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However, little is known about the frequency or determinants of gut feelings or the diagnostic value of gut feelings for cancer and other serious diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of gut feelings in general practice, examine their determinants and impact on patient management, and measure their diagnostic value for cancer and other serious diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This prospective observational study was performed using the Gut Feelings Questionnaire (GFQ).<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Participants included 155 GPs and 1487 of their patients, from four Spanish provinces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Measures<\/jats:title><jats:p>Sociodemographic data from patients and GPs; the reasoning style of GPs; the characteristics of the consultation; the presence and kind of gut feeling; the patient\u2019s subsequent contacts with the health system; and new cancer and serious disease diagnoses reported at 2 and 6 months post-consultation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>GPs experienced a gut feeling during 97% of the consultations: a sense of reassurance in 75% of consultations and a sense of alarm in 22% of consultations. A sense of alarm was felt at higher frequency given an older patient, the presence of at least one cancer-associated symptom, or a non-urban setting. GPs took diagnostic action more frequently after a sense of alarm. After 2 months, the sense of alarm had a sensitivity of 59% for cancer and other serious diseases (95% CI 47\u201371), a specificity of 79% (95% CI 77\u201382), a positive predictive value of 12% (95% CI 9\u201316), and a negative predictive value of 98% (95% CI 86\u201398).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gut feelings are consistently present in primary care medicine, and they play a substantial role in a GP\u2019s clinical reasoning and timely diagnosis of serious disease. The sense of alarm must be taken seriously and used to support diagnostic evaluation in patients with a new reason for encounter.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11606-021-07352-w","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T18:02:52Z","timestamp":1643306572000},"page":"3823-3831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prospective Observational Study on the Prevalence and Diagnostic Value of General Practitioners\u2019 Gut Feelings for Cancer and Serious Diseases"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7861-1168","authenticated-orcid":false,"given":"Bernardino","family":"Oliva-Fanlo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e0","family":"March","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gadea-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stolper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Esteva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the CORap group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"7352_CR1","volume-title":"Oxford Textbook of Primary Medical Care","author":"G Dinant","year":"2004","unstructured":"Dinant G. 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