessed 3 February 2016."},{"key":"3700_CR29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ahj.2012.10.010","volume":"165","author":"MP Turakhia","year":"2013","unstructured":"Turakhia MP, Hoang DD, Xu X, et al. Differences and trends in stroke prevention anticoagulation in primary care vs cardiology specialty management of new atrial fibrillation: The Retrospective Evaluation and Assessment of Therapies in AF (TREAT-AF) study. Am Heart J. 2013;165:93\u2013101.","journal-title":"Am Heart J"}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-016-3700-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11606-016-3700-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-016-3700-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:59:44Z","timestamp":1567987184000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11606-016-3700-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,27]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["3700"],"URL":"https:\/\/doi.org\/10.1007\/s11606-016-3700-8","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,27]]}}}