{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:43:44Z","timestamp":1769582624623,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000028","name":"Institute of Circulatory and Respiratory Health","doi-asserted-by":"publisher","award":["#102626"],"award-info":[{"award-number":["#102626"]}],"id":[{"id":"10.13039\/501100000028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s11606-021-06665-0","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T18:04:33Z","timestamp":1614967473000},"page":"2975-2981","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alcohol Exerts a Shifted U-Shaped Effect on Central Blood Pressure in Young Adults"],"prefix":"10.1007","volume":"36","author":[{"given":"Alice","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra B.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Scheffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Doonan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4774-2549","authenticated-orcid":false,"given":"Stella S.","family":"Daskalopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"6665_CR1","unstructured":"Canadian Centre on Substance Use and Addiction. CCSA Canadian Drug Summary Alcohol. 2019."},{"key":"6665_CR2","first-page":"7","volume":"38","author":"E Delker","year":"2016","unstructured":"Delker E, Brown Q, Hasin DS. Alcohol consumption in demographic subpopulations: an epidemiologic overview. Alc Res. 2016; 38:7-15.","journal-title":"Alc Res."},{"key":"6665_CR3","doi-asserted-by":"publisher","first-page":"j909","DOI":"10.1136\/bmj.j909","volume":"356","author":"S Bell","year":"2017","unstructured":"Bell S, Daskalopoulou M, Rapsomaniki E, et al. Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records. BMJ. 2017; 356:j909.","journal-title":"BMJ."},{"key":"6665_CR4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jacc.2017.06.054","volume":"70","author":"B Xi","year":"2017","unstructured":"Xi B, Veeranki SP, Zhao M, Ma C, Yan Y, Mi J. Relationship of alcohol consumption to all-cause, cardiovascular, and cancer-related mortality in U.S. adults. J Am Coll Cardiol. 2017; 70:913-922.","journal-title":"J Am Coll Cardiol."},{"key":"6665_CR5","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1093\/ije\/dyt154","volume":"42","author":"MM Bergmann","year":"2013","unstructured":"Bergmann MM, Rehm J, Klipstein-Grobusch K, et al. The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. Int J Epidemiol. 2013; 42:1772-1790.","journal-title":"Int J Epidemiol."},{"key":"6665_CR6","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1161\/01.ATV.0000110784.52412.8f","volume":"24","author":"A Sierksma","year":"2004","unstructured":"Sierksma A, Lebrun CEI, Schouw YTVD, et al. Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women. Arterioscler Thromb Vasc Biol. 2004; 24:342-348.","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"6665_CR7","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.amjcard.2004.12.051","volume":"95","author":"H Hougaku","year":"2005","unstructured":"Hougaku H, Fleg JL, Lakatta EG, et al. Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening. Am J Cardiol. 2005; 95:1006-1010.","journal-title":"Am J Cardiol."},{"key":"6665_CR8","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1093\/gerona\/60.11.1479","volume":"60","author":"FU Mattace-Raso","year":"2005","unstructured":"Mattace-Raso FU, van der Cammen TJ, van den Elzen AP, et al. Moderate alcohol consumption is associated with reduced arterial stiffness in older adults: the Rotterdam study. J Gerontol A Biol Sci Med Sci. 2005; 60:1479-1483.","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"6665_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/00004872-200402000-00020","volume":"22","author":"A Sierksma","year":"2004","unstructured":"Sierksma A, Muller M, van der Schouw YT, Grobbee DE, Hendriks HF, Bots ML. Alcohol consumption and arterial stiffness in men. J Hypertens. 2004; 22:357-362.","journal-title":"J Hypertens."},{"key":"6665_CR10","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.alcohol.2013.10.003","volume":"47","author":"S Sasaki","year":"2013","unstructured":"Sasaki S, Yoshioka E, Saijo Y, et al. Relation between alcohol consumption and arterial stiffness: A cross-sectional study of middle-aged Japanese women and men. Alcohol. 