{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:40:03Z","timestamp":1790383203330,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shalvi Foundation for Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J GEN INTERN MED"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s11606-021-07241-2","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:02:40Z","timestamp":1649710960000},"page":"3283-3288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ankylosing Spondylitis and the Risk of Hip Fractures: a Matched Cohort Study"],"prefix":"10.1007","volume":"37","author":[{"given":"Avishai M.","family":"Tsur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulla","family":"Watad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nissan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"issue":"3","key":"7241_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4065\/76.3.295","volume":"76","author":"JM Huddleston","year":"2001","unstructured":"Huddleston JM, Whitford KJ. Medical Care of Elderly Patients With Hip Fractures. Mayo Clin Proc. 2001;76(3):295-298. https:\/\/doi.org\/10.4065\/76.3.295","journal-title":"Mayo Clin Proc."},{"issue":"2","key":"7241_CR2","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1016\/S0002-9343(97)90027-9","volume":"103","author":"AR Lyons","year":"1997","unstructured":"Lyons AR. Clinical outcomes and treatment of hip fractures. Am J Med. 1997;103(2):S51-S64. https:\/\/doi.org\/10.1016\/S0002-9343(97)90027-9","journal-title":"Am J Med."},{"key":"7241_CR3","doi-asserted-by":"crossref","unstructured":"Cummings SR, Rubin SM, Black D. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res. 1990;(252):163-166. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2302881","DOI":"10.1097\/00003086-199003000-00024"},{"issue":"5","key":"7241_CR4","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/PL00004148","volume":"7","author":"B Gullberg","year":"1997","unstructured":"Gullberg B, Johnell O, Kanis JA. World-wide Projections for Hip Fracture. Osteoporos Int. 1997;7(5):407-413. https:\/\/doi.org\/10.1007\/PL00004148","journal-title":"Osteoporos Int."},{"issue":"1","key":"7241_CR5","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13584-018-0235-y","volume":"7","author":"R Barnea","year":"2018","unstructured":"Barnea R, Weiss Y, Abadi-Korek I, Shemer J. The epidemiology and economic burden of hip fractures in Israel. Isr J Health Policy Res. 2018;7(1):38. https:\/\/doi.org\/10.1186\/s13584-018-0235-y","journal-title":"Isr J Health Policy Res."},{"issue":"1","key":"7241_CR6","doi-asserted-by":"publisher","first-page":"e0045","DOI":"10.2106\/JBJS.OA.18.00045","volume":"4","author":"A Adeyemi","year":"2019","unstructured":"Adeyemi A, Delhougne G. Incidence and Economic Burden of Intertrochanteric Fracture. JBJS Open Access. 2019;4(1):e0045. https:\/\/doi.org\/10.2106\/JBJS.OA.18.00045","journal-title":"JBJS Open Access."},{"issue":"9570","key":"7241_CR7","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J. Ankylosing spondylitis. Lancet. 2007;369(9570):1379-1390. https:\/\/doi.org\/10.1016\/S0140-6736(07)60635-7","journal-title":"Lancet."},{"issue":"1","key":"7241_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/rheumatology\/39.1.85","volume":"39","author":"D Mitra","year":"2000","unstructured":"Mitra D, Elvins DM, Speden DJ, Collins AJ. The prevalence of vertebral fractures in mild ankylosing spondylitis and their relationship to bone mineral density. Rheumatology. 2000;39(1):85-89. https:\/\/doi.org\/10.1093\/rheumatology\/39.1.85","journal-title":"Rheumatology."},{"issue":"4","key":"7241_CR9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/BOR.0b013e3283620777","volume":"25","author":"N Davey-Ranasinghe","year":"2013","unstructured":"Davey-Ranasinghe N, Deodhar A. Osteoporosis and vertebral fractures in ankylosing spondylitis. Curr Opin Rheumatol. 2013;25(4):509-516. https:\/\/doi.org\/10.1097\/BOR.0b013e3283620777","journal-title":"Curr Opin Rheumatol."