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The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of GI cancers were calculated by Cox regression. The CAUSALMED procedure was used to perform the mediation analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During a median follow-up of 5.61 (5.18\u2009~\u20096.08) years, 369 incident GI cancer cases were identified. Participants who consumed 1\u20132 times breakfasts per week exhibited an increased risk of stomach (HR\u2009=\u20093.45, 95% CI: 1.06\u201311.20) and liver cancer (HR\u2009=\u20093.42, 95% CI: 1.22\u20139.53). Participants who did not eat breakfast had an elevated risk of esophageal (HR\u2009=\u20092.72, 95% CI: 1.05\u20137.03), colorectal (HR\u2009=\u20092.32, 95% CI: 1.34\u20134.01), liver (HR\u2009=\u20092.41, 95% CI: 1.23\u20134.71), gallbladder, and extrahepatic bile duct cancer (HR\u2009=\u20095.43, 95% CI: 1.34\u201321.93). In the mediation effect analyses, BMI, CRP, and TyG (fasting triglyceride-glucose) index did not mediate the association between breakfast frequency and the risk of GI cancer incidence (all <jats:italic>P<\/jats:italic> for mediation effect\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Habitually skipping breakfast was associated with a greater risk of GI cancers including esophageal, gastric, colorectal, liver, gallbladder, and extrahepatic bile duct cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>Kailuan study, ChiCTR\u2013TNRC\u201311001489. Registered 24 August, 2011-Retrospectively registered, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.chictr.org.cn\/showprojen.aspx?proj=8050\">http:\/\/www.chictr.org.cn\/showprojen.aspx?proj=8050<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11606-023-08094-7","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T21:10:36Z","timestamp":1677877836000},"page":"2527-2536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Habitually Skipping Breakfast Is Associated with the Risk of Gastrointestinal Cancers: Evidence from the Kailuan Cohort Study"],"prefix":"10.1007","volume":"38","author":[{"given":"Tong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4514-8693","authenticated-orcid":false,"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"3","key":"8094_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H., J. 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