2013; 47:643-649.","journal-title":"Alcohol."},{"key":"6665_CR11","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1161\/HYPERTENSIONAHA.107.104968","volume":"51","author":"HD Sesso","year":"2008","unstructured":"Sesso HD, Cook NR, Buring JE, Manson JE, Gaziano JM. Alcohol consumption and the risk of hypertension in women and men. Hypertension. 2008; 51:1080-1087.","journal-title":"Hypertension."},{"key":"6665_CR12","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1161\/01.HYP.37.5.1242","volume":"37","author":"FD Fuchs","year":"2001","unstructured":"Fuchs FD, Chambless LE, Whelton PK, Nieto FJ, Heiss G. Alcohol consumption and the incidence of hypertension: The Atherosclerosis Risk in Communities Study. Hypertension. 2001; 37:1242-1250.","journal-title":"Hypertension."},{"key":"6665_CR13","unstructured":"United States Department of Health and Human Services. 2015-2020 Dietary Guidelines - Appendix 9 - Alcohol. 2020."},{"key":"6665_CR14","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.cjca.2018.02.022","volume":"34","author":"KA Nerenberg","year":"2018","unstructured":"Nerenberg KA, Zarnke KB, Leung AA, et al. Hypertension Canada\u2019s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2018; 34:506-525.","journal-title":"Can J Cardiol."},{"key":"6665_CR15","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1097\/HJH.0b013e3280114f23","volume":"25","author":"AD Protogerou","year":"2007","unstructured":"Protogerou AD, Papaioannou TG, Blacher J, Papamichael CM, Lekakis JP, Safar ME. Central blood pressures: do we need them in the management of cardiovascular disease? Is it a feasible therapeutic target? J Hypertens. 2007; 25:265-272.","journal-title":"J Hypertens."},{"key":"6665_CR16","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/hr.2010.25","volume":"33","author":"RJ Doonan","year":"2010","unstructured":"Doonan RJ, Hausvater A, Scallan C, Mikhailidis DP, Pilote L, Daskalopoulou SS. The effect of smoking on arterial stiffness. Hypertens Res. 2010; 33:398-410.","journal-title":"Hypertens Res."},{"key":"6665_CR17","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1159\/000452448","volume":"4","author":"M Butlin","year":"2017","unstructured":"Butlin M, Qasem A. Large Artery Stiffness Assessment Using SphygmoCor Technology. Pulse (Basel). 2017; 4:180-192.","journal-title":"Pulse (Basel)."},{"key":"6665_CR18","unstructured":"National Institutes of Health. Racial and Ethnic Categories and Definitions for NIH Diversity Programs and for Other Reporting Purposes."},{"key":"6665_CR19","doi-asserted-by":"publisher","first-page":"d643","DOI":"10.1136\/bmj.d643","volume":"342","author":"J Sundstrom","year":"2011","unstructured":"Sundstrom J, Neovius M, Tynelius P, Rasmussen F. Association of blood pressure in late adolescence with subsequent mortality: cohort study of Swedish male conscripts. BMJ. 2011; 342:d643.","journal-title":"BMJ."},{"key":"6665_CR20","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1093\/eurheartj\/ehq024","volume":"31","author":"C Vlachopoulos","year":"2010","unstructured":"Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J. 2010; 31:1865-1871.","journal-title":"Eur Heart J."},{"key":"6665_CR21","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.amjcard.2005.04.036","volume":"96","author":"JA Chirinos","year":"2005","unstructured":"Chirinos JA, Zambrano JP, Chakko S, et al. Relation between ascending aortic pressures and outcomes in patients with angiographically demonstrated coronary artery disease. Am J Cardiol. 2005; 96:645-648.","journal-title":"Am J Cardiol."},{"key":"6665_CR22","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1161\/01.HYP.38.3.434","volume":"38","author":"GM London","year":"2001","unstructured":"London GM, Blacher J, Pannier B, Guerin AP, Marchais SJ, Safar ME. Arterial wave reflections and survival in end-stage renal failure. Hypertension. 2001; 38:434-438.","journal-title":"Hypertension."