},{"issue":"8","key":"7241_CR10","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1007\/s00198-004-1791-2","volume":"16","author":"M Sinaki","year":"2005","unstructured":"Sinaki M, Brey RH, Hughes CA, Larson DR, Kaufman KR. Balance disorder and increased risk of falls in osteoporosis and kyphosis: Significance of kyphotic posture and muscle strength. Osteoporos Int. 2005;16(8):1004-1010. https:\/\/doi.org\/10.1007\/s00198-004-1791-2","journal-title":"Osteoporos Int."},{"key":"7241_CR11","unstructured":"Amor B, Silva Santos R, Nahal R, Listrat V, Dougados M. Predictive factors for the longterm outcome of spondyloarthropathies. J Rheumatol. 1994;21(10):1883-1887. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7837155"},{"key":"7241_CR12","doi-asserted-by":"publisher","unstructured":"Will R, Bhalla AK, Palmer R, Ring F, Calin A. Osteoporosis in Early Ankylosing Spondylitis: a Primary Pathological Event? Lancet. 1989;334(8678-8679):1483-1485. https:\/\/doi.org\/10.1016\/S0140-6736(89)92932-2","DOI":"10.1016\/S0140-6736(89)92932-2"},{"issue":"3","key":"7241_CR13","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3899\/jrheum.170079","volume":"45","author":"KY Kang","year":"2018","unstructured":"Kang KY, Chung MK, Kim HN, Hong YS, Ju JH, Park S-H. Severity of Sacroiliitis and Erythrocyte Sedimentation Rate are Associated with a Low Trabecular Bone Score in Young Male Patients with Ankylosing Spondylitis. J Rheumatol. 2018;45(3):349-356. https:\/\/doi.org\/10.3899\/jrheum.170079","journal-title":"J Rheumatol."},{"issue":"2","key":"7241_CR14","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s11914-003-0013-8","volume":"1","author":"LE Wehren","year":"2003","unstructured":"Wehren LE, Magaziner J. Hip fracture: Risk factors and outcomes. Curr Osteoporos Rep. 2003;1(2):78-85. https:\/\/doi.org\/10.1007\/s11914-003-0013-8","journal-title":"Curr Osteoporos Rep."},{"issue":"2","key":"7241_CR15","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s00223-017-0274-3","volume":"101","author":"C Pray","year":"2017","unstructured":"Pray C, Feroz NI, Nigil Haroon N. Bone Mineral Density and Fracture Risk in Ankylosing Spondylitis: A Meta-Analysis. Calcif Tissue Int. 2017;101(2):182-192. https:\/\/doi.org\/10.1007\/s00223-017-0274-3","journal-title":"Calcif Tissue Int."},{"key":"7241_CR16","unstructured":"Cooper C, Carbone L, Michet CJ, Atkinson EJ, O\u2019Fallon WM, Melton LJ. Fracture risk in patients with ankylosing spondylitis: a population based study. J Rheumatol. 1994;21(10):1877-1882. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7837154"},{"issue":"12","key":"7241_CR17","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1136\/ard.2008.100503","volume":"68","author":"D Vosse","year":"2009","unstructured":"Vosse D, Landewe R, van der Heijde D, van der Linden S, van Staa T-P, Geusens P. Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control study. Ann Rheum Dis. 2009;68(12):1839-1842. https:\/\/doi.org\/10.1136\/ard.2008.100503","journal-title":"Ann Rheum Dis."},{"issue":"11","key":"7241_CR18","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.3899\/jrheum.100363","volume":"37","author":"RJ Weiss","year":"2010","unstructured":"Weiss RJ, Wick MC, Ackermann PW, Montgomery SM. Increased fracture risk in patients with rheumatic disorders and other inflammatory diseases - A case-control study with 53,108 patients with fracture. J Rheumatol. 2010;37(11):2247-2250. https:\/\/doi.org\/10.3899\/jrheum.100363","journal-title":"J Rheumatol."},{"issue":"9596","key":"7241_CR19","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453-1457. https:\/\/doi.org\/10.1016\/S0140-6736(07)61602-X","journal-title":"Lancet."},{"issue":"15","key":"7241_CR20","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1056\/NEJMoa2101765","volume":"384","author":"N Dagan","year":"2021","unstructured":"Dagan N, Barda N, Kepten E, et al. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med. 2021;384(15):1412-1423. https:\/\/doi.org\/10.1056\/NEJMoa2101765","journal-title":"N Engl J Med."