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We tested how providing older women with the rationale for breast screening cessation impacted informed choice (adequate knowledge; screening attitudes aligned with intention).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a three-arm online randomized trial, eligible participants were females aged 70\u201374\u00a0years who had recently participated in breast screening (within 5\u00a0years), without personal breast cancer history, recruited through Qualtrics. Participants read a hypothetical scenario in which they received a BreastScreen letter reporting no abnormalities on their mammogram. They were randomized to receive the letter: (1) without any rationale for screening cessation (control); (2) with screening cessation rationale in printed-text form (e.g., downsides of screening outweigh the benefits after age 74); or (3) with screening cessation rationale presented in an animation video form. The primary outcome was informed choice about continuing\/stopping breast screening beyond 74\u00a0years.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 376 participant responses were analyzed. Compared to controls (<jats:italic>n<\/jats:italic>\u2009=\u2009122), intervention arm participants (text [<jats:italic>n<\/jats:italic>\u2009=\u2009132] or animation [<jats:italic>n<\/jats:italic>\u2009=\u2009122]) were more likely to make an informed choice (control 18.0%; text 32.6%, <jats:italic>p<\/jats:italic>\u2009=\u2009.010; animation 40.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Intervention arm participants had more adequate knowledge (control 23.8%; text 59.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; animation 68.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), lower screening intentions (control 17.2%; text 36.4%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; animation 49.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and fewer positive screening attitudes regarding screening for themselves in the animation arm, but not in the text arm (control 65.6%; text 51.5%, <jats:italic>p<\/jats:italic>\u2009=\u2009.023; animation 40.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Providing information to older women about the rationale for breast cancer screening cessation increased informed decision-making in a hypothetical scenario. This study is an important first step in improving messaging provided by national cancer screening providers direct to older adults. Further research is needed to assess the impact of different elements of the intervention and the impact of providing this information in clinical practice, with more diverse samples.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>ANZCTRN12623000033640.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11606-024-08656-3","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T17:02:12Z","timestamp":1708966932000},"page":"1332-1341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized Trial of Information for Older Women About Cessation of Breast Cancer Screening Invitations"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-8125","authenticated-orcid":false,"given":"Jenna","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Cvejic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehmat","family":"Houssami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara A.","family":"Schonberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasi","family":"Naganathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael H.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Wallis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten J.","family":"McCaffery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"13","key":"8656_CR1","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1001\/jama.2014.2834","volume":"311","author":"LC Walter","year":"2014","unstructured":"Walter LC, Schonberg MA. 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