},{"key":"6665_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1161\/HYPERTENSIONAHA.107.089078","volume":"50","author":"MJ Roman","year":"2007","unstructured":"Roman MJ, Devereux RB, Kizer JR, et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension. 2007; 50:197-203.","journal-title":"Hypertension."},{"key":"6665_CR24","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1161\/hy0202.098325","volume":"39","author":"ME Safar","year":"2002","unstructured":"Safar ME, Blacher J, Pannier B, et al. Central pulse pressure and mortality in end-stage renal disease. Hypertension. 2002; 39:735-738.","journal-title":"Hypertension."},{"key":"6665_CR25","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/hy1001.096107","volume":"38","author":"TK Waddell","year":"2001","unstructured":"Waddell TK, Dart AM, Medley TL, Cameron JD, Kingwell BA. Carotid pressure is a better predictor of coronary artery disease severity than brachial pressure. Hypertension. 2001; 38:927-931.","journal-title":"Hypertension."},{"key":"6665_CR26","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","volume":"113","author":"B Williams","year":"2006","unstructured":"Williams B, Lacy PS, Thom SM, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006; 113:1213-1225.","journal-title":"Circulation."},{"key":"6665_CR27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.2174\/138161209787354195","volume":"15","author":"K Karatzi","year":"2009","unstructured":"Karatzi K, Papaioannou TG, Papamichael C, Lekakis J, Stefanadis C, Zampelas A. Red wine, arterial stiffness and central hemodynamics. Curr Pharm Des. 2009; 15:321-328.","journal-title":"Curr Pharm Des."},{"key":"6665_CR28","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1291\/hypres.27.669","volume":"27","author":"T Kurihara","year":"2004","unstructured":"Kurihara T, Tomiyama H, Hashimoto H, Yamamoto Y, Yano E, Yamashina A. Excessive alcohol intake increases the risk of arterial stiffening in men with normal blood pressure. Hypertens Res. 2004; 27:669-673.","journal-title":"Hypertens Res."},{"key":"6665_CR29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2486\/indhealth.39.24","volume":"39","author":"N Nakanishi","year":"2001","unstructured":"Nakanishi N, Kawashimo H, Nakamura K, et al. Association of alcohol consumption with increase in aortic stiffness: a 9-year longitudinal study in middle-aged Japanese men. Ind Health. 2001; 39:24-28.","journal-title":"Ind Health."},{"key":"6665_CR30","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.amjhyper.2004.12.011","volume":"18","author":"MJ van Trijp","year":"2005","unstructured":"van Trijp MJ, Beulens JW, Bos WJ, et al. Alcohol consumption and augmentation index in healthy young men: the ARYA study. Am J Hypertens. 2005; 18:792-796.","journal-title":"Am J Hypertens."},{"key":"6665_CR31","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.jacc.2009.10.056","volume":"55","author":"KJ Mukamal","year":"2010","unstructured":"Mukamal KJ, Chen CM, Rao SR, Breslow RA. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol. 2010; 55:1328-1335.","journal-title":"J Am Coll Cardiol."},{"key":"6665_CR32","doi-asserted-by":"publisher","first-page":"d636","DOI":"10.1136\/bmj.d636","volume":"342","author":"SE Brien","year":"2011","unstructured":"Brien SE, Ronksley PE, Turner BJ, Mukamal KJ, Ghali WA. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ. 2011; 342:d636.","journal-title":"BMJ."},{"key":"6665_CR33","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3945\/an.115.011627","volume":"7","author":"S Weiskirchen","year":"2016","unstructured":"Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Adv Nutr. 2016; 7:706-718.","journal-title":"Adv Nutr."},{"key":"6665_CR34","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1001\/archinte.162.5.569","volume":"162","author":"R Thadhani","year":"2002","unstructured":"Thadhani R, Camargo CA, Jr., Stampfer MJ, Curhan GC, Willett WC, Rimm EB. Prospective study of moderate alcohol consumption and risk of hypertension in young women. Arch Intern Med. 2002; 162:569-574.","journal-title":"Arch Intern Med."