},{"key":"7241_CR21","doi-asserted-by":"publisher","unstructured":"Tsur AM, Watad A, Gendelman O, Nissan D, Cohen AD, Amital H. Familial Mediterranean fever and asthma. Rheumatology. Published online February 16, 2021. https:\/\/doi.org\/10.1093\/rheumatology\/keab159","DOI":"10.1093\/rheumatology\/keab159"},{"issue":"3","key":"7241_CR22","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S2213-8587(20)30019-X","volume":"8","author":"A Furer","year":"2020","unstructured":"Furer A, Afek A, Sommer A, et al. Adolescent obesity and midlife cancer risk: a population-based cohort study of 2\u00b73 million adolescents in Israel. Lancet Diabetes Endocrinol. 2020;8(3):216-225. https:\/\/doi.org\/10.1016\/S2213-8587(20)30019-X","journal-title":"Lancet Diabetes Endocrinol."},{"key":"7241_CR23","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s13075-016-1093-z","volume":"18","author":"JJ de Winter","year":"2016","unstructured":"de Winter JJ, van Mens LJ, van der Heijde D, Landew\u00e9 R, Baeten DL. Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis. Arthritis Res Ther. 2016;18:196. https:\/\/doi.org\/10.1186\/s13075-016-1093-z","journal-title":"Arthritis Res Ther."},{"key":"7241_CR24","unstructured":"LeBlanc KE, Muncie HL, LeBlanc LL. Hip fracture: diagnosis, treatment, and secondary prevention. Am Fam Physician. 2014;89(12):945-951. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25162161"},{"issue":"11","key":"7241_CR25","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.3899\/jrheum.190675","volume":"47","author":"M Ognjenovic","year":"2020","unstructured":"Ognjenovic M, Raymond WD, Inderjeeth CA, Keen HI, Preen DB, Nossent JC. The Risk and Consequences of Vertebral Fracture in Patients with Ankylosing Spondylitis: A Population-based Data Linkage Study. J Rheumatol. 2020;47(11):1629-1636. https:\/\/doi.org\/10.3899\/jrheum.190675","journal-title":"J Rheumatol."},{"key":"7241_CR26","unstructured":"Mewes KB, Longo B, Campos APB, Simioni J, Skare TL. Balance and falls in axial Spondyloarthritis: a cross sectional study. Acta Reumatol Port. 44(4):248-253. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32281612"},{"issue":"2","key":"7241_CR27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/RHU.0000000000000216","volume":"21","author":"N Dursun","year":"2015","unstructured":"Dursun N, Sarkaya S, Ozdolap S, et al. Risk of falls in patients with ankylosing spondylitis. J Clin Rheumatol. 2015;21(2):76-80. https:\/\/doi.org\/10.1097\/RHU.0000000000000216","journal-title":"J Clin Rheumatol."},{"issue":"5","key":"7241_CR28","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/rheumatology\/39.5.497","volume":"39","author":"HC Murray","year":"2000","unstructured":"Murray HC, Elliott C, Barton SE, Murray A. Do patients with ankylosing spondylitis have poorer balance than normal subjects? Rheumatology. 2000;39(5):497-500. https:\/\/doi.org\/10.1093\/rheumatology\/39.5.497","journal-title":"Rheumatology."},{"issue":"6","key":"7241_CR29","doi-asserted-by":"publisher","first-page":"R179","DOI":"10.1186\/ar4368","volume":"15","author":"E Klingberg","year":"2013","unstructured":"Klingberg E, Lorentzon M, G\u00f6thlin J, et al. Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes. Arthritis Res Ther. 2013;15(6):R179. https:\/\/doi.org\/10.1186\/ar4368","journal-title":"Arthritis Res Ther."},{"key":"7241_CR30","unstructured":"Jun J-B, Joo K-B, Her M-Y, et al. Femoral bone mineral density is associated with vertebral fractures in patients with ankylosing spondylitis: a cross-sectional study. J Rheumatol. 2006;33(8):1637-1641. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16881119"},{"issue":"10","key":"7241_CR31","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.3899\/jrheum.120316","volume":"39","author":"E Klingberg","year":"2012","unstructured":"Klingberg E, Geijer M, G\u00f6thlin J, et al. Vertebral fractures in ankylosing spondylitis are associated with lower bone mineral density in both central and peripheral skeleton. J Rheumatol. 2012;39(10):1987-1995. https:\/\/doi.org\/10.3899\/jrheum.120316","journal-title":"J Rheumatol."},{"issue":"11","key":"7241_CR32","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s10067-012-2018-0","volume":"31","author":"MAC van der Weijden","year":"2012","unstructured":"van der Weijden MAC, Claushuis TAM, Nazari T, Lems WF, Dijkmans BAC, van der Horst-Bruinsma IE. High prevalence of low bone mineral density in patients within 10 years of onset of ankylosing spondylitis: a systematic review. Clin Rheumatol. 2012;31(11):1529-1535. https:\/\/doi.org\/10.1007\/s10067-012-2018-0","journal-title":"Clin Rheumatol."},{"key":"7241_CR33","doi-asserted-by":"crossref","unstructured":"Gowen M, Mundy GR. Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. J Immunol. 1986;136(7):2478-2482. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3081643","DOI":"10.4049\/jimmunol.136.7.2478"},{"issue":"7","key":"7241_CR34","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","volume":"275","author":"Y Azuma","year":"2000","unstructured":"Azuma Y, Kaji K, Katogi R, Takeshita S, Kudo A. Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclasts. J Biol Chem. 2000;275(7):4858-4864. https:\/\/doi.org\/10.1074\/jbc.275.7.4858","journal-title":"J Biol Chem."},{"issue":"10","key":"7241_CR35","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1002\/art.23901","volume":"58","author":"D Van Der Heijde","year":"2008","unstructured":"Van Der Heijde D, Landew\u00e9 R, Baraliakos X, et al. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Arthritis Rheum. 2008;58(10):3063-3070. https:\/\/doi.org\/10.1002\/art.23901","journal-title":"Arthritis Rheum."},{"issue":"5","key":"7241_CR36","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1002\/art.23471","volume":"58","author":"D Van Der Heijde","year":"2008","unstructured":"Van Der Heijde D, Landew\u00e9 R, Einstein S, et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum. 2008;58(5):1324-1331. https:\/\/doi.org\/10.1002\/art.23471","journal-title":"Arthritis Rheum."},{"issue":"4","key":"7241_CR37","doi-asserted-by":"publisher","first-page":"R127","DOI":"10.1186\/ar2794","volume":"11","author":"D Van der Heijde","year":"2009","unstructured":"Van der Heijde D, Salonen D, Weissman BN, et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther. 2009;11(4):R127. https:\/\/doi.org\/10.1186\/ar2794","journal-title":"Arthritis Res Ther."},{"issue":"7","key":"7241_CR38","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrrheum.2010.79","volume":"6","author":"LS Tam","year":"2010","unstructured":"Tam LS, Gu J, Yu D. Pathogenesis of ankylosing spondylitis. Nat Rev Rheumatol. 2010;6(7):399-405. https:\/\/doi.org\/10.1038\/nrrheum.2010.79","journal-title":"Nat Rev Rheumatol."}],"container-title":["Journal of General Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-021-07241-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11606-021-07241-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11606-021-07241-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:04:43Z","timestamp":1681171483000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11606-021-07241-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":38,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["7241"],"URL":"https:\/\/doi.org\/10.1007\/s11606-021-07241-2","relation":{},"ISSN":["0884-8734","1525-1497"],"issn-type":[{"value":"0884-8734","type":"print"},{"value":"1525-1497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]},"assertion":[{"value":"19 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of the Clalit Health Services approved this study and waived the requirement for written informed consent based on the strict maintenance of participants\u2019 anonymity.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval Information"}},{"value":"The authors report no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"There has been no patient and public involvement in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient and Public Involvement"}},{"value":"The current manuscript was based on a database with limited access. Summaries and aggregated data may be made available upon request; requests should be directed to avishaitsur@gmail.com.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}