},{"key":"6665_CR35","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1016\/S2468-2667(17)30003-8","volume":"2","author":"M Roerecke","year":"2017","unstructured":"Roerecke M, Kaczorowski J, Tobe SW, Gmel G, Hasan OSM, Rehm J. The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis. Lancet Public Health. 2017; 2:e108-e120.","journal-title":"Lancet Public Health."},{"issue":"Suppl 2","key":"6665_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1359-6357.2003.00586.x","volume":"98","author":"FK Del Boca","year":"2003","unstructured":"Del Boca FK, Darkes J. The validity of self-reports of alcohol consumption: state of the science and challenges for research. Addiction. 2003; 98 Suppl 2:1-12.","journal-title":"Addiction."},{"key":"6665_CR37","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.drugalcdep.2019.01.030","volume":"202","author":"P Toner","year":"2019","unstructured":"Toner P, B\u00f6hnke JR, Andersen P, McCambridge J. Alcohol screening and assessment measures for young people: A systematic review and meta-analysis of validation studies. Drug Alcohol Depend. 2019; 202:39-49.","journal-title":"Drug Alcohol Depend."},{"key":"6665_CR38","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.ehj.2003.12.022","volume":"25","author":"JB Ruidavets","year":"2004","unstructured":"Ruidavets JB, Bataille V, Dallongeville J, et al. Alcohol intake and diet in France, the prominent role of lifestyle. Eur Heart J. 2004; 25:1153-1162.","journal-title":"Eur Heart J."},{"key":"6665_CR39","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1161\/HYPERTENSIONAHA.115.05672","volume":"66","author":"SV Eastwood","year":"2015","unstructured":"Eastwood SV, Tillin T, Chaturvedi N, Hughes AD. Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men. Hypertension. 2015; 66:481-488.","journal-title":"Hypertension."},{"key":"6665_CR40","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1001\/jamacardio.2016.5678","volume":"2","author":"Y Yano","year":"2017","unstructured":"Yano Y, Reis JP, Tedla YG, et al. Racial Differences in Associations of Blood Pressure Components in Young Adulthood With Incident Cardiovascular Disease by Middle Age: Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Cardiol. 2017; 2:381-389.","journal-title":"JAMA Cardiol."},{"key":"6665_CR41","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1161\/01.CIR.95.7.1827","volume":"95","author":"CH Chen","year":"1997","unstructured":"Chen CH, Nevo E, Fetics B, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation. 1997; 95:1827-1836.","journal-title":"Circulation."},{"key":"6665_CR42","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1046\/j.0306-5251.2001.01400.x","volume":"51","author":"MF O\u2019Rourke","year":"2001","unstructured":"O\u2019Rourke MF, Pauca A, Jiang XJ. Pulse wave analysis. Br J Clin Pharmacol. 2001; 51:507-522.","journal-title":"Br J Clin Pharmacol."},{"key":"6665_CR43","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1161\/hy1001.096106","volume":"38","author":"AL Pauca","year":"2001","unstructured":"Pauca AL, O'Rourke MF, Kon ND. Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension. 2001; 38:932-937.","journal-title":"Hypertension."},{"key":"6665_CR44","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008733","volume":"7","author":"MR Piano","year":"2018","unstructured":"Piano MR, Burke L, Kang M, Phillips SA. Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011-2014. J Am Heart Assoc. 2018; 7:e008733.","journal-title":"J Am Heart Assoc."}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-021-06665-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11606-021-06665-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-021-06665-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T21:10:21Z","timestamp":1675026621000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11606-021-06665-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["6665"],"URL":"https:\/\/doi.org\/10.1007\/s11606-021-06665-0","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,5]]},"assertion":[{"value":"12 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"DECLARATIONS"}},{"value":"The authors declare that they do